Cardinals vs. Dodgers
Prediction, Odds & Props
Aug 06 | MLB AI Picks

Updated: 2025-08-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals head west to Dodger Stadium to face the Los Angeles Dodgers on August 6, 2025, with first pitch set for 4:10 PM ET. Los Angeles enters as the favorite at approximately –1.5 on the run line, with total runs projected around 7.5, reflecting a series-closing tilt where home comfort matters.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Aug 06, 2025

Start Time: 4:10 PM EST​

Venue: Dodger Stadium​

Dodgers Record: (66-48)

Cardinals Record: (57-58)

OPENING ODDS

STL Moneyline: +173

LAD Moneyline: -209

STL Spread: +1.5

LAD Spread: -1.5

Over/Under: 9

STL
Betting Trends

  • St. Louis has performed slightly above .500 on the run line, covering in roughly 52.5 percent of their games this season, showing competitiveness even as underdogs.

LAD
Betting Trends

  • The Dodgers have struggled ATS, covering only 44.6 percent of games overall—despite their dominance in wins—making them less reliable in spread-based markets at home.

MATCHUP TRENDS

  • Head-to-head this season, the Cardinals swept a two-game series in St. Louis with dominant pitching both games—5–0 and 2–1 wins—which may signal potential value in St. Louis despite Dodger status as home favorites.

STL vs. LAD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Ohtani over 9.5 Fantasy Score.

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St. Louis vs Los Angeles Dodgers Prediction & Odds:
Free MLB Betting Insights for 8/6/25

The Cardinals and Dodgers close out their three-game series at Dodger Stadium on August 6 in a contest that offers a fascinating contrast: Los Angeles boasts a 66–48 record, stands atop the NL West, and continues last year’s championship-level momentum, yet their recent ATS performance has been poor—they’ve covered just 44.6 percent of games—while St. Louis enters hovering around .500 overall and covers the run line slightly better than the Dodgers despite a middling record. With Shohei Ohtani on the mound for Los Angeles—returning from a minor cramp scare but still sitting on a 2.40 ERA over 15 innings—and St. Louis countering with Matthew Liberatore—or another mid-rotation arm—this matchup hinges on whether Ohtani can bounce back to full strength against a Cardinals offense that has already beaten the Dodgers twice this season. St. Louis pitching stifled Los Angeles in both head-to-head games in June, yielding only one combined earned run across two wins, and their approach of mixing control and situational execution may fluster even a star-studded lineup.

The Dodgers offense is anchored by Ohtani, Mookie Betts, Will Smith, Max Muncy, and Andy Pages—dynamic hitters who thrive in Dodger Stadium’s friendly conditions—but they have been inconsistent lately, and Muncy is coming off an IL stint. Meanwhile, St. Louis counters with Brandon Donovan, Alec Burleson, Willson Contreras at first base occasionally, Masyn Winn and Lars Nootbaar providing speed and occasional pop. The betting edge appears in the run line: while the Dodgers are favored at home, their poor cover rate and the Cardinals’ success in this series suggest value on St. Louis receiving the spread. Total sits around 7.5, implying a likely mid-score contest if Ohtani delivers quality innings; otherwise, an early exit could open the door for St. Louis to capitalize. Given historical H2H results, ATS trends, and pitching matchups, bettors might view the Cardinals as a contrarian play on the run line, even in Los Angeles.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter Dodger Stadium for their August 6, 2025 matchup against the Los Angeles Dodgers carrying a record near .500, and they bring with them the confidence of having beaten this powerhouse team twice earlier in the season in St. Louis, including a 5–0 shutout and a 2–1 nail‑biter that showcased their ability to win tight, low‑scoring games against elite opponents. Their ATS record of 52.5 percent demonstrates that even as underdogs they remain competitive, often keeping games within striking distance and rewarding run‑line bettors when their pitching holds up. The Cardinals are expected to start left‑hander Matthew Liberatore, or a comparable mid‑rotation arm, whose season has been defined by stretches of competence punctuated by occasional trouble with command; he will need to work carefully through a Dodgers lineup stacked with right‑handed power, mixing fastballs and secondary pitches to induce weak contact and ground balls. St. Louis leans on a balanced lineup rather than pure star power, with Brendan Donovan, Masyn Winn, and Alec Burleson forming a scrappy core at the top, while Willson Contreras provides veteran leadership and the ability to change the game with one swing.

Lars Nootbaar’s speed and defensive range in the outfield add a key dynamic to both run prevention and manufacturing scoring chances, and young bats like Jordan Walker and Nolan Gorman can deliver opportunistic power if mistakes are made over the plate. The Cardinals’ bullpen has been a strength in tight contests, with Ryan Helsley anchoring the ninth inning and middle relievers proving capable of holding narrow leads, which was crucial in their early‑season wins over Los Angeles. Defensively, St. Louis has been above average, particularly in the infield, where their ability to turn double plays and protect pitchers from long innings is vital against a team like the Dodgers that thrives on extending at‑bats. The Cardinals’ strategy in this game will revolve around suppressing the Dodgers’ early offense, avoiding big innings, and capitalizing on any scoring opportunities, particularly if Ohtani shows any sign of fatigue or control issues after his recent minor health concern. From a betting standpoint, St. Louis presents intriguing value as a run‑line underdog, given their prior success against this opponent and their tendency to keep games close, even on the road. To secure a win, they will need Liberatore to provide at least five solid innings, the offense to execute situational hitting, and the bullpen to maintain its composure in the late innings. Ultimately, while the Dodgers possess the superior roster and home‑field advantage, the Cardinals’ resilience, prior head‑to‑head success, and balanced approach give them a realistic path to another upset if they can combine pitching discipline, defensive sharpness, and timely hitting in a game that promises postseason‑level intensity.

The St. Louis Cardinals head west to Dodger Stadium to face the Los Angeles Dodgers on August 6, 2025, with first pitch set for 4:10 PM ET. Los Angeles enters as the favorite at approximately –1.5 on the run line, with total runs projected around 7.5, reflecting a series-closing tilt where home comfort matters. St. Louis vs Los Angeles Dodgers AI Prediction: Free MLB Betting Insights for Aug 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Los Angeles Dodgers Dodgers MLB Preview

The Los Angeles Dodgers enter their August 6, 2025 matchup against the St. Louis Cardinals at Dodger Stadium with a 66–48 record, sitting firmly atop the NL West and continuing to project as one of baseball’s most dangerous teams, yet their performance against the run line has been underwhelming, with a 44.6 percent cover rate that reflects a tendency to win close rather than blow teams out. Shohei Ohtani takes the mound for Los Angeles, giving them a premier two‑way star whose pitching line this season has been elite, with a 2.40 ERA across 15 starts, an impressive strikeout rate, and the kind of command that suppresses both walks and home runs in a ballpark that rewards disciplined pitching. Ohtani’s mix of high‑velocity fastballs and devastating splitters is expected to neutralize St. Louis’ aggressive lineup, but his effectiveness will depend on early control and avoiding long counts against contact‑oriented hitters like Brendan Donovan and Masyn Winn. Offensively, the Dodgers are built to score in bursts with a lineup featuring Ohtani, Mookie Betts, Will Smith, Max Muncy, and emerging outfielder Andy Pages, who bring a combination of power, plate discipline, and situational hitting that can flip games quickly; Betts remains the tone‑setter at the top of the order with his blend of speed and extra‑base power, while Smith provides stability in the middle and Muncy’s left‑handed bat remains a threat to clear the bases in any at‑bat.

The team has been slightly streaky at home this season, occasionally leaving runners stranded despite high OPS numbers, which has contributed to their uneven ATS record, and their bullpen performance has oscillated between dominance and vulnerability in high‑leverage situations. Los Angeles relies heavily on late‑inning arms like Evan Phillips and Brusdar Graterol to protect leads, and manager Dave Roberts’ usage patterns will be critical if Ohtani pitches into the seventh inning before handing things off. Defensively, the Dodgers remain one of the most efficient teams in MLB, with an above‑average double‑play conversion rate and strong outfield range that is particularly valuable in suppressing extra‑base hits in the gaps at Dodger Stadium. The game plan for the Dodgers will be straightforward: use Ohtani’s ace‑level outing to control the pace, leverage early offensive pressure to generate at least a multi‑run cushion, and rely on a bullpen that, while inconsistent, has the talent to close out a tight game if handed a lead. For bettors, Los Angeles carries heavy favorite status, but their poor ATS record and history of struggling to cover at home present risk; they will need to execute flawlessly to both win and cover, especially against a Cardinals team that already swept them in St. Louis earlier this year. The Dodgers’ best chance lies in converting early scoring chances, allowing Ohtani to settle into rhythm, and maintaining defensive sharpness, as their overall talent and home‑field advantage provide the foundation for success in a game that could still be closer than the odds suggest.

St. Louis vs. Los Angeles Dodgers Prop Picks (AI)

Remi is pouring through tons of data on each line. In fact, anytime the Cardinals and Dodgers play there’s always several intriguing trends to key in on. Not to mention games played at Dodger Stadium in Aug rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Ohtani over 9.5 Fantasy Score.

St. Louis vs. Los Angeles Dodgers Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Cardinals and Dodgers and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the trending emphasis emotional bettors regularly put on St. Louis’s strength factors between a Cardinals team going up against a possibly strong Dodgers team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Los Angeles Dodgers picks, computer picks Cardinals vs Dodgers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Cardinals Betting Trends

St. Louis has performed slightly above .500 on the run line, covering in roughly 52.5 percent of their games this season, showing competitiveness even as underdogs.

Dodgers Betting Trends

The Dodgers have struggled ATS, covering only 44.6 percent of games overall—despite their dominance in wins—making them less reliable in spread-based markets at home.

Cardinals vs. Dodgers Matchup Trends

Head-to-head this season, the Cardinals swept a two-game series in St. Louis with dominant pitching both games—5–0 and 2–1 wins—which may signal potential value in St. Louis despite Dodger status as home favorites.

St. Louis vs. Los Angeles Dodgers Game Info

St. Louis vs Los Angeles Dodgers starts on August 06, 2025 at 4:10 PM EST.

Spread: Los Angeles Dodgers -1.5
Moneyline: St. Louis +173, Los Angeles Dodgers -209
Over/Under: 9

St. Louis: (57-58)  |  Los Angeles Dodgers: (66-48)

Remi's searched hard and found the best prop for this matchup: S. Ohtani over 9.5 Fantasy Score.. Prices move—always shop for the best number.

Head-to-head this season, the Cardinals swept a two-game series in St. Louis with dominant pitching both games—5–0 and 2–1 wins—which may signal potential value in St. Louis despite Dodger status as home favorites.

STL trend: St. Louis has performed slightly above .500 on the run line, covering in roughly 52.5 percent of their games this season, showing competitiveness even as underdogs.

LAD trend: The Dodgers have struggled ATS, covering only 44.6 percent of games overall—despite their dominance in wins—making them less reliable in spread-based markets at home.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Los Angeles Dodgers Odds

AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the St. Louis vs Los Angeles Dodgers trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.

St. Louis vs Los Angeles Dodgers Opening Odds

STL Moneyline: +173
LAD Moneyline: -209
STL Spread: +1.5
LAD Spread: -1.5
Over/Under: 9

St. Louis vs Los Angeles Dodgers Live Odds

Games PTS ML SPR O/U
In Progress
Cincinnati Reds
Milwaukee Brewers
In Progress
Reds
Brewers
7
4
-1400
+750
-2.5 (-170)
+2.5 (+135)
O 12.5 (+110)
U 12.5 (-140)
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Texas Rangers
Cleveland Guardians
In Progress
Rangers
Guardians
2
2
+100
-130
-1 (+240)
+1 (-420)
O 5.5 (-112)
U 5.5 (-127)
In Progress
Pittsburgh Pirates
Atlanta Braves
In Progress
Pirates
Braves
3
1
-800
+475
-2 (-115)
+2 (-115)
O 5.5 (-105)
U 5.5 (-125)
In Progress
Arizona Diamondbacks
San Diego Padres
In Progress
Diamondbacks
Padres
0
5
+600
-1667
+5.5 (-125)
-5.5 (-105)
O 9.5 (+110)
U 9.5 (-140)
In Progress
Houston Astros
Los Angeles Angels
In Progress
Astros
Angels
0
0
-125
-105
-1.5 (+135)
+1.5 (-170)
O 8.5 (-110)
U 8.5 (-120)
In Progress
Los Angeles Dodgers
Seattle Mariners
In Progress
Dodgers
Mariners
0
0
+150
-190
+1.5 (-135)
-1.5 (+105)
O 6.5 (-135)
U 6.5 (+105)
In Progress
Kansas City Royals
Oakland Athletics
In Progress
Royals
Athletics
+105
-125
+1.5 (-190)
-1.5 (+158)
O 10 (-115)
U 10 (-105)
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+158
-190
+1.5 (-125)
-1.5 (+105)
O 8.5 (-120)
U 8.5 (+100)
Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
+240
-305
+1.5 (+118)
-1.5 (-140)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8 (-120)
U 8 (+100)
Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
+100
-120
+1.5 (-190)
-1.5 (+158)
O 8.5 (-120)
U 8.5 (+100)
Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8 (+100)
U 8 (-120)
Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
-110
-110
-1.5 (+150)
+1.5 (-178)
O 8 (-120)
U 8 (+100)
Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
+110
-130
+1.5 (-170)
-1.5 (+140)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
Braves
+175
-210
+1.5 (-120)
-1.5 (+100)
O 7.5 (-110)
U 7.5 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Los Angeles Dodgers Dodgers on August 06, 2025 at Dodger Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS