Rays vs. Guardians
Prediction, Odds & Props
Aug 25 | MLB AI Picks

Updated: 2025-08-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Tampa Bay Rays visit Progressive Field on August 25, 2025, facing off against the Cleveland Guardians in a pivotal interleague matchup. Both teams hover around .500, making this game a potential momentum-changer in their push toward playoff positioning.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Aug 25, 2025

Start Time: 6:40 PM EST​

Venue: Progressive Field​

Guardians Record: (64-65)

Rays Record: (63-67)

OPENING ODDS

TB Moneyline: +128

CLE Moneyline: -153

TB Spread: +1.5

CLE Spread: -1.5

Over/Under: 8

TB
Betting Trends

  • Favored at −143 moneyline and −1.5 on the run line, with a 58.8% implied win probability.

CLE
Betting Trends

  • Favored at −143 moneyline and −1.5 on the run line, with a 58.8% implied win probability.

MATCHUP TRENDS

  • Guardians have been strong when favored, winning 60% of such matchups—while the Rays win underdog games about 39% of the time—a substantial edge for Cleveland in similar roles.

TB vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Lowe over 5.5 Fantasy Score.

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Tampa Bay vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 8/25/25

The Tampa Bay Rays and Cleveland Guardians face off on Monday, August 25, 2025, at Progressive Field in what promises to be a tightly contested matchup between two American League teams hovering just below .500 and jockeying for momentum in the final stretch of the season. The Guardians, entering at 64–65, are slight home favorites with a moneyline hovering around –143 and a run line of –1.5, while the Rays, at 63–67, are available to bettors at +121, signaling how closely matched these teams are on paper and in recent form. Cleveland will hand the ball to right-hander Tanner Bibee, who has posted a 9–9 record with a 4.62 ERA and 129 strikeouts over 140+ innings this season, offering durability and occasional dominance but also a tendency to allow crooked innings when his command falters. Opposing him is Tampa Bay’s lefty Ian Seymour, a young arm making his second big-league start after showing promise in a recent win, where he held opponents to a modest three runs while demonstrating solid fastball command and deceptive movement on his off-speed pitches. The betting total is set at 8 runs, reflecting expectations of a modestly low-scoring contest shaped by mid-rotation starters and bullpens that have carried significant workloads. Offensively, both teams are missing contributors—Tampa Bay is without key infielders Ha-Seong Kim and Taylor Walls, plus outfield depth in Jonny DeLuca and Jonathan Aranda, while Cleveland’s Paul Sewald and Lane Thomas are questionable, which could impact their late-inning leverage strategy and outfield coverage, respectively.

These injuries may push both managers—Stephen Vogt for Cleveland and Kevin Cash for Tampa Bay—into creative lineup adjustments, defensive shuffles, and earlier bullpen use. Tampa Bay has shown resilience all season, especially with a pitching staff stretched thin by the loss of Shane McClanahan and others, but their offense has also demonstrated a knack for scraping together runs through contact hitting, aggressive base running, and situational execution. Cleveland, meanwhile, relies more on disciplined at-bats, high-contact hitters, and timely power, especially from their middle infielders and corner bats who thrive in home splits. The Guardians have a slight edge in terms of familiarity and rest at home, but Tampa’s unpredictability, paired with a young pitcher few Guardians have seen, adds an element of volatility that could work in the Rays’ favor. Both teams know the postseason is slipping further away with each series loss, so urgency will be high, particularly in tight moments where bullpen matchups and fielding execution could decide the game. If Seymour can navigate the Cleveland lineup twice through without damage and Bibee avoids the long ball—a weakness in his recent outings—this could shape up to be a pitcher’s duel with late scoring, particularly if either bullpen cracks under pressure. With so much on the line and the margins this thin, the game likely comes down to one or two pivotal at-bats, and with both teams struggling for consistency, the matchup remains as wide open as the odds suggest, promising a tightly fought, strategic battle from first pitch to final out.

Tampa Bay Rays MLB Preview

The Tampa Bay Rays enter Monday’s matchup against the Cleveland Guardians as underdogs both in the standings and in the betting markets, sitting at 63–67 on the season and priced around +121 on the moneyline, yet they continue to embody the kind of gritty, strategic baseball that has made them a perennial threat even in years where injuries and roster turnover have challenged consistency. Tampa’s pitching staff has been particularly strained this year, with ace Shane McClanahan out for the season and others in and out of the rotation, which has opened the door for young arms like Ian Seymour, a 25-year-old lefty who will take the mound for just his second big-league start. Seymour impressed in his debut, showing poise and command over his three-pitch mix, including a fastball in the low 90s and a tight slider that induced weak contact, and the Guardians’ unfamiliarity with him could work in Tampa’s favor as they look to steal a road win with a pitcher who presents an unknown variable. The Rays are still down several regulars, with Ha-Seong Kim and Taylor Walls both listed day-to-day, while outfield depth has taken a hit with injuries to Jonny DeLuca and Jonathan Aranda, forcing manager Kevin Cash to shuffle his lineup card and rely more heavily on platoons, bench bats, and speed to manufacture offense.

That has become the Rays’ calling card—smart situational hitting, aggressive base running, and a bullpen that remains quietly effective, even if stretched at times due to short starts and close games. Tampa Bay’s ability to turn over its lineup with productive at-bats will be key, especially if they can force Tanner Bibee into high pitch counts early—Bibee, though durable, has been prone to allowing traffic on the bases and occasionally lets innings spiral when he loses fastball command. The Rays will likely look to test Cleveland’s defense with bunts, stolen base attempts, and hit-and-run plays, and if they can scratch out a couple of runs early, they’ll be able to lean on their bullpen in the later innings. Even with diminished firepower, Tampa has remained competitive in games expected to be low scoring, as evidenced by the tight betting total of 8 runs for this contest. What gives them an edge is unpredictability—where other teams live and die by the home run, the Rays thrive in chaos, creating offense through hustle, defense, and depth. That approach, combined with the element of surprise that Seymour brings, makes them a dangerous team to overlook. While Cleveland may have the slight advantage on paper with home-field support and a more seasoned starter, Tampa Bay’s ability to capitalize on opponent mistakes, grind out at-bats, and shorten the game with a savvy bullpen gives them a real chance to flip the script in a game that oddsmakers consider close. If Seymour can get through the Guardians’ lineup twice and hand over a lead or tie to the relievers, the Rays may be poised to snatch a critical late-August win and keep their postseason hopes flickering.

The Tampa Bay Rays visit Progressive Field on August 25, 2025, facing off against the Cleveland Guardians in a pivotal interleague matchup. Both teams hover around .500, making this game a potential momentum-changer in their push toward playoff positioning. Tampa Bay vs Cleveland AI Prediction: Free MLB Betting Insights for Aug 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians return home to Progressive Field on Monday, August 25, 2025, looking to regain their footing against a scrappy Tampa Bay Rays team that has historically thrived in tight, low-scoring matchups, but the Guardians will enter this game as slight favorites with a moneyline around –143 and a run line of –1.5, reflecting both home-field advantage and the steadiness of right-hander Tanner Bibee, who takes the mound with a 9–9 record, 4.62 ERA, and 129 strikeouts over the course of more than 140 innings this season. Bibee has been a pillar of durability for Cleveland’s rotation, even if his ERA doesn’t suggest dominance—he consistently delivers five or six innings of competitive baseball and has shown the ability to pitch out of jams with his rising fastball and biting slider, two pitches that could prove effective against a Tampa Bay lineup that lacks key contributors due to injuries. Cleveland, sitting just below .500 at 64–65, knows it must capitalize on winnable matchups at home if it hopes to keep pace in the AL Wild Card race, and this contest offers a prime opportunity to take advantage of a young, inexperienced Rays starter in Ian Seymour, a lefty making only his second big-league start and still adjusting to the pace and pressure of major league competition.

Offensively, the Guardians have dealt with their own issues, including injuries to Paul Sewald and Lane Thomas, both listed as questionable, which may impact their bullpen structure and outfield defense, but their everyday lineup remains largely intact and capable of stringing together quality at-bats against lesser-known arms. Manager Stephen Vogt will likely lean on his team’s situational hitting, putting runners in motion and applying pressure early to rattle Seymour and potentially chase him by the middle innings, which would expose Tampa Bay’s bullpen to heavier use after a long series. Bibee’s key to success will be avoiding walks and minimizing early pitch counts so he can bridge the game to Cleveland’s high-leverage arms, especially if Sewald is unavailable and the late innings fall on secondary relievers. The Guardians will need timely hitting from their middle-of-the-order bats—those who have succeeded in home splits all season—to jump-start the offense and prevent the Rays from playing the kind of grind-it-out baseball that keeps games close into the seventh and eighth innings. Even without significant power output, Cleveland thrives on exploiting small opportunities, drawing walks, moving runners, and staying within their approach, especially at home where they’ve played competitive baseball all year. If Bibee can avoid early damage and maintain a lead, and if the Guardians can make life difficult for Seymour with aggressive base running and disciplined at-bats, they are in a strong position to take the opener of this series and build momentum down the stretch. With so little margin for error in the standings and the postseason push intensifying, this game offers Cleveland a clear path to victory—control the tempo, win the middle innings, and let their veteran poise and home crowd energy guide them through the late stages of a winnable contest.

Tampa Bay vs. Cleveland Prop Picks (AI)

Remi is pouring through tons of data on each player. In fact, anytime the Rays and Guardians play there’s always several intriguing angles to key in on. Not to mention games played at Progressive Field in Aug almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Lowe over 5.5 Fantasy Score.

Tampa Bay vs. Cleveland Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Rays and Guardians and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the trending factor knucklehead sportsbettors often put on coaching factors between a Rays team going up against a possibly deflated Guardians team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line in particular.

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Below is our current AI Tampa Bay vs Cleveland picks, computer picks Rays vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Rays Betting Trends

Favored at −143 moneyline and −1.5 on the run line, with a 58.8% implied win probability.

Guardians Betting Trends

Favored at −143 moneyline and −1.5 on the run line, with a 58.8% implied win probability.

Rays vs. Guardians Matchup Trends

Guardians have been strong when favored, winning 60% of such matchups—while the Rays win underdog games about 39% of the time—a substantial edge for Cleveland in similar roles.

Tampa Bay vs. Cleveland Game Info

Tampa Bay vs Cleveland starts on August 25, 2025 at 6:40 PM EST.

Spread: Cleveland -1.5
Moneyline: Tampa Bay +128, Cleveland -153
Over/Under: 8

Tampa Bay: (63-67)  |  Cleveland: (64-65)

Remi's searched hard and found the best prop for this matchup: J. Lowe over 5.5 Fantasy Score.. Prices move—always shop for the best number.

Guardians have been strong when favored, winning 60% of such matchups—while the Rays win underdog games about 39% of the time—a substantial edge for Cleveland in similar roles.

TB trend: Favored at −143 moneyline and −1.5 on the run line, with a 58.8% implied win probability.

CLE trend: Favored at −143 moneyline and −1.5 on the run line, with a 58.8% implied win probability.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Tampa Bay vs. Cleveland Odds

Remi is pouring through loads of stats on each team. In fact, anytime the Tampa Bay vs Cleveland trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.

Tampa Bay vs Cleveland Opening Odds

TB Moneyline: +128
CLE Moneyline: -153
TB Spread: +1.5
CLE Spread: -1.5
Over/Under: 8

Tampa Bay vs Cleveland Live Odds

Games PTS ML SPR O/U
Sep 30, 2025 2:30PM EDT
Boston Red Sox
New York Yankees
9/30/25 2:30PM
Red Sox
Yankees
+107
-130
pk
pk
Sep 30, 2025 2:30PM EDT
Detroit Tigers
Cleveland Guardians
9/30/25 2:30PM
Tigers
Guardians
-164
+138
-1.5 (+112)
+1.5 (-134)
O 6.5 (-106)
U 6.5 (-114)
Sep 30, 2025 2:30PM EDT
San Diego Padres
Chicago Cubs
9/30/25 2:30PM
Padres
Cubs
+102
-120
pk
pk
Sep 30, 2025 6:09PM EDT
Boston Red Sox
New York Yankees
9/30/25 6:09PM
Red Sox
Yankees
+112
-132
+1.5 (-200)
-1.5 (+164)
O 7 (-115)
U 7 (-105)
Sep 30, 2025 9:08PM EDT
Cincinnati Reds
Los Angeles Dodgers
9/30/25 9:08PM
Reds
Dodgers
+142
-168
+1.5 (-166)
-1.5 (+138)
O 7.5 (+100)
U 7.5 (-122)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Tampa Bay Rays vs. Cleveland Guardians on August 25, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS