Astros vs. Diamondbacks
Prediction, Odds & Props
Jul 23 | MLB AI Picks
Updated: 2025-07-21T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Houston Astros (59–42) roll into Chase Field to face the Arizona Diamondbacks (50–52) on Wednesday, July 23. Houston is a slim favorite at –115 on the moneyline, with the total set at 8.5 runs—suggesting a tight, slightly offensive-leaning contest.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 23, 2025
Start Time: 3:40 PM EST
Venue: Chase Field
Diamondbacks Record: (50-52)
Astros Record: (59-42)
OPENING ODDS
HOU Moneyline: -100
ARI Moneyline: -120
HOU Spread: -1.5
ARI Spread: +1.5
Over/Under: 8.5
HOU
Betting Trends
- The Astros have been strong in interleague play, going 20–13 this season, and carry improved road performance lately, trimming their overall ERA from 4.74 to around 3.35—evidence of stronger pitching across the board.
ARI
Betting Trends
- Arizona has gone 23–25 at home and is 4–6 ATS in their past ten games, reflecting a rollercoaster stretch post-All-Star break that saw them rally to .500 but still lack consistency.
MATCHUP TRENDS
- Despite a power-heavy Chase Field environment, eight of their last ten matchups have stayed under the total—underscoring pitching and situational execution as drivers in this series.
HOU vs. ARI
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: E. Suarez over 5.5 Fantasy Score.
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Houston vs Arizona Prediction & Odds:
Free MLB Betting Insights for 7/23/25
This game could hinge on bullpen execution and mid-inning adjustments; Arizona’s relief corps has been shaky, especially since losing a few key arms to injury, while Houston’s pen has settled in and played a major role in their run differential surge over the past month. Defensively, the Diamondbacks have been cleaner, but Houston has made gains there too, with sharper infield play and more reliable outfield range. A tight pitching duel early could give way to a late-inning swing depending on who manages bullpen matchups better and which offense capitalizes on opportunities with runners in scoring position. Both teams know the stakes: Houston is trying to pad its division lead and test its depth, while Arizona is trying to claw back to .500 and keep their playoff hopes flickering. The betting line hovering around Houston –115 with a total of 8.5 suggests oddsmakers expect a competitive game with a slight edge to the road team. Given both teams’ recent form and how their strengths and weaknesses offset each other, fans can expect a smart, tactical game that may not be high-scoring but should feature playoff-caliber tension. Houston’s more complete profile gives them the edge, but Arizona’s urgency and power at home keep them dangerous if they can get ahead early. A close game seems likely, with late-game decision-making and relief pitching determining who walks away with a vital win.
Defanged#BuiltForThis x @MethodistHosp pic.twitter.com/7httf1s1Yu
— Houston Astros (@astros) July 23, 2025
Houston Astros MLB Preview
The Houston Astros enter this matchup riding a strong July surge that has seen them regain control of the AL West with a blend of timely hitting, resilient pitching, and veteran leadership. Their offense has remained one of the most balanced in the league, with José Altuve continuing to shine atop the order while Yordan Álvarez, Alex Bregman, and Kyle Tucker supply power and consistency through the middle. What makes Houston so dangerous right now is not just their star power, but their ability to manufacture runs with disciplined at-bats, situational hitting, and speed when needed. Brandon Walter will start on the mound, and although he hasn’t yet built a dominant win-loss record, his poise and command of the strike zone have given the Astros a lift during a stretch when other starters were on the mend. With Framber Valdez and Cristian Javier still ramping back up, Walter’s contributions have been crucial in keeping Houston’s rotation effective and limiting exposure to the bullpen. Speaking of which, the Astros’ bullpen has quietly become a strength, with closer Ryan Pressly returning to form and Bryan Abreu continuing to pitch at an elite level in high-leverage situations.
Defensively, Houston has cleaned up significantly in recent weeks, especially in the infield where Jeremy Peña and Bregman have formed a smooth and reliable left side. Their recent series wins against top-tier teams show that the Astros have re-established the championship-level focus and composure that has defined them over the past several seasons. Against Arizona, they will look to continue applying pressure early in counts, extending at-bats, and testing the Diamondbacks’ pitching depth. Their recent ATS record also shows strength on the road, particularly in low-total games, and they’ve often covered when listed as slight favorites. If the Astros can get a quality start from Walter and jump on Pfaadt early, they’re in a strong position to keep rolling and take another win back to the American League. What separates Houston right now is not just talent, but their playoff mentality—they know how to close out winnable games and minimize mistakes late. That’s the kind of identity that travels well, especially into a hitter’s park like Chase Field. Expect the Astros to remain aggressive yet smart, fully aware that every road win counts big in a tight AL race.

Credit: USA TODAY/IMAGN
Arizona Diamondbacks MLB Preview
The Arizona Diamondbacks return home to Chase Field on July 23 looking to spark a bounce-back victory against one of the American League’s toughest clubs in the Houston Astros. Despite a recent skid, Arizona remains very much in the National League playoff picture and continues to flash the promise that carried them to the World Series just two seasons ago. They will send right-hander Brandon Pfaadt to the mound, who has shown steady improvement throughout the summer. While his win-loss record may not reflect dominance, Pfaadt has displayed excellent control, a developing slider, and the ability to pitch deep into games when he’s locating early. His biggest challenge will be limiting Houston’s early count swings and keeping runners off base ahead of their dangerous middle-of-the-order hitters. Arizona’s offense is still fueled by the dynamic presence of Corbin Carroll, who continues to serve as the team’s sparkplug with elite speed and above-average on-base skills. Ketel Marte remains the most consistent hitter in the lineup, while Christian Walker continues to supply power and timely RBIs from the cleanup spot. The Diamondbacks have found recent success when they’re aggressive on the basepaths, forcing mistakes and turning singles into scoring opportunities.
Defensively, the club remains athletic and well-positioned, with solid infield play from Geraldo Perdomo and Marte, and an outfield that covers a ton of ground. The biggest area of concern for Arizona has been bullpen consistency, especially in tight, late-inning situations. Kevin Ginkel and Paul Sewald have shown flashes of reliability, but walks and inherited runners have cost the Diamondbacks several games over the past few weeks. Playing at home, though, Arizona has historically performed better ATS, especially in underdog roles, and they’ve covered frequently against right-handed starters with high groundball rates. Facing Houston, Arizona will need to cash in on any early scoring opportunities, as allowing the Astros’ bullpen to control the late innings has proven disastrous for many opponents. This is a moment for the D-backs to reassert their offensive identity—one built on pressure, pace, and patience at the plate. If Pfaadt can deliver five to six strong innings and the offense supports him with early run production, Arizona has the tools to snap Houston’s momentum and flip the narrative of this series. What they must avoid is falling behind early and leaning too hard on a bullpen that’s still finding its late-game rhythm. With the home crowd behind them, a strong performance from Pfaadt, and a return to their energetic, aggressive brand of baseball, the Diamondbacks could very well walk away with a statement win that reignites their postseason drive in the heart of the second half.
Final. pic.twitter.com/M6wNbzGHB3
— Arizona Diamondbacks (@Dbacks) July 23, 2025
Houston vs. Arizona Prop Picks (AI)
Houston vs. Arizona Prediction (AI)

Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Astros and Diamondbacks and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Remi has been most focused on the growing weight emotional bettors often put on coaching factors between a Astros team going up against a possibly strong Diamondbacks team. It appears the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Houston vs Arizona picks, computer picks Astros vs Diamondbacks, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Astros Betting Trends
The Astros have been strong in interleague play, going 20–13 this season, and carry improved road performance lately, trimming their overall ERA from 4.74 to around 3.35—evidence of stronger pitching across the board.
Diamondbacks Betting Trends
Arizona has gone 23–25 at home and is 4–6 ATS in their past ten games, reflecting a rollercoaster stretch post-All-Star break that saw them rally to .500 but still lack consistency.
Astros vs. Diamondbacks Matchup Trends
Despite a power-heavy Chase Field environment, eight of their last ten matchups have stayed under the total—underscoring pitching and situational execution as drivers in this series.
Houston vs. Arizona Game Info
What time does Houston vs Arizona start on July 23, 2025?
Houston vs Arizona starts on July 23, 2025 at 3:40 PM EST.
Where is Houston vs Arizona being played?
Venue: Chase Field.
What are the opening odds for Houston vs Arizona?
Spread: Arizona +1.5
Moneyline: Houston -100, Arizona -120
Over/Under: 8.5
What are the records for Houston vs Arizona?
Houston: (59-42) | Arizona: (50-52)
What is the AI best bet for Houston vs Arizona?
Remi's searched hard and found the best prop for this matchup: E. Suarez over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Houston vs Arizona trending bets?
Despite a power-heavy Chase Field environment, eight of their last ten matchups have stayed under the total—underscoring pitching and situational execution as drivers in this series.
What are Houston trending bets?
HOU trend: The Astros have been strong in interleague play, going 20–13 this season, and carry improved road performance lately, trimming their overall ERA from 4.74 to around 3.35—evidence of stronger pitching across the board.
What are Arizona trending bets?
ARI trend: Arizona has gone 23–25 at home and is 4–6 ATS in their past ten games, reflecting a rollercoaster stretch post-All-Star break that saw them rally to .500 but still lack consistency.
Where can I find AI Picks for Houston vs Arizona?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Houston vs. Arizona Odds
Remi is pouring through mountains of data on each team. In fact, anytime the Houston vs Arizona trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.
Houston vs Arizona Opening Odds
HOU Moneyline:
-100 ARI Moneyline: -120
HOU Spread: -1.5
ARI Spread: +1.5
Over/Under: 8.5
Houston vs Arizona Live Odds
Games | PTS | ML | SPR | O/U | |
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Cincinnati Reds
Milwaukee Brewers
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Reds
Brewers
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7
4
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-6000
+1800
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-2.5 (-400)
+2.5 (+290)
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O 11.5 (+150)
U 11.5 (-190)
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Texas Rangers
Cleveland Guardians
In Progress
Rangers
Guardians
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2
2
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+125
-167
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-1.5 (+475)
+1.5 (-1000)
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O 7 (-120)
U 7 (+100)
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Arizona Diamondbacks
San Diego Padres
In Progress
Diamondbacks
Padres
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1
5
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+850
-1800
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+3.5 (+120)
-3.5 (-150)
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O 9.5 (+100)
U 9.5 (-130)
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Houston Astros
Los Angeles Angels
In Progress
Astros
Angels
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2
0
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-280
+215
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-2.5 (-105)
+2.5 (-125)
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O 9.5 (-105)
U 9.5 (-125)
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Los Angeles Dodgers
Seattle Mariners
In Progress
Dodgers
Mariners
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0
0
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+115
-145
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+1.5 (-200)
-1.5 (+160)
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O 5.5 (-125)
U 5.5 (-105)
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Kansas City Royals
Oakland Athletics
In Progress
Royals
Athletics
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0
0
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-105
-125
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+1.5 (-180)
-1.5 (+145)
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O 10.5 (+100)
U 10.5 (-130)
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Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
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–
–
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+158
-190
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+1.5 (-125)
-1.5 (+105)
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O 8.5 (-120)
U 8.5 (+100)
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Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
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–
–
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+240
-305
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+1.5 (+118)
-1.5 (-140)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
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–
–
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+175
-210
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+1.5 (-120)
-1.5 (+100)
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O 8 (-120)
U 8 (+100)
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Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
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–
–
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+100
-120
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+1.5 (-190)
-1.5 (+158)
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O 8.5 (-120)
U 8.5 (+100)
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Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
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–
–
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+170
-205
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+1.5 (-120)
-1.5 (+100)
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O 7.5 (-115)
U 7.5 (-105)
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Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
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–
–
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-110
-110
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-1.5 (+150)
+1.5 (-178)
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O 8 (-120)
U 8 (+100)
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Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
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–
–
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+110
-130
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+1.5 (-170)
-1.5 (+140)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
Braves
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–
–
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+175
-210
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+1.5 (-120)
-1.5 (+100)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 28, 2025 3:20PM EDT
St Louis Cardinals
Chicago Cubs
9/28/25 3:20PM
Cardinals
Cubs
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–
–
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-165
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pk
pk
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Houston Astros vs. Arizona Diamondbacks on July 23, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |