Orioles vs. Guardians
Prediction, Odds & Props
Jul 21 | MLB AI Picks
Updated: 2025-07-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Baltimore Orioles (58–59) travel to Cleveland seeking to halt a mid-season slump, while the Guardians (55–61) hope to bounce back from a similar stretch on home soil. Cleveland is favored (about –138 ML, –1.5 run line), with the total set at 8.5—suggesting a moderately tight pitchers’ duel with occasional offense.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 21, 2025
Start Time: 6:40 PM EST
Venue: Progressive Field
Guardians Record: (48-50)
Orioles Record: (44-54)
OPENING ODDS
BAL Moneyline: +117
CLE Moneyline: -139
BAL Spread: +1.5
CLE Spread: -1.5
Over/Under: 8.5
BAL
Betting Trends
- Baltimore has gone just 4–6 in their last 10 games and is struggling to cover when playing away, often slipping under team expectations due to an inconsistent offense.
CLE
Betting Trends
- Cleveland is 3–6 over their last 10 at Progressive Field but has been solid when favored, going 8–3 this season with comparable lines.
MATCHUP TRENDS
- The Guardians have gone Over in 7 of their last 10 games, highlighting a tendency for their matchups—especially at home—to produce more than expected offense.
BAL vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: A. Martinez over 4.5 Fantasy Score.
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Baltimore vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 7/21/25
One key difference is defensive efficiency—Cleveland remains among the best in turning double plays and preventing extra bases, which may force Baltimore to be more aggressive on the basepaths. The Orioles have covered more effectively in road games where they’re slight underdogs, especially when the bullpen is rested and the offense scratches early runs, while Cleveland has excelled as home favorites, particularly when playing teams that rely on left-handed pitching. With the total hovering around 8.5 runs and a runline favoring the Guardians, the market suggests a tight game with a slight lean toward the home team, especially if they can wear down Sugano and capitalize in the middle innings. Baltimore’s path to victory likely involves taking advantage of early mistakes, getting into Cleveland’s bullpen by the sixth inning, and trusting Bautista to lock down the final outs in a low-scoring finish. For Cleveland, the formula hinges on Allen generating groundballs and quick innings, then handing it off to a bullpen that has been shaky but capable when rested. This game shapes up to be a chess match between two teams with similar records but different styles, and the result may hinge on which starter blinks first or which offense cashes in during a critical two-out scenario. A well-pitched, evenly contested battle is expected, with bettors eyeing the under and the Guardians’ moneyline in a game where every pitch will matter.
Finished the job. pic.twitter.com/LVpxft1w0N
— Baltimore Orioles (@Orioles) July 20, 2025
Baltimore Orioles MLB Preview
The Baltimore Orioles enter Monday’s matchup against the Cleveland Guardians looking to reverse a bumpy midseason stretch and regain consistency, particularly on the road where they’ve struggled to string together wins. Baltimore currently hovers just above the .500 mark and has gone 4–6 in its last ten games, a skid that has exposed the team’s ongoing issues with run production away from Camden Yards. Despite the inconsistency, the Orioles remain dangerous thanks to a strong bullpen and the leadership of key players like Gunnar Henderson and Cedric Mullins, both of whom offer a mix of speed, defense, and clutch hitting. On the mound, Baltimore turns to Tomoyuki Sugano, their veteran right-hander from Japan who has been solid this season with a reliable ERA in the mid-3.00s and excellent command that keeps walks to a minimum. Sugano doesn’t overpower hitters but excels at disrupting timing and inducing soft contact, which will be critical in navigating a contact-heavy Guardians lineup. Baltimore’s offense needs to come alive early in this one, as they have struggled to recover when falling behind, especially on the road. Anthony Santander and Ryan Mountcastle must provide pop in the middle of the order, while Henderson and Mullins will be tasked with getting on base and creating scoring opportunities through aggressive baserunning. A major bright spot for the Orioles remains their bullpen, anchored by Félix Bautista, who has been nearly untouchable in the closer role and is supported by reliable setup men like Danny Coulombe and Yennier Cano.
If Baltimore can hand their relievers a lead by the sixth or seventh inning, their chances of securing a road win improve dramatically. However, the key will be making the most of limited scoring opportunities against a Guardians team that thrives on preventing big innings and turning double plays. Defensively, the Orioles have held their own, but they’ll need to stay sharp in the infield and outfield to back up Sugano’s contact-oriented pitching style. Another factor to watch is how the Orioles handle Logan Allen’s pitching mix—if they can force him into high pitch counts early, they might get into Cleveland’s bullpen by the middle innings, where they could exploit recent fatigue and struggles in relief. With their backs slightly against the wall and a series-opening win up for grabs, the Orioles must rely on pitching efficiency, defensive discipline, and timely hitting to outduel a Cleveland team that plays particularly well when scoring early. Though Baltimore has been underwhelming in series openers lately, this matchup presents a real opportunity to set the tone with Sugano’s veteran presence and the high-leverage arms ready to close the door. For the Orioles to succeed Monday night, they must execute the fundamentals, take advantage of scoring chances when they arise, and avoid the prolonged offensive droughts that have haunted them in recent weeks.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians return home to Progressive Field on Monday to open their series against the Baltimore Orioles, looking to take advantage of a favorable pitching matchup and build on flashes of recent offensive momentum. While their overall record has hovered slightly below .500, the Guardians have performed better than their record suggests in games where they’re favored, especially at home, and they will lean on right-hander Logan Allen to help set the tone. Allen, known for his ability to generate ground balls and eat innings efficiently, enters the game with an ERA near the low 4.00s and has shown improvement in his last few starts, particularly when working with early run support. The Guardians’ offense has been trending upward in July, especially at home, with players like Steven Kwan and José Ramírez sparking multi-run innings with aggressive at-bats and smart baserunning. Ramírez continues to be the engine of the offense, delivering with runners in scoring position and offering both power and contact at the heart of the lineup. Behind him, Will Brennan and Josh Naylor have delivered timely hits, while the bench depth has provided added flexibility against both right- and left-handed pitching. Cleveland’s defense remains one of the most efficient in the league, particularly in turning double plays and limiting extra bases, which could be a key factor against a Baltimore lineup that depends heavily on speed and situational offense.
On the mound, Allen will be tasked with keeping the Orioles’ top hitters like Gunnar Henderson and Anthony Santander off balance by mixing his sinker with a sharp-breaking slider, aiming to avoid hard contact and induce early-count outs. The bullpen, though inconsistent in recent weeks, has performed better at home, with Emmanuel Clase still among the most trusted closers in the American League when given a clean ninth inning. Setup relievers like Trevor Stephan and Sam Hentges will be crucial in bridging the gap from Allen to Clase, especially if the Guardians are clinging to a narrow lead late in the game. From a gameplan perspective, Cleveland must emphasize plate discipline early against Baltimore starter Tomoyuki Sugano, who thrives on command and soft contact—if they can work deep counts and force pitches over the plate, they could turn what’s expected to be a pitchers’ duel into a breakout night. The Guardians will also look to capitalize on home-field advantage, where their lineup typically generates more traffic and energy, particularly in the middle innings. If Allen can deliver six solid innings and the bullpen avoids traffic, Cleveland’s edge in defensive consistency and late-inning execution may give them the upper hand. In a tightly projected game with a total of 8.5 runs, the Guardians’ focus will be on clean defense, aggressive at-bats, and timely pitching—areas they’ve historically excelled in when playing as slight home favorites. With playoff contention still within reach and an opportunity to start the week strong, Cleveland has all the tools to set the tone in Game 1 and protect their turf against a Baltimore team still searching for offensive consistency.
Series win to start the second half!#GuardsBall | #GuardiWins pic.twitter.com/ltk1ACLiL5
— Cleveland Guardians (@CleGuardians) July 20, 2025
Baltimore vs. Cleveland Prop Picks (AI)
Baltimore vs. Cleveland Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every angle between the Orioles and Guardians and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Remi has been most fixated on the linear correlation of emphasis emotional bettors often put on coaching factors between a Orioles team going up against a possibly unhealthy Guardians team. It appears the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Baltimore vs Cleveland picks, computer picks Orioles vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Orioles Betting Trends
Baltimore has gone just 4–6 in their last 10 games and is struggling to cover when playing away, often slipping under team expectations due to an inconsistent offense.
Guardians Betting Trends
Cleveland is 3–6 over their last 10 at Progressive Field but has been solid when favored, going 8–3 this season with comparable lines.
Orioles vs. Guardians Matchup Trends
The Guardians have gone Over in 7 of their last 10 games, highlighting a tendency for their matchups—especially at home—to produce more than expected offense.
Baltimore vs. Cleveland Game Info
What time does Baltimore vs Cleveland start on July 21, 2025?
Baltimore vs Cleveland starts on July 21, 2025 at 6:40 PM EST.
Where is Baltimore vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Baltimore vs Cleveland?
Spread: Cleveland -1.5
Moneyline: Baltimore +117, Cleveland -139
Over/Under: 8.5
What are the records for Baltimore vs Cleveland?
Baltimore: (44-54) | Cleveland: (48-50)
What is the AI best bet for Baltimore vs Cleveland?
Remi's searched hard and found the best prop for this matchup: A. Martinez over 4.5 Fantasy Score.. Prices move—always shop for the best number.
What are Baltimore vs Cleveland trending bets?
The Guardians have gone Over in 7 of their last 10 games, highlighting a tendency for their matchups—especially at home—to produce more than expected offense.
What are Baltimore trending bets?
BAL trend: Baltimore has gone just 4–6 in their last 10 games and is struggling to cover when playing away, often slipping under team expectations due to an inconsistent offense.
What are Cleveland trending bets?
CLE trend: Cleveland is 3–6 over their last 10 at Progressive Field but has been solid when favored, going 8–3 this season with comparable lines.
Where can I find AI Picks for Baltimore vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Baltimore vs. Cleveland Odds
AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the Baltimore vs Cleveland trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps rarely follow normal, predictable betting trends.
Baltimore vs Cleveland Opening Odds
BAL Moneyline:
+117 CLE Moneyline: -139
BAL Spread: +1.5
CLE Spread: -1.5
Over/Under: 8.5
Baltimore vs Cleveland Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+190
-235
|
+1.5 (-105)
-1.5 (-115)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-175
|
-1.5 (+115)
|
O 9.5 (-105)
U 9.5 (-115)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+130
-155
|
+1.5 (-155)
-1.5 (+130)
|
O 8.5 (+100)
U 8.5 (-120)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
|
-1.5 (+160)
+1.5 (-195)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+185
-225
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+125)
+1.5 (-150)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+155
-190
|
+1.5 (-152)
-1.5 (+120)
|
O 8 (-108)
U 8 (-117)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+135
-165
|
+1.5 (-180)
-1.5 (+150)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+125
-152
|
+1.5 (-186)
-1.5 (+145)
|
O 7.5 (-120)
U 7.5 (-107)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-155
+130
|
-1.5 (+105)
+1.5 (-125)
|
O 8.5 (-120)
U 8.5 (+100)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+105
-125
|
+1.5 (-205)
-1.5 (+170)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
-1.5 (+150)
+1.5 (-180)
|
O 10 (-115)
U 10 (-105)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Baltimore Orioles vs. Cleveland Guardians on July 21, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |