Royals vs. Cubs
Prediction, Odds & Props
Jul 21 | MLB AI Picks

Updated: 2025-07-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Kansas City Royals (48–52) travel to Wrigley Field to face the surging Chicago Cubs (57–39), who have bounced back from a slow start and currently hold the top spot in the NL Central. Chicago enters slightly favored (–150 ML, –1.5 run line), with the total set around 8 runs, suggesting an evenly matched game with potential for both offensive swings and pitching control.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jul 21, 2025

Start Time: 8:05 PM EST​

Venue: Wrigley Field​

Cubs Record: (59-40)

Royals Record: (48-52)

OPENING ODDS

KC Moneyline: +118

CHC Moneyline: -140

KC Spread: +1.5

CHC Spread: -1.5

Over/Under: 8

KC
Betting Trends

  • As road underdogs, Kansas City has covered the run line roughly 46% of the time this season, reflecting a middle-of-the-pack performance.

CHC
Betting Trends

  • Chicago boasts a sturdy 57–39 overall record and has covered the spread consistently at Wrigley, especially in games where they’re favored.

MATCHUP TRENDS

  • In their last five visits to Wrigley, Kansas City has managed to hold Chase Field close, pushing late but rarely pulling away—three of those games have stayed under 8 runs, indicating low-scoring potential.

KC vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.

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Kansas City vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 7/21/25

The upcoming matchup between the Kansas City Royals and the Chicago Cubs on July 21, 2025, at Wrigley Field promises an intriguing interleague clash between a rebuilding Royals squad and a surging Cubs team eyeing postseason momentum. With the Cubs sitting near the top of the NL Central and the Royals hovering around the .500 mark in the AL Central, both teams enter with different aspirations but mutual urgency to capitalize on the latter half of the season. The Cubs have been one of the more consistent teams in baseball this year, especially at home, where their pitching and defense have been reliably sharp, helping them string together one of the National League’s better records. They are expected to send out either Shota Imanaga or Jameson Taillon—both of whom have delivered strong outings at Wrigley and have a combined ERA under 3.80. Kansas City, meanwhile, will likely turn to one of its veteran arms such as Michael Wacha or Seth Lugo to handle the start. Both are capable of keeping games competitive, though they’ll need support from an offense that has at times been streaky. Bobby Witt Jr. continues to be Kansas City’s offensive catalyst, combining power and speed to keep opposing defenses on their heels, while MJ Melendez and Vinnie Pasquantino round out a lineup that can flash extra-base potential but too often leaves runners stranded.

For Chicago, the offense is more balanced and has performed well situationally. Ian Happ, Seiya Suzuki, and Pete Crow-Armstrong are all heating up, and with better on-base percentages and fewer strikeouts in key moments, the Cubs have built a habit of pressuring pitchers early. Defensively, the Cubs are among the better teams in the NL, showing marked improvement from last year with clean infield play and aggressive outfield coverage. The Royals, on the other hand, still commit costly defensive errors and are below league average in fielding percentage. The total for this game is hovering around 8 runs, which reflects respect for both rotations and a hint at limited offensive outbursts, especially if the wind at Wrigley plays neutral or inward. Betting-wise, the Cubs are favored for good reason—they’ve covered well as home favorites and own a significantly better home run differential than the Royals. Kansas City tends to struggle in late innings when their bullpen is exposed, and against a team as efficient as Chicago, even one bad inning could tilt the game irreversibly. While Kansas City has enough talent to keep things interesting, they’ll need to play a clean, fundamentally sound game and hope for timely hits against a deep Cubs pitching staff. If Chicago jumps ahead early, their bullpen is strong enough to seal things without much drama. Overall, this feels like a spot where the Cubs’ all-around consistency and home-field advantage outweigh Kansas City’s high-risk, high-reward style, setting the stage for another Cubs win in a game that could lean under the total depending on the pace of early innings.

Kansas City Royals MLB Preview

The Kansas City Royals head into Wrigley Field on July 21, 2025, looking to rebound from an uneven stretch that has seen them struggle to consistently execute on both sides of the ball. Despite possessing a lineup with young stars like Bobby Witt Jr. and promising contributors such as MJ Melendez and Vinnie Pasquantino, the Royals have been plagued by inconsistent offensive output, particularly in clutch moments with runners in scoring position. Witt Jr. has emerged as one of the premier shortstops in baseball this season, showcasing elite baserunning, timely power, and highlight-reel defense, but he hasn’t had the consistent support behind him in the batting order to turn individual success into team wins. On the mound, Kansas City has relied heavily on the veteran steadiness of pitchers like Seth Lugo, Brady Singer, and Michael Wacha, with Lugo and Wacha both offering experience and pitchability that help limit hard contact and stretch games into the sixth and seventh innings. However, one of the major pitfalls of this Royals team continues to be bullpen vulnerability, especially in late-inning scenarios where walks and command issues have repeatedly unraveled close contests.

The Royals have shown flashes of potential, particularly in mid-series games when facing unfamiliar arms, but they remain one of the more unreliable road teams when it comes to sustaining momentum from game to game. Defensively, Kansas City is improving but still ranks in the lower third of the league in errors and fielding percentage, often letting tight games slip away due to lapses in focus or execution. Manager Matt Quatraro continues to focus on developing his young core while trying to extract every ounce of value from his veterans, but the margin for error against a playoff-contending team like the Cubs is slim. The Royals tend to rely on manufacturing runs through stolen bases and hit-and-run tactics, which can be neutralized against disciplined pitching staffs that control the zone and hold runners well. If the Royals are to pull off the upset, they’ll need one of their starters to pitch deep into the game and limit the Cubs’ early offensive output while the offense scrapes together timely hits. Kansas City’s ATS record on the road this season has been spotty, especially against teams with winning records, and they’ve often failed to cover spreads when listed as underdogs in nationally televised or marquee matchups. That said, they can’t be completely discounted, as they’ve played spoiler before and tend to elevate their energy when facing historical franchises in big-name stadiums. If Witt Jr. can ignite the offense early and the bullpen can piece together a clean finish, the Royals have a puncher’s chance, but anything less than a near-flawless performance will likely result in a long afternoon in Chicago. Ultimately, Kansas City arrives as a team with talent but too many variables still unresolved to be trusted in this spot, making them the riskier side of the betting equation in this interleague clash.

The Kansas City Royals (48–52) travel to Wrigley Field to face the surging Chicago Cubs (57–39), who have bounced back from a slow start and currently hold the top spot in the NL Central. Chicago enters slightly favored (–150 ML, –1.5 run line), with the total set around 8 runs, suggesting an evenly matched game with potential for both offensive swings and pitching control. Kansas City vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Jul 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs enter their July 21, 2025, matchup against the Kansas City Royals at Wrigley Field riding a wave of late-summer momentum that has kept them firmly in the hunt for the National League Central crown. Under the leadership of manager Craig Counsell, the Cubs have found a rhythm built on strong pitching, improved defensive fundamentals, and an increasingly balanced lineup that has learned to grind out games with professional at-bats. At the center of this consistency is a starting rotation that has outperformed expectations, with Japanese lefty Shota Imanaga and veteran Jameson Taillon anchoring a staff that ranks in the top ten in ERA and quality starts. The bullpen has also taken significant strides from last season’s inconsistency, as Julian Merryweather and Adbert Alzolay have embraced high-leverage roles with increased command and pitch efficiency. Offensively, the Cubs are seeing encouraging signs from young players like Pete Crow-Armstrong and Alexander Canario, while established bats such as Ian Happ, Nico Hoerner, and Seiya Suzuki continue to deliver timely hits and work counts deep into at-bats. With Cody Bellinger’s veteran presence also adding maturity to the lineup, Chicago has become harder to pitch to than in previous seasons, showing versatility against both power arms and finesse pitchers. Wrigley Field remains a decisive advantage, where the Cubs’ home splits show a notable bump in OBP, slugging, and run production, and their comfort playing in front of packed crowds is evident in their body language and pace of play.

Defensively, Chicago has become one of the more dependable teams in the league, with clean double-play execution, smart shifts, and athletic outfield coverage that limits extra bases. The Cubs’ approach is rarely flashy, but it’s effective, and when they build early leads, they tend to close games confidently and without unnecessary drama. Betting-wise, they’ve been one of the more profitable teams at home against non-contending or sub-.500 opponents, especially when favored by 1.5 runs. The total for this game may lean under if wind patterns at Wrigley favor pitchers, and Chicago has proven capable of adapting to low-scoring contests just as well as offensive showcases. Facing a Royals team that has been inconsistent and vulnerable in late innings, the Cubs will look to capitalize early with pressure on the bases and opportunistic hitting, often setting the tone within the first three frames. The game plan will likely be to get into Kansas City’s bullpen by the sixth inning, where the advantage leans heavily toward the home team. If the Cubs continue their sharp fielding and strike early with runs, they’ll be tough to catch on a day when playoff positioning adds urgency to every inning. In short, Chicago is well-positioned not only to win but also to cover, especially if their frontline starters command the zone and avoid letting the Royals’ speed game become a factor. This is a Cubs team with a clear identity and the confidence to execute it, and they’ll look to put it on display again in a favorable Sunday matinee at home.

Kansas City vs. Chicago Cubs Prop Picks (AI)

Remi is pouring through mountains of stats on each team. In fact, anytime the Royals and Cubs play there’s always several intriguing trends to key in on. Not to mention games played at Wrigley Field in Jul seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.

Kansas City vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every angle between the Royals and Cubs and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned weight emotional bettors tend to put on coaching factors between a Royals team going up against a possibly healthy Cubs team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Kansas City vs Chicago Cubs picks, computer picks Royals vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Royals Betting Trends

As road underdogs, Kansas City has covered the run line roughly 46% of the time this season, reflecting a middle-of-the-pack performance.

Cubs Betting Trends

Chicago boasts a sturdy 57–39 overall record and has covered the spread consistently at Wrigley, especially in games where they’re favored.

Royals vs. Cubs Matchup Trends

In their last five visits to Wrigley, Kansas City has managed to hold Chase Field close, pushing late but rarely pulling away—three of those games have stayed under 8 runs, indicating low-scoring potential.

Kansas City vs. Chicago Cubs Game Info

Kansas City vs Chicago Cubs starts on July 21, 2025 at 8:05 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: Kansas City +118, Chicago Cubs -140
Over/Under: 8

Kansas City: (48-52)  |  Chicago Cubs: (59-40)

Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.. Prices move—always shop for the best number.

In their last five visits to Wrigley, Kansas City has managed to hold Chase Field close, pushing late but rarely pulling away—three of those games have stayed under 8 runs, indicating low-scoring potential.

KC trend: As road underdogs, Kansas City has covered the run line roughly 46% of the time this season, reflecting a middle-of-the-pack performance.

CHC trend: Chicago boasts a sturdy 57–39 overall record and has covered the spread consistently at Wrigley, especially in games where they’re favored.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Kansas City vs. Chicago Cubs Odds

AI algorithm Remi is pouring through mountains of data points on each player. In fact, anytime the Kansas City vs Chicago Cubs trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.

Kansas City vs Chicago Cubs Opening Odds

KC Moneyline: +118
CHC Moneyline: -140
KC Spread: +1.5
CHC Spread: -1.5
Over/Under: 8

Kansas City vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Kansas City Royals vs. Chicago Cubs Cubs on July 21, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN