Tigers vs Pirates Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jul 21)

Updated: 2025-07-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Detroit (59–40) brings its powerhouse ace Tarik Skubal to the mound, aiming to continue its dominant stretch, while Pittsburgh (39–60) looks to capitalize at home with Nick Gonzales and Andrew McCutchen leading the charge. The Pirates are favored at roughly –124 on the moneyline (–1.5 on the run line), with the total sitting at 7—signaling a low-scoring duel, though recent trends hint at potential underachieving runs or pitching surprises.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jul 21, 2025

Start Time: 6:40 PM EST​

Venue: PNC Park​

Pirates Record: (39-61)

Tigers Record: (60-40)

OPENING ODDS

DET Moneyline: +104

PIT Moneyline: -124

DET Spread: +1.5

PIT Spread: -1.5

Over/Under: 7

DET
Betting Trends

  • Detroit has been impressive as road favorites, covering the run line consistently thanks to strong performance when Skubal starts and support from a deep lineup.

PIT
Betting Trends

  • Pittsburgh has been solid at PNC Park, particularly with home starts, and has frequently covered –1.5 lines in midweek affairs.

MATCHUP TRENDS

  • In the five most recent Pirates home victories, games ended in pitches’ duels with combined totals under seven—highlighting the tendency for low-scoring affairs when they win.

DET vs. PIT
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: P. Skenes over 26.5 Fantasy Score.

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Detroit vs Pittsburgh Prediction & Odds:
Free MLB Betting Insights for 7/21/25

Monday night’s interleague showdown between the Detroit Tigers and Pittsburgh Pirates at PNC Park promises to showcase a clash of pitching dominance versus gritty offensive opportunism, with the Tigers looking to extend their exceptional season and the Pirates aiming to play spoiler on home turf. The Tigers enter the matchup with one of the best records in the American League, riding the electric arm of left-hander Tarik Skubal, who has emerged as a true ace in 2025 with a 10–3 record, 2.23 ERA, and a WHIP well under 1.00. Skubal has dominated both left- and right-handed batters thanks to his elite command, mid-to-upper 90s velocity, and devastating off-speed mix, which allows him to control the pace of the game and neutralize big bats early. Detroit’s offense, led by the consistent presence of Riley Greene, the lefty power of Kerry Carpenter, and strong situational contributors like Zach McKinstry and Spencer Torkelson, gives them a potent top-to-bottom order that’s capable of generating runs in a variety of ways. They also rank among the league’s best in extra-base hits on the road and have been highly efficient in late-game scoring when the bullpen keeps things close. Pittsburgh, by contrast, sits well below .500 and has spent most of the season rotating through inconsistent starting pitching, relying heavily on bullpen matchups and hoping for timely offense from veterans like Bryan Reynolds, Andrew McCutchen, and emerging youngster Nick Gonzales.

The Pirates are at their best when they’re able to manufacture runs with base hits, small ball, and pressure defense, but that approach becomes significantly tougher when facing elite arms like Skubal. A potential bright spot for Pittsburgh is their 1.5-run line record at home, which has covered at a profitable rate in games where the opponent underperforms or the Pirates steal early leads. However, with Detroit expected to control the tempo from the start and PNC Park typically being friendly to left-handed pitching, the matchup leans heavily in the Tigers’ favor unless the Pirates can scrape together early offense and force Detroit to tap into their bullpen earlier than usual. If Skubal delivers his typical six or seven dominant innings, Detroit has plenty of reliable late-game arms to shut the door, including Jason Foley and Alex Lange, both of whom have handled high-leverage innings with poise. This game sets up as a textbook case of power versus resilience: Detroit boasting elite starting pitching and solid lineup depth, while Pittsburgh leans on home-field advantage and hopes to exploit any cracks in the Tigers’ rhythm. Bettors will likely lean toward Detroit on the moneyline and run line, especially with Skubal starting and the offense playing with confidence, while the total set around 7 suggests a low-scoring game unless Pittsburgh finds unexpected power. Ultimately, the Tigers have all the tools to dominate this matchup, but they’ll need to stay sharp against a Pirates squad that plays with chip-on-the-shoulder energy in front of their home crowd.

Detroit Tigers MLB Preview

The Detroit Tigers continue to assert themselves as one of the premier teams in the American League and head into Monday’s road game against the Pittsburgh Pirates with strong momentum and a clear advantage in both pitching and offensive production. With a record pushing toward 60 wins, Detroit has been fueled by a well-balanced roster that combines young talent, aggressive base running, and top-tier pitching, all of which have contributed to their dominant road performance this season. Leading the charge is left-handed ace Tarik Skubal, who has emerged as a true Cy Young candidate with a 10–3 record, a sparkling 2.23 ERA, and a strikeout-to-walk ratio that speaks to his elite control and ability to shut down lineups. Skubal has been especially dominant away from home, where he’s shown the ability to keep hitters guessing by working the corners, limiting walks, and getting swings and misses with both his changeup and slider. The Tigers’ offense has consistently provided run support for Skubal, with key contributions from Riley Greene, who has blossomed into a reliable top-of-the-order threat with excellent on-base skills, and Kerry Carpenter, whose power has added another layer of danger to the heart of the lineup.

Spencer Torkelson has also flashed signs of power resurgence, giving Detroit timely pop, while utility players like Zach McKinstry have contributed clutch situational hitting and defensive versatility. Detroit’s offensive strategy doesn’t rely solely on the long ball—they execute hit-and-run plays, steal bases when needed, and have one of the league’s best records in scoring runners from third with less than two outs. The Tigers also boast one of the most dependable bullpens in baseball, headlined by Jason Foley and Alex Lange, who have been consistent in high-leverage situations and have often been the difference in close road wins. The defensive efficiency of the team has complemented their pitching, with strong outfield reads, quick infield transfers, and a catcher tandem that’s done well controlling the run game. In matchups like this against lower-tier teams like the Pirates, the Tigers understand the importance of maintaining focus and finishing the job early, often jumping on starting pitchers with aggressive first-inning approaches. A big key will be getting Skubal early run support and allowing him to settle in, which has historically led to dominance through six or seven innings and an easy handoff to the bullpen. The Tigers will also aim to pressure Pittsburgh’s defense and pitching depth by extending at-bats and driving up pitch counts, forcing them into their bullpen sooner than planned. With playoff aspirations and top-seed positioning in the AL on their minds, Detroit cannot afford to let up in these road games and will view this contest as a prime opportunity to keep their momentum rolling. All signs point to the Tigers playing a complete, professional game, with Skubal setting the tone, the offense capitalizing on early chances, and the bullpen locking it down late if needed.

Detroit (59–40) brings its powerhouse ace Tarik Skubal to the mound, aiming to continue its dominant stretch, while Pittsburgh (39–60) looks to capitalize at home with Nick Gonzales and Andrew McCutchen leading the charge. The Pirates are favored at roughly –124 on the moneyline (–1.5 on the run line), with the total sitting at 7—signaling a low-scoring duel, though recent trends hint at potential underachieving runs or pitching surprises. Detroit vs Pittsburgh AI Prediction: Free MLB Betting Insights for Jul 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Pittsburgh Pirates MLB Preview

The Pittsburgh Pirates return to PNC Park on Monday to host the red-hot Detroit Tigers, fully aware of the challenge ahead but hopeful they can channel some of their recent home-field resilience into an upset. At 39–60, the Pirates remain in a developmental stage, building around a young core while leaning on veteran leadership to keep them competitive, especially in matchups against top-tier opponents. Their best hope lies in their ability to manufacture runs, play clean defense, and squeeze solid innings from a pitching staff that has had flashes of promise but has struggled to consistently execute against elite lineups. Offensively, Bryan Reynolds and Andrew McCutchen remain the emotional and statistical leaders of the team, offering both clutch hitting and steadiness in the lineup, while players like Oneil Cruz and Nick Gonzales add speed and raw power that can spark rallies when things click. However, the Pirates have had issues with run production in low-scoring games, and with Detroit sending Tarik Skubal—arguably the American League’s best pitcher—to the mound, Pittsburgh will need to take advantage of every opportunity they get. The key for the Pirates will be making Skubal work early, drawing walks, extending at-bats, and hoping to get into the Tigers’ bullpen by the sixth inning, as their chances diminish significantly if Skubal dominates deep into the game.

Defensively, Pittsburgh has been more than serviceable this season, turning double plays efficiently and maintaining above-average fielding metrics in both the infield and outfield, which will be crucial in preventing extra-base damage from Detroit’s well-rounded lineup. On the mound, the Pirates may opt for a bullpen-heavy game or lean on a young starter like Luis Ortiz or Bailey Falter, both of whom have shown flashes of brilliance but also inconsistency against teams that work the count well. Their ability to hold the Tigers to two or three runs through the first five innings will be vital, as the Pirates’ offense isn’t built to play from behind against high-leverage relievers. The home crowd at PNC Park continues to provide energy, particularly in the early innings, and the Pirates have historically been better at home when facing unfamiliar AL teams. Strategically, manager Derek Shelton might utilize small-ball tactics—such as bunts, hit-and-runs, and aggressive baserunning—to disrupt Detroit’s rhythm and generate pressure situations that could lead to defensive mistakes. The Pirates have also covered the +1.5 run line in several recent home games against stronger opponents, indicating their ability to hang close even in matchups where they are underdogs. While a win over Detroit would be considered a mild upset, Pittsburgh has the tools to make this a tight game if their pitching holds and they can steal a couple of key moments on offense. With nothing to lose and an opportunity to build on the development of their young core, the Pirates will approach this contest as both a test and a statement opportunity against one of baseball’s elite teams.

Detroit vs. Pittsburgh Prop Picks (AI)

Remi is pouring through tons of datapoints on each line. In fact, anytime the Tigers and Pirates play there’s always several intriguing angles to key in on. Not to mention games played at PNC Park in Jul seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: P. Skenes over 26.5 Fantasy Score.

Detroit vs. Pittsburgh Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every angle between the Tigers and Pirates and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Interestingly enough, the data has been most fixated on the linear correlation of weight human bettors tend to put on Detroit’s strength factors between a Tigers team going up against a possibly deflated Pirates team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Detroit vs Pittsburgh picks, computer picks Tigers vs Pirates, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Tigers Betting Trends

Detroit has been impressive as road favorites, covering the run line consistently thanks to strong performance when Skubal starts and support from a deep lineup.

Pirates Betting Trends

Pittsburgh has been solid at PNC Park, particularly with home starts, and has frequently covered –1.5 lines in midweek affairs.

Tigers vs. Pirates Matchup Trends

In the five most recent Pirates home victories, games ended in pitches’ duels with combined totals under seven—highlighting the tendency for low-scoring affairs when they win.

Detroit vs. Pittsburgh Game Info

Detroit vs Pittsburgh starts on July 21, 2025 at 6:40 PM EST.

Spread: Pittsburgh -1.5
Moneyline: Detroit +104, Pittsburgh -124
Over/Under: 7

Detroit: (60-40)  |  Pittsburgh: (39-61)

Remi's searched hard and found the best prop for this matchup: P. Skenes over 26.5 Fantasy Score.. Prices move—always shop for the best number.

In the five most recent Pirates home victories, games ended in pitches’ duels with combined totals under seven—highlighting the tendency for low-scoring affairs when they win.

DET trend: Detroit has been impressive as road favorites, covering the run line consistently thanks to strong performance when Skubal starts and support from a deep lineup.

PIT trend: Pittsburgh has been solid at PNC Park, particularly with home starts, and has frequently covered –1.5 lines in midweek affairs.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. Pittsburgh Odds

AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Detroit vs Pittsburgh trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Detroit vs Pittsburgh Opening Odds

DET Moneyline: +104
PIT Moneyline: -124
DET Spread: +1.5
PIT Spread: -1.5
Over/Under: 7

Detroit vs Pittsburgh Live Odds

Games PTS ML SPR O/U
Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
-150
+125
-1.5 (+120)
+1.5 (-145)
O 7.5 (+100)
U 7.5 (-120)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Tigers vs. Pittsburgh Pirates on July 21, 2025 at PNC Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN