Cardinals vs. Diamondbacks
Prediction, Odds & Props
Jul 18 | MLB AI Picks

Updated: 2025-07-16T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals visit Chase Field on July 18 to take on the Arizona Diamondbacks in a mid-summer National League West showdown, characterized by complementary strengths and weaknesses. With Arizona’s offense humming and St. Louis reliant on pitching, this game is shaping up as a classic pitcher’s duel with potential for a late-game shift.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jul 18, 2025

Start Time: 9:40 PM EST​

Venue: Chase Field​

Diamondbacks Record: (47-50)

Cardinals Record: (51-46)

OPENING ODDS

STL Moneyline: +110

ARI Moneyline: -130

STL Spread: +1.5

ARI Spread: -1.5

Over/Under: 9

STL
Betting Trends

  • The Cardinals are underdogs at +109, and they’ve struggled recently, going just 3–7 ATS in their last 10 games despite a .526 win percentage.

ARI
Betting Trends

  • The Diamondbacks are favored at –130 and have posted a modest .536 win rate, going 15–13 on the run line this season.

MATCHUP TRENDS

  • With a total of 8.5 and mid-rotation starters on the mound, the under has cashed in roughly 65% of similar matchups, making run suppression a key angle.

STL vs. ARI
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: E. Suarez over 5.5 Fantasy Score.

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St. Louis vs Arizona Prediction & Odds:
Free MLB Betting Insights for 7/18/25

Friday’s matchup between the St. Louis Cardinals and the Arizona Diamondbacks at Chase Field brings together two teams hovering around .500 but trending in different directions as they seek to solidify their postseason ambitions. Arizona enters the game with a 43–43 record, slightly ahead of St. Louis in the Wild Card chase, and will look to continue leveraging their explosive offense and the comforts of home to gain ground in the National League. The Cardinals, sitting at 42–45, are coming off a rocky stretch that includes a 3–7 ATS mark in their last 10 games, but they remain dangerous with a well-coached, disciplined lineup and a bullpen that can hold leads if given the opportunity. The Diamondbacks will send ace Zac Gallen to the mound, who, despite showing some midseason inconsistency, remains their most dependable starter with a strike-throwing approach and the ability to rack up strikeouts. St. Louis counters with a mid-rotation arm, likely Miles Mikolas or Steven Matz, both of whom are contact-oriented pitchers who will need to navigate Arizona’s patient and powerful top half of the order. The D-backs’ lineup is anchored by Eugenio Suárez and Josh Naylor—both capable of changing the game with one swing—and complemented by high-OBP table-setters like Corbin Carroll and Geraldo Perdomo, making them a threat to score in any inning.

The Cardinals will look to their veteran core of Nolan Arenado, Lars Nootbaar, and Brendan Donovan to provide timely offense, while hoping younger hitters like Alec Burleson continue to develop consistency in run-producing spots. Defensively, both clubs are above average, with Arizona boasting a particularly strong outfield and St. Louis maintaining its reputation for clean infield play and double-play efficiency. The bullpens are where these teams diverge more sharply: the Cardinals’ relief corps, while not elite, is more consistent in late innings than Arizona’s, which has struggled to close games and protect slim leads, especially when Gallen exits before the seventh. The over/under is set at 8.5 runs, a figure that reflects both the offensive upside and the potential for steady starting pitching on both sides, though the trends suggest a modest lean toward the under in games like these where one team’s bullpen tends to implode. Arizona has done well at home, but they are just 2–4 in their last six at Chase Field, while St. Louis has shown some resilience on the road, often keeping games close even when they fail to pull out a win. For the Diamondbacks, the formula is simple: ride Gallen deep into the game, get a multi-run lead early, and hope the bullpen doesn’t unravel. For the Cardinals, it’s about getting Gallen’s pitch count up early, exploiting Arizona’s weak middle relievers, and turning it into a tight, low-scoring affair late. If both teams execute, this could shape up as a one- or two-run game decided by bullpen performance and defensive sharpness, with either side capable of stealing a win to begin the series.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their July 18 matchup at Chase Field with a 42–45 record and a sense of urgency as the second half of the season gets underway, knowing every win is crucial in a crowded National League playoff picture. They’ve dropped seven of their last ten against the spread, reflecting a troubling inability to string together complete performances, though they remain within striking distance thanks to their experience, versatility, and above-average defensive play. Offensively, the Cardinals have relied heavily on veterans like Nolan Arenado, who has delivered timely hits despite a dip in overall power numbers, and Lars Nootbaar, who brings plate discipline and on-base consistency near the top of the lineup. Alec Burleson has quietly become one of the club’s most important hitters, sporting a near .300 average and providing extra-base hit potential from the left side, while Brendan Donovan continues to be a Swiss army knife, hitting close to .300 and playing multiple positions. However, the team’s offensive production has been inconsistent, with too many games hinging on sporadic run support and a lack of slugging in key moments, especially against higher-end pitching. On the mound, the Cardinals will likely go with Miles Mikolas or Steven Matz, both of whom profile as pitch-to-contact arms who rely on defense behind them, a risky proposition in a hitter-friendly park like Chase Field.

Mikolas has had difficulty missing bats, while Matz has been prone to early trouble when he loses command, so whichever one gets the start must be sharp early and induce quick outs to avoid overexposing the bullpen. The bullpen has been a relative strength for St. Louis, with JoJo Romero, Ryan Helsley, and Giovanny Gallegos offering reliable late-inning options when deployed strategically, but they’ve often been asked to protect slim leads or keep deficits manageable due to inconsistent starts. The key for St. Louis will be grinding out at-bats against Zac Gallen early in the game, forcing him into deep counts and creating traffic on the bases to expose a Diamondbacks bullpen that has been among the least reliable in the National League. Defensively, the Cardinals remain one of the sharper clubs in the league, particularly on the infield where Arenado, Paul Goldschmidt, and Tommy Edman (if healthy) combine for Gold Glove-caliber work. With Arizona’s offense boasting several powerful and patient hitters, the Cardinals must control the pace of the game, keep basepaths clean, and avoid the kind of crooked-number innings that can quickly derail their game plan. If they can weather Gallen’s early push and stay within a run or two into the late innings, the Cardinals’ veteran lineup and dependable bullpen give them a real chance to pull off an upset and cover the spread, even in a hostile environment. A low-scoring, grind-it-out win would be right in their wheelhouse, but to get there, they’ll need early baserunners, solid execution with runners in scoring position, and six competitive innings from whoever takes the mound.

The St. Louis Cardinals visit Chase Field on July 18 to take on the Arizona Diamondbacks in a mid-summer National League West showdown, characterized by complementary strengths and weaknesses. With Arizona’s offense humming and St. Louis reliant on pitching, this game is shaping up as a classic pitcher’s duel with potential for a late-game shift. St. Louis vs Arizona AI Prediction: Free MLB Betting Insights for Jul 18. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Arizona Diamondbacks MLB Preview

The Arizona Diamondbacks return to Chase Field on July 18 with a 43–43 record and a golden opportunity to gain traction in the tightly packed National League playoff race as they host the St. Louis Cardinals in a matchup that highlights their offensive firepower and home-field potential. Though Arizona has been uneven over the last few weeks, particularly with a 2–4 mark in their most recent homestand, they continue to pose a consistent threat thanks to a dynamic offense led by Eugenio Suárez, Josh Naylor, and Corbin Carroll. Suárez has clubbed 31 home runs so far this season, bringing the kind of instant offense that can shift momentum with one swing, while Naylor’s .357 OBP and ability to drive in runs from the middle of the order has made him one of the Diamondbacks’ most valuable bats. Carroll, despite a bit of a sophomore slump compared to his breakout 2023 campaign, remains a disruptive force on the bases and in the outfield, giving Arizona speed and energy at the top of the lineup. Arizona’s game plan is built around early run production, aggressive base running, and forcing opposing pitchers into high-stress innings—a recipe that aligns well with their starting pitcher for this game, ace Zac Gallen. Gallen, who opened the year as the team’s most trusted starter and signed a lucrative $13.5 million deal, continues to deliver quality innings when healthy, using his fastball-curveball combination and sharp command to navigate lineups efficiently.

However, his recent outings have been somewhat inconsistent, and Arizona knows they’ll need him to go at least six innings to protect their vulnerable bullpen, which has been a major weak spot this season. The relief corps, headlined by closer Paul Sewald and setup man Kevin Ginkel, has posted one of the highest ERAs among NL playoff contenders and has repeatedly struggled to maintain leads in the seventh through ninth innings. That puts extra pressure on the offense to build a cushion, especially against a Cardinals team that has a knack for staying close and clawing back late. Defensively, the Diamondbacks are one of the sharper clubs in the league, with Carroll and Alek Thomas covering tons of ground in the outfield and the infield flashing good hands and athleticism across the board. At Chase Field, Arizona typically enjoys a slight offensive boost thanks to the stadium’s friendly dimensions and lively surface, and they’ll look to exploit that edge by jumping on whichever mid-rotation starter St. Louis deploys—likely a contact-reliant pitcher like Mikolas or Matz. If Arizona can execute their typical formula—early runs, steady starting pitching, and just enough from the bullpen—they have the advantage to win this opener and set the tone for the weekend series. But if Gallen gets chased early or if the bullpen is forced to cover too many outs, things could unravel quickly. The Diamondbacks will look to their core hitters to set the tempo, generate rallies, and give Gallen a lead to protect, which remains their most dependable path to victory at home in a must-win series opener.

St. Louis vs. Arizona Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Cardinals and Diamondbacks play there’s always several intriguing trends to key in on. Not to mention games played at Chase Field in Jul can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: E. Suarez over 5.5 Fantasy Score.

St. Louis vs. Arizona Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Cardinals and Diamondbacks and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned factor emotional bettors regularly put on player performance factors between a Cardinals team going up against a possibly tired Diamondbacks team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Arizona picks, computer picks Cardinals vs Diamondbacks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Cardinals Betting Trends

The Cardinals are underdogs at +109, and they’ve struggled recently, going just 3–7 ATS in their last 10 games despite a .526 win percentage.

Diamondbacks Betting Trends

The Diamondbacks are favored at –130 and have posted a modest .536 win rate, going 15–13 on the run line this season.

Cardinals vs. Diamondbacks Matchup Trends

With a total of 8.5 and mid-rotation starters on the mound, the under has cashed in roughly 65% of similar matchups, making run suppression a key angle.

St. Louis vs. Arizona Game Info

St. Louis vs Arizona starts on July 18, 2025 at 9:40 PM EST.

Spread: Arizona -1.5
Moneyline: St. Louis +110, Arizona -130
Over/Under: 9

St. Louis: (51-46)  |  Arizona: (47-50)

Remi's searched hard and found the best prop for this matchup: E. Suarez over 5.5 Fantasy Score.. Prices move—always shop for the best number.

With a total of 8.5 and mid-rotation starters on the mound, the under has cashed in roughly 65% of similar matchups, making run suppression a key angle.

STL trend: The Cardinals are underdogs at +109, and they’ve struggled recently, going just 3–7 ATS in their last 10 games despite a .526 win percentage.

ARI trend: The Diamondbacks are favored at –130 and have posted a modest .536 win rate, going 15–13 on the run line this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Arizona Odds

Remi is pouring through mountains of stats on each player. In fact, anytime the St. Louis vs Arizona trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.

St. Louis vs Arizona Opening Odds

STL Moneyline: +110
ARI Moneyline: -130
STL Spread: +1.5
ARI Spread: -1.5
Over/Under: 9

St. Louis vs Arizona Live Odds

Games PTS ML SPR O/U
In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
3
5
 
-7000
 
-3.5 (-450)
O 10.5 (+145)
U 10.5 (-180)
In Progress
Tampa Bay Rays
Toronto Blue Jays
In Progress
Rays
Blue Jays
0
3
+1200
-4000
+4.5 (-150)
-4.5 (+120)
O 7.5 (+120)
U 7.5 (-150)
In Progress
Colorado Rockies
San Francisco Giants
In Progress
Rockies
Giants
2
3
+260
-350
+2.5 (-145)
-2.5 (+115)
O 10.5 (-150)
U 10.5 (+120)
In Progress
New York Mets
Miami Marlins
In Progress
Mets
Marlins
1
0
-220
+175
-1.5 (-125)
+1.5 (-105)
O 7.5 (-110)
U 7.5 (-120)
In Progress
Detroit Tigers
Boston Red Sox
In Progress
Tigers
Red Sox
0
0
+135
-170
+1.5 (-150)
-1.5 (+120)
O 7.5 (+100)
U 7.5 (-130)
Sep 27, 2025 4:45PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:45PM
White Sox
Nationals
-110
-110
+1.5 (-210)
-1.5 (+175)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+126
-150
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+130
-155
+1.5 (-170)
-1.5 (+143)
O 7.5 (-105)
U 7.5 (-115)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-210)
-1.5 (+175)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+144
-172
+1.5 (-146)
-1.5 (+122)
O 9 (-122)
U 9 (+100)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Arizona Diamondbacks on July 18, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS