Guardians vs White Sox Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jul 13)
Updated: 2025-07-11T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Cleveland visits Chicago as solid favorites, riding a strong season and healthy pitching advantage while the White Sox remain mired in a long losing slide. Despite the lopsided records, history suggests ATS value for fans riding the underdog momentum or fade trends.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 13, 2025
Start Time: 2:10 PM EST
Venue: Rate Field
White Sox Record: (32-64)
Guardians Record: (45-49)
OPENING ODDS
CLE Moneyline: -137
CHW Moneyline: +115
CLE Spread: -1.5
CHW Spread: +1.5
Over/Under: 8.5
CLE
Betting Trends
- Cleveland has been excellent ATS lately, going 8–2 against the run line over their past ten games versus the White Sox.
CHW
Betting Trends
- Chicago has struggled to cover runs overall, posting a 46–62 ATS record this season.
MATCHUP TRENDS
- Despite the season’s struggles, Chicago shines in the direct matchup as they hold a 7–2 run-line advantage against Cleveland in their last ten meetings.
CLE vs. CHW
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Ramirez over 1.5 Hits+Runs+RBI.
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Cleveland vs Chicago White Sox Prediction & Odds:
Free MLB Betting Insights for 7/13/25
Offensively, Chicago relies heavily on sporadic production from Lenyn Sosa, Andrew Benintendi, and Miguel Vargas, but the lineup collectively lacks consistent run-producing ability, making it difficult to sustain pressure against opponents with strong pitching staffs. Despite these apparent disadvantages, the White Sox have intriguingly managed to remain competitive against Cleveland in recent matchups, maintaining a solid ATS record, suggesting a tendency to keep games tight even when losing outright. This could offer potential value to bettors considering Chicago as a run-line underdog, especially given that the Guardians, while strong overall, have also shown occasional vulnerability late in games. The key for Chicago will be to disrupt Cleveland’s early-game rhythm, capitalizing on mistakes and applying consistent pressure to extend innings and drive pitch counts upward. For Cleveland, establishing an early lead, ideally by leveraging their offensive depth against Chicago’s shaky rotation, will be essential to controlling the game’s pace and negating any potential momentum swings in favor of the White Sox. Defensive execution will also be crucial; Cleveland has generally been sound in the field, limiting opponents’ opportunities, while Chicago has had occasional lapses leading to unearned runs and defensive miscues. Given these dynamics, the Guardians enter as clear favorites, positioned well to capitalize on their strengths in pitching and balanced hitting, though bettors mindful of recent ATS trends may find value in Chicago’s resilience. Fans should expect Cleveland to set the tone early, though Chicago’s ability to remain competitive in close contests will keep intrigue alive deep into the game.
Kyle puts us back on top!#GuardsBall pic.twitter.com/iWnpoQBRMq
— Cleveland Guardians (@CleGuardians) July 12, 2025
Cleveland Guardians MLB Preview
The Cleveland Guardians arrive at Guaranteed Rate Field on July 13, 2025, bringing substantial momentum into their matchup against the struggling Chicago White Sox. Cleveland, with an impressive 56–37 record, is entrenched firmly in the AL Central division race, driven by consistent execution both at the plate and on the mound. Offensively, the Guardians have constructed a lineup adept at manufacturing runs, anchored by the potent and ever-reliable José Ramírez. Ramírez continues to demonstrate exceptional discipline and clutch-hitting capabilities, serving as the linchpin around whom the entire batting order revolves. He is complemented seamlessly by the versatile Steven Kwan, whose contact-heavy approach consistently frustrates opposing pitchers, forcing them into extended pitch counts and difficult situations. Kwan’s ability to consistently reach base sets the stage for the team’s potent run producers, creating numerous scoring opportunities early in games. The Guardians’ recent offensive surge has also been significantly boosted by the unexpected resurgence of veteran Carlos Santana, whose return to form has injected substantial power and experience into the middle of their lineup. Santana, hitting exceptionally well since rejoining Cleveland, provides additional balance to the batting order and ensures opposing pitchers face relentless pressure at every stage of the game. Defensively, Cleveland remains fundamentally sound, frequently minimizing mistakes and preventing unnecessary baserunners, effectively supporting their pitching staff through efficient fielding and accurate throws.
On the mound, Cleveland’s success is built around one of the most effective and consistent rotations in the league, headlined by Logan Allen, whose reliability has been crucial in stabilizing the pitching staff. Allen routinely delivers quality outings, going deep into games and managing difficult situations with a maturity beyond his years. His presence on the mound often sets a commanding tone, allowing Cleveland’s bullpen to remain fresh and strategically utilized. Tanner Bibee, another talented arm, has contributed significantly, offering high-quality innings and providing dependable performances even against tough lineups. This rotation depth not only gives the Guardians a distinct advantage over many opponents but also ensures they remain highly competitive throughout series, particularly when facing struggling pitching staffs like Chicago’s. The bullpen, once viewed as Cleveland’s weakness, has evolved into a genuine strength over the course of the season, demonstrating newfound reliability in late-game scenarios. Guardians’ relievers have grown adept at neutralizing scoring threats, maintaining leads, and securing tight victories—an asset that could prove decisive against the White Sox. Despite their clear advantages, the Guardians must remain cautious. The White Sox, although mired in difficulties, have managed to stay notably competitive against Cleveland in recent matchups, particularly against the spread. Therefore, the Guardians will need to maintain relentless pressure offensively and avoid complacency late in games. They must exploit Chicago’s pitching vulnerabilities early, generating momentum and building insurmountable leads before the White Sox can gain confidence. If Cleveland can maintain their disciplined offensive approach, leverage their clear pitching advantage, and execute defensively, they’ll be well-positioned to emerge victorious and continue their strong march toward postseason contention.

Credit: USA TODAY/IMAGN
Chicago White Sox White Sox MLB Preview
The Chicago White Sox return home to Guaranteed Rate Field on July 13, 2025, hoping to reverse their current trajectory against a formidable opponent in the Cleveland Guardians. Unfortunately, the White Sox enter this matchup amid one of their worst campaigns in franchise history, holding a disappointing 32–64 record that reflects systemic challenges both on and off the field. They have endured prolonged losing stretches, highlighted by a troubling inability to win close games, evidenced by their concerning 7–22 record in one-run contests. Offensively, the White Sox lineup continues to struggle significantly, collectively batting near the bottom of the league with an average hovering around .220. Key hitters such as Lenyn Sosa, Andrew Benintendi, Miguel Vargas, and Edgar Quero have each provided intermittent sparks, but none have been able to establish sustained momentum, leaving the lineup fragmented and inconsistent. Power remains particularly elusive for Chicago this season, as evidenced by their minimal home-run totals, placing additional pressure on an offense already struggling to produce consistent scoring threats. Defensively, the White Sox have been equally problematic, plagued by untimely errors, lapses in concentration, and poor execution in fundamental plays, all factors contributing heavily to their losing record. The pitching staff, including projected starter Sean Burke, who carries a middling 4.40 ERA, has also been a central area of concern. While Burke has occasionally shown the ability to pitch effectively in short bursts, he has rarely been able to deliver deep into games, placing extra strain on an already overtaxed bullpen that consistently struggles in high-leverage situations.
Chicago’s relief pitching has been prone to late-game collapses throughout the season, routinely conceding leads and allowing opponents to rally in the final innings, a weakness that has severely impacted their ability to secure victories. Manager Will Venable faces an uphill battle to maintain clubhouse morale, emphasizing resilience and effort in the face of continuous adversity. Nevertheless, despite these significant hurdles, the White Sox have periodically demonstrated their capacity to surprise stronger teams, occasionally pulling off unexpected victories at home, where they have been marginally more competitive compared to their dismal road performance. Indeed, their home-field advantage at Guaranteed Rate Field might offer the White Sox a slight boost, especially given their historical competitiveness against Cleveland in recent matchups, where they’ve managed to keep games closer than expected despite overall struggles. For Chicago to have any realistic chance of success in this upcoming game, they must capitalize early on Cleveland’s pitching by establishing disciplined at-bats, drawing walks, and manufacturing runs through aggressive base-running and situational hitting. Simultaneously, the White Sox pitching staff, particularly Burke, must find ways to neutralize the Guardians’ patient and potent lineup, avoiding early deficits that force the offense to play catch-up. While the White Sox remain clear underdogs entering this contest, a combination of improved execution, timely hitting, sharper defensive play, and effective pitching might offer an opportunity to create an upset and provide a much-needed morale boost to a struggling ballclub.
Teel ties it up! pic.twitter.com/u7eUaPvA26
— Chicago White Sox (@whitesox) July 12, 2025
Cleveland vs. Chicago White Sox Prop Picks (AI)
Cleveland vs. Chicago White Sox Prediction (AI)

Remi, our AI sports genius, has been pouring over mountains of data from every angle between the Guardians and White Sox and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Interestingly enough, the data has been most watching on the linear correlation of factor human bettors tend to put on Cleveland’s strength factors between a Guardians team going up against a possibly strong White Sox team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cleveland vs Chicago White Sox picks, computer picks Guardians vs White Sox, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Guardians Betting Trends
Cleveland has been excellent ATS lately, going 8–2 against the run line over their past ten games versus the White Sox.
White Sox Betting Trends
Chicago has struggled to cover runs overall, posting a 46–62 ATS record this season.
Guardians vs. White Sox Matchup Trends
Despite the season’s struggles, Chicago shines in the direct matchup as they hold a 7–2 run-line advantage against Cleveland in their last ten meetings.
Cleveland vs. Chicago White Sox Game Info
What time does Cleveland vs Chicago White Sox start on July 13, 2025?
Cleveland vs Chicago White Sox starts on July 13, 2025 at 2:10 PM EST.
Where is Cleveland vs Chicago White Sox being played?
Venue: Rate Field.
What are the opening odds for Cleveland vs Chicago White Sox?
Spread: Chicago White Sox +1.5
Moneyline: Cleveland -137, Chicago White Sox +115
Over/Under: 8.5
What are the records for Cleveland vs Chicago White Sox?
Cleveland: (45-49) | Chicago White Sox: (32-64)
What is the AI best bet for Cleveland vs Chicago White Sox?
Remi's searched hard and found the best prop for this matchup: J. Ramirez over 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Cleveland vs Chicago White Sox trending bets?
Despite the season’s struggles, Chicago shines in the direct matchup as they hold a 7–2 run-line advantage against Cleveland in their last ten meetings.
What are Cleveland trending bets?
CLE trend: Cleveland has been excellent ATS lately, going 8–2 against the run line over their past ten games versus the White Sox.
What are Chicago White Sox trending bets?
CHW trend: Chicago has struggled to cover runs overall, posting a 46–62 ATS record this season.
Where can I find AI Picks for Cleveland vs Chicago White Sox?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. Chicago White Sox Odds
AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Cleveland vs Chicago White Sox trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.
Cleveland vs Chicago White Sox Opening Odds
CLE Moneyline:
-137 CHW Moneyline: +115
CLE Spread: -1.5
CHW Spread: +1.5
Over/Under: 8.5
Cleveland vs Chicago White Sox Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 9:08PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 9:08PM
Dodgers
Blue Jays
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–
–
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-140
+127
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-1.5 (+124)
+1.5 (-140)
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O 7.5 (+107)
U 7.5 (-123)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Guardians vs. Chicago White Sox White Sox on July 13, 2025 at Rate Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |