Cardinals vs Diamondbacks Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jul 19)
Updated: 2025-07-17T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals (51–46) travel to Scottsdale as slight underdogs against the Arizona Diamondbacks (47–50), a team riding a one-game win streak at home. Arizona is favored at –110 on the ML and –1.5 run line, with the total set around 9 runs.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 19, 2025
Start Time: 7:15 PM EST
Venue: Chase Field
Diamondbacks Record: (48-50)
Cardinals Record: (51-47)
OPENING ODDS
STL Moneyline: -119
ARI Moneyline: -100
STL Spread: -1.5
ARI Spread: +1.5
Over/Under: 8.5
STL
Betting Trends
- As road underdogs, St. Louis has gone 5–8 ATS overall, covering just 2 of their last 11 games away, highlighting vulnerability on the road.
ARI
Betting Trends
- Arizona is 12–13 ATS this season and 5–8 at home, including a shaky 1–3 mark when favored, even as they enter this series as home favorites.
MATCHUP TRENDS
- The D-backs have been favored 62 times this season at –110 or shorter and are exactly 31–31 in those games. Meanwhile, St. Louis fares better as home underdogs (7–2), but struggles on the road.
STL vs. ARI
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: W. Contreras over 5.5 Fantasy Score.
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St. Louis vs Arizona Prediction & Odds:
Free MLB Betting Insights for 7/19/25
The Cardinals, on the other hand, rely on a more contact-heavy approach, anchored by the consistency of Brendan Donovan, the veteran bat of Paul Goldschmidt, and the streaky but dangerous power potential of Nolan Gorman. While the D-backs have gone just 12–13 against the spread overall and 5–8 ATS at home, they’ve historically matched up well against the Cardinals, winning seven of the last ten meetings. The over/under for this game is set around nine runs, reflecting a balance of capable offense on both sides against two starting pitchers who can limit scoring if in command. The matchup should favor early stability on the mound, with both clubs likely aiming to grind out runs rather than rely solely on the long ball. Key swing moments could occur in the sixth or seventh innings, particularly if either team has to reach into a bullpen that’s been inconsistent this season. St. Louis has been better at home but tends to falter in high-scoring road games, while Arizona often struggles to convert close games into covers when playing as a favorite. Whichever team controls the pace early and capitalizes on runners in scoring position will hold the edge in what should be a closely fought contest. While Arizona holds the slight edge at home, especially behind Gallen, the Cardinals have the veteran pitching, playoff-tested core, and clutch potential to make this a toss-up late. Expect a tight, strategy-laden game where one or two mistakes could decide who walks away with the crucial midseason victory.
Updated lineup from Phoenix: https://t.co/jgVyna4V9t pic.twitter.com/XHAPxLHhSj
— St. Louis Cardinals (@Cardinals) July 18, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter their July 19, 2025, matchup against the Arizona Diamondbacks with a 51–46 record, battling for playoff position in the NL Central but burdened by inconsistent performances on the road that have contributed to a troubling 2–11 ATS record away from home over their last 13 such contests. Led by veteran right-hander Sonny Gray, the Cardinals will look to steady the ship with a dependable arm who brings a 9–3 record and 3.50 ERA into a matchup that demands control and finesse in a park that has traditionally favored hitters. Gray’s ability to command the zone, avoid walks, and change speeds effectively makes him St. Louis’s most reliable road option, especially with the bullpen showing signs of vulnerability late in games. Offensively, the Cardinals rely heavily on a blend of steady veterans and emerging power threats, starting with Brendan Donovan, who has been a model of consistency at the plate, batting .284 while contributing timely RBIs and defensive versatility. Paul Goldschmidt continues to provide the core veteran presence with solid defense and clutch at-bats, though his power numbers have dipped slightly this season. Nolan Gorman adds pop from the left side with the ability to punish mistakes, though he remains streaky and prone to high strikeout totals when pressing.
This matchup with Arizona, and specifically with their ace Zac Gallen, puts pressure on the Cardinals to capitalize early before Gallen finds rhythm, as Arizona’s bullpen, while shaky overall, has been serviceable when entering with leads. St. Louis will need a disciplined offensive approach, working deep counts and forcing Gallen to elevate pitches in hitter-friendly counts, especially with runners on base where the Cardinals have at times struggled to produce. Defensively, St. Louis remains one of the cleaner teams in the league, turning double plays at an above-average rate and boasting a strong fielding percentage anchored by Goldschmidt at first and Tommy Edman up the middle. Their pathway to covering the run line or winning outright as a slight underdog hinges on Gray giving them six quality innings and the offense delivering in situational hitting—particularly in the fifth through seventh innings, where opposing pitchers begin to tire and mistakes can be exploited. The Cardinals are just 5–8 ATS as road underdogs overall and will need to overcome a Diamondbacks team that’s had recent head-to-head success against them, winning seven of the last ten meetings. Despite their recent road woes, the Cardinals have the experience and pitching edge to hang with or upset Arizona if they control the pace of play, minimize defensive errors, and get contributions beyond just the top third of the lineup. If St. Louis can put together a clean, methodical game plan behind Gray and keep the pressure on Arizona’s bullpen, this could be the kind of gritty, low-scoring win that helps turn around their fortunes away from home and solidifies their presence in the NL playoff picture as the second half of the season intensifies.

Credit: USA TODAY/IMAGN
Arizona Diamondbacks MLB Preview
The Arizona Diamondbacks come into their July 19, 2025 home matchup against the St. Louis Cardinals with a 47–50 record and a sense of urgency as they try to claw their way back into the thick of the National League Wild Card race. After a sluggish first half filled with injuries and offensive inconsistency, Arizona has shown recent signs of life, including a well-played win heading into this contest and an upcoming homestand that offers the opportunity to build crucial momentum. Their chances of success in this game hinge heavily on the performance of ace right-hander Zac Gallen, who is expected to take the mound and leads the staff with a solid ERA, sharp strikeout-to-walk ratio, and the kind of poise that’s made him one of the more dependable starters in the National League. Gallen’s ability to keep the ball in the park and induce weak contact should serve him well against a Cardinals lineup that struggles with power on the road and has been vulnerable to high-quality starting pitching. Backing Gallen is a lineup led by All-Star second baseman Ketel Marte, who is batting just under .300 with excellent slugging and on-base metrics, along with first baseman Josh Naylor, who brings muscle to the middle of the order with 30 home runs and timely RBI production. Corbin Carroll adds an element of speed and versatility, often creating chaos on the basepaths and pressuring opposing defenses into mistakes.
The D-backs have historically matched up well with St. Louis, having won seven of their last ten head-to-head meetings, and they’ll look to continue that trend by jumping on Sonny Gray early before the veteran righty can settle into a groove. From a betting standpoint, Arizona has been a mixed bag, sitting at 12–13 against the spread overall and just 5–8 ATS at Chase Field, including a subpar 1–3 record when favored at home. Still, their record when favored at –110 or shorter stands at an even 31–31, suggesting that when expectations are modest and lines are tight, Arizona tends to stay competitive and often finds a way to win close games. The Diamondbacks’ bullpen has been serviceable but far from dominant, meaning the onus will fall on Gallen to pitch deep into the game and give the back end of the staff as much margin for error as possible. Defensively, Arizona has improved in recent weeks, with fewer miscues and better infield range, especially from Marte and Geraldo Perdomo up the middle. If the D-backs are to win and cover, they’ll need a strong six-plus innings from Gallen, a couple of timely extra-base hits from their power bats, and clean execution in high-leverage situations—a formula that has worked for them in previous tight home games. With a home crowd behind them and momentum slowly beginning to tilt in their favor, Arizona has the tools to outlast a veteran Cardinals squad and use this game as a launching pad for a strong second-half surge toward playoff relevancy in a still-wide-open National League race.
It's Friday night, and we feel alright. pic.twitter.com/kY5pWAXoAm
— Arizona Diamondbacks (@Dbacks) July 19, 2025
St. Louis vs. Arizona Prop Picks (AI)
St. Louis vs. Arizona Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every past game between the Cardinals and Diamondbacks and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Remi has been most keyed in on the growing factor knucklehead sportsbettors often put on Arizona’s strength factors between a Cardinals team going up against a possibly deflated Diamondbacks team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Arizona picks, computer picks Cardinals vs Diamondbacks, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
As road underdogs, St. Louis has gone 5–8 ATS overall, covering just 2 of their last 11 games away, highlighting vulnerability on the road.
Diamondbacks Betting Trends
Arizona is 12–13 ATS this season and 5–8 at home, including a shaky 1–3 mark when favored, even as they enter this series as home favorites.
Cardinals vs. Diamondbacks Matchup Trends
The D-backs have been favored 62 times this season at –110 or shorter and are exactly 31–31 in those games. Meanwhile, St. Louis fares better as home underdogs (7–2), but struggles on the road.
St. Louis vs. Arizona Game Info
What time does St. Louis vs Arizona start on July 19, 2025?
St. Louis vs Arizona starts on July 19, 2025 at 7:15 PM EST.
Where is St. Louis vs Arizona being played?
Venue: Chase Field.
What are the opening odds for St. Louis vs Arizona?
Spread: Arizona +1.5
Moneyline: St. Louis -119, Arizona -100
Over/Under: 8.5
What are the records for St. Louis vs Arizona?
St. Louis: (51-47) | Arizona: (48-50)
What is the AI best bet for St. Louis vs Arizona?
Remi's searched hard and found the best prop for this matchup: W. Contreras over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are St. Louis vs Arizona trending bets?
The D-backs have been favored 62 times this season at –110 or shorter and are exactly 31–31 in those games. Meanwhile, St. Louis fares better as home underdogs (7–2), but struggles on the road.
What are St. Louis trending bets?
STL trend: As road underdogs, St. Louis has gone 5–8 ATS overall, covering just 2 of their last 11 games away, highlighting vulnerability on the road.
What are Arizona trending bets?
ARI trend: Arizona is 12–13 ATS this season and 5–8 at home, including a shaky 1–3 mark when favored, even as they enter this series as home favorites.
Where can I find AI Picks for St. Louis vs Arizona?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Arizona Odds
Remi is pouring through mountains of data points on each player. In fact, anytime the St. Louis vs Arizona trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.
St. Louis vs Arizona Opening Odds
STL Moneyline:
-119 ARI Moneyline: -100
STL Spread: -1.5
ARI Spread: +1.5
Over/Under: 8.5
St. Louis vs Arizona Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
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–
–
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-148
+126
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-1.5 (+114)
+1.5 (-137)
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O 7.5 (+100)
U 7.5 (-122)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Arizona Diamondbacks on July 19, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |