Cardinals vs. Brewers
Prediction, Odds & Props
Sep 13 | MLB AI Picks
Updated: 2025-09-11T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Milwaukee Brewers arrive in this game riding high after an 8-2 win over the St. Louis Cardinals in the opener of their three-game series, snapping a three-game losing skid and further cementing their position atop the NL Central with 90 wins. In contrast, the Cardinals have now dropped four in a row, including mounting deficits in recent games and injury issues that have chipped away at their depth and ability to compete down the stretch.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Sep 13, 2025
Start Time: 8:15 PM EST
Venue: American Family Field
Brewers Record: (90-58)
Cardinals Record: (72-76)
OPENING ODDS
STL Moneyline: +141
MIL Moneyline: -168
STL Spread: +1.5
MIL Spread: -1.5
Over/Under: 7.5
STL
Betting Trends
- The Cardinals have been underdogs frequently in recent games, especially in matchups where the opponent is favored and playing at home; their ATS performance has suffered in those spots as their pitching and offense have both shown signs of strain under pressure.
MIL
Betting Trends
- Milwaukee has had stronger ATS outcomes lately, particularly at home, benefitting from both their depth and ability to win games more comfortably — when favored, they’ve often covered run-lines and shut down opponents in critical innings.
MATCHUP TRENDS
- In the betting lines for this game, Milwaukee is favored (moneyline around −166) with a −1.5 run line, and the over/under is set around 7.5 runs. Recent betting previews suggest that bettors are leaning toward the Brewers not just to win but to win by multiple runs. Also notable: Christian Yelich recently hit his 28th home run, and Quinn Priester extended his personal streak of winning decisions, showing both offense and pitching are trending in Milwaukee’s favor.
STL vs. MIL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: T. Saggese over 3.5 Fantasy Score.
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St. Louis vs Milwaukee Prediction & Odds:
Free MLB Betting Insights for 9/13/25
St. Louis, meanwhile, has been plagued by starting pitching that struggles to contain early damage, putting their bullpen in constant high-leverage situations, and their offense has been far too inconsistent, with Paul Goldschmidt and Nolan Arenado trying to carry a load that is too heavy without complementary pieces producing. Defensively, the Cardinals have also shown cracks, with costly errors adding to their woes, something they cannot afford against a Milwaukee lineup that thrives on capitalizing on mistakes. In terms of betting, the Brewers have been favored, and rightfully so, as their ability to cover the run line at home has made them a profitable team in this spot, while the Cardinals have been struggling ATS as underdogs, reflecting their on-field struggles. The over/under of 7.5 reflects the tension between Milwaukee’s pitching stability and the potential for their bats to open up another game, especially against a Cardinals team that has given up crooked innings far too often lately. For Milwaukee, the formula for success is straightforward: lean on their home field advantage, get another solid outing from their starter to preserve the bullpen, and let their lineup pressure St. Louis from the start to force them into mistakes. For St. Louis, the path is much narrower and requires a clean defensive performance, early production from the middle of the order, and a starter who can deliver at least six innings to minimize strain on their pen; without that, they risk another lopsided result. This game represents two teams heading in opposite directions — Milwaukee aiming to fine-tune ahead of the postseason and St. Louis trying to salvage pride and prevent an already difficult season from slipping further away — and unless the Cardinals summon a near-perfect performance, all signs point toward the Brewers taking control once again.
Donnie's back! pic.twitter.com/rN5mngKc8d
— St. Louis Cardinals (@Cardinals) September 12, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter their September 13, 2025 clash with the Milwaukee Brewers desperate to turn things around after dropping four straight games, including an 8-2 defeat in the series opener that underscored the problems plaguing their roster. This season has been defined by inconsistency for St. Louis, with flashes of competitive baseball undone by long stretches of underperformance, injuries, and a lack of depth that have left veterans like Paul Goldschmidt and Nolan Arenado carrying too much of the burden. Goldschmidt remains a professional hitter capable of sparking the offense, and Arenado’s defensive brilliance at third base continues to shine, but when those two are not producing at peak levels, the lineup looks vulnerable and often struggles to create sustained rallies. Young players have been asked to step up, but the results have been uneven, and the lack of consistent contact hitting has left the team overly reliant on solo home runs and sporadic bursts rather than steady production. On the mound, the rotation has been one of the team’s biggest weaknesses, with starters frequently failing to work deep into games, forcing the bullpen to shoulder too many innings.
That overuse has exposed flaws in the relief corps, leading to blown leads and late-inning collapses that frustrate both players and fans. Friday’s game was yet another example, as the Cardinals’ pitchers fell behind early and the offense was unable to claw back, a pattern that has repeated itself too often in recent weeks. Defensively, the Cardinals pride themselves on being sharp, but even that has slipped in recent games, with costly errors extending innings and allowing opponents like the Brewers to pile on. Managerial decisions have also come under scrutiny, as fans and analysts alike wonder whether changes to the rotation, bullpen usage, or lineup construction could spark better results, though the options remain limited given the roster’s current makeup. From a psychological standpoint, this team knows it is running out of time to salvage the season, and games against division-leading Milwaukee offer both a daunting challenge and an opportunity to prove they can still compete with the best. To have any chance at pulling off the upset, the Cardinals will need their starter to deliver one of his best outings of the year, keeping Milwaukee’s bats quiet long enough to allow Goldschmidt, Arenado, and perhaps one or two unlikely heroes to scratch across runs early. Avoiding defensive lapses and playing a clean, mistake-free game will be essential, as the Brewers thrive on capitalizing when teams give them extra outs. If the Cardinals can finally get a cohesive performance from pitching, defense, and offense in the same game, they could snap their skid and gain a small measure of redemption, but given recent form, the margin for error is razor thin. For St. Louis, this game is not just about standings but about pride and proving to themselves and their fans that they still have fight left, even in a season that has been filled with frustration.

Credit: USA TODAY/IMAGN
Milwaukee Brewers MLB Preview
The Milwaukee Brewers approach their September 13, 2025 matchup with the St. Louis Cardinals in a strong position, not just within the series but also in the broader NL Central race, after securing a dominant 8-2 win in the opener that reminded everyone why they’ve been the class of the division all year. With 90 wins already in the bank, Milwaukee has managed to blend steady pitching with timely hitting, and Friday’s victory reflected that balance perfectly: Quinn Priester delivered a composed outing that kept the Cardinals at bay while the offense, fueled by Christian Yelich’s 28th home run and supported by young star Jackson Chourio and consistent contributor William Contreras, kept the scoreboard active. The Brewers’ offensive formula has been consistent all season — mix disciplined at-bats with opportunistic power — and when Yelich is locked in, this lineup can put pressure on opponents quickly, forcing mistakes and creating big innings. Chourio’s emergence has been a storyline in itself, with his athleticism and energy injecting freshness into a team already rich in playoff experience, and his production has helped take some of the weight off veterans. The pitching staff has been a strength, with Priester joining a rotation that has consistently eaten innings and given the bullpen manageable workloads, while the relief corps, when not stretched thin, has shown itself capable of closing down games in the later innings with efficiency and composure.
Defensively, Milwaukee continues to be one of the most fundamentally sound teams in the league, making few errors and playing the kind of crisp baseball that prevents opponents from extending innings or manufacturing easy runs. Manager Pat Murphy has also pressed the right buttons, keeping his team motivated and engaged even through brief dips in form, such as the three-game losing streak before this series began, and Friday’s rebound performance showed the group’s resilience. From a betting perspective, Milwaukee has been reliable at home, not only winning games but frequently covering the run line when favored, a reflection of their ability to win by multiple runs and avoid the one-run nail-biters that can trip up bettors. Looking ahead to this matchup, the Brewers’ path to victory is clear: get another steady performance from the starter to keep the bullpen fresh, let their lineup generate early traffic on the bases, and force St. Louis’ shaky pitching staff into high-leverage situations where mistakes are inevitable. With home-field advantage and a deep roster clicking again, Milwaukee is in prime position to both secure another series win and move one step closer to clinching the division, leaving their rivals with little room to counterpunch. For the Brewers, this is not just about winning one game but about sustaining momentum, sharpening their edge, and continuing to prove that they are one of the National League’s most complete and dangerous teams heading into October.
Win column doing some HEAVY lifting pic.twitter.com/HybwtPw8Xm
— Milwaukee Brewers (@Brewers) September 13, 2025
St. Louis vs. Milwaukee Prop Picks (AI)
St. Louis vs. Milwaukee Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Cardinals and Brewers and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the trending emphasis emotional bettors regularly put on coaching factors between a Cardinals team going up against a possibly healthy Brewers team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Milwaukee picks, computer picks Cardinals vs Brewers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | SD@CHC | UNLOCK THIS PICK | 4 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 3 |
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MLB | 10/1 | CIN@LAD | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 2 |
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MLB | 10/1 | DET@CLE | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 1 |
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MLB | 10/1 | CIN@LAD | GET FREE PICK NOW | 1 | – | |
MLB | 10/1 | BOS@NYY | UNLOCK THIS PICK | 0 |
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MLB | 10/1 | BOS@NYY | GET FREE PICK NOW | 0 | – |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals have been underdogs frequently in recent games, especially in matchups where the opponent is favored and playing at home; their ATS performance has suffered in those spots as their pitching and offense have both shown signs of strain under pressure.
Brewers Betting Trends
Milwaukee has had stronger ATS outcomes lately, particularly at home, benefitting from both their depth and ability to win games more comfortably — when favored, they’ve often covered run-lines and shut down opponents in critical innings.
Cardinals vs. Brewers Matchup Trends
In the betting lines for this game, Milwaukee is favored (moneyline around −166) with a −1.5 run line, and the over/under is set around 7.5 runs. Recent betting previews suggest that bettors are leaning toward the Brewers not just to win but to win by multiple runs. Also notable: Christian Yelich recently hit his 28th home run, and Quinn Priester extended his personal streak of winning decisions, showing both offense and pitching are trending in Milwaukee’s favor.
St. Louis vs. Milwaukee Game Info
What time does St. Louis vs Milwaukee start on September 13, 2025?
St. Louis vs Milwaukee starts on September 13, 2025 at 8:15 PM EST.
Where is St. Louis vs Milwaukee being played?
Venue: American Family Field.
What are the opening odds for St. Louis vs Milwaukee?
Spread: Milwaukee -1.5
Moneyline: St. Louis +141, Milwaukee -168
Over/Under: 7.5
What are the records for St. Louis vs Milwaukee?
St. Louis: (72-76) | Milwaukee: (90-58)
What is the AI best bet for St. Louis vs Milwaukee?
Remi's searched hard and found the best prop for this matchup: T. Saggese over 3.5 Fantasy Score.. Prices move—always shop for the best number.
What are St. Louis vs Milwaukee trending bets?
In the betting lines for this game, Milwaukee is favored (moneyline around −166) with a −1.5 run line, and the over/under is set around 7.5 runs. Recent betting previews suggest that bettors are leaning toward the Brewers not just to win but to win by multiple runs. Also notable: Christian Yelich recently hit his 28th home run, and Quinn Priester extended his personal streak of winning decisions, showing both offense and pitching are trending in Milwaukee’s favor.
What are St. Louis trending bets?
STL trend: The Cardinals have been underdogs frequently in recent games, especially in matchups where the opponent is favored and playing at home; their ATS performance has suffered in those spots as their pitching and offense have both shown signs of strain under pressure.
What are Milwaukee trending bets?
MIL trend: Milwaukee has had stronger ATS outcomes lately, particularly at home, benefitting from both their depth and ability to win games more comfortably — when favored, they’ve often covered run-lines and shut down opponents in critical innings.
Where can I find AI Picks for St. Louis vs Milwaukee?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Milwaukee Odds
Remi is pouring through loads of data on each player. In fact, anytime the St. Louis vs Milwaukee trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.
St. Louis vs Milwaukee Opening Odds
STL Moneyline:
+141 MIL Moneyline: -168
STL Spread: +1.5
MIL Spread: -1.5
Over/Under: 7.5
St. Louis vs Milwaukee Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
|
–
–
|
+100
-120
|
-1.5 (+175)
+1.5 (-215)
|
O 7 (-105)
U 7 (-115)
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Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
|
–
–
|
+100
-118
|
-1.5 (+172)
+1.5 (-210)
|
O 7.5 (-110)
U 7.5 (-110)
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Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
|
–
–
|
+136
-162
|
+1.5 (-160)
-1.5 (+130)
|
O 7.5 (-120)
U 7.5 (-102)
|
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Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
|
–
–
|
+110
-130
|
pk
pk
|
|
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Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
|
–
–
|
+108
-126
|
pk
pk
|
O 7 (-135)
U 7 (+115)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Milwaukee Brewers on September 13, 2025 at American Family Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |