Padres vs. Cardinals
Prediction, Odds & Props
Jul 27 | MLB AI Picks
Updated: 2025-07-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Milwaukee Brewers return home to American Family Field for their July 27 clash against the Miami Marlins with clear momentum and the composure of a team that has steadily climbed the National League standings behind a well-balanced roster and elite starting pitching. Anchored by Freddy Peralta, who has been nothing short of dominant over the past month, Milwaukee enters this matchup with a firm grip on their pitching identity—ranking near the top of the NL in strikeouts, ERA, and WHIP since the All-Star break. Peralta has struck out at least eight in three of his last four starts and has kept opposing hitters off-balance with an explosive fastball and sharp slider that has generated whiffs at an elite rate. His consistency has stabilized the rotation and taken pressure off a bullpen that has performed admirably but has been used heavily due to a few short starts from the back end of the rotation. The Brewers’ offense, often maligned in past seasons for inconsistency, has made notable strides in 2025, led by the continued development of Brice Turang, a resurgent season from Christian Yelich, and steady contributions from William Contreras and Willy Adames. Against right-handed pitching, Milwaukee has been especially potent, ranking among the league’s best in runs scored, OBP, and team batting average in home contests. The club’s plate discipline has been evident in high walk rates, while their ability to steal bases has made them an opportunistic offense capable of creating havoc even when the long ball doesn’t come into play. Defensively, the Brewers have excelled with strong infield play and one of the most consistent outfield groups in terms of range and arm strength, rarely giving away extra bases and often converting high-leverage plays into momentum-saving outs. Manager Pat Murphy has managed matchups well, mixing veteran savvy with a willingness to trust younger pieces in late-inning roles, and the overall vibe in the clubhouse has been positive and focused as they navigate the heart of the summer stretch. Against a Marlins squad that has struggled in nearly every offensive category away from home, the Brewers enter this game as clear favorites and will look to apply early pressure with aggressive base running and quality at-bats, particularly in the first two innings where Peralta has been given the strongest run support this season. If the Brewers execute their game plan—solid starting pitching, timely hitting, and a clean defensive effort—they should be in a strong position to secure another home win and maintain their lead in the division. The matchup sets up well for Milwaukee to continue asserting themselves as a legitimate postseason threat in the National League, and they’ll look to capitalize on every edge in this series finale to extend their hot streak in front of a lively home crowd.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Jul 27, 2025
Start Time: 2:15 PM EST
Venue: Busch Stadium
Cardinals Record: (54-52)
Padres Record: (56-49)
OPENING ODDS
SD Moneyline: +109
STL Moneyline: -131
SD Spread: +1.5
STL Spread: -1.5
Over/Under: 9
SD
Betting Trends
- The Padres are about 45–42 against the run line this season—solid overall but underwhelming away from Petco Park, where they’ve struggled to cover as underdogs or small favorites.
STL
Betting Trends
- St. Louis holds a strong 53–47 ATS record, covering at a ~53% rate and performing especially well at home when favored in short lines.
MATCHUP TRENDS
- In the first three games of this series, Cleveland has covered run line each time—sorry mixing teams actually, the Cardinals covered in two of three and sharp money shows consistent support on St. Louis at –1.5, even as public action edges toward the Padres at +1.5
SD vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: W. Contreras over 5.5 Fantasy Score.
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San Diego vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 7/27/25
The betting lines show the Cardinals as modest favorites, usually around –125 to –135 at home with the run line set at –1.5 and a total of 8.5, indicating an expectation of a competitive but relatively low-scoring affair. Both teams come in with similar records ATS, but the Cardinals are one of the stronger home cover teams in MLB, especially as short favorites. The Padres struggle to cover when listed as slight underdogs or in coin-flip matchups, particularly in the second half of the season. This sets up a clash where the edges lie with the Cardinals’ recent form, home consistency, and the strong veteran presence of Gray, who is capable of delivering six efficient innings against a San Diego lineup that tends to press on the road. The Padres’ hopes likely hinge on Darvish finding his command early and limiting hard contact, as well as the bullpen’s ability to hold in the late innings, but given the Cardinals’ solid approach at the plate and their ability to manufacture runs even without big power, the lean is toward a St. Louis win with value on the run line. Bettors should also take note that both teams trend toward unders in these pitching-driven matchups, especially in day games at Busch Stadium, which can play a bit slower offensively. All signs suggest a tight contest with the Cardinals owning the slight edge due to home-field execution, consistent at-bats, and steadier pitching.
Got it done. pic.twitter.com/wfoFbvofAG
— San Diego Padres (@Padres) July 27, 2025
San Diego Padres MLB Preview
The San Diego Padres enter Sunday’s series finale in St. Louis trying to salvage a tough road trip and recapture the momentum that’s eluded them since the All-Star break. Sitting around the .500 mark and falling behind in the Wild Card standings, the Padres have found themselves once again wrestling with underachievement despite a roster packed with talent. Offensively, they feature a potent top of the lineup with Luis Arraez setting the tone as the league’s contact king, Fernando Tatis Jr. providing power and speed, and Manny Machado and Xander Bogaerts offering veteran presence, though the results have often been inconsistent and matchup-dependent. The lack of depth in the bottom third of the order and an underwhelming bench have created offensive lulls that have led to narrow losses, especially on the road. Sunday’s scheduled starter, Yu Darvish, still flashes his signature movement and a deep arsenal, but his command has occasionally wavered, especially in the later innings, and he’s struggled to miss bats against disciplined lineups like St. Louis.
San Diego’s bullpen, while showing some promise with arms like Robert Suarez and Jeremiah Estrada, has been overworked and prone to leaks in high-leverage spots, a key reason why the Padres have been underwhelming in close games. In terms of defense, the Padres remain sound in the field with Ha-Seong Kim and Arraez offering range and intelligence up the middle, but lapses in situational awareness have cost them at times. Manager Mike Shildt has experimented with lineup adjustments and bullpen matchups to inject life into a team that’s underperformed in high-pressure spots, but with the postseason picture tightening, urgency is at an all-time high. The Padres’ ATS record on the road as slight underdogs remains one of the worst among contending teams, especially against clubs with winning home records, and their inconsistent run production continues to undermine quality pitching efforts. To turn things around Sunday, San Diego will need Darvish to navigate through the top of the Cardinals order cleanly, and they’ll need one of their big bats—be it Tatis, Machado, or Soto—to deliver a signature performance early to take pressure off the bullpen. The Padres have shown flashes of elite play, and if they can generate offense early and cleanly hand the ball off to the back end of the bullpen, they have the tools to take a win on the road. However, unless they show sharper execution and capitalize on run-scoring opportunities, especially with runners in scoring position, they risk falling further into the middle-tier of the National League and continuing their pattern of inconsistency that has haunted them all season long.
Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
The St. Louis Cardinals will look to continue their strong second-half surge as they host the San Diego Padres at Busch Stadium in the finale of a pivotal three-game series on July 27, 2025. Following an up-and-down first half of the season, the Cardinals have come out of the All-Star break with renewed energy and urgency, climbing back into the thick of the National League Central race and contending in the Wild Card picture. A large part of their resurgence has been fueled by improved health and consistency in both their starting rotation and bullpen, with manager Oliver Marmol making aggressive in-game decisions to maximize matchups and keep arms fresh. Sunday’s probable starter, left-hander Steven Matz, has quietly turned in one of the more effective stretches of his career over the past month, mixing his changeup and sinker well to induce weak contact while limiting free passes. He’ll look to continue his rhythm against a Padres team that has struggled against left-handed pitching on the road this year. Offensively, the Cardinals have found their groove behind the heart of the lineup featuring Paul Goldschmidt, Nolan Arenado, and breakout performer Masyn Winn, whose plate discipline and speed on the bases have brought a new dynamic to the offense. Lars Nootbaar and Brendan Donovan have also emerged as on-base machines, giving the Cardinals a steady table-setting presence that has helped them manufacture runs even when the long ball isn’t coming.
Behind the plate, Willson Contreras’ return from injury has not only boosted the power output but stabilized the team’s defensive game-calling, which has positively impacted the performance of the pitching staff. In the bullpen, Ryan Helsley remains a dominant force in the closer role, while JoJo Romero and Giovanny Gallegos have settled into key setup roles, providing confidence in late-game scenarios. The Cardinals’ defense has also been sharp, with Goldschmidt and Arenado continuing to flash Gold Glove-caliber leather while outfield defense has improved thanks to better positioning and athleticism. St. Louis has been one of the league’s most profitable teams against the spread at home when favored by less than -150, especially in day games, and they’ve shown a knack for finishing series strong when playing at home. With momentum on their side, a solid starter on the mound, and an opponent vulnerable to left-handed pitching and bullpen fatigue, the Cardinals are in a strong position to take this series finale. Execution will be key, particularly in limiting San Diego’s top-of-the-order threats early and capitalizing on their own early scoring chances. If Matz can deliver six efficient innings and the offense continues to grind out at-bats and force the Padres’ bullpen into action by the middle innings, St. Louis should be well-positioned to pick up another win and maintain their upward trajectory in a tightly packed NL postseason race.
DONNIE DOES DEFENSE! ⭐️ pic.twitter.com/b8cpOUrBhX
— St. Louis Cardinals (@Cardinals) July 27, 2025
San Diego vs. St. Louis Prop Picks (AI)
San Diego vs. St. Louis Prediction (AI)
Remi, our AI sports genius, has been pouring over tons of data from every facet between the Padres and Cardinals and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Remi has been most keyed in on the linear correlation of emphasis human bettors regularly put on player performance factors between a Padres team going up against a possibly strong Cardinals team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Diego vs St. Louis picks, computer picks Padres vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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| MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
INTEL
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| MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
INTEL
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| MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
| MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
INTEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Padres Betting Trends
The Padres are about 45–42 against the run line this season—solid overall but underwhelming away from Petco Park, where they’ve struggled to cover as underdogs or small favorites.
Cardinals Betting Trends
St. Louis holds a strong 53–47 ATS record, covering at a ~53% rate and performing especially well at home when favored in short lines.
Padres vs. Cardinals Matchup Trends
In the first three games of this series, Cleveland has covered run line each time—sorry mixing teams actually, the Cardinals covered in two of three and sharp money shows consistent support on St. Louis at –1.5, even as public action edges toward the Padres at +1.5
San Diego vs. St. Louis Game Info
What time does San Diego vs St. Louis start on July 27, 2025?
San Diego vs St. Louis starts on July 27, 2025 at 2:15 PM EST.
Where is San Diego vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for San Diego vs St. Louis?
Spread: St. Louis -1.5
Moneyline: San Diego +109, St. Louis -131
Over/Under: 9
What are the records for San Diego vs St. Louis?
San Diego: (56-49) | St. Louis: (54-52)
What is the AI best bet for San Diego vs St. Louis?
Remi's searched hard and found the best prop for this matchup: W. Contreras over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are San Diego vs St. Louis trending bets?
In the first three games of this series, Cleveland has covered run line each time—sorry mixing teams actually, the Cardinals covered in two of three and sharp money shows consistent support on St. Louis at –1.5, even as public action edges toward the Padres at +1.5
What are San Diego trending bets?
SD trend: The Padres are about 45–42 against the run line this season—solid overall but underwhelming away from Petco Park, where they’ve struggled to cover as underdogs or small favorites.
What are St. Louis trending bets?
STL trend: St. Louis holds a strong 53–47 ATS record, covering at a ~53% rate and performing especially well at home when favored in short lines.
Where can I find AI Picks for San Diego vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Diego vs. St. Louis Odds
AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the San Diego vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.
San Diego vs St. Louis Opening Odds
SD Moneyline:
+109 STL Moneyline: -131
SD Spread: +1.5
STL Spread: -1.5
Over/Under: 9
San Diego vs St. Louis Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+190
-235
|
+1.5 (-105)
-1.5 (-115)
|
O 9 (+100)
U 9 (-120)
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|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-175
|
-1.5 (+115)
|
O 9.5 (-105)
U 9.5 (-115)
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|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+130
-155
|
+1.5 (-155)
-1.5 (+130)
|
O 8.5 (+100)
U 8.5 (-120)
|
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
|
-1.5 (+160)
+1.5 (-195)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+185
-225
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+125)
+1.5 (-150)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+155
-190
|
+1.5 (-152)
-1.5 (+120)
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O 8 (-108)
U 8 (-117)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
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+135
-165
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+1.5 (-180)
-1.5 (+150)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
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+125
-152
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+1.5 (-186)
-1.5 (+145)
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O 7.5 (-120)
U 7.5 (-107)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
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-155
+130
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-1.5 (+105)
+1.5 (-125)
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O 8.5 (-120)
U 8.5 (+100)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
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+105
-125
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+1.5 (-205)
-1.5 (+170)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
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–
–
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+100
-120
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-1.5 (+150)
+1.5 (-180)
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O 10 (-115)
U 10 (-105)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Diego Padres vs. St. Louis Cardinals on July 27, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
| MLB |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
| HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
| NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
| STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
| KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
| MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
| MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
| WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
| LAA@COL | COL +108 | 50.5% | 3 | WIN |
| TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
| SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
| NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
| MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
| MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
| SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
| PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
| NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
| KC@PHI | PHI -130 | 58.3% | 4 | WIN |
| LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
| NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
| KC@CLE | KC -104 | 52.0% | 3 | WIN |
| CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
| WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
| LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
| TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
| SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
| SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
| MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
| NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
| TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
| TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
| ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
| PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
| ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
| SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
| CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
| NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
| PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
| LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
| KC@CHW | KC -109 | 54.2% | 4 | WIN |
| SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
| SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
| MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
| SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
| TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
| CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
| BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
| KC@DET | DET -115 | 56.1% | 5 | WIN |
| CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
| CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
| LAD@SD | SD +110 | 50.9% | 6 | WIN |