Cardinals vs. Diamondbacks
Prediction, Odds & Props
Jul 18 | MLB AI Picks
Updated: 2025-07-16T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals visit Chase Field on July 18 to take on the Arizona Diamondbacks in a mid-summer National League West showdown, characterized by complementary strengths and weaknesses. With Arizona’s offense humming and St. Louis reliant on pitching, this game is shaping up as a classic pitcher’s duel with potential for a late-game shift.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 18, 2025
Start Time: 9:40 PM EST
Venue: Chase Field
Diamondbacks Record: (47-50)
Cardinals Record: (51-46)
OPENING ODDS
STL Moneyline: +110
ARI Moneyline: -130
STL Spread: +1.5
ARI Spread: -1.5
Over/Under: 9
STL
Betting Trends
- The Cardinals are underdogs at +109, and they’ve struggled recently, going just 3–7 ATS in their last 10 games despite a .526 win percentage.
ARI
Betting Trends
- The Diamondbacks are favored at –130 and have posted a modest .536 win rate, going 15–13 on the run line this season.
MATCHUP TRENDS
- With a total of 8.5 and mid-rotation starters on the mound, the under has cashed in roughly 65% of similar matchups, making run suppression a key angle.
STL vs. ARI
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: E. Suarez over 5.5 Fantasy Score.
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St. Louis vs Arizona Prediction & Odds:
Free MLB Betting Insights for 7/18/25
The Cardinals will look to their veteran core of Nolan Arenado, Lars Nootbaar, and Brendan Donovan to provide timely offense, while hoping younger hitters like Alec Burleson continue to develop consistency in run-producing spots. Defensively, both clubs are above average, with Arizona boasting a particularly strong outfield and St. Louis maintaining its reputation for clean infield play and double-play efficiency. The bullpens are where these teams diverge more sharply: the Cardinals’ relief corps, while not elite, is more consistent in late innings than Arizona’s, which has struggled to close games and protect slim leads, especially when Gallen exits before the seventh. The over/under is set at 8.5 runs, a figure that reflects both the offensive upside and the potential for steady starting pitching on both sides, though the trends suggest a modest lean toward the under in games like these where one team’s bullpen tends to implode. Arizona has done well at home, but they are just 2–4 in their last six at Chase Field, while St. Louis has shown some resilience on the road, often keeping games close even when they fail to pull out a win. For the Diamondbacks, the formula is simple: ride Gallen deep into the game, get a multi-run lead early, and hope the bullpen doesn’t unravel. For the Cardinals, it’s about getting Gallen’s pitch count up early, exploiting Arizona’s weak middle relievers, and turning it into a tight, low-scoring affair late. If both teams execute, this could shape up as a one- or two-run game decided by bullpen performance and defensive sharpness, with either side capable of stealing a win to begin the series.
When Coldplay starts playing your song: pic.twitter.com/B3CIn5Y4lr
— St. Louis Cardinals (@Cardinals) July 17, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter their July 18 matchup at Chase Field with a 42–45 record and a sense of urgency as the second half of the season gets underway, knowing every win is crucial in a crowded National League playoff picture. They’ve dropped seven of their last ten against the spread, reflecting a troubling inability to string together complete performances, though they remain within striking distance thanks to their experience, versatility, and above-average defensive play. Offensively, the Cardinals have relied heavily on veterans like Nolan Arenado, who has delivered timely hits despite a dip in overall power numbers, and Lars Nootbaar, who brings plate discipline and on-base consistency near the top of the lineup. Alec Burleson has quietly become one of the club’s most important hitters, sporting a near .300 average and providing extra-base hit potential from the left side, while Brendan Donovan continues to be a Swiss army knife, hitting close to .300 and playing multiple positions. However, the team’s offensive production has been inconsistent, with too many games hinging on sporadic run support and a lack of slugging in key moments, especially against higher-end pitching. On the mound, the Cardinals will likely go with Miles Mikolas or Steven Matz, both of whom profile as pitch-to-contact arms who rely on defense behind them, a risky proposition in a hitter-friendly park like Chase Field.
Mikolas has had difficulty missing bats, while Matz has been prone to early trouble when he loses command, so whichever one gets the start must be sharp early and induce quick outs to avoid overexposing the bullpen. The bullpen has been a relative strength for St. Louis, with JoJo Romero, Ryan Helsley, and Giovanny Gallegos offering reliable late-inning options when deployed strategically, but they’ve often been asked to protect slim leads or keep deficits manageable due to inconsistent starts. The key for St. Louis will be grinding out at-bats against Zac Gallen early in the game, forcing him into deep counts and creating traffic on the bases to expose a Diamondbacks bullpen that has been among the least reliable in the National League. Defensively, the Cardinals remain one of the sharper clubs in the league, particularly on the infield where Arenado, Paul Goldschmidt, and Tommy Edman (if healthy) combine for Gold Glove-caliber work. With Arizona’s offense boasting several powerful and patient hitters, the Cardinals must control the pace of the game, keep basepaths clean, and avoid the kind of crooked-number innings that can quickly derail their game plan. If they can weather Gallen’s early push and stay within a run or two into the late innings, the Cardinals’ veteran lineup and dependable bullpen give them a real chance to pull off an upset and cover the spread, even in a hostile environment. A low-scoring, grind-it-out win would be right in their wheelhouse, but to get there, they’ll need early baserunners, solid execution with runners in scoring position, and six competitive innings from whoever takes the mound.

Credit: USA TODAY/IMAGN
Arizona Diamondbacks MLB Preview
The Arizona Diamondbacks return to Chase Field on July 18 with a 43–43 record and a golden opportunity to gain traction in the tightly packed National League playoff race as they host the St. Louis Cardinals in a matchup that highlights their offensive firepower and home-field potential. Though Arizona has been uneven over the last few weeks, particularly with a 2–4 mark in their most recent homestand, they continue to pose a consistent threat thanks to a dynamic offense led by Eugenio Suárez, Josh Naylor, and Corbin Carroll. Suárez has clubbed 31 home runs so far this season, bringing the kind of instant offense that can shift momentum with one swing, while Naylor’s .357 OBP and ability to drive in runs from the middle of the order has made him one of the Diamondbacks’ most valuable bats. Carroll, despite a bit of a sophomore slump compared to his breakout 2023 campaign, remains a disruptive force on the bases and in the outfield, giving Arizona speed and energy at the top of the lineup. Arizona’s game plan is built around early run production, aggressive base running, and forcing opposing pitchers into high-stress innings—a recipe that aligns well with their starting pitcher for this game, ace Zac Gallen. Gallen, who opened the year as the team’s most trusted starter and signed a lucrative $13.5 million deal, continues to deliver quality innings when healthy, using his fastball-curveball combination and sharp command to navigate lineups efficiently.
However, his recent outings have been somewhat inconsistent, and Arizona knows they’ll need him to go at least six innings to protect their vulnerable bullpen, which has been a major weak spot this season. The relief corps, headlined by closer Paul Sewald and setup man Kevin Ginkel, has posted one of the highest ERAs among NL playoff contenders and has repeatedly struggled to maintain leads in the seventh through ninth innings. That puts extra pressure on the offense to build a cushion, especially against a Cardinals team that has a knack for staying close and clawing back late. Defensively, the Diamondbacks are one of the sharper clubs in the league, with Carroll and Alek Thomas covering tons of ground in the outfield and the infield flashing good hands and athleticism across the board. At Chase Field, Arizona typically enjoys a slight offensive boost thanks to the stadium’s friendly dimensions and lively surface, and they’ll look to exploit that edge by jumping on whichever mid-rotation starter St. Louis deploys—likely a contact-reliant pitcher like Mikolas or Matz. If Arizona can execute their typical formula—early runs, steady starting pitching, and just enough from the bullpen—they have the advantage to win this opener and set the tone for the weekend series. But if Gallen gets chased early or if the bullpen is forced to cover too many outs, things could unravel quickly. The Diamondbacks will look to their core hitters to set the tempo, generate rallies, and give Gallen a lead to protect, which remains their most dependable path to victory at home in a must-win series opener.
That's our third baseman 🫶 pic.twitter.com/pvBBPU4hBn
— Arizona Diamondbacks (@Dbacks) July 16, 2025
St. Louis vs. Arizona Prop Picks (AI)
St. Louis vs. Arizona Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Cardinals and Diamondbacks and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned factor emotional bettors regularly put on player performance factors between a Cardinals team going up against a possibly tired Diamondbacks team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Arizona picks, computer picks Cardinals vs Diamondbacks, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Cardinals Betting Trends
The Cardinals are underdogs at +109, and they’ve struggled recently, going just 3–7 ATS in their last 10 games despite a .526 win percentage.
Diamondbacks Betting Trends
The Diamondbacks are favored at –130 and have posted a modest .536 win rate, going 15–13 on the run line this season.
Cardinals vs. Diamondbacks Matchup Trends
With a total of 8.5 and mid-rotation starters on the mound, the under has cashed in roughly 65% of similar matchups, making run suppression a key angle.
St. Louis vs. Arizona Game Info
What time does St. Louis vs Arizona start on July 18, 2025?
St. Louis vs Arizona starts on July 18, 2025 at 9:40 PM EST.
Where is St. Louis vs Arizona being played?
Venue: Chase Field.
What are the opening odds for St. Louis vs Arizona?
Spread: Arizona -1.5
Moneyline: St. Louis +110, Arizona -130
Over/Under: 9
What are the records for St. Louis vs Arizona?
St. Louis: (51-46) | Arizona: (47-50)
What is the AI best bet for St. Louis vs Arizona?
Remi's searched hard and found the best prop for this matchup: E. Suarez over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are St. Louis vs Arizona trending bets?
With a total of 8.5 and mid-rotation starters on the mound, the under has cashed in roughly 65% of similar matchups, making run suppression a key angle.
What are St. Louis trending bets?
STL trend: The Cardinals are underdogs at +109, and they’ve struggled recently, going just 3–7 ATS in their last 10 games despite a .526 win percentage.
What are Arizona trending bets?
ARI trend: The Diamondbacks are favored at –130 and have posted a modest .536 win rate, going 15–13 on the run line this season.
Where can I find AI Picks for St. Louis vs Arizona?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Arizona Odds
Remi is pouring through mountains of stats on each player. In fact, anytime the St. Louis vs Arizona trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.
St. Louis vs Arizona Opening Odds
STL Moneyline:
+110 ARI Moneyline: -130
STL Spread: +1.5
ARI Spread: -1.5
Over/Under: 9
St. Louis vs Arizona Live Odds
Games | PTS | ML | SPR | O/U | |
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St Louis Cardinals
Chicago Cubs
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Cubs
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3
5
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-7000
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-3.5 (-450)
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O 10.5 (+145)
U 10.5 (-180)
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Tampa Bay Rays
Toronto Blue Jays
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Rays
Blue Jays
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0
3
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+1200
-4000
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+4.5 (-150)
-4.5 (+120)
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O 7.5 (+120)
U 7.5 (-150)
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Colorado Rockies
San Francisco Giants
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Rockies
Giants
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2
3
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+260
-350
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+2.5 (-145)
-2.5 (+115)
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O 10.5 (-150)
U 10.5 (+120)
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New York Mets
Miami Marlins
In Progress
Mets
Marlins
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1
0
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-220
+175
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-1.5 (-125)
+1.5 (-105)
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O 7.5 (-110)
U 7.5 (-120)
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Detroit Tigers
Boston Red Sox
In Progress
Tigers
Red Sox
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0
0
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+135
-170
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+1.5 (-150)
-1.5 (+120)
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O 7.5 (+100)
U 7.5 (-130)
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Sep 27, 2025 4:45PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:45PM
White Sox
Nationals
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–
–
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-110
-110
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+1.5 (-210)
-1.5 (+175)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
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+192
-235
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+1.5 (-110)
-1.5 (-110)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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–
–
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+115
-135
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+1.5 (-190)
-1.5 (+158)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
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–
–
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+150
-178
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+1.5 (-145)
-1.5 (+122)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
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–
–
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+126
-150
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+1.5 (-190)
-1.5 (+158)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
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–
–
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+130
-155
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+1.5 (-170)
-1.5 (+143)
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O 7.5 (-105)
U 7.5 (-115)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
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–
–
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-140
+118
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-1.5 (+115)
+1.5 (-135)
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O 9 (-110)
U 9 (-110)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
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–
–
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+100
-120
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+1.5 (-210)
-1.5 (+175)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
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–
–
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+100
-120
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+1.5 (-195)
-1.5 (+162)
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O 10 (-115)
U 10 (-105)
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Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
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–
–
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+144
-172
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+1.5 (-146)
-1.5 (+122)
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O 9 (-122)
U 9 (+100)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Arizona Diamondbacks on July 18, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |