Yankees vs Cardinals Prediction — AI Finds CAN'T MISS MLB Lines & Props (Aug 16)

Updated: 2025-08-14T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The New York Yankees (approximately 64–57, holding onto a Wild Card spot) visit Busch Stadium to take on the St. Louis Cardinals (around 61–61, hovering at .500)—a tilt that showcases a fading powerhouse aiming to reassert control against a middling home squad.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Aug 16, 2025

Start Time: 7:15 PM EST​

Venue: Busch Stadium​

Cardinals Record: (61-62)

Yankees Record: (65-57)

OPENING ODDS

NYY Moneyline: -147

STL Moneyline: +123

NYY Spread: -1.5

STL Spread: +1.5

Over/Under: 8

NYY
Betting Trends

  • The Yankees have struggled to cover the spread, sitting at just 51–66 ATS, one of the lower percentages in MLB.

STL
Betting Trends

  • St. Louis has fared better on their home turf, going 22–18 against the run line—a positive indicator at Busch Stadium this season.

MATCHUP TRENDS

  • Despite the Yankees’ stronger record, their poor performance against the spread suggests potential value in backing the Cardinals at home, especially on the +1.5 run line. Given New York’s faltering form and St. Louis’ recent home success, bettors considering a cautious play might lean Cardinals +1.5 or explore total run props if the offenses awaken.

NYY vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: G. Stanton over 0.5 Total Bases.

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New York vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 8/16/25

The August 16, 2025 showdown between the New York Yankees and the St. Louis Cardinals at Busch Stadium sets up as a fascinating interleague clash between two historic franchises facing different trajectories and expectations. The Yankees, despite hovering above the .500 mark at around 64–57, are fighting for a Wild Card spot but are plagued by inconsistency, especially against the spread, where they’ve struggled to a 51–66 ATS mark this season. Meanwhile, the Cardinals, sitting at approximately 61–61, are aiming to keep their season alive and inject momentum into their late playoff push. At home, St. Louis has performed admirably, going 22–18 ATS at Busch Stadium and showcasing a balanced team effort with a strong bullpen and defense-first approach. This game becomes particularly important for both sides, as the Yankees aim to stop their recent backslide while the Cardinals look to take advantage of home-field comfort to turn a .500 record into a winning stretch that could lift them in a tightly contested National League. From a stylistic standpoint, this matchup pits the high-profile, power-heavy Yankees lineup, led by Aaron Judge and Juan Soto, against a scrappy, contact-oriented Cardinals team that thrives on small ball, smart base-running, and timely pitching. If recent trends hold, the Yankees will likely enter as favorites based on name value and record, but the Cardinals’ strong recent form at home and ability to win tight games could make them a sneaky value pick.

Much of the attention will be on how New York’s starting pitching can hold up against a disciplined Cardinals offense, and whether the Yankees’ bullpen, which has been unreliable of late, can close the door if given a lead in the late innings. On the other side, St. Louis has found success relying on quality relief work and home crowd energy, which could play a factor if the game stays close through the middle innings. With both teams facing pressure—New York to maintain playoff positioning and St. Louis to remain relevant—expect this to be a tightly contested, emotionally charged game. For bettors, the Yankees’ poor ATS performance suggests caution, particularly when facing a home team that has outperformed them in that regard, while the total runs market may also draw interest given the potential for both offenses to find opportunities. This is the kind of matchup that could swing either way depending on situational hitting, bullpen usage, and defensive execution, and it presents one of the more compelling games on the August 16 slate. Whether it’s the Yankees asserting their postseason intent or the Cardinals defending their turf with resilience, fans and bettors alike can expect a well-matched, competitive, and potentially pivotal late-summer contest in St. Louis.

New York Yankees MLB Preview

The New York Yankees enter this August 16 matchup against the St. Louis Cardinals carrying both the weight of tradition and the burden of unmet expectations in 2025. With a record hovering around 64–57, the Yankees find themselves in the thick of the American League Wild Card race but struggling to generate consistent momentum. Their biggest problem has been delivering value in betting markets, as their ATS record sits at a disappointing 51–66—indicative of a team that often wins, but not always convincingly. The Yankees still possess one of the league’s most dangerous lineups, anchored by stars like Aaron Judge, Juan Soto, and Giancarlo Stanton, all of whom are capable of turning games around with one swing. However, their recent offensive production has been underwhelming, hitting just .216 as a team over the last two months, a troubling trend that coincides with a slide in the standings. The rotation remains talented, with Gerrit Cole headlining and steady performances from Nestor Cortes and Marcus Stroman, but depth has been tested due to injuries and underperformance in the bullpen. A major source of concern has been late-game execution—New York has blown multiple eighth- and ninth-inning leads since July, prompting questions about whether they can close out winnable games. Their road record is middling, and although they often travel well thanks to their veteran core, the team has shown signs of fatigue and lack of urgency in recent series, including dropped games to teams below .500.

Against the Cardinals, they’ll need to show poise, discipline, and better situational hitting, as St. Louis thrives in low-scoring, high-leverage games. The Yankees’ inability to consistently cover the spread means they’ve been overvalued in the betting market—backers have paid the price for inflated moneyline and run line expectations. In order to flip their recent fortunes, the Yankees must not only win, but do so convincingly, something they’ve struggled with even in favorable matchups. A win in St. Louis could be a tone-setter for the final stretch of the season, but anything less would deepen the concerns about whether this roster—despite its payroll and pedigree—has the right formula for postseason success. Manager Aaron Boone remains under scrutiny, particularly for bullpen management and motivational tactics, and how he handles pitching changes and lineup flexibility could be pivotal in this road series. New York may have the edge in talent and star power, but their recent results suggest that effort, urgency, and execution—not just names on jerseys—will determine the outcome against a Cardinals team that’s quietly dangerous at home. This game could be a microcosm of the Yankees’ season: full of promise, stacked with expectations, but still needing to prove they can rise above mediocrity when it counts most.

The New York Yankees (approximately 64–57, holding onto a Wild Card spot) visit Busch Stadium to take on the St. Louis Cardinals (around 61–61, hovering at .500)—a tilt that showcases a fading powerhouse aiming to reassert control against a middling home squad. New York vs St. Louis AI Prediction: Free MLB Betting Insights for Aug 16. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals approach this August 16, 2025 matchup against the New York Yankees with cautious optimism, holding a balanced record near 61–61 as they fight to stay alive in the National League postseason picture. Though their playoff odds have fluctuated throughout the summer, recent strong play at home—highlighted by a solid 22–18 ATS mark at Busch Stadium—has given the team hope and fans reason to believe in a potential late-season surge. Unlike the Yankees, who often rely on superstar power to carry them through, the Cardinals’ success is rooted in discipline, consistency, and a cohesive team-first approach that emphasizes run manufacturing, opportunistic base running, and well-managed pitching. Key veterans like Paul Goldschmidt and Nolan Arenado continue to set the tone on both sides of the ball, providing timely hitting and gold-glove caliber defense that has helped stabilize the team through patches of inconsistency. Meanwhile, younger contributors such as Jordan Walker and Masyn Winn are steadily finding their roles, creating a nice blend of experience and youthful energy that has made the Cardinals competitive even against superior rosters. The rotation has been better than expected, with Miles Mikolas and Steven Matz offering dependable innings, while the bullpen, led by closer Ryan Helsley, has shown an ability to shut down opponents late—particularly at home where familiarity and crowd support come into play. A key strength for St. Louis is their ability to keep games close and capitalize on mistakes, an important attribute when facing a Yankees team that has struggled to finish games and often underperforms relative to the betting line. Manager Oliver Marmol has leaned into situational baseball, effectively using platoons and aggressive baserunning to create scoring opportunities without relying on the long ball.

Defensively, the Cardinals remain one of the most efficient teams in the National League, with a league-leading fielding percentage and minimal unearned runs allowed. This defensive backbone will be critical when dealing with New York’s power bats, as even the smallest mistake could swing momentum. Offensively, the Cardinals lack the home run punch of their counterparts, but they make up for it with contact hitting, long at-bats, and a willingness to grind through pitching staffs—a trait that has worn down opposing bullpens in several recent series. Against the Yankees, St. Louis must look to jump on New York’s starting pitching early, establish a lead, and hand the game over to their reliable relievers to secure a win. Given the Yankees’ poor ATS record, especially on the road, the Cardinals may be undervalued in betting markets, making them an appealing underdog pick with both the analytics and recent home trends pointing in their favor. This is a winnable game for St. Louis—not by overpowering their opponent, but by out-executing them in the fundamentals, something this team has done well when at home. For the Cardinals, this is more than just another game—it’s a litmus test for their resilience and a chance to gain meaningful ground in a playoff race that remains wide open in the National League.

New York vs. St. Louis Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each line. In fact, anytime the Yankees and Cardinals play there’s always several intriguing angles to key in on. Not to mention games played at Busch Stadium in Aug seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: G. Stanton over 0.5 Total Bases.

New York vs. St. Louis Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every facet between the Yankees and Cardinals and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the growing weight emotional bettors tend to put on New York’s strength factors between a Yankees team going up against a possibly improved Cardinals team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI New York vs St. Louis picks, computer picks Yankees vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Yankees Betting Trends

The Yankees have struggled to cover the spread, sitting at just 51–66 ATS, one of the lower percentages in MLB.

Cardinals Betting Trends

St. Louis has fared better on their home turf, going 22–18 against the run line—a positive indicator at Busch Stadium this season.

Yankees vs. Cardinals Matchup Trends

Despite the Yankees’ stronger record, their poor performance against the spread suggests potential value in backing the Cardinals at home, especially on the +1.5 run line. Given New York’s faltering form and St. Louis’ recent home success, bettors considering a cautious play might lean Cardinals +1.5 or explore total run props if the offenses awaken.

New York vs. St. Louis Game Info

New York vs St. Louis starts on August 16, 2025 at 7:15 PM EST.

Spread: St. Louis +1.5
Moneyline: New York -147, St. Louis +123
Over/Under: 8

New York: (65-57)  |  St. Louis: (61-62)

Remi's searched hard and found the best prop for this matchup: G. Stanton over 0.5 Total Bases.. Prices move—always shop for the best number.

Despite the Yankees’ stronger record, their poor performance against the spread suggests potential value in backing the Cardinals at home, especially on the +1.5 run line. Given New York’s faltering form and St. Louis’ recent home success, bettors considering a cautious play might lean Cardinals +1.5 or explore total run props if the offenses awaken.

NYY trend: The Yankees have struggled to cover the spread, sitting at just 51–66 ATS, one of the lower percentages in MLB.

STL trend: St. Louis has fared better on their home turf, going 22–18 against the run line—a positive indicator at Busch Stadium this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

New York vs. St. Louis Odds

AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the New York vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.

New York vs St. Louis Opening Odds

NYY Moneyline: -147
STL Moneyline: +123
NYY Spread: -1.5
STL Spread: +1.5
Over/Under: 8

New York vs St. Louis Live Odds

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O 7.5 (+126)
U 7.5 (-168)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New York Yankees vs. St. Louis Cardinals on August 16, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN