Padres vs. Cardinals
Prediction, Odds & Props
Jul 26 | MLB AI Picks

Updated: 2025-07-24T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Diego Padres visit Busch Stadium to face the St. Louis Cardinals on Saturday, July 26, 2025, with first pitch at 7:15 p.m. ET. St. Louis opens as a slight favorite at about –159 moneyline and −1.5 run line, while the total is set at 9 runs.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jul 26, 2025

Start Time: 7:15 PM EST​

Venue: Busch Stadium​

Cardinals Record: (54-51)

Padres Record: (55-49)

OPENING ODDS

SD Moneyline: +135

STL Moneyline: -160

SD Spread: +1.5

STL Spread: -1.5

Over/Under: 9

SD
Betting Trends

  • San Diego has been competitive overall and is roughly 31–18 at home and 21–26 on the road. As road underdogs of +133 or worse this season, they’ve won approximately 47.9% of those games—moderate underdog value.

STL
Betting Trends

  • St. Louis holds a solid record when favored at home; they’ve won about 55% of games as favorites, and posted a strong 70% win rate in games favored by −159 or steeper. Their ATS performance as home favorites has been reliable.

MATCHUP TRENDS

  • Only five of the Cardinals’ last ten games have gone over the total—pointing toward lower-scoring trends—but the Padres have hit the over in four of their last ten, suggesting a possible clash of styles around a 9-run line.

SD vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: I. Herrera over 5.5 Fantasy Score.

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San Diego vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 7/26/25

Saturday’s matchup between the San Diego Padres and the St. Louis Cardinals at Busch Stadium offers a compelling clash between two teams still fighting for playoff positioning in their respective leagues, with each relying on differing formulas for success. The Cardinals, hovering just above .500, are expected to start veteran right-hander Sonny Gray, who has been relatively solid despite some inconsistencies, entering with a 9–4 record and a 4.04 ERA. Gray thrives when he keeps the ball down and induces soft contact, relying heavily on his slider and curve to limit damage against aggressive lineups. On the other side, the Padres are likely to counter with Dylan Cease or Nick Pivetta, though Pivetta has been the more effective of late, posting a 10–2 record with a 2.81 ERA and giving San Diego a puncher’s chance against any opponent. Offensively, both teams bring experienced and talented cores: the Cardinals feature Nolan Arenado, Alec Burleson, Willson Contreras, and Brendan Donovan, providing a mix of power, contact, and smart baserunning, while the Padres offer a deeper middle of the lineup with Fernando Tatis Jr., Manny Machado, Luis Arraez, and Xander Bogaerts. Tatis and Machado have combined for 36 home runs this season, and Arraez continues to be a menace with runners on base thanks to his elite contact ability.

While the Padres may have the more explosive lineup, the Cardinals have the edge in bullpen depth and defensive execution, both of which could prove crucial in a tight game. St. Louis also tends to thrive at home as moderate favorites, winning 70% of games when favored by odds similar to Saturday’s –159 line, and they’ve been particularly strong in keeping games under the total—only five of their last ten games have hit the over. San Diego, in contrast, has hovered near .500 both in the standings and ATS performance, especially when entering as road underdogs, which they’ve done often this season with mixed results. If Gray can navigate the top half of the Padres’ lineup and avoid long innings early, the Cardinals are well-positioned to take control through fundamental execution and timely hitting in the sixth and seventh innings. Conversely, the Padres’ chances hinge on their ability to jump on Gray early, get a lead, and protect it with a bullpen that has been erratic on the road. The total is set at 9, reflecting the potential for both teams to put up runs, though St. Louis’ recent under trend suggests a lean toward a lower-scoring affair if the starters are sharp. Ultimately, the game projects to be decided by starting pitcher efficiency and bullpen command, with St. Louis holding a slight edge due to home-field advantage, recent trends in their favor, and a slightly more consistent defensive profile that could prove critical in preventing extra-base runners and protecting narrow leads late.

San Diego Padres MLB Preview

The San Diego Padres enter Saturday’s game against the St. Louis Cardinals with a 55–48 record and sitting in the thick of the National League Wild Card race, looking to rebound after a stretch of uneven performances on the road and against quality opponents. While their offense remains the backbone of their identity, inconsistencies in their starting rotation and bullpen have made it difficult for the Padres to string together extended winning streaks, especially away from Petco Park. The offensive core is formidable: Manny Machado continues to deliver at a high level with 19 home runs and a near-.290 average, while Fernando Tatis Jr. provides game-changing power and athleticism in both right field and the batter’s box. Xander Bogaerts and Luis Arraez round out a talented infield group, with Arraez excelling at getting on base and Bogaerts continuing to be a steady two-way presence despite some minor injury concerns earlier in the year. Jake Cronenworth and Ha-Seong Kim have also chipped in with clutch hits and aggressive baserunning, helping the Padres create scoring opportunities beyond just the heart of the order. However, their biggest challenges lie on the mound, particularly with Dylan Cease, who despite his electric stuff, has posted a 3–9 record and a 4.64 ERA, struggling with command and failing to escape trouble when his pitch count climbs early. If Nick Pivetta gets the nod instead, San Diego’s chances improve dramatically—Pivetta has quietly turned into a staff ace with a 10–2 record and sub-3.00 ERA, showcasing sharp control, a plus curveball, and the ability to pitch deep into games.

The bullpen has been inconsistent, often relying on matchups and situational usage that sometimes backfire, especially in tight contests on the road. Closer Robert Suarez has been steady, but middle relief remains a concern, particularly if the starter doesn’t make it past five innings. Defensively, San Diego has improved, with Tatis showcasing one of the best arms in baseball from the outfield and the infield solidifying as Bogaerts and Kim get more reps together. From a betting angle, the Padres are underdogs in this game and have performed decently in that role, winning just under 48% of games when entering with odds of +133 or worse, which is above league average for teams in that slot. Their ability to cover the run line has been tied closely to how effectively they score early and how deep their starters pitch, as blown leads have plagued them when forced to rely on extended bullpen work. Against a Cardinals team that prefers low-scoring, methodical games, the Padres will need to assert themselves early with aggressive at-bats and pressure on the basepaths to disrupt St. Louis’ rhythm. If San Diego can force Sonny Gray out of the game before the sixth inning and jump on the middle relievers, they have a good shot at stealing a road win, especially if they get a strong performance from Pivetta or a bounce-back outing from Cease. Execution in the early innings and capitalizing on mistakes will be the blueprint for the Padres to snap their road inconsistency and continue pushing for a postseason berth.

The San Diego Padres visit Busch Stadium to face the St. Louis Cardinals on Saturday, July 26, 2025, with first pitch at 7:15 p.m. ET. St. Louis opens as a slight favorite at about –159 moneyline and −1.5 run line, while the total is set at 9 runs. San Diego vs St. Louis AI Prediction: Free MLB Betting Insights for Jul 26. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals come into Saturday’s game against the San Diego Padres with cautious optimism and the benefit of home-field advantage at Busch Stadium, where they’ve consistently played tighter, smarter baseball, especially when favored. Holding a 53–51 record and sitting in the mix of the NL Central and Wild Card races, the Cardinals have managed to stay afloat through a season marked by inconsistent stretches and key injuries, particularly to power-hitting second baseman Nolan Gorman, whose absence slightly thins their lineup depth. Despite the personnel challenges, St. Louis has performed reliably when playing as home favorites, especially with moneyline odds of –159 or steeper, where they’ve converted roughly 70% of such matchups into victories, an encouraging betting trend. On the mound, veteran right-hander Sonny Gray is expected to get the start, bringing a 9–4 record and a 4.04 ERA into the contest while serving as one of the team’s most trusted arms. Gray’s strength lies in his ability to work through trouble and manage contact-heavy lineups, and against a power-laden Padres offense, his command and sequencing will be critical. Gray will be backed by a bullpen that has performed well above expectations this season, with closer Ryan Helsley and high-leverage arms like JoJo Romero and Giovanny Gallegos locking down late leads with reliable efficiency.

Offensively, the Cardinals are anchored by a core of experienced hitters including Nolan Arenado, who continues to deliver with power and clutch hitting, Alec Burleson with his .289 average and sneaky power, and Willson Contreras who provides run production and veteran presence behind the plate. Brendan Donovan’s ability to get on base and spark rallies has become vital, especially in Gorman’s absence, and rookie shortstop Masyn Winn has also contributed timely hits and defensive highlights to keep the infield steady. From a strategic standpoint, St. Louis will look to keep the game low-scoring and manageable, leaning into their defensive fundamentals and patient approach at the plate to wear down San Diego’s pitching. The Cardinals are particularly dangerous when they can score early and put pressure on opposing bullpens, as their own late-inning staff has proven adept at protecting one- or two-run leads. The total for the game is set around 9 runs, and considering St. Louis has only gone over that total in five of their last ten games, the expectation is for another game dictated by strong pitching and situational offense. Defensively, St. Louis has maintained solid metrics in turning double plays, limiting errors, and fielding balls cleanly, which could prove especially important against a Padres lineup that thrives on aggressive baserunning and extra-base hits. The game plan will center on controlling the pace, getting six solid innings from Gray, and executing in the middle frames where they can expose San Diego’s vulnerable bullpen. If they can limit damage from Machado and Tatis while getting contributions from the top of the order, the Cardinals are in strong position to secure a win, cover the spread, and continue their push toward postseason relevance in an NL field still wide open.

San Diego vs. St. Louis Prop Picks (AI)

AI algorithm Remi is pouring through loads of stats on each line. In fact, anytime the Padres and Cardinals play there’s always several intriguing trends to key in on. Not to mention games played at Busch Stadium in Jul almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: I. Herrera over 5.5 Fantasy Score.

San Diego vs. St. Louis Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every angle between the Padres and Cardinals and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Interestingly enough, the data has been most keyed in on the growing factor knucklehead sportsbettors often put on coaching factors between a Padres team going up against a possibly tired Cardinals team. In reality, the true game analytics might reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Diego vs St. Louis picks, computer picks Padres vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Padres Betting Trends

San Diego has been competitive overall and is roughly 31–18 at home and 21–26 on the road. As road underdogs of +133 or worse this season, they’ve won approximately 47.9% of those games—moderate underdog value.

Cardinals Betting Trends

St. Louis holds a solid record when favored at home; they’ve won about 55% of games as favorites, and posted a strong 70% win rate in games favored by −159 or steeper. Their ATS performance as home favorites has been reliable.

Padres vs. Cardinals Matchup Trends

Only five of the Cardinals’ last ten games have gone over the total—pointing toward lower-scoring trends—but the Padres have hit the over in four of their last ten, suggesting a possible clash of styles around a 9-run line.

San Diego vs. St. Louis Game Info

San Diego vs St. Louis starts on July 26, 2025 at 7:15 PM EST.

Spread: St. Louis -1.5
Moneyline: San Diego +135, St. Louis -160
Over/Under: 9

San Diego: (55-49)  |  St. Louis: (54-51)

Remi's searched hard and found the best prop for this matchup: I. Herrera over 5.5 Fantasy Score.. Prices move—always shop for the best number.

Only five of the Cardinals’ last ten games have gone over the total—pointing toward lower-scoring trends—but the Padres have hit the over in four of their last ten, suggesting a possible clash of styles around a 9-run line.

SD trend: San Diego has been competitive overall and is roughly 31–18 at home and 21–26 on the road. As road underdogs of +133 or worse this season, they’ve won approximately 47.9% of those games—moderate underdog value.

STL trend: St. Louis holds a solid record when favored at home; they’ve won about 55% of games as favorites, and posted a strong 70% win rate in games favored by −159 or steeper. Their ATS performance as home favorites has been reliable.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Diego vs. St. Louis Odds

Remi is pouring through mountains of data on each line. In fact, anytime the San Diego vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable patterns.

San Diego vs St. Louis Opening Odds

SD Moneyline: +135
STL Moneyline: -160
SD Spread: +1.5
STL Spread: -1.5
Over/Under: 9

San Diego vs St. Louis Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Diego Padres vs. St. Louis Cardinals on July 26, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN