Cardinals vs. Brewers
Prediction, Odds & Props
Sep 13 | MLB AI Picks

Updated: 2025-09-11T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Milwaukee Brewers arrive in this game riding high after an 8-2 win over the St. Louis Cardinals in the opener of their three-game series, snapping a three-game losing skid and further cementing their position atop the NL Central with 90 wins. In contrast, the Cardinals have now dropped four in a row, including mounting deficits in recent games and injury issues that have chipped away at their depth and ability to compete down the stretch.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 13, 2025

Start Time: 8:15 PM EST​

Venue: American Family Field​

Brewers Record: (90-58)

Cardinals Record: (72-76)

OPENING ODDS

STL Moneyline: +141

MIL Moneyline: -168

STL Spread: +1.5

MIL Spread: -1.5

Over/Under: 7.5

STL
Betting Trends

  • The Cardinals have been underdogs frequently in recent games, especially in matchups where the opponent is favored and playing at home; their ATS performance has suffered in those spots as their pitching and offense have both shown signs of strain under pressure.

MIL
Betting Trends

  • Milwaukee has had stronger ATS outcomes lately, particularly at home, benefitting from both their depth and ability to win games more comfortably — when favored, they’ve often covered run-lines and shut down opponents in critical innings.

MATCHUP TRENDS

  • In the betting lines for this game, Milwaukee is favored (moneyline around −166) with a −1.5 run line, and the over/under is set around 7.5 runs. Recent betting previews suggest that bettors are leaning toward the Brewers not just to win but to win by multiple runs. Also notable: Christian Yelich recently hit his 28th home run, and Quinn Priester extended his personal streak of winning decisions, showing both offense and pitching are trending in Milwaukee’s favor.

STL vs. MIL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: T. Saggese over 3.5 Fantasy Score.

LIVE MLB ODDS

MLB ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
310-227
VAULT
NET UNITS
(INCL VIG)
+390.9
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$39,086
EXECUTIVE
VS. SPREAD
1564-1335
EXECUTIVE
NET UNITS
(INCL VIG)
+387.3
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$38,728

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

St. Louis vs Milwaukee Prediction & Odds:
Free MLB Betting Insights for 9/13/25

The September 13, 2025 matchup between the St. Louis Cardinals and the Milwaukee Brewers at American Family Field comes at a pivotal point in the season, with Milwaukee pushing toward playoff security and St. Louis desperately searching for answers to halt their downward slide. The Brewers, riding high with 90 wins after an emphatic 8-2 victory in the series opener, look like a team firing on all cylinders again after a brief three-game losing skid, while the Cardinals, who have now dropped four straight, are limping through a September stretch marred by inconsistency and injuries that have stripped their roster of stability. Milwaukee’s offense has found its rhythm again, powered by Christian Yelich’s leadership and timely blasts, like his 28th home run that helped seal Friday’s opener, while the supporting cast of Jackson Chourio and William Contreras keeps finding ways to drive in runs and sustain rallies. The Brewers’ pitching, highlighted by Quinn Priester’s ability to limit damage in his latest start, has been steady enough to support their offense, and their bullpen, when not overextended, remains one of the most dependable in the league at closing out games.

St. Louis, meanwhile, has been plagued by starting pitching that struggles to contain early damage, putting their bullpen in constant high-leverage situations, and their offense has been far too inconsistent, with Paul Goldschmidt and Nolan Arenado trying to carry a load that is too heavy without complementary pieces producing. Defensively, the Cardinals have also shown cracks, with costly errors adding to their woes, something they cannot afford against a Milwaukee lineup that thrives on capitalizing on mistakes. In terms of betting, the Brewers have been favored, and rightfully so, as their ability to cover the run line at home has made them a profitable team in this spot, while the Cardinals have been struggling ATS as underdogs, reflecting their on-field struggles. The over/under of 7.5 reflects the tension between Milwaukee’s pitching stability and the potential for their bats to open up another game, especially against a Cardinals team that has given up crooked innings far too often lately. For Milwaukee, the formula for success is straightforward: lean on their home field advantage, get another solid outing from their starter to preserve the bullpen, and let their lineup pressure St. Louis from the start to force them into mistakes. For St. Louis, the path is much narrower and requires a clean defensive performance, early production from the middle of the order, and a starter who can deliver at least six innings to minimize strain on their pen; without that, they risk another lopsided result. This game represents two teams heading in opposite directions — Milwaukee aiming to fine-tune ahead of the postseason and St. Louis trying to salvage pride and prevent an already difficult season from slipping further away — and unless the Cardinals summon a near-perfect performance, all signs point toward the Brewers taking control once again.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their September 13, 2025 clash with the Milwaukee Brewers desperate to turn things around after dropping four straight games, including an 8-2 defeat in the series opener that underscored the problems plaguing their roster. This season has been defined by inconsistency for St. Louis, with flashes of competitive baseball undone by long stretches of underperformance, injuries, and a lack of depth that have left veterans like Paul Goldschmidt and Nolan Arenado carrying too much of the burden. Goldschmidt remains a professional hitter capable of sparking the offense, and Arenado’s defensive brilliance at third base continues to shine, but when those two are not producing at peak levels, the lineup looks vulnerable and often struggles to create sustained rallies. Young players have been asked to step up, but the results have been uneven, and the lack of consistent contact hitting has left the team overly reliant on solo home runs and sporadic bursts rather than steady production. On the mound, the rotation has been one of the team’s biggest weaknesses, with starters frequently failing to work deep into games, forcing the bullpen to shoulder too many innings.

That overuse has exposed flaws in the relief corps, leading to blown leads and late-inning collapses that frustrate both players and fans. Friday’s game was yet another example, as the Cardinals’ pitchers fell behind early and the offense was unable to claw back, a pattern that has repeated itself too often in recent weeks. Defensively, the Cardinals pride themselves on being sharp, but even that has slipped in recent games, with costly errors extending innings and allowing opponents like the Brewers to pile on. Managerial decisions have also come under scrutiny, as fans and analysts alike wonder whether changes to the rotation, bullpen usage, or lineup construction could spark better results, though the options remain limited given the roster’s current makeup. From a psychological standpoint, this team knows it is running out of time to salvage the season, and games against division-leading Milwaukee offer both a daunting challenge and an opportunity to prove they can still compete with the best. To have any chance at pulling off the upset, the Cardinals will need their starter to deliver one of his best outings of the year, keeping Milwaukee’s bats quiet long enough to allow Goldschmidt, Arenado, and perhaps one or two unlikely heroes to scratch across runs early. Avoiding defensive lapses and playing a clean, mistake-free game will be essential, as the Brewers thrive on capitalizing when teams give them extra outs. If the Cardinals can finally get a cohesive performance from pitching, defense, and offense in the same game, they could snap their skid and gain a small measure of redemption, but given recent form, the margin for error is razor thin. For St. Louis, this game is not just about standings but about pride and proving to themselves and their fans that they still have fight left, even in a season that has been filled with frustration.

The Milwaukee Brewers arrive in this game riding high after an 8-2 win over the St. Louis Cardinals in the opener of their three-game series, snapping a three-game losing skid and further cementing their position atop the NL Central with 90 wins. In contrast, the Cardinals have now dropped four in a row, including mounting deficits in recent games and injury issues that have chipped away at their depth and ability to compete down the stretch. St. Louis vs Milwaukee AI Prediction: Free MLB Betting Insights for Sep 13. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Milwaukee Brewers MLB Preview

The Milwaukee Brewers approach their September 13, 2025 matchup with the St. Louis Cardinals in a strong position, not just within the series but also in the broader NL Central race, after securing a dominant 8-2 win in the opener that reminded everyone why they’ve been the class of the division all year. With 90 wins already in the bank, Milwaukee has managed to blend steady pitching with timely hitting, and Friday’s victory reflected that balance perfectly: Quinn Priester delivered a composed outing that kept the Cardinals at bay while the offense, fueled by Christian Yelich’s 28th home run and supported by young star Jackson Chourio and consistent contributor William Contreras, kept the scoreboard active. The Brewers’ offensive formula has been consistent all season — mix disciplined at-bats with opportunistic power — and when Yelich is locked in, this lineup can put pressure on opponents quickly, forcing mistakes and creating big innings. Chourio’s emergence has been a storyline in itself, with his athleticism and energy injecting freshness into a team already rich in playoff experience, and his production has helped take some of the weight off veterans. The pitching staff has been a strength, with Priester joining a rotation that has consistently eaten innings and given the bullpen manageable workloads, while the relief corps, when not stretched thin, has shown itself capable of closing down games in the later innings with efficiency and composure.

Defensively, Milwaukee continues to be one of the most fundamentally sound teams in the league, making few errors and playing the kind of crisp baseball that prevents opponents from extending innings or manufacturing easy runs. Manager Pat Murphy has also pressed the right buttons, keeping his team motivated and engaged even through brief dips in form, such as the three-game losing streak before this series began, and Friday’s rebound performance showed the group’s resilience. From a betting perspective, Milwaukee has been reliable at home, not only winning games but frequently covering the run line when favored, a reflection of their ability to win by multiple runs and avoid the one-run nail-biters that can trip up bettors. Looking ahead to this matchup, the Brewers’ path to victory is clear: get another steady performance from the starter to keep the bullpen fresh, let their lineup generate early traffic on the bases, and force St. Louis’ shaky pitching staff into high-leverage situations where mistakes are inevitable. With home-field advantage and a deep roster clicking again, Milwaukee is in prime position to both secure another series win and move one step closer to clinching the division, leaving their rivals with little room to counterpunch. For the Brewers, this is not just about winning one game but about sustaining momentum, sharpening their edge, and continuing to prove that they are one of the National League’s most complete and dangerous teams heading into October.

St. Louis vs. Milwaukee Prop Picks (AI)

Remi is pouring through mountains of data on each line. In fact, anytime the Cardinals and Brewers play there’s always several intriguing observations to key in on. Not to mention games played at American Family Field in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: T. Saggese over 3.5 Fantasy Score.

St. Louis vs. Milwaukee Prediction (AI)

Remi Robot Icon

Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Cardinals and Brewers and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the trending emphasis emotional bettors regularly put on coaching factors between a Cardinals team going up against a possibly healthy Brewers team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Milwaukee picks, computer picks Cardinals vs Brewers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 10/1 SD@CHC UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
MLB 10/1 CIN@LAD UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/1 DET@CLE UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 BOS@NYY UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 10/1 CIN@LAD GET FREE PICK NOW 1
MLB 10/1 BOS@NYY UNLOCK THIS PICK 0 INTEL Locked INTEL
MLB 10/1 BOS@NYY GET FREE PICK NOW 0

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have been underdogs frequently in recent games, especially in matchups where the opponent is favored and playing at home; their ATS performance has suffered in those spots as their pitching and offense have both shown signs of strain under pressure.

Brewers Betting Trends

Milwaukee has had stronger ATS outcomes lately, particularly at home, benefitting from both their depth and ability to win games more comfortably — when favored, they’ve often covered run-lines and shut down opponents in critical innings.

Cardinals vs. Brewers Matchup Trends

In the betting lines for this game, Milwaukee is favored (moneyline around −166) with a −1.5 run line, and the over/under is set around 7.5 runs. Recent betting previews suggest that bettors are leaning toward the Brewers not just to win but to win by multiple runs. Also notable: Christian Yelich recently hit his 28th home run, and Quinn Priester extended his personal streak of winning decisions, showing both offense and pitching are trending in Milwaukee’s favor.

St. Louis vs. Milwaukee Game Info

St. Louis vs Milwaukee starts on September 13, 2025 at 8:15 PM EST.

Venue: American Family Field.

Spread: Milwaukee -1.5
Moneyline: St. Louis +141, Milwaukee -168
Over/Under: 7.5

St. Louis: (72-76)  |  Milwaukee: (90-58)

Remi's searched hard and found the best prop for this matchup: T. Saggese over 3.5 Fantasy Score.. Prices move—always shop for the best number.

In the betting lines for this game, Milwaukee is favored (moneyline around −166) with a −1.5 run line, and the over/under is set around 7.5 runs. Recent betting previews suggest that bettors are leaning toward the Brewers not just to win but to win by multiple runs. Also notable: Christian Yelich recently hit his 28th home run, and Quinn Priester extended his personal streak of winning decisions, showing both offense and pitching are trending in Milwaukee’s favor.

STL trend: The Cardinals have been underdogs frequently in recent games, especially in matchups where the opponent is favored and playing at home; their ATS performance has suffered in those spots as their pitching and offense have both shown signs of strain under pressure.

MIL trend: Milwaukee has had stronger ATS outcomes lately, particularly at home, benefitting from both their depth and ability to win games more comfortably — when favored, they’ve often covered run-lines and shut down opponents in critical innings.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Milwaukee Odds

Remi is pouring through loads of data on each player. In fact, anytime the St. Louis vs Milwaukee trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.

St. Louis vs Milwaukee Opening Odds

STL Moneyline: +141
MIL Moneyline: -168
STL Spread: +1.5
MIL Spread: -1.5
Over/Under: 7.5

St. Louis vs Milwaukee Live Odds

Games PTS ML SPR O/U
Oct 2, 2025 3:08PM EDT
Detroit Tigers
Cleveland Guardians
10/2/25 3:08PM
Tigers
Guardians
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-105)
U 7 (-115)
Oct 2, 2025 5:08PM EDT
San Diego Padres
Chicago Cubs
10/2/25 5:08PM
Padres
Cubs
+100
-118
-1.5 (+172)
+1.5 (-210)
O 7.5 (-110)
U 7.5 (-110)
Oct 2, 2025 8:08PM EDT
Boston Red Sox
New York Yankees
10/2/25 8:08PM
Red Sox
Yankees
+136
-162
+1.5 (-160)
-1.5 (+130)
O 7.5 (-120)
U 7.5 (-102)
Oct 4, 2025 2:30PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 2:30PM
Dodgers
Phillies
+110
-130
pk
pk
Oct 4, 2025 5:09PM EDT
Los Angeles Dodgers
Philadelphia Phillies
10/4/25 5:09PM
Dodgers
Phillies
+108
-126
pk
pk
O 7 (-135)
U 7 (+115)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Milwaukee Brewers on September 13, 2025 at American Family Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS