Cardinals vs. Rays
Prediction, Odds & Props
Aug 21 | MLB AI Picks
Updated: 2025-08-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals (57–58) head to Tampa Bay on August 21 to face the Rays, looking to climb above .500 and regain some mojo in the NL Central. The Rays (57–60), meanwhile, aim to stay in the AL East hunt while settling into their temporary Tampa home.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Aug 21, 2025
Start Time: 7:35 PM EST
Venue: George M. Steinbrenner Field
Rays Record: (61-66)
Cardinals Record: (63-65)
OPENING ODDS
STL Moneyline: -121
TB Moneyline: +101
STL Spread: -1.5
TB Spread: +1.5
Over/Under: 8.5
STL
Betting Trends
- The Cardinals are 2–8 in their last 10 road games, showing clear struggles away from home.
TB
Betting Trends
- Tampa Bay has gone 5–5 in their last 10 games at home—solid but unspectacular.
MATCHUP TRENDS
- Despite similar records, Rays offer significantly stronger pitching and offensive depth compared to the Cardinals, making this matchup more lopsided than standings alone suggest.
STL vs. TB
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Hits+Runs+RBI.
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St. Louis vs Tampa Bay Prediction & Odds:
Free MLB Betting Insights for 8/21/25
From a betting standpoint, this contest is shaping up as markedly tilted in Tampa Bay’s favor despite St. Louis entering on some momentum, especially given the quality of starters and the Rays’ comfort in their home venue—even if it’s not their usual park—and their depth across pitching and offense that rivals most clubs in either league. That said, the Cardinals boast a blend of postseason gravity and managerial savvy that can’t be discounted; these division games often come down to late-inning nerves, clutch execution, and how fatigue might creep into young arms, creating conditions where an otherwise superior Rays team could find itself vulnerable if the Cardinals strike early and energize their bullpen. Key matchup markers include how both pitching staffs navigate high-leverage innings and whether Tampa can avoid the lapses that occasionally surface under pressure, while St. Louis must lean on opportunistic baserunning and efficient innings to stay competitive. In essence, even if Tampa Bay enters with the better roster and recent form, the Cardinals still represent a dangerous out when backed into a corner—a dynamic late‑summer rerun of David vs. Goliath that reminds us every game matters and that legacy, hustle, and grit still write the best chapters in August baseball.
Willson Contreras got ALL of this baseball! pic.twitter.com/up5LleVYMH
— St. Louis Cardinals (@Cardinals) August 21, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter this August 21 road matchup against the Tampa Bay Rays clinging to playoff aspirations that have grown more tenuous by the week, sitting below .500 yet still within reach in a wide-open NL Central where no team has fully pulled away. With a 7–3 record over their last 10 games, the Cardinals have shown flashes of the consistency and veteran savvy that once made them perennial contenders, relying on a mix of youthful energy and the poise of long-time stars like Paul Goldschmidt and Nolan Arenado. Goldschmidt continues to provide professional at-bats, driving the ball with power to all fields, while Arenado remains one of the league’s premier defensive third basemen and a clutch run producer when the game tightens. Recent call-ups have also sparked the team, including dynamic infielder Masyn Winn and slugging catcher Pedro Pagés, each of whom has stepped into their roles with surprising maturity and production. On the mound, the Cardinals have shuffled through inconsistent starts, but Miles Mikolas and Lance Lynn have occasionally anchored the rotation with reliable innings, even as command lapses and high pitch counts have been a problem. The bullpen has been stretched thin, but Giovanny Gallegos and Ryan Helsley have delivered solid late-inning work when given a lead, though the lack of dependable middle relief remains a concern. St. Louis knows that keeping games close early is paramount, as their offensive production tends to pick up in the middle innings when opponents dip into less dominant relievers.
Manager Oliver Marmol has pushed all the buttons he can with limited flexibility, deploying platoons and pinch hitters at a high rate to gain edges, especially in left-right matchups where the Cardinals can take advantage of handedness splits. They’ll face a difficult challenge in Tampa’s strong pitching staff, but St. Louis will look to grind out at-bats, work walks, and find scoring opportunities through situational hitting and aggressive baserunning, areas where they’ve quietly improved as the season has progressed. Defensively, the Cardinals are above average with Gold Glove-caliber players around the infield and capable arms in the outfield, although occasional lapses in focus have led to costly errors. What will be key in this contest is whether St. Louis can get a quality start from their rotation and avoid overtaxing a bullpen that’s already carried a heavy load. If they fall behind early, it may be difficult to recover against a Tampa Bay team that capitalizes on mistakes and thrives with a lead. However, if the Cardinals can strike first and build momentum, they have the offensive firepower and leadership to pull off a road upset. With time running out on the season and every win taking on added meaning, the Cardinals will need to summon their postseason pedigree and take the game to Tampa Bay from the first pitch, treating this like a must-win if they hope to stay in the conversation for October. Every inning, every pitch, and every decision will matter—and St. Louis knows it.

Credit: USA TODAY/IMAGN
Tampa Bay Rays MLB Preview
The Tampa Bay Rays enter this August 21 home matchup against the St. Louis Cardinals as a team looking to solidify its postseason standing in the highly competitive American League, where margins are razor-thin and every game down the stretch carries playoff implications. After weathering injuries and slumps through the summer, the Rays have started to string together key wins behind a balanced mix of timely hitting, elite bullpen work, and strong home-field performances at Tropicana Field. Offensively, the Rays are paced by Yandy Díaz, who continues to hit over .300 with professional approaches at the plate, while Isaac Paredes leads the team in home runs and RBIs, offering a dependable middle-of-the-order bat. Outfielder Randy Arozarena remains a wildcard threat—capable of carrying the offense for stretches—but he’s also battled inconsistency, especially against right-handed pitching. Jose Caballero has brought speed and energy to the bottom of the lineup, while Jonathan Aranda has started seeing more at-bats and offers high-contact upside that plays well against weaker rotations like St. Louis’s. The Rays continue to use a committee approach to their rotation, especially with ongoing injuries, but they are expected to start Zack Littell or another bulk reliever depending on bullpen usage from the previous series. Littell has given them competitive innings, relying on pinpoint control and keeping the ball in the park, which is crucial in their pitcher-friendly home park.
The real strength of Tampa Bay lies in its bullpen, where Jason Adam, Pete Fairbanks, and Garrett Cleavinger have provided lockdown innings late in games, allowing the Rays to shorten contests and aggressively deploy matchups. Kevin Cash remains one of the league’s most analytically savvy managers, never afraid to use an opener, pinch-run early, or shift lineups to gain marginal edges that often become decisive late. Defensively, the Rays are elite, with run-saving plays from infielders like Taylor Walls and outfielders who cover ground efficiently with above-average arms. They rank near the top of the league in defensive metrics and consistently convert balls in play into outs, which gives their pitchers confidence to attack the strike zone early and often. Against the Cardinals, Tampa Bay will look to exploit weaknesses in the opposing bullpen and stay patient at the plate, knowing that walks and singles can quickly snowball into crooked innings. The Rays thrive when they keep pressure on their opponents and take the lead early, allowing their bullpen to protect slim advantages. With the postseason approaching, Tampa Bay knows it cannot afford to let beatable teams like St. Louis sneak away with wins, especially at home. The Rays have been particularly tough at Tropicana Field all season, using the turf to their advantage and producing significantly better run differentials in home games compared to road contests. With a top-tier bullpen, solid defensive fundamentals, and a lineup that can beat you through contact or power depending on the night, the Rays are in strong position to handle their business, especially if they strike early and get quality innings from their bullpen-led approach. Expect a sharp, focused effort from a team fully aware that the time to lock in is now.
Mini series finale 📺 pic.twitter.com/GRUIxYRHDE
— Tampa Bay Rays (@RaysBaseball) August 20, 2025
St. Louis vs. Tampa Bay Prop Picks (AI)
St. Louis vs. Tampa Bay Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Cardinals and Rays and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most keyed in on the growing emphasis emotional bettors often put on player performance factors between a Cardinals team going up against a possibly unhealthy Rays team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Tampa Bay picks, computer picks Cardinals vs Rays, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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ACTIVE PICKS LOCKED - SEE NOW |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals are 2–8 in their last 10 road games, showing clear struggles away from home.
Rays Betting Trends
Tampa Bay has gone 5–5 in their last 10 games at home—solid but unspectacular.
Cardinals vs. Rays Matchup Trends
Despite similar records, Rays offer significantly stronger pitching and offensive depth compared to the Cardinals, making this matchup more lopsided than standings alone suggest.
St. Louis vs. Tampa Bay Game Info
What time does St. Louis vs Tampa Bay start on August 21, 2025?
St. Louis vs Tampa Bay starts on August 21, 2025 at 7:35 PM EST.
Where is St. Louis vs Tampa Bay being played?
Venue: George M. Steinbrenner Field.
What are the opening odds for St. Louis vs Tampa Bay?
Spread: Tampa Bay +1.5
Moneyline: St. Louis -121, Tampa Bay +101
Over/Under: 8.5
What are the records for St. Louis vs Tampa Bay?
St. Louis: (63-65) | Tampa Bay: (61-66)
What is the AI best bet for St. Louis vs Tampa Bay?
Remi's searched hard and found the best prop for this matchup: P. Pages over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are St. Louis vs Tampa Bay trending bets?
Despite similar records, Rays offer significantly stronger pitching and offensive depth compared to the Cardinals, making this matchup more lopsided than standings alone suggest.
What are St. Louis trending bets?
STL trend: The Cardinals are 2–8 in their last 10 road games, showing clear struggles away from home.
What are Tampa Bay trending bets?
TB trend: Tampa Bay has gone 5–5 in their last 10 games at home—solid but unspectacular.
Where can I find AI Picks for St. Louis vs Tampa Bay?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Tampa Bay Odds
Remi is pouring through loads of data on each line. In fact, anytime the St. Louis vs Tampa Bay trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.
St. Louis vs Tampa Bay Opening Odds
STL Moneyline:
-121 TB Moneyline: +101
STL Spread: -1.5
TB Spread: +1.5
Over/Under: 8.5
St. Louis vs Tampa Bay Live Odds
Games | PTS | ML | SPR | O/U | |
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In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
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3
5
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-7000
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-3.5 (-450)
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O 10.5 (+145)
U 10.5 (-180)
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In Progress
Tampa Bay Rays
Toronto Blue Jays
In Progress
Rays
Blue Jays
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0
3
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+1200
-4000
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+4.5 (-150)
-4.5 (+120)
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O 7.5 (+120)
U 7.5 (-150)
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In Progress
Colorado Rockies
San Francisco Giants
In Progress
Rockies
Giants
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2
3
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+260
-350
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+2.5 (-145)
-2.5 (+115)
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O 10.5 (-150)
U 10.5 (+120)
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In Progress
New York Mets
Miami Marlins
In Progress
Mets
Marlins
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1
0
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-220
+175
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-1.5 (-125)
+1.5 (-105)
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O 7.5 (-110)
U 7.5 (-120)
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In Progress
Detroit Tigers
Boston Red Sox
In Progress
Tigers
Red Sox
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0
0
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+135
-170
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+1.5 (-150)
-1.5 (+120)
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O 7.5 (+100)
U 7.5 (-130)
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Sep 27, 2025 4:45PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:45PM
White Sox
Nationals
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–
–
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-110
-110
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+1.5 (-210)
-1.5 (+175)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
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+192
-235
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+1.5 (-110)
-1.5 (-110)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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–
–
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+115
-135
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+1.5 (-190)
-1.5 (+158)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
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–
–
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+150
-178
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+1.5 (-145)
-1.5 (+122)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
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–
–
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+126
-150
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+1.5 (-190)
-1.5 (+158)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
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–
–
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+130
-155
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+1.5 (-170)
-1.5 (+143)
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O 7.5 (-105)
U 7.5 (-115)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
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–
–
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-140
+118
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-1.5 (+115)
+1.5 (-135)
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O 9 (-110)
U 9 (-110)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
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–
–
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+100
-120
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+1.5 (-210)
-1.5 (+175)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
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–
–
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+100
-120
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+1.5 (-195)
-1.5 (+162)
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O 10 (-115)
U 10 (-105)
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Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
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–
–
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+144
-172
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+1.5 (-146)
-1.5 (+122)
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O 9 (-122)
U 9 (+100)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Tampa Bay Rays on August 21, 2025 at George M. Steinbrenner Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |