Reds vs Cubs Prediction — AI Finds CAN'T MISS MLB Lines & Props (Aug 05)
Updated: 2025-08-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cincinnati Reds head to Wrigley Field on Tuesday, August 5, 2025 to take on the Chicago Cubs in a pivotal National League Central matchup with playoff implications for both teams. The Cubs enter as moderate favorites—approximately –185 to –190 on the money line and –1.5 run line, with the total set near 8.5 runs—reflecting confidence in Chicago’s pitching and home-field strength despite both teams battling similar standings.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Aug 05, 2025
Start Time: 8:05 PM EST
Venue: Wrigley Field
Cubs Record: (65-47)
Reds Record: (59-54)
OPENING ODDS
CIN Moneyline: +153
CHC Moneyline: -185
CIN Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
CIN
Betting Trends
- Cincinnati sits near a 43‑44% ATS cover rate, though they’ve shown pockets of value in interdivision games and struggled against higher-caliber rotations.
CHC
Betting Trends
- Chicago holds a stronger ATS mark in 2025, covering closer to 55% overall, and particularly effective at home in control matchups.
MATCHUP TRENDS
- Head-to-head in 2025, the Cubs have covered multiple short spreads against Cincinnati—even in close losses—while Cincinnati has struggled to cover on the road, especially at Wrigley Field.
CIN vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: E. De La Cruz over 5.5 Fantasy Score.
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Cincinnati vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 8/5/25
Offensively, the Reds are led by the electrifying Elly De La Cruz, who combines speed, power, and dynamic base-running to generate scoring opportunities, along with supporting pieces who thrive in aggressive, small-ball scenarios, though overall the team ranks in the middle of the league for OBP and runs produced. Chicago, by contrast, boasts a deep and balanced attack anchored by Seiya Suzuki, Kyle Tucker, and Pete Crow‑Armstrong, delivering a mixture of consistent contact, situational power, and patience that allows them to capitalize on mistakes and wear down opposing pitchers. Defensively, the Cubs are among the league’s best at converting outs and turning double plays, an area where they hold a clear edge over a Cincinnati team that has shown occasional sloppiness under pressure, particularly on the road. The bullpens could decide the outcome if the game remains close into the seventh or eighth inning, with Chicago’s late-inning corps offering more reliability and composure than Cincinnati’s relief unit, which has struggled with command and inherited runners in high-leverage spots. For the Reds to find value or pull off the upset, Littell will need to work efficiently and keep the ball down, the lineup must generate early base traffic, and their defense must play clean to avoid giving Chicago extra opportunities. The Cubs’ path to victory is straightforward: Imanaga needs to establish rhythm early, their lineup must press advantages with runners in scoring position, and the bullpen should be ready to lock down any narrow lead. Given head-to-head history, home-field confidence, and recent ATS trends favoring Chicago, this matchup sets up as an opportunity for the Cubs to reinforce their divisional grip, while the Reds must execute near-flawlessly to keep pace in a series that could shape their playoff hopes.
Series opener W!#ATOBTTR pic.twitter.com/99wywhb2JO
— Cincinnati Reds (@Reds) August 5, 2025
Cincinnati Reds MLB Preview
The Cincinnati Reds arrive at Wrigley Field on Tuesday, August 5, 2025, with a 59‑54 record and carrying their usual underdog status as they aim to remain competitive in the National League Central. Their ATS record hovers around 43–44%, reflecting ongoing inconsistency in covering spreads, especially at road venues. However, recent trends hint at uptick in form and value: the Reds have gone 7‑3 over their last ten games and hold an 11‑13 ATS mark away over the past 30 contests, signaling renewed focus under pressure. In Chicago, they’ll send Zack Littell to the mound—a veteran right-hander sitting at approximately 8–8 with a 3.58 ERA and 1.12 WHIP—who needs to execute low pitch counts and soft contact to stay competitive. Littell’s style demands active defense behind him and consistent ball placement; otherwise, the Cubs’ disciplined lineup will force early traffic and expose gaps in Cleveland’s bullpen depth. At the plate, Cincinnati relies heavily on Elly De La Cruz, whose blend of speed, power, and fielding excellence injects energy at the top of the lineup and provides their best chance to manufacture scoring through steals, mixed contact, and situational hitting. Supporting cast includes up-and-coming contributors like Michael Massey and TJ Friedl—players capable of altering momentum when they capitalize on extended at-bats or defensive miscues. Yet the offense lacks consistency beyond its core, often failing to convert on opportunities with runners in scoring position, which is a critical disadvantage at Wrigley, where momentum can shift quickly. Without consistent on-base production, the Reds must rely on timely small-ball execution, drawing walks, and thoughtful base running to keep this game within reach.
Defensively, Cincinnati plays steady but has shown moments of slippage, particularly in Wrigley’s turf where pressure prompts fielding errors in tight games. Turning double plays and securing routine plays under pressure are essential, especially as Chicago seeks to exploit one bad hop or missed relay into a multi-run frame. The Reds’ defensive structure is a big part of their ATS formula: when it holds up, they stay close; when errors creep in, leads can grow quickly through Chicago’s disciplined offense. Their bullpen, while featuring capable arms like Cole Ragans and Ryan Yarbrough, lacks the depth and high-leverage stability of the Cubs. To cover the +1.5 run line, Cleveland must force scenarios in which they only trail by one run or fewer into the middle innings—preferably with Littell still in the game. If he exits early or allows early stress innings, the relief corps will be tested in tight conditions without commanding control. For underdog value, their plan is clear: extend at-bats to wear down Shōta Imanaga, punish mistakes, and force him to work deep into the lineup repeatedly. Aggressive base running, patient discipline at the plate, and a clean defensive performance must converge. If Littell can operate efficiently and the Reds can manufacture a run or two early, they create an avenue to hang around into the late innings. Clean defense and bullpen reliability will also be key. Cincinnati’s window hinges on flawless fundamentals—their margins for error are thin—but their recent ATS form suggests they remain dangerous when executing their game plan. If they can stretch this into a tight contest beyond the seventh inning, any late mistakes from a favored Cubs team could open the door for a comeback or value ATS cover. It won’t be easy, but disciplined baseball and opportunistic pressure give the Reds a formula to stay relevant on the road in this critical August showdown.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Chicago Cubs head into tonight’s game at Wrigley Field on August 5, 2025 with a strong 65–47 record, firmly leading the NL Central and seeking to extend their divisional grip at home. While their ATS performance hovers around 55%, the Cubs have consistently delivered cover value in home matchups—especially when favored heavily—using disciplined starting pitching, situational offense, and a strong bullpen to control late-game outcomes. Their starter, Shōta Imanaga, brings an impressive 8–4 record with a 3.25 ERA and a 1.04 WHIP, excelling at inducing ground balls and neutralizing playoff-caliber lineups; his performance tonight will be pivotal in setting the tone against a lineup that thrives on speed and contact over power. Offensively, the Cubs boast a dynamic core led by Seiya Suzuki, who combines extra-base pop with high OBP; Kyle Tucker, who wields power and discipline; and Pete Crow‑Armstrong, whose speed sets the table at the top.
Supported by veterans like Alec Bohm and Nick Castellanos, the lineup has balanced depth and situational execution, drawing walks, avoiding chase outs, and delivering timely base hits—especially critical in interdivisional play at Wrigley. Defensively, the Cubs are among MLB’s most efficient, converting double plays decisively and capitalizing on infield grounders to suppress extra-base hits; their ability to support Imanaga and back relievers through routine execution remains a key aspect of their home advantage. Their bullpen, with a mix of dependable setup men and a reliable closer, offers confidence in closing tight games where the run line matters. To secure both the win and the run line cover against Cincinnati, Chicago will need to establish early rhythm: attacking first-pitch fastballs, manufacturing traffic with runners aboard, and avoiding long, error-prone innings that allow Cincinnati’s speed-based approach to leapfrog. If Imanaga delivers length and control, the offense sustains momentum with runners in scoring position, and the relief corps shuts down late threats, the Cubs are well-positioned to reinforce their ATS strength and maintain their momentum in the NL Central.
Tell us Nico is good at baseball without telling us Nico is good at baseball: pic.twitter.com/IbKoqv9cOG
— Chicago Cubs (@Cubs) August 5, 2025
Cincinnati vs. Chicago Cubs Prop Picks (AI)
Cincinnati vs. Chicago Cubs Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every facet between the Reds and Cubs and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the growing emphasis human bettors often put on Chicago Cubs’s strength factors between a Reds team going up against a possibly deflated Cubs team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cincinnati vs Chicago Cubs picks, computer picks Reds vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Reds Betting Trends
Cincinnati sits near a 43‑44% ATS cover rate, though they’ve shown pockets of value in interdivision games and struggled against higher-caliber rotations.
Cubs Betting Trends
Chicago holds a stronger ATS mark in 2025, covering closer to 55% overall, and particularly effective at home in control matchups.
Reds vs. Cubs Matchup Trends
Head-to-head in 2025, the Cubs have covered multiple short spreads against Cincinnati—even in close losses—while Cincinnati has struggled to cover on the road, especially at Wrigley Field.
Cincinnati vs. Chicago Cubs Game Info
What time does Cincinnati vs Chicago Cubs start on August 05, 2025?
Cincinnati vs Chicago Cubs starts on August 05, 2025 at 8:05 PM EST.
Where is Cincinnati vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for Cincinnati vs Chicago Cubs?
Spread: Chicago Cubs -1.5
Moneyline: Cincinnati +153, Chicago Cubs -185
Over/Under: 8
What are the records for Cincinnati vs Chicago Cubs?
Cincinnati: (59-54) | Chicago Cubs: (65-47)
What is the AI best bet for Cincinnati vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: E. De La Cruz over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Cincinnati vs Chicago Cubs trending bets?
Head-to-head in 2025, the Cubs have covered multiple short spreads against Cincinnati—even in close losses—while Cincinnati has struggled to cover on the road, especially at Wrigley Field.
What are Cincinnati trending bets?
CIN trend: Cincinnati sits near a 43‑44% ATS cover rate, though they’ve shown pockets of value in interdivision games and struggled against higher-caliber rotations.
What are Chicago Cubs trending bets?
CHC trend: Chicago holds a stronger ATS mark in 2025, covering closer to 55% overall, and particularly effective at home in control matchups.
Where can I find AI Picks for Cincinnati vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cincinnati vs. Chicago Cubs Odds
Remi is pouring through loads of data on each line. In fact, anytime the Cincinnati vs Chicago Cubs trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps rarely follow normal, predictable betting trends.
Cincinnati vs Chicago Cubs Opening Odds
CIN Moneyline:
+153 CHC Moneyline: -185
CIN Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
Cincinnati vs Chicago Cubs Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 9:08PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 9:08PM
Dodgers
Blue Jays
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–
–
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-149
+122
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-1.5 (+119)
+1.5 (-145)
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O 7 (-125)
U 7 (+103)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cincinnati Reds vs. Chicago Cubs Cubs on August 05, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |