Reds vs. Cubs
Prediction, Odds & Props
Aug 04 | MLB AI Picks
Updated: 2025-08-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cincinnati Reds travel to Wrigley Field on August 4, 2025 to take on the host Chicago Cubs in what shapes up as a critical interleague test for both teams. Chicago enters as a moderately favored team on the money line and run line (-1.5), with an over/under set near 8 runs, signaling market confidence in Wrigley‑friendly scoring while anticipating a competitive outing.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Aug 04, 2025
Start Time: 8:05 PM EST
Venue: Wrigley Field
Cubs Record: (65-46)
Reds Record: (58-54)
OPENING ODDS
CIN Moneyline: +118
CHC Moneyline: -140
CIN Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
CIN
Betting Trends
- Cincinnati has covered the spread in about 32 of their first 58 games this season, including a strong 18–12 mark on the road, showing value as underdogs and in close contests.
CHC
Betting Trends
- The Cubs have posted a 29–28 ATS record overall, covering just over half of their home games at Wrigley despite recent home dominance.
MATCHUP TRENDS
- In the last ten head‑to‑head meetings, the Reds have gone 6–4 ATS versus the Cubs—including several road covers—despite Chicago holding an edge in straight‑up wins.
CIN vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: I. Happ over 4.5 Fantasy Score.
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Cincinnati vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 8/4/25
He is complemented by a mix of young hitters and situational bats who can exploit defensive lapses and leverage aggressive base running to manufacture runs. Chicago counters with a deep and balanced lineup highlighted by rising star Pete Crow‑Armstrong, whose power-speed combo and defensive excellence energize the team, along with veteran contributors who thrive in Wrigley Field’s hitter-friendly environment. The Cubs’ bullpen, steady in recent weeks, has turned narrow leads into victories, while the Reds’ relief corps has also been reliable, keeping them in games even when the offense has lagged. Betting lines reflect a modest scoring expectation with a total of about 8 runs, as both teams have shown a mix of explosive potential and stretches of offensive quiet, depending on weather conditions and pitching form. For Cincinnati to pull the upset, they must execute their small-ball strategy, pressure Chicago’s defense, and get a quality start from Lodolo that limits early damage; the Cubs, on the other hand, will aim to strike early, support Soroka with run production, and let their bullpen secure the lead. This game likely comes down to situational hitting, defensive sharpness, and late-inning execution, with the Cubs holding the home-field edge but the Reds carrying underdog value and recent ATS success in this divisional rivalry. Fans can expect a tightly contested matchup where each team’s identity—Chicago’s balanced power and home efficiency versus Cincinnati’s speed, pitching, and opportunistic play—will be on full display, making for a compelling battle at Wrigley Field.
Final from the #SpeedwayClassic: pic.twitter.com/Hq7STjRIYi
— Cincinnati Reds (@Reds) August 3, 2025
Cincinnati Reds MLB Preview
The Cincinnati Reds enter their August 4, 2025 matchup against the Chicago Cubs at Wrigley Field with a 69–61 record, bringing the identity of a resilient, opportunistic team that has leaned on pitching and speed to remain firmly in the National League playoff picture. As road underdogs, the Reds have proven reliable against the spread with an 18–12 run‑line record in away games, thriving in tight, low‑scoring contests where fundamentals and aggressive base running can create the margins for victory. Their offensive engine is Elly De La Cruz, who has become one of baseball’s most electrifying young stars, combining elite speed and game‑changing power with a .259 batting average, 56 home runs, and 127 stolen bases to date, constantly pressuring opposing pitchers and defenses. The Reds’ lineup around him is a mix of developing talent and situational contributors, with players like Spencer Steer, Will Benson, and TJ Friedl providing timely hitting and speed that complement De La Cruz’s explosive presence. On the mound, Cincinnati is expected to start left‑hander Nick Lodolo, who has emerged as a dependable frontline arm, carrying an 8–6 record with a 3.09 ERA and 123 strikeouts in 128 innings, using command, a lively fastball, and a sharp breaking ball to induce weak contact and keep hitters off balance.
The Reds’ bullpen has been one of their strengths, with high‑leverage arms capable of holding narrow leads and keeping games winnable when the offense scratches out small advantages, a key reason why Cincinnati has managed to cover six of the last ten matchups against the Cubs despite often entering as underdogs. Defensively, Cincinnati has tightened its play in recent weeks, turning double plays efficiently and limiting errors to support its pitching staff, which is vital in the tight confines and unpredictable conditions of Wrigley Field. To succeed in this contest, the Reds must execute their identity perfectly: create early pressure with aggressive baserunning, extend at‑bats to elevate Michael Soroka’s pitch count, and rely on Lodolo to deliver a quality start that bridges effectively to their bullpen. Limiting Chicago’s middle‑of‑the‑order threats, particularly Pete Crow‑Armstrong, while avoiding giving away free baserunners, will be critical in preventing the Cubs from seizing momentum in front of their home crowd. Cincinnati’s path to victory rests on their ability to turn speed into scoring opportunities, maintain defensive precision, and exploit any Cubs bullpen instability in the later innings. If De La Cruz continues to spark the offense, Lodolo neutralizes Chicago’s early threats, and the bullpen performs to standard, the Reds have a strong chance to cover the spread and potentially steal an important divisional win at Wrigley Field, bolstering their playoff ambitions with a signature road performance.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Chicago Cubs welcome the Cincinnati Reds to Wrigley Field on August 4, 2025, with a 77–63 record and the confidence of a team that has protected its home turf while staying firmly in the NL Central hunt. Chicago has posted a 29–28 ATS record overall and sits just over .500 against the spread at home, showing that while they consistently win outright, they have occasionally struggled to separate enough to cover larger run lines. The Cubs’ offensive attack is spearheaded by rising star Pete Crow‑Armstrong, whose power‑speed combination has elevated him to one of the league’s most dynamic players, complementing his elite defense and knack for game‑changing moments in the leadoff or top‑order spots. Supporting him is a balanced lineup of veteran and young contributors, including contact hitters who thrive at Wrigley and power bats capable of leveraging favorable wind and weather conditions to drive in runs. Michael Soroka is expected to take the mound for Chicago, bringing experience and a 3‑8 record with a 4.87 ERA that reflects inconsistency, though he has shown flashes of efficiency when his command is sharp and his off‑speed pitches find the zone. The Cubs’ bullpen has solidified in recent weeks, capable of protecting narrow leads and converting late‑game opportunities into wins, a crucial factor against a Reds team that thrives in tight, low‑scoring contests.
Defensively, Chicago has been reliable, with its infield executing double plays cleanly and its outfield minimizing mistakes, critical in a matchup against the speed and aggressive baserunning of Cincinnati. Strategically, the Cubs will look to seize control early, generating traffic on the bases to pressure Nick Lodolo and forcing the Reds into high‑leverage defensive scenarios, while also taking advantage of any wind‑aided scoring chances typical at Wrigley. Keys to victory for Chicago will include capitalizing with runners in scoring position, minimizing walks and errors that could fuel Cincinnati’s small‑ball approach, and ensuring Soroka hands the game to the bullpen with a lead intact. Their moderate ATS performance this season suggests they must find early offensive separation to cover the run line, especially against a Reds team that has shown a knack for hanging around as an underdog and covering late. If the Cubs can pair their home‑field energy with disciplined plate appearances, execute in the field, and leverage their bullpen effectively, they will have a strong chance not only to secure a win but to deliver a cover as favorites. A clean start from Soroka combined with the spark of Crow‑Armstrong and the timely hitting of the supporting cast could be the formula Chicago needs to protect Wrigley, maintain their division position, and take the opener against a scrappy divisional rival.
neeeeded that. ☺️ pic.twitter.com/vGQhkm9loP
— Chicago Cubs (@Cubs) August 3, 2025
Cincinnati vs. Chicago Cubs Prop Picks (AI)
Cincinnati vs. Chicago Cubs Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Reds and Cubs and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.
Remi has been most keyed in on the growing factor emotional bettors often put on Chicago Cubs’s strength factors between a Reds team going up against a possibly strong Cubs team. In reality, the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cincinnati vs Chicago Cubs picks, computer picks Reds vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Reds Betting Trends
Cincinnati has covered the spread in about 32 of their first 58 games this season, including a strong 18–12 mark on the road, showing value as underdogs and in close contests.
Cubs Betting Trends
The Cubs have posted a 29–28 ATS record overall, covering just over half of their home games at Wrigley despite recent home dominance.
Reds vs. Cubs Matchup Trends
In the last ten head‑to‑head meetings, the Reds have gone 6–4 ATS versus the Cubs—including several road covers—despite Chicago holding an edge in straight‑up wins.
Cincinnati vs. Chicago Cubs Game Info
What time does Cincinnati vs Chicago Cubs start on August 04, 2025?
Cincinnati vs Chicago Cubs starts on August 04, 2025 at 8:05 PM EST.
Where is Cincinnati vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for Cincinnati vs Chicago Cubs?
Spread: Chicago Cubs -1.5
Moneyline: Cincinnati +118, Chicago Cubs -140
Over/Under: 8
What are the records for Cincinnati vs Chicago Cubs?
Cincinnati: (58-54) | Chicago Cubs: (65-46)
What is the AI best bet for Cincinnati vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: I. Happ over 4.5 Fantasy Score.. Prices move—always shop for the best number.
What are Cincinnati vs Chicago Cubs trending bets?
In the last ten head‑to‑head meetings, the Reds have gone 6–4 ATS versus the Cubs—including several road covers—despite Chicago holding an edge in straight‑up wins.
What are Cincinnati trending bets?
CIN trend: Cincinnati has covered the spread in about 32 of their first 58 games this season, including a strong 18–12 mark on the road, showing value as underdogs and in close contests.
What are Chicago Cubs trending bets?
CHC trend: The Cubs have posted a 29–28 ATS record overall, covering just over half of their home games at Wrigley despite recent home dominance.
Where can I find AI Picks for Cincinnati vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cincinnati vs. Chicago Cubs Odds
Remi is pouring through tons of stats on each player. In fact, anytime the Cincinnati vs Chicago Cubs trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.
Cincinnati vs Chicago Cubs Opening Odds
CIN Moneyline:
+118 CHC Moneyline: -140
CIN Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
Cincinnati vs Chicago Cubs Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
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–
–
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+194
-235
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+1.5 (-105)
-1.5 (-114)
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O 8.5 (-122)
U 8.5 (+100)
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Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
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Cardinals
Cubs
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–
–
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-168
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-1.5 (+118)
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O 9 (-122)
U 9 (+100)
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Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
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+132
-156
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+1.5 (-154)
-1.5 (+128)
|
O 8.5 (-106)
U 8.5 (-114)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
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+102
-120
|
-1.5 (+162)
+1.5 (-196)
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O 8.5 (-110)
U 8.5 (-110)
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|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
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+198
-240
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-108)
U 8 (-112)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
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-124
+106
|
-1.5 (+130)
+1.5 (-156)
|
O 8.5 (-112)
U 8.5 (-108)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+172
-205
|
+1.5 (-118)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+128
-152
|
+1.5 (-178)
-1.5 (+146)
|
O 7.5 (-120)
U 7.5 (-102)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+136
-162
|
+1.5 (-150)
-1.5 (+125)
|
O 8 (-105)
U 8 (-115)
|
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+138
-164
|
+1.5 (-164)
-1.5 (+136)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+120
-142
|
+1.5 (-182)
-1.5 (+150)
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O 7.5 (-118)
U 7.5 (-104)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-162
+136
|
-1.5 (+100)
+1.5 (-120)
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O 9 (+100)
U 9 (-122)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+102
-120
|
+1.5 (-215)
-1.5 (+180)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-118
|
-1.5 (+152)
+1.5 (-184)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cincinnati Reds vs. Chicago Cubs Cubs on August 04, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |