Orioles vs Guardians Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jul 22)
Updated: 2025-07-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Baltimore Orioles (51–50) head to Progressive Field to face the Cleveland Guardians (59–50) on July 22, 2025. Cleveland enters as a modest favorite (–141 ML, –1.5 run line) with an 8.5 total, setting up expectations for a well-pitched, potentially low-scoring contest.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 22, 2025
Start Time: 6:40 PM EST
Venue: Progressive Field
Guardians Record: (49-50)
Orioles Record: (44-55)
OPENING ODDS
BAL Moneyline: +114
CLE Moneyline: -136
BAL Spread: +1.5
CLE Spread: -1.5
Over/Under: 8.5
BAL
Betting Trends
- Baltimore has struggled as an underdog on the road, posting a lackluster ATS record in such matchups, particularly when up against teams with superior pitching and offensive efficiency.
CLE
Betting Trends
- Cleveland has been profitable at home, going 7–3 ATS in their last 10 games and 6–4 ATS as MLB favorites (–141 or better), demonstrating consistency and home-field dominance in key matchups.
MATCHUP TRENDS
- While the Guardians have been strong ATS, they’ve also gone Over the total in 7 of their last 10 games, suggesting their games tend to include more offensive fireworks than expected, even in matchups where pitching is favored.
BAL vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Ramirez over 1.5 Hits+Runs+RBI.
LIVE MLB ODDS
MLB ODDS COMPARISON
WANT MORE AI PICKS?
VS. SPREAD
325-240
NET UNITS
(INCL VIG)
+395.4
NET PROFIT
(INCL VIG)
$100/UNIT
$39,540
VS. SPREAD
1593-1364
NET UNITS
(INCL VIG)
+371.9
NET PROFIT
(INCL VIG)
$100/UNIT
$37,192
AI SPORTS PICK PRODUCTS
Create a Free Account

Remi Finds New Picks

Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Baltimore vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 7/22/25
Both teams feature capable bullpens, though Cleveland’s relief corps has been notably sharp in late-inning scenarios, a potential difference-maker in close contests. Statistically, Cleveland has covered the spread in seven of its last ten games, showing not just that they’re winning, but they’re doing it convincingly, especially at home. Meanwhile, Baltimore has faltered in recent road matchups when cast as underdogs, particularly against teams with potent offenses and solid pitching at the top of the rotation. Interestingly, Cleveland games have gone over the total in seven of their last ten outings, indicating that while their pitching has done enough to win, it hasn’t always stifled opposing bats, which could offer Baltimore some hope of producing offense. The key to the matchup likely lies in the first five innings—if Irvin can keep the Guardians off balance and Santander or Henderson can deliver a timely long ball, Baltimore can seize early momentum. However, Cleveland’s recent combination of steady hitting, solid bullpen work, and effective managerial tactics gives them the upper hand in what could be a closely contested but ultimately decisive game for both squads. Given the Guardians’ ATS success, home advantage, and recent scoring outbursts, they appear poised to take control of the series, while Baltimore must rediscover their early-season rhythm to pull off a much-needed win on the road.
Laureano LAUNCHED pic.twitter.com/aDsVRh4nWX
— Baltimore Orioles (@Orioles) July 21, 2025
Baltimore Orioles MLB Preview
The Baltimore Orioles enter this matchup against the Cleveland Guardians on July 22, 2025, hoping to reverse a troubling midseason trend that has seen them fall below .500 and lose their grip on momentum in a competitive American League race. Sitting at 51–50, the Orioles are mired in a four-game losing streak that has exposed both offensive inconsistencies and late-game pitching vulnerabilities. Cole Irvin will take the mound for Baltimore, and his 3.45 ERA coupled with a reliable WHIP under 1.20 suggests he has been one of the steadier arms in the Orioles’ rotation. His ability to generate weak contact and induce double plays could be crucial against a Guardians lineup that has recently found a rhythm. The Orioles’ offense, once the team’s calling card, has gone quiet lately, failing to score more than four runs in any of their last four games. Gunnar Henderson and Anthony Santander remain Baltimore’s most dangerous bats, with Henderson flashing consistent power and plate discipline while Santander offers switch-hitting versatility and occasional fireworks. However, the supporting cast has not stepped up, with players like Ryan Mountcastle and Cedric Mullins struggling to maintain productive stretches.
Defensively, the Orioles remain solid up the middle, but bullpen woes—particularly with leads in tight games—have begun to surface more often. While closer Craig Kimbrel has experience and strikeout ability, command issues and inherited runners have resulted in a few too many blown saves and late-game falters. From a betting standpoint, Baltimore has struggled in recent ATS scenarios, particularly on the road as underdogs, and their performance in series finales has not inspired confidence. They’ve dropped six of their last eight rubber matches or concluding games on the road, and when their offense gets off to a slow start, they rarely recover. The team’s overall pitching depth is being tested as the long summer continues, and the lack of consistency among the lineup’s bottom half limits their margin for error. That said, if Irvin can give them six or seven strong innings and keep José Ramírez and Josh Naylor quiet, Baltimore has a fighting chance to steal a win. The Orioles’ path to victory likely hinges on early scoring and forcing Cleveland into their bullpen before the seventh inning, which may neutralize the Guardians’ late-game advantage. Baltimore has shown flashes of resilience throughout the season, and while this series hasn’t gone their way so far, a rebound performance on the road would be crucial in reestablishing their confidence and playoff viability. Ultimately, the Orioles are a team with talent but in need of sharper execution, and this contest offers an opportunity to reset against a streaking division leader.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians continue to ride one of the hottest stretches in Major League Baseball as they host the Baltimore Orioles on July 22, 2025, with momentum and confidence squarely on their side. Now sitting atop the AL Central with a strong 60–40 record, Cleveland has put together a solid 6–2 run over their last eight games, driven by timely hitting, elite bullpen work, and a lockdown defense that continues to smother opponents. Tanner Bibee is scheduled to start for the Guardians, and the young right-hander has been sensational of late, stringing together three consecutive quality starts with a combined ERA under 2.00 in that span. His rising strikeout numbers, paired with excellent command, make him a dangerous matchup for a Baltimore offense that has been sluggish during their current four-game skid. José Ramírez remains the heartbeat of Cleveland’s offense, consistently producing in high-leverage moments while anchoring the infield with elite glove work. Josh Naylor has been an equally potent force, particularly in clutch RBI situations, and the continued emergence of Steven Kwan and Andrés Giménez gives this lineup depth and speed from top to bottom.
Defensively, the Guardians have been nearly flawless in July, committing fewer than three errors all month and showcasing elite range up the middle with Giménez and Brayan Rocchio. The bullpen remains a major asset, with Emmanuel Clase leading the league in saves and the likes of Scott Barlow and Nick Sandlin forming a dependable bridge from the starters to the ninth inning. What’s made Cleveland particularly formidable at home is their ability to capitalize on mistakes—whether that’s a passed ball, a wild pitch, or a misplayed fly ball—and their aggressive baserunning often forces the issue. In betting terms, Cleveland has been one of the most profitable ATS teams in the American League when playing at home against teams with winning percentages between .490 and .510, a window that currently fits the Orioles. The Guardians are also 9–3 in series finale games at Progressive Field this season and have covered the spread in five of their last seven Sunday contests. Their ability to play small ball and manufacture runs without relying solely on the long ball makes them a tough out even when the bats aren’t red-hot. Entering this matchup, Cleveland holds every intangible edge—form, pitching, momentum, and home-field advantage—and with Bibee dealing and the bullpen rested, the Guardians will aim to sweep or take another series with a professional, fundamentally sound approach. If they can keep Henderson and Santander in check and avoid early deficits, they’re poised to keep their AL Central cushion intact and continue building their postseason résumé. With Terry Francona’s methodical style still imprinting the team culture, this group plays clean, poised baseball, and they’ve proven time and again they can win in different ways—something that could make them dangerous deep into October.
Nobody does it better than José Ramírez.#GuardsBall | #GuardiWWins pic.twitter.com/zOXIKHvQQC
— Cleveland Guardians (@CleGuardians) July 22, 2025
Baltimore vs. Cleveland Prop Picks (AI)
Baltimore vs. Cleveland Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Orioles and Guardians and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Interestingly enough, the data has been most keyed in on the unproportionally assigned factor knucklehead sportsbettors often put on Baltimore’s strength factors between a Orioles team going up against a possibly improved Guardians team. In reality, the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Baltimore vs Cleveland picks, computer picks Orioles vs Guardians, best bets, model edges, confidence ratings.
![]() |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
![]() |
|
MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
![]() |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Orioles Betting Trends
Baltimore has struggled as an underdog on the road, posting a lackluster ATS record in such matchups, particularly when up against teams with superior pitching and offensive efficiency.
Guardians Betting Trends
Cleveland has been profitable at home, going 7–3 ATS in their last 10 games and 6–4 ATS as MLB favorites (–141 or better), demonstrating consistency and home-field dominance in key matchups.
Orioles vs. Guardians Matchup Trends
While the Guardians have been strong ATS, they’ve also gone Over the total in 7 of their last 10 games, suggesting their games tend to include more offensive fireworks than expected, even in matchups where pitching is favored.
Baltimore vs. Cleveland Game Info
What time does Baltimore vs Cleveland start on July 22, 2025?
Baltimore vs Cleveland starts on July 22, 2025 at 6:40 PM EST.
Where is Baltimore vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Baltimore vs Cleveland?
Spread: Cleveland -1.5
Moneyline: Baltimore +114, Cleveland -136
Over/Under: 8.5
What are the records for Baltimore vs Cleveland?
Baltimore: (44-55) | Cleveland: (49-50)
What is the AI best bet for Baltimore vs Cleveland?
Remi's searched hard and found the best prop for this matchup: J. Ramirez over 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Baltimore vs Cleveland trending bets?
While the Guardians have been strong ATS, they’ve also gone Over the total in 7 of their last 10 games, suggesting their games tend to include more offensive fireworks than expected, even in matchups where pitching is favored.
What are Baltimore trending bets?
BAL trend: Baltimore has struggled as an underdog on the road, posting a lackluster ATS record in such matchups, particularly when up against teams with superior pitching and offensive efficiency.
What are Cleveland trending bets?
CLE trend: Cleveland has been profitable at home, going 7–3 ATS in their last 10 games and 6–4 ATS as MLB favorites (–141 or better), demonstrating consistency and home-field dominance in key matchups.
Where can I find AI Picks for Baltimore vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Baltimore vs. Cleveland Odds
Remi is pouring through loads of stats on each line. In fact, anytime the Baltimore vs Cleveland trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.
Baltimore vs Cleveland Opening Odds
BAL Moneyline:
+114 CLE Moneyline: -136
BAL Spread: +1.5
CLE Spread: -1.5
Over/Under: 8.5
Baltimore vs Cleveland Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
|
–
–
|
-157
+129
|
-1.5 (+113)
+1.5 (-137)
|
O 7.5 (+101)
U 7.5 (-123)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Baltimore Orioles vs. Cleveland Guardians on July 22, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
![]() |
LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |