Cardinals vs Rockies Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jul 22)

Updated: 2025-07-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (52–49) head to Coors Field to face the Colorado Rockies (24–75) on Tuesday, July 22, 2025. St. Louis arrives as a solid favorite at around –158 on the moneyline, with a 1.5-run line and a lofty 12-run total—suggesting expectations for a fairly high-scoring affair.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jul 22, 2025

Start Time: 8:40 PM EST​

Venue: Coors Field​

Rockies Record: (24-76)

Cardinals Record: (52-49)

OPENING ODDS

STL Moneyline: -156

COL Moneyline: +130

STL Spread: -1.5

COL Spread: +1.5

Over/Under: 12

STL
Betting Trends

  • St. Louis has gone roughly .500 ATS over their last ten games (5–5–0) and holds a winning record as moneyline favorites this season, hitting approximately 56.5%.

COL
Betting Trends

  • Colorado has struggled at Coors Field, entering the matchup with a sub-.250 moneyline win rate as underdogs (+132 line) and just 1 series win before this homestand.

MATCHUP TRENDS

  • Only four of the last ten Cardinals vs. Rockies games have gone over the total, despite Coors Field’s nickname as a run-happy park, hinting that recent matchups have stayed tighter than expected.

STL vs. COL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: G. Hampson under 1.5 Hits+Runs+RBI.

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St. Louis vs Colorado Prediction & Odds:
Free MLB Betting Insights for 7/22/25

The matchup between the St. Louis Cardinals and the Colorado Rockies on July 22, 2025, at Coors Field presents a compelling contrast in form, talent, and stakes. St. Louis comes in with a 52–49 record, fighting to stay in the National League playoff race, while the Rockies remain far out of contention, entering the game at 24–75 and struggling to find consistency in any facet of their game. The Cardinals are expected to send right-hander Erick Fedde to the mound, a veteran with experience navigating both tough lineups and challenging environments. He’ll be tested at altitude against a Rockies team that—while flawed—has flashed improved offensive output in recent games, including a rare series win against Minnesota. Colorado is countering with young righty Bradley Blalock, a developing arm whose outings have been a mix of promise and growing pains. The total for this contest opened at 12 runs, appropriate for the hitter-friendly nature of Coors Field, though recent matchups between these two clubs have tended to stay under that mark. The Cardinals’ offensive core of Nolan Arenado, Paul Goldschmidt, and Willson Contreras gives them a clear advantage in both power and discipline, particularly against a Rockies bullpen that has been overexposed and ineffective much of the season. St. Louis also boasts a more stable relief corps that has helped preserve leads late in games, especially on the road. Defensively, the Cardinals hold an edge in both infield range and outfield efficiency, which is crucial in a park with sprawling dimensions and a history of defensive miscues.

For Colorado, the key to staying competitive will be putting pressure on Fedde early and trying to string together rallies before the Cardinals’ bullpen gets involved. If Blalock can limit traffic on the bases and keep the ball in the park, the Rockies might keep it close. But with the way the Cardinals’ lineup grinds out at-bats and punishes mistakes, the margin for error is razor thin. In terms of recent betting patterns, St. Louis has hovered around .500 ATS in its last ten but has been strong when favored, while the Rockies have continued to underperform both straight up and against the spread, especially at home. Even in a venue where anything can happen, the Cardinals come into this matchup with a significant advantage in pitching, lineup depth, and playoff urgency. The high total reflects both teams’ potential to contribute runs, but it’s more likely the Cardinals will carry the load unless Colorado’s young core continues its upward trend. Look for St. Louis to try to build an early lead and then lean on its superior bullpen and defensive fundamentals to close out what should be a favorable matchup. If the Rockies keep it within range, it will likely be due to a standout outing from Blalock or some timely power from their young hitters, but on paper, the Cardinals appear better positioned in nearly every aspect.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter this July 22 matchup at Coors Field aiming to build momentum in their pursuit of a postseason spot in the National League. With a 52–49 record and a sense of urgency as the second half of the season unfolds, the Cardinals understand the importance of winning games against struggling teams like the Colorado Rockies. They’ll send Erick Fedde to the mound, a dependable right-hander who has provided stability in the middle of the rotation. Fedde’s ability to induce ground balls and limit big innings will be key in a ballpark known for offensive explosions. St. Louis has leaned on its veteran bats—Paul Goldschmidt and Nolan Arenado—for leadership and timely production, but younger hitters like Masyn Winn and Alec Burleson have also stepped up in recent series. The Cardinals’ offense ranks near the middle of the league in both home runs and OPS, but they’ve been more productive on the road of late, especially when facing inexperienced pitching staffs. Defensively, they remain one of the better fielding teams in the National League, with solid range in the infield and outfield despite recent minor injuries. The bullpen, anchored by Ryan Helsley and JoJo Romero, has been a reliable late-game unit, particularly when playing with a lead.

The Cardinals are also tactically sound, rarely beating themselves with errors or baserunning gaffes, which could give them a strategic edge against a Rockies team known for sloppy execution. St. Louis has played under the total in many of its recent road finales, suggesting a tendency to play cleaner, lower-scoring games when series wrap up. This pattern could repeat if Fedde delivers six or more solid innings and the offense does just enough against Bradley Blalock and Colorado’s inconsistent relief corps. In the larger picture, the Cardinals need every win they can get to keep pace in the Wild Card race, and they’ve shown they can handle lesser opponents with professionalism and focus. This series finale represents not just an opportunity to bank a win, but to reinforce winning habits as the schedule toughens. While Coors Field presents challenges for any visiting pitcher, Fedde’s command and St. Louis’s balanced approach at the plate give them a strong chance to control the tempo of this game. The Cardinals’ path to victory hinges on avoiding the big inning and capitalizing on the Rockies’ pitching vulnerabilities early, allowing their own bullpen to take over with a lead. As long as they stay sharp defensively and continue to execute with runners in scoring position, they should have the tools to secure a much-needed road win in Denver.

The St. Louis Cardinals (52–49) head to Coors Field to face the Colorado Rockies (24–75) on Tuesday, July 22, 2025. St. Louis arrives as a solid favorite at around –158 on the moneyline, with a 1.5-run line and a lofty 12-run total—suggesting expectations for a fairly high-scoring affair. St. Louis vs Colorado AI Prediction: Free MLB Betting Insights for Jul 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Colorado Rockies MLB Preview

The Colorado Rockies will close out their series against the St. Louis Cardinals on July 22 at Coors Field, looking to salvage a win in what has been a frustrating season defined by inconsistency and injuries. With a record deep below .500, the Rockies are again staring down the barrel of a last-place finish in the NL West, and while they’ve embraced a youth movement across the roster, their lack of pitching depth and defensive lapses continue to plague them. Rookie right-hander Bradley Blalock is expected to get the start, and while he’s flashed potential with a solid fastball-changeup mix, his command and poise will be tested against a veteran-laden St. Louis lineup. Pitching at altitude is never easy, especially for young arms, and Blalock will need early run support and clean defense behind him if he hopes to last through the middle innings. Offensively, the Rockies have been carried in bursts by players like Ezequiel Tovar, Brenton Doyle, and Ryan McMahon, who continue to produce despite limited lineup protection. Still, Colorado remains near the bottom of the league in most offensive categories, including runs per game, home runs, and team OPS—even at the hitter-friendly confines of Coors Field. Injuries to key contributors and a lack of consistent power from the corners have hindered their ability to sustain rallies. Defensively, the Rockies rank among the worst in errors committed and fielding percentage, issues that tend to magnify in tight, late-game situations.

Their bullpen has been taxed heavily, particularly during high-scoring games at home, and they’ll enter this contest without many fresh arms, which could be a liability against a methodical Cardinals lineup. Still, Colorado has shown occasional fight in series finales at home, leaning on the energy of the Denver crowd and the unpredictability of the Coors environment to steal a win. If they’re to do that Sunday, they’ll need to strike early and often, ideally putting pressure on St. Louis starter Erick Fedde with a barrage of aggressive baserunning and situational hitting. The Rockies’ path to success involves minimizing mistakes, taking advantage of any defensive lapses by the Cardinals, and managing the game closely from the dugout—something manager Bud Black has experience doing despite the thin margin for error this season. Ultimately, this game represents a chance for younger Rockies to continue showcasing their development while the front office evaluates which pieces may form part of the long-term rebuild. While expectations are low, the Rockies have occasionally played spoiler in these late-July series, and a hot start combined with a few timely hits could be enough to create doubt in a more experienced, but sometimes streaky, Cardinals team. The key will be whether the Rockies can stay competitive after the fifth inning, where they’ve repeatedly let games slip away due to poor relief outings and defensive miscues. If Blalock can keep the game within reach and the bats produce early, the Rockies could end the weekend on a rare high note.

St. Louis vs. Colorado Prop Picks (AI)

Remi is pouring through loads of data on each team. In fact, anytime the Cardinals and Rockies play there’s always several intriguing angles to key in on. Not to mention games played at Coors Field in Jul seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: G. Hampson under 1.5 Hits+Runs+RBI.

St. Louis vs. Colorado Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every facet between the Cardinals and Rockies and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the linear correlation of emphasis knucklehead sportsbettors regularly put on coaching factors between a Cardinals team going up against a possibly healthy Rockies team. In reality, the true game analytics appear to reflect a strong lean against one Vegas line specifically.

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Below is our current AI St. Louis vs Colorado picks, computer picks Cardinals vs Rockies, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

St. Louis has gone roughly .500 ATS over their last ten games (5–5–0) and holds a winning record as moneyline favorites this season, hitting approximately 56.5%.

Rockies Betting Trends

Colorado has struggled at Coors Field, entering the matchup with a sub-.250 moneyline win rate as underdogs (+132 line) and just 1 series win before this homestand.

Cardinals vs. Rockies Matchup Trends

Only four of the last ten Cardinals vs. Rockies games have gone over the total, despite Coors Field’s nickname as a run-happy park, hinting that recent matchups have stayed tighter than expected.

St. Louis vs. Colorado Game Info

St. Louis vs Colorado starts on July 22, 2025 at 8:40 PM EST.

Spread: Colorado +1.5
Moneyline: St. Louis -156, Colorado +130
Over/Under: 12

St. Louis: (52-49)  |  Colorado: (24-76)

Remi's searched hard and found the best prop for this matchup: G. Hampson under 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

Only four of the last ten Cardinals vs. Rockies games have gone over the total, despite Coors Field’s nickname as a run-happy park, hinting that recent matchups have stayed tighter than expected.

STL trend: St. Louis has gone roughly .500 ATS over their last ten games (5–5–0) and holds a winning record as moneyline favorites this season, hitting approximately 56.5%.

COL trend: Colorado has struggled at Coors Field, entering the matchup with a sub-.250 moneyline win rate as underdogs (+132 line) and just 1 series win before this homestand.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Colorado Odds

Remi is pouring through tons of stats on each line. In fact, anytime the St. Louis vs Colorado trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

St. Louis vs Colorado Opening Odds

STL Moneyline: -156
COL Moneyline: +130
STL Spread: -1.5
COL Spread: +1.5
Over/Under: 12

St. Louis vs Colorado Live Odds

Games PTS ML SPR O/U
Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
-157
+129
-1.5 (+118)
+1.5 (-144)
O 7.5 (+102)
U 7.5 (-125)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Colorado Rockies on July 22, 2025 at Coors Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN