Royals vs Cubs Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jul 21)
Updated: 2025-07-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Kansas City Royals (48–52) travel to Wrigley Field to face the surging Chicago Cubs (57–39), who have bounced back from a slow start and currently hold the top spot in the NL Central. Chicago enters slightly favored (–150 ML, –1.5 run line), with the total set around 8 runs, suggesting an evenly matched game with potential for both offensive swings and pitching control.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 21, 2025
Start Time: 8:05 PM EST
Venue: Wrigley Field
Cubs Record: (59-40)
Royals Record: (48-52)
OPENING ODDS
KC Moneyline: +118
CHC Moneyline: -140
KC Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
KC
Betting Trends
- As road underdogs, Kansas City has covered the run line roughly 46% of the time this season, reflecting a middle-of-the-pack performance.
CHC
Betting Trends
- Chicago boasts a sturdy 57–39 overall record and has covered the spread consistently at Wrigley, especially in games where they’re favored.
MATCHUP TRENDS
- In their last five visits to Wrigley, Kansas City has managed to hold Chase Field close, pushing late but rarely pulling away—three of those games have stayed under 8 runs, indicating low-scoring potential.
KC vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.
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Kansas City vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 7/21/25
For Chicago, the offense is more balanced and has performed well situationally. Ian Happ, Seiya Suzuki, and Pete Crow-Armstrong are all heating up, and with better on-base percentages and fewer strikeouts in key moments, the Cubs have built a habit of pressuring pitchers early. Defensively, the Cubs are among the better teams in the NL, showing marked improvement from last year with clean infield play and aggressive outfield coverage. The Royals, on the other hand, still commit costly defensive errors and are below league average in fielding percentage. The total for this game is hovering around 8 runs, which reflects respect for both rotations and a hint at limited offensive outbursts, especially if the wind at Wrigley plays neutral or inward. Betting-wise, the Cubs are favored for good reason—they’ve covered well as home favorites and own a significantly better home run differential than the Royals. Kansas City tends to struggle in late innings when their bullpen is exposed, and against a team as efficient as Chicago, even one bad inning could tilt the game irreversibly. While Kansas City has enough talent to keep things interesting, they’ll need to play a clean, fundamentally sound game and hope for timely hits against a deep Cubs pitching staff. If Chicago jumps ahead early, their bullpen is strong enough to seal things without much drama. Overall, this feels like a spot where the Cubs’ all-around consistency and home-field advantage outweigh Kansas City’s high-risk, high-reward style, setting the stage for another Cubs win in a game that could lean under the total depending on the pace of early innings.
Secured the win.#HEYHEYHEYHEY pic.twitter.com/CNYpURDSgA
— Kansas City Royals (@Royals) July 20, 2025
Kansas City Royals MLB Preview
The Kansas City Royals head into Wrigley Field on July 21, 2025, looking to rebound from an uneven stretch that has seen them struggle to consistently execute on both sides of the ball. Despite possessing a lineup with young stars like Bobby Witt Jr. and promising contributors such as MJ Melendez and Vinnie Pasquantino, the Royals have been plagued by inconsistent offensive output, particularly in clutch moments with runners in scoring position. Witt Jr. has emerged as one of the premier shortstops in baseball this season, showcasing elite baserunning, timely power, and highlight-reel defense, but he hasn’t had the consistent support behind him in the batting order to turn individual success into team wins. On the mound, Kansas City has relied heavily on the veteran steadiness of pitchers like Seth Lugo, Brady Singer, and Michael Wacha, with Lugo and Wacha both offering experience and pitchability that help limit hard contact and stretch games into the sixth and seventh innings. However, one of the major pitfalls of this Royals team continues to be bullpen vulnerability, especially in late-inning scenarios where walks and command issues have repeatedly unraveled close contests.
The Royals have shown flashes of potential, particularly in mid-series games when facing unfamiliar arms, but they remain one of the more unreliable road teams when it comes to sustaining momentum from game to game. Defensively, Kansas City is improving but still ranks in the lower third of the league in errors and fielding percentage, often letting tight games slip away due to lapses in focus or execution. Manager Matt Quatraro continues to focus on developing his young core while trying to extract every ounce of value from his veterans, but the margin for error against a playoff-contending team like the Cubs is slim. The Royals tend to rely on manufacturing runs through stolen bases and hit-and-run tactics, which can be neutralized against disciplined pitching staffs that control the zone and hold runners well. If the Royals are to pull off the upset, they’ll need one of their starters to pitch deep into the game and limit the Cubs’ early offensive output while the offense scrapes together timely hits. Kansas City’s ATS record on the road this season has been spotty, especially against teams with winning records, and they’ve often failed to cover spreads when listed as underdogs in nationally televised or marquee matchups. That said, they can’t be completely discounted, as they’ve played spoiler before and tend to elevate their energy when facing historical franchises in big-name stadiums. If Witt Jr. can ignite the offense early and the bullpen can piece together a clean finish, the Royals have a puncher’s chance, but anything less than a near-flawless performance will likely result in a long afternoon in Chicago. Ultimately, Kansas City arrives as a team with talent but too many variables still unresolved to be trusted in this spot, making them the riskier side of the betting equation in this interleague clash.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Chicago Cubs enter their July 21, 2025, matchup against the Kansas City Royals at Wrigley Field riding a wave of late-summer momentum that has kept them firmly in the hunt for the National League Central crown. Under the leadership of manager Craig Counsell, the Cubs have found a rhythm built on strong pitching, improved defensive fundamentals, and an increasingly balanced lineup that has learned to grind out games with professional at-bats. At the center of this consistency is a starting rotation that has outperformed expectations, with Japanese lefty Shota Imanaga and veteran Jameson Taillon anchoring a staff that ranks in the top ten in ERA and quality starts. The bullpen has also taken significant strides from last season’s inconsistency, as Julian Merryweather and Adbert Alzolay have embraced high-leverage roles with increased command and pitch efficiency. Offensively, the Cubs are seeing encouraging signs from young players like Pete Crow-Armstrong and Alexander Canario, while established bats such as Ian Happ, Nico Hoerner, and Seiya Suzuki continue to deliver timely hits and work counts deep into at-bats. With Cody Bellinger’s veteran presence also adding maturity to the lineup, Chicago has become harder to pitch to than in previous seasons, showing versatility against both power arms and finesse pitchers. Wrigley Field remains a decisive advantage, where the Cubs’ home splits show a notable bump in OBP, slugging, and run production, and their comfort playing in front of packed crowds is evident in their body language and pace of play.
Defensively, Chicago has become one of the more dependable teams in the league, with clean double-play execution, smart shifts, and athletic outfield coverage that limits extra bases. The Cubs’ approach is rarely flashy, but it’s effective, and when they build early leads, they tend to close games confidently and without unnecessary drama. Betting-wise, they’ve been one of the more profitable teams at home against non-contending or sub-.500 opponents, especially when favored by 1.5 runs. The total for this game may lean under if wind patterns at Wrigley favor pitchers, and Chicago has proven capable of adapting to low-scoring contests just as well as offensive showcases. Facing a Royals team that has been inconsistent and vulnerable in late innings, the Cubs will look to capitalize early with pressure on the bases and opportunistic hitting, often setting the tone within the first three frames. The game plan will likely be to get into Kansas City’s bullpen by the sixth inning, where the advantage leans heavily toward the home team. If the Cubs continue their sharp fielding and strike early with runs, they’ll be tough to catch on a day when playoff positioning adds urgency to every inning. In short, Chicago is well-positioned not only to win but also to cover, especially if their frontline starters command the zone and avoid letting the Royals’ speed game become a factor. This is a Cubs team with a clear identity and the confidence to execute it, and they’ll look to put it on display again in a favorable Sunday matinee at home.
a happ rbi to start us off 🫡 pic.twitter.com/FNQslEw0U9
— Chicago Cubs (@Cubs) July 20, 2025
Kansas City vs. Chicago Cubs Prop Picks (AI)
Kansas City vs. Chicago Cubs Prediction (AI)

Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every past game between the Royals and Cubs and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
The Algorithm has been most keyed in on the linear correlation of factor human bettors regularly put on player performance factors between a Royals team going up against a possibly strong Cubs team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Kansas City vs Chicago Cubs picks, computer picks Royals vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Royals Betting Trends
As road underdogs, Kansas City has covered the run line roughly 46% of the time this season, reflecting a middle-of-the-pack performance.
Cubs Betting Trends
Chicago boasts a sturdy 57–39 overall record and has covered the spread consistently at Wrigley, especially in games where they’re favored.
Royals vs. Cubs Matchup Trends
In their last five visits to Wrigley, Kansas City has managed to hold Chase Field close, pushing late but rarely pulling away—three of those games have stayed under 8 runs, indicating low-scoring potential.
Kansas City vs. Chicago Cubs Game Info
What time does Kansas City vs Chicago Cubs start on July 21, 2025?
Kansas City vs Chicago Cubs starts on July 21, 2025 at 8:05 PM EST.
Where is Kansas City vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for Kansas City vs Chicago Cubs?
Spread: Chicago Cubs -1.5
Moneyline: Kansas City +118, Chicago Cubs -140
Over/Under: 8
What are the records for Kansas City vs Chicago Cubs?
Kansas City: (48-52) | Chicago Cubs: (59-40)
What is the AI best bet for Kansas City vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.. Prices move—always shop for the best number.
What are Kansas City vs Chicago Cubs trending bets?
In their last five visits to Wrigley, Kansas City has managed to hold Chase Field close, pushing late but rarely pulling away—three of those games have stayed under 8 runs, indicating low-scoring potential.
What are Kansas City trending bets?
KC trend: As road underdogs, Kansas City has covered the run line roughly 46% of the time this season, reflecting a middle-of-the-pack performance.
What are Chicago Cubs trending bets?
CHC trend: Chicago boasts a sturdy 57–39 overall record and has covered the spread consistently at Wrigley, especially in games where they’re favored.
Where can I find AI Picks for Kansas City vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Kansas City vs. Chicago Cubs Odds
Remi is pouring through tons of data points on each team. In fact, anytime the Kansas City vs Chicago Cubs trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.
Kansas City vs Chicago Cubs Opening Odds
KC Moneyline:
+118 CHC Moneyline: -140
KC Spread: +1.5
CHC Spread: -1.5
Over/Under: 8
Kansas City vs Chicago Cubs Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
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–
–
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-148
+126
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-1.5 (+118)
+1.5 (-142)
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O 7.5 (+100)
U 7.5 (-122)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Kansas City Royals vs. Chicago Cubs Cubs on July 21, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |