Cardinals vs Rockies Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jul 22)
Updated: 2025-07-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals (52–49) head to Coors Field to face the Colorado Rockies (24–75) on Tuesday, July 22, 2025. St. Louis arrives as a solid favorite at around –158 on the moneyline, with a 1.5-run line and a lofty 12-run total—suggesting expectations for a fairly high-scoring affair.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 22, 2025
Start Time: 8:40 PM EST
Venue: Coors Field
Rockies Record: (24-76)
Cardinals Record: (52-49)
OPENING ODDS
STL Moneyline: -156
COL Moneyline: +130
STL Spread: -1.5
COL Spread: +1.5
Over/Under: 12
STL
Betting Trends
- St. Louis has gone roughly .500 ATS over their last ten games (5–5–0) and holds a winning record as moneyline favorites this season, hitting approximately 56.5%.
COL
Betting Trends
- Colorado has struggled at Coors Field, entering the matchup with a sub-.250 moneyline win rate as underdogs (+132 line) and just 1 series win before this homestand.
MATCHUP TRENDS
- Only four of the last ten Cardinals vs. Rockies games have gone over the total, despite Coors Field’s nickname as a run-happy park, hinting that recent matchups have stayed tighter than expected.
STL vs. COL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: G. Hampson under 1.5 Hits+Runs+RBI.
LIVE MLB ODDS
MLB ODDS COMPARISON
WANT MORE AI PICKS?
VS. SPREAD
325-240
NET UNITS
(INCL VIG)
+395.4
NET PROFIT
(INCL VIG)
$100/UNIT
$39,540
VS. SPREAD
1593-1364
NET UNITS
(INCL VIG)
+371.9
NET PROFIT
(INCL VIG)
$100/UNIT
$37,192
AI SPORTS PICK PRODUCTS
Create a Free Account

Remi Finds New Picks

Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
St. Louis vs Colorado Prediction & Odds:
Free MLB Betting Insights for 7/22/25
For Colorado, the key to staying competitive will be putting pressure on Fedde early and trying to string together rallies before the Cardinals’ bullpen gets involved. If Blalock can limit traffic on the bases and keep the ball in the park, the Rockies might keep it close. But with the way the Cardinals’ lineup grinds out at-bats and punishes mistakes, the margin for error is razor thin. In terms of recent betting patterns, St. Louis has hovered around .500 ATS in its last ten but has been strong when favored, while the Rockies have continued to underperform both straight up and against the spread, especially at home. Even in a venue where anything can happen, the Cardinals come into this matchup with a significant advantage in pitching, lineup depth, and playoff urgency. The high total reflects both teams’ potential to contribute runs, but it’s more likely the Cardinals will carry the load unless Colorado’s young core continues its upward trend. Look for St. Louis to try to build an early lead and then lean on its superior bullpen and defensive fundamentals to close out what should be a favorable matchup. If the Rockies keep it within range, it will likely be due to a standout outing from Blalock or some timely power from their young hitters, but on paper, the Cardinals appear better positioned in nearly every aspect.
That's a Winner!! pic.twitter.com/ipKeIOYEJC
— St. Louis Cardinals (@Cardinals) July 22, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter this July 22 matchup at Coors Field aiming to build momentum in their pursuit of a postseason spot in the National League. With a 52–49 record and a sense of urgency as the second half of the season unfolds, the Cardinals understand the importance of winning games against struggling teams like the Colorado Rockies. They’ll send Erick Fedde to the mound, a dependable right-hander who has provided stability in the middle of the rotation. Fedde’s ability to induce ground balls and limit big innings will be key in a ballpark known for offensive explosions. St. Louis has leaned on its veteran bats—Paul Goldschmidt and Nolan Arenado—for leadership and timely production, but younger hitters like Masyn Winn and Alec Burleson have also stepped up in recent series. The Cardinals’ offense ranks near the middle of the league in both home runs and OPS, but they’ve been more productive on the road of late, especially when facing inexperienced pitching staffs. Defensively, they remain one of the better fielding teams in the National League, with solid range in the infield and outfield despite recent minor injuries. The bullpen, anchored by Ryan Helsley and JoJo Romero, has been a reliable late-game unit, particularly when playing with a lead.
The Cardinals are also tactically sound, rarely beating themselves with errors or baserunning gaffes, which could give them a strategic edge against a Rockies team known for sloppy execution. St. Louis has played under the total in many of its recent road finales, suggesting a tendency to play cleaner, lower-scoring games when series wrap up. This pattern could repeat if Fedde delivers six or more solid innings and the offense does just enough against Bradley Blalock and Colorado’s inconsistent relief corps. In the larger picture, the Cardinals need every win they can get to keep pace in the Wild Card race, and they’ve shown they can handle lesser opponents with professionalism and focus. This series finale represents not just an opportunity to bank a win, but to reinforce winning habits as the schedule toughens. While Coors Field presents challenges for any visiting pitcher, Fedde’s command and St. Louis’s balanced approach at the plate give them a strong chance to control the tempo of this game. The Cardinals’ path to victory hinges on avoiding the big inning and capitalizing on the Rockies’ pitching vulnerabilities early, allowing their own bullpen to take over with a lead. As long as they stay sharp defensively and continue to execute with runners in scoring position, they should have the tools to secure a much-needed road win in Denver.

Credit: USA TODAY/IMAGN
Colorado Rockies MLB Preview
The Colorado Rockies will close out their series against the St. Louis Cardinals on July 22 at Coors Field, looking to salvage a win in what has been a frustrating season defined by inconsistency and injuries. With a record deep below .500, the Rockies are again staring down the barrel of a last-place finish in the NL West, and while they’ve embraced a youth movement across the roster, their lack of pitching depth and defensive lapses continue to plague them. Rookie right-hander Bradley Blalock is expected to get the start, and while he’s flashed potential with a solid fastball-changeup mix, his command and poise will be tested against a veteran-laden St. Louis lineup. Pitching at altitude is never easy, especially for young arms, and Blalock will need early run support and clean defense behind him if he hopes to last through the middle innings. Offensively, the Rockies have been carried in bursts by players like Ezequiel Tovar, Brenton Doyle, and Ryan McMahon, who continue to produce despite limited lineup protection. Still, Colorado remains near the bottom of the league in most offensive categories, including runs per game, home runs, and team OPS—even at the hitter-friendly confines of Coors Field. Injuries to key contributors and a lack of consistent power from the corners have hindered their ability to sustain rallies. Defensively, the Rockies rank among the worst in errors committed and fielding percentage, issues that tend to magnify in tight, late-game situations.
Their bullpen has been taxed heavily, particularly during high-scoring games at home, and they’ll enter this contest without many fresh arms, which could be a liability against a methodical Cardinals lineup. Still, Colorado has shown occasional fight in series finales at home, leaning on the energy of the Denver crowd and the unpredictability of the Coors environment to steal a win. If they’re to do that Sunday, they’ll need to strike early and often, ideally putting pressure on St. Louis starter Erick Fedde with a barrage of aggressive baserunning and situational hitting. The Rockies’ path to success involves minimizing mistakes, taking advantage of any defensive lapses by the Cardinals, and managing the game closely from the dugout—something manager Bud Black has experience doing despite the thin margin for error this season. Ultimately, this game represents a chance for younger Rockies to continue showcasing their development while the front office evaluates which pieces may form part of the long-term rebuild. While expectations are low, the Rockies have occasionally played spoiler in these late-July series, and a hot start combined with a few timely hits could be enough to create doubt in a more experienced, but sometimes streaky, Cardinals team. The key will be whether the Rockies can stay competitive after the fifth inning, where they’ve repeatedly let games slip away due to poor relief outings and defensive miscues. If Blalock can keep the game within reach and the bats produce early, the Rockies could end the weekend on a rare high note.
Bardo called it a career 💜 pic.twitter.com/QVGyftzSdE
— Colorado Rockies (@Rockies) July 20, 2025
St. Louis vs. Colorado Prop Picks (AI)
St. Louis vs. Colorado Prediction (AI)

Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every past game between the Cardinals and Rockies and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Remi has been most focused on the unproportionally assigned factor human bettors tend to put on player performance factors between a Cardinals team going up against a possibly deflated Rockies team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Colorado picks, computer picks Cardinals vs Rockies, best bets, model edges, confidence ratings.
![]() |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
![]() |
|
MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
![]() |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
St. Louis has gone roughly .500 ATS over their last ten games (5–5–0) and holds a winning record as moneyline favorites this season, hitting approximately 56.5%.
Rockies Betting Trends
Colorado has struggled at Coors Field, entering the matchup with a sub-.250 moneyline win rate as underdogs (+132 line) and just 1 series win before this homestand.
Cardinals vs. Rockies Matchup Trends
Only four of the last ten Cardinals vs. Rockies games have gone over the total, despite Coors Field’s nickname as a run-happy park, hinting that recent matchups have stayed tighter than expected.
St. Louis vs. Colorado Game Info
What time does St. Louis vs Colorado start on July 22, 2025?
St. Louis vs Colorado starts on July 22, 2025 at 8:40 PM EST.
Where is St. Louis vs Colorado being played?
Venue: Coors Field.
What are the opening odds for St. Louis vs Colorado?
Spread: Colorado +1.5
Moneyline: St. Louis -156, Colorado +130
Over/Under: 12
What are the records for St. Louis vs Colorado?
St. Louis: (52-49) | Colorado: (24-76)
What is the AI best bet for St. Louis vs Colorado?
Remi's searched hard and found the best prop for this matchup: G. Hampson under 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are St. Louis vs Colorado trending bets?
Only four of the last ten Cardinals vs. Rockies games have gone over the total, despite Coors Field’s nickname as a run-happy park, hinting that recent matchups have stayed tighter than expected.
What are St. Louis trending bets?
STL trend: St. Louis has gone roughly .500 ATS over their last ten games (5–5–0) and holds a winning record as moneyline favorites this season, hitting approximately 56.5%.
What are Colorado trending bets?
COL trend: Colorado has struggled at Coors Field, entering the matchup with a sub-.250 moneyline win rate as underdogs (+132 line) and just 1 series win before this homestand.
Where can I find AI Picks for St. Louis vs Colorado?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Colorado Odds
Remi is pouring through mountains of stats on each player. In fact, anytime the St. Louis vs Colorado trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.
St. Louis vs Colorado Opening Odds
STL Moneyline:
-156 COL Moneyline: +130
STL Spread: -1.5
COL Spread: +1.5
Over/Under: 12
St. Louis vs Colorado Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
|
–
–
|
-143
+130
|
-1.5 (+120)
+1.5 (-140)
|
O 7.5 (+105)
U 7.5 (-125)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Colorado Rockies on July 22, 2025 at Coors Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
![]() |
LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |