Yankees vs Cardinals Prediction — AI Finds CAN'T MISS MLB Lines & Props (Aug 16)
Updated: 2025-08-14T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The New York Yankees (approximately 64–57, holding onto a Wild Card spot) visit Busch Stadium to take on the St. Louis Cardinals (around 61–61, hovering at .500)—a tilt that showcases a fading powerhouse aiming to reassert control against a middling home squad.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Aug 16, 2025
Start Time: 7:15 PM EST
Venue: Busch Stadium
Cardinals Record: (61-62)
Yankees Record: (65-57)
OPENING ODDS
NYY Moneyline: -147
STL Moneyline: +123
NYY Spread: -1.5
STL Spread: +1.5
Over/Under: 8
NYY
Betting Trends
- The Yankees have struggled to cover the spread, sitting at just 51–66 ATS, one of the lower percentages in MLB.
STL
Betting Trends
- St. Louis has fared better on their home turf, going 22–18 against the run line—a positive indicator at Busch Stadium this season.
MATCHUP TRENDS
- Despite the Yankees’ stronger record, their poor performance against the spread suggests potential value in backing the Cardinals at home, especially on the +1.5 run line. Given New York’s faltering form and St. Louis’ recent home success, bettors considering a cautious play might lean Cardinals +1.5 or explore total run props if the offenses awaken.
NYY vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: G. Stanton over 0.5 Total Bases.
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New York vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 8/16/25
Much of the attention will be on how New York’s starting pitching can hold up against a disciplined Cardinals offense, and whether the Yankees’ bullpen, which has been unreliable of late, can close the door if given a lead in the late innings. On the other side, St. Louis has found success relying on quality relief work and home crowd energy, which could play a factor if the game stays close through the middle innings. With both teams facing pressure—New York to maintain playoff positioning and St. Louis to remain relevant—expect this to be a tightly contested, emotionally charged game. For bettors, the Yankees’ poor ATS performance suggests caution, particularly when facing a home team that has outperformed them in that regard, while the total runs market may also draw interest given the potential for both offenses to find opportunities. This is the kind of matchup that could swing either way depending on situational hitting, bullpen usage, and defensive execution, and it presents one of the more compelling games on the August 16 slate. Whether it’s the Yankees asserting their postseason intent or the Cardinals defending their turf with resilience, fans and bettors alike can expect a well-matched, competitive, and potentially pivotal late-summer contest in St. Louis.
A win was in the cards tonight. #RepBX pic.twitter.com/JfzTJm24DC
— New York Yankees (@Yankees) August 16, 2025
New York Yankees MLB Preview
The New York Yankees enter this August 16 matchup against the St. Louis Cardinals carrying both the weight of tradition and the burden of unmet expectations in 2025. With a record hovering around 64–57, the Yankees find themselves in the thick of the American League Wild Card race but struggling to generate consistent momentum. Their biggest problem has been delivering value in betting markets, as their ATS record sits at a disappointing 51–66—indicative of a team that often wins, but not always convincingly. The Yankees still possess one of the league’s most dangerous lineups, anchored by stars like Aaron Judge, Juan Soto, and Giancarlo Stanton, all of whom are capable of turning games around with one swing. However, their recent offensive production has been underwhelming, hitting just .216 as a team over the last two months, a troubling trend that coincides with a slide in the standings. The rotation remains talented, with Gerrit Cole headlining and steady performances from Nestor Cortes and Marcus Stroman, but depth has been tested due to injuries and underperformance in the bullpen. A major source of concern has been late-game execution—New York has blown multiple eighth- and ninth-inning leads since July, prompting questions about whether they can close out winnable games. Their road record is middling, and although they often travel well thanks to their veteran core, the team has shown signs of fatigue and lack of urgency in recent series, including dropped games to teams below .500.
Against the Cardinals, they’ll need to show poise, discipline, and better situational hitting, as St. Louis thrives in low-scoring, high-leverage games. The Yankees’ inability to consistently cover the spread means they’ve been overvalued in the betting market—backers have paid the price for inflated moneyline and run line expectations. In order to flip their recent fortunes, the Yankees must not only win, but do so convincingly, something they’ve struggled with even in favorable matchups. A win in St. Louis could be a tone-setter for the final stretch of the season, but anything less would deepen the concerns about whether this roster—despite its payroll and pedigree—has the right formula for postseason success. Manager Aaron Boone remains under scrutiny, particularly for bullpen management and motivational tactics, and how he handles pitching changes and lineup flexibility could be pivotal in this road series. New York may have the edge in talent and star power, but their recent results suggest that effort, urgency, and execution—not just names on jerseys—will determine the outcome against a Cardinals team that’s quietly dangerous at home. This game could be a microcosm of the Yankees’ season: full of promise, stacked with expectations, but still needing to prove they can rise above mediocrity when it counts most.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
The St. Louis Cardinals approach this August 16, 2025 matchup against the New York Yankees with cautious optimism, holding a balanced record near 61–61 as they fight to stay alive in the National League postseason picture. Though their playoff odds have fluctuated throughout the summer, recent strong play at home—highlighted by a solid 22–18 ATS mark at Busch Stadium—has given the team hope and fans reason to believe in a potential late-season surge. Unlike the Yankees, who often rely on superstar power to carry them through, the Cardinals’ success is rooted in discipline, consistency, and a cohesive team-first approach that emphasizes run manufacturing, opportunistic base running, and well-managed pitching. Key veterans like Paul Goldschmidt and Nolan Arenado continue to set the tone on both sides of the ball, providing timely hitting and gold-glove caliber defense that has helped stabilize the team through patches of inconsistency. Meanwhile, younger contributors such as Jordan Walker and Masyn Winn are steadily finding their roles, creating a nice blend of experience and youthful energy that has made the Cardinals competitive even against superior rosters. The rotation has been better than expected, with Miles Mikolas and Steven Matz offering dependable innings, while the bullpen, led by closer Ryan Helsley, has shown an ability to shut down opponents late—particularly at home where familiarity and crowd support come into play. A key strength for St. Louis is their ability to keep games close and capitalize on mistakes, an important attribute when facing a Yankees team that has struggled to finish games and often underperforms relative to the betting line. Manager Oliver Marmol has leaned into situational baseball, effectively using platoons and aggressive baserunning to create scoring opportunities without relying on the long ball.
Defensively, the Cardinals remain one of the most efficient teams in the National League, with a league-leading fielding percentage and minimal unearned runs allowed. This defensive backbone will be critical when dealing with New York’s power bats, as even the smallest mistake could swing momentum. Offensively, the Cardinals lack the home run punch of their counterparts, but they make up for it with contact hitting, long at-bats, and a willingness to grind through pitching staffs—a trait that has worn down opposing bullpens in several recent series. Against the Yankees, St. Louis must look to jump on New York’s starting pitching early, establish a lead, and hand the game over to their reliable relievers to secure a win. Given the Yankees’ poor ATS record, especially on the road, the Cardinals may be undervalued in betting markets, making them an appealing underdog pick with both the analytics and recent home trends pointing in their favor. This is a winnable game for St. Louis—not by overpowering their opponent, but by out-executing them in the fundamentals, something this team has done well when at home. For the Cardinals, this is more than just another game—it’s a litmus test for their resilience and a chance to gain meaningful ground in a playoff race that remains wide open in the National League.
Leather Larceny from Victor Scott II!#ForTheLou x @GetSpectrum pic.twitter.com/F2qTv889o5
— St. Louis Cardinals (@Cardinals) August 16, 2025
New York vs. St. Louis Prop Picks (AI)
New York vs. St. Louis Prediction (AI)

Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every facet between the Yankees and Cardinals and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the growing weight emotional bettors tend to put on New York’s strength factors between a Yankees team going up against a possibly improved Cardinals team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI New York vs St. Louis picks, computer picks Yankees vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Yankees Betting Trends
The Yankees have struggled to cover the spread, sitting at just 51–66 ATS, one of the lower percentages in MLB.
Cardinals Betting Trends
St. Louis has fared better on their home turf, going 22–18 against the run line—a positive indicator at Busch Stadium this season.
Yankees vs. Cardinals Matchup Trends
Despite the Yankees’ stronger record, their poor performance against the spread suggests potential value in backing the Cardinals at home, especially on the +1.5 run line. Given New York’s faltering form and St. Louis’ recent home success, bettors considering a cautious play might lean Cardinals +1.5 or explore total run props if the offenses awaken.
New York vs. St. Louis Game Info
What time does New York vs St. Louis start on August 16, 2025?
New York vs St. Louis starts on August 16, 2025 at 7:15 PM EST.
Where is New York vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for New York vs St. Louis?
Spread: St. Louis +1.5
Moneyline: New York -147, St. Louis +123
Over/Under: 8
What are the records for New York vs St. Louis?
New York: (65-57) | St. Louis: (61-62)
What is the AI best bet for New York vs St. Louis?
Remi's searched hard and found the best prop for this matchup: G. Stanton over 0.5 Total Bases.. Prices move—always shop for the best number.
What are New York vs St. Louis trending bets?
Despite the Yankees’ stronger record, their poor performance against the spread suggests potential value in backing the Cardinals at home, especially on the +1.5 run line. Given New York’s faltering form and St. Louis’ recent home success, bettors considering a cautious play might lean Cardinals +1.5 or explore total run props if the offenses awaken.
What are New York trending bets?
NYY trend: The Yankees have struggled to cover the spread, sitting at just 51–66 ATS, one of the lower percentages in MLB.
What are St. Louis trending bets?
STL trend: St. Louis has fared better on their home turf, going 22–18 against the run line—a positive indicator at Busch Stadium this season.
Where can I find AI Picks for New York vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
New York vs. St. Louis Odds
AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the New York vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.
New York vs St. Louis Opening Odds
NYY Moneyline:
-147 STL Moneyline: +123
NYY Spread: -1.5
STL Spread: +1.5
Over/Under: 8
New York vs St. Louis Live Odds
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers New York Yankees vs. St. Louis Cardinals on August 16, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |