Guardians vs. White Sox
Prediction, Odds & Props
Jul 12 | MLB AI Picks

Updated: 2025-07-10T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On Saturday, July 12, 2025, the Cleveland Guardians (50–40) will visit the Chicago White Sox (48–53) at Guaranteed Rate Field, with first pitch scheduled for 4:10 p.m. ET. Cleveland is favored at –150 on the moneyline and –1.5 on the run line, with an over/under set at 8.5 runs.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jul 12, 2025

Start Time: 4:10 PM EST​

Venue: Rate Field​

White Sox Record: (32-63)

Guardians Record: (44-49)

OPENING ODDS

CLE Moneyline: -149

CHW Moneyline: +124

CLE Spread: -1.5

CHW Spread: +1.5

Over/Under: 8.5

CLE
Betting Trends

  • The Guardians have been strong ATS as favorites recently, covering the spread in 8 of their last 10 games.

CHW
Betting Trends

  • Chicago has been just 3–5 ATS as underdogs in their last 8 games, showing inconsistency against the spread.

MATCHUP TRENDS

  • As a moneyline favorite this season, Cleveland has won 33 of 57 games (about 58%) and handled the –150 price well. Meanwhile, the White Sox have pulled off the upset in 31 of 93 games when listed at +126 or longer.

CLE vs. CHW
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Martinez over 0.5 Total Bases.

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Cleveland vs Chicago White Sox Prediction & Odds:
Free MLB Betting Insights for 7/12/25

Saturday’s matchup between the Cleveland Guardians and the Chicago White Sox at Guaranteed Rate Field presents a divisional showdown between two AL Central teams heading in very different directions. Cleveland enters the contest at 50–40, sitting atop the division and continuing to play consistent, fundamentally sound baseball under first-year manager Stephen Vogt. Chicago, meanwhile, is buried at 48–53 and increasingly looking like a team stuck in transition despite the emergence of a few promising young pieces. The Guardians won Friday’s series opener and will look to build on their strong recent stretch, which includes an 8–2 ATS run over their last ten games and a notable improvement in late-game execution. While Cleveland has leaned on strong pitching, timely hitting, and veteran leadership, the White Sox have continued to flounder in close contests, as evidenced by a 7–22 record in one-run games this season. Saturday’s projected pitching matchup favors Cleveland again, with left-hander Logan Allen expected to take the mound for the Guardians. Allen has been quietly effective, consistently pitching into the sixth inning and keeping his ERA below 4.00 while limiting damage and minimizing walks. Chicago’s starter remains to be confirmed, but if recent rotation trends hold, it will likely be a mid-tier arm or possibly a spot-starter, which gives Cleveland another key advantage. The Guardians’ offense, led by the resurgence of Carlos Santana and consistent contributions from José Ramírez and Andrés Giménez, has found a rhythm, combining situational hitting with just enough power to be dangerous in any ballpark.

Meanwhile, Chicago’s offense, while showing brief signs of life through the bats of Lenyn Sosa and Miguel Vargas, remains largely inconsistent and prone to cold stretches with runners in scoring position. Defensively, the edge also tilts toward Cleveland, which ranks among the top teams in fielding percentage and fewest errors committed, while the White Sox have often found themselves victimized by miscues and mental lapses in critical spots. In the bullpen, the Guardians have gradually formed one of the more dependable relief corps in the American League, anchored by a strong closer and well-defined late-inning roles, while Chicago continues to struggle with blown saves and inconsistent middle relief. The betting markets reflect this gap as well—Cleveland is around –150 favorites, and their success in this role has been evident, winning 33 of 57 games when favored. The White Sox have managed to pull off some underdog wins, but they’ve been few and far between when facing top-tier AL Central competition. For Saturday’s contest, the Guardians have all the pieces aligned—momentum, superior pitching, a more reliable offense, and fewer question marks across the board. If Cleveland can strike early and get a lead into the sixth, they’re well-positioned to extend their series lead and continue asserting their control over the division. The White Sox will need a near-flawless performance, capitalizing on every scoring opportunity and avoiding defensive miscues, to have a shot at pulling off the upset. Otherwise, the Guardians look poised to continue their steady march toward the postseason.

Cleveland Guardians MLB Preview

The Cleveland Guardians head into Saturday’s matchup against the Chicago White Sox with confidence and momentum, having taken the series opener and continuing their push to maintain first place in the AL Central. At 50–40, Cleveland has steadily proven itself as one of the most balanced and reliable clubs in the American League, largely because of its deep starting rotation, clutch hitting, and dependable bullpen. The probable starter for Saturday, left-hander Logan Allen, has quietly been a major contributor to Cleveland’s rotation, showcasing poise and command in recent outings. Allen has pitched into the sixth inning in four of his last six starts, maintaining an ERA under 4.00 and giving his team a chance to win nearly every time he takes the mound. His ability to induce ground balls and avoid big innings will be especially valuable against a White Sox lineup that has shown flashes of pop but often struggles to string together sustained offense. Offensively, the Guardians have been efficient rather than explosive, relying on timely hits from Carlos Santana—who is enjoying a strong bounce-back season—and consistent output from cornerstone players like José Ramírez, Steven Kwan, and Andrés Giménez.

This lineup is built to grind out wins with quality at-bats, strong situational hitting, and low strikeout rates, making them particularly dangerous against weaker or inconsistent pitching staffs like Chicago’s. Cleveland’s defense has also played a crucial role in their success, ranking among the league leaders in fielding percentage and turning key double plays that have helped them escape jams. But perhaps their biggest strength lies in the bullpen, where closer Emmanuel Clase and setup men Sam Hentges and Eli Morgan have helped convert late leads into wins with remarkable consistency. The Guardians are 8–2 ATS in their last 10 games and have won 33 of the 57 contests in which they’ve been listed as moneyline favorites—a testament to their ability to take care of business against weaker competition. They’ve also been sharp on the road, showing mental toughness in tight games and capitalizing on opponent mistakes. Against the White Sox, Cleveland’s path to victory is clear: get a solid start from Allen, manufacture early runs with smart at-bats, and turn things over to a rested and reliable bullpen. If their lineup continues to execute and Allen keeps the ball down in the zone, the Guardians will be in a strong position to win another divisional game and keep pressure on the rest of the AL Central. With a team identity rooted in discipline, experience, and chemistry, Cleveland doesn’t need to be flashy to win—they just need to stay true to their system, and that formula has served them well all season. Saturday’s contest is yet another opportunity for them to separate from the pack and head into the break with momentum on their side.

On Saturday, July 12, 2025, the Cleveland Guardians (50–40) will visit the Chicago White Sox (48–53) at Guaranteed Rate Field, with first pitch scheduled for 4:10 p.m. ET. Cleveland is favored at –150 on the moneyline and –1.5 on the run line, with an over/under set at 8.5 runs. Cleveland vs Chicago White Sox AI Prediction: Free MLB Betting Insights for Jul 12. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago White Sox White Sox MLB Preview

The Chicago White Sox enter Saturday’s home matchup against the Cleveland Guardians with their backs against the wall, sitting at 48–53 and struggling to stay afloat in the American League playoff picture. Despite being only a few games below .500, the White Sox have consistently failed to seize momentum during crucial stretches, with their inconsistency showing up in both the standings and the betting markets. They’ve gone just 3–5 against the spread in their last eight games as underdogs and are just 7–22 in one-run contests, a damning stat that highlights their inability to execute in late-game situations. Offensively, there are some reasons for optimism—young infielders Lenyn Sosa and Miguel Vargas have begun to deliver, with Sosa hitting .272 and Vargas providing occasional power with 10 home runs—but the lineup lacks balance and depth. Veterans like Andrew Benintendi and Eloy Jiménez have had up-and-down seasons, with extended slumps undermining any hope of sustained offensive production. On the pitching side, Chicago’s rotation has been in flux due to injuries and poor performances, and with no confirmed starter for Saturday at the time of preview, the team may be forced to rely on a spot starter or a bullpen game—neither of which bodes well against a sharp Cleveland team.

The bullpen remains a sore spot, frequently asked to cover multiple innings due to short outings from the rotation, and that overexposure has led to several late-game collapses. Defensively, the White Sox continue to commit costly errors and rank near the bottom of the league in key defensive metrics, further compounding the issues caused by inconsistent pitching. Their inability to turn potential double plays or convert routine outs into clean innings has extended rallies and led to disastrous big innings. At Guaranteed Rate Field, Chicago has not capitalized on home-field advantage, often drawing thin crowds and showing signs of frustration that bleed into their on-field play. Manager Will Venable has emphasized effort and player development, but his club continues to play from behind far too often and lacks the veteran leadership necessary to overcome adversity. Saturday’s game against Cleveland presents a significant challenge: the Guardians are fundamentally sound, deep in pitching, and methodical in their approach, all traits that contrast with Chicago’s erratic tendencies. If the White Sox hope to upset Cleveland, they’ll need an exceptional offensive day from the middle of their order and a strong performance from a starter who can get them at least five innings without allowing the game to get out of hand. Without those elements, and unless they play the cleanest game of their season defensively, Chicago is likely looking at another frustrating loss against a division rival that continues to set the standard for consistency and execution. With time running out to make a meaningful push, the White Sox are under pressure not just to compete—but to prove they can even stay in the fight.

Cleveland vs. Chicago White Sox Prop Picks (AI)

Remi is pouring through tons of datapoints on each line. In fact, anytime the Guardians and White Sox play there’s always several intriguing angles to key in on. Not to mention games played at Rate Field in Jul seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: A. Martinez over 0.5 Total Bases.

Cleveland vs. Chicago White Sox Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every past game between the Guardians and White Sox and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.

The Algorithm has been most watching on the linear correlation of emphasis knucklehead sportsbettors regularly put on coaching factors between a Guardians team going up against a possibly healthy White Sox team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs Chicago White Sox picks, computer picks Guardians vs White Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Guardians Betting Trends

The Guardians have been strong ATS as favorites recently, covering the spread in 8 of their last 10 games.

White Sox Betting Trends

Chicago has been just 3–5 ATS as underdogs in their last 8 games, showing inconsistency against the spread.

Guardians vs. White Sox Matchup Trends

As a moneyline favorite this season, Cleveland has won 33 of 57 games (about 58%) and handled the –150 price well. Meanwhile, the White Sox have pulled off the upset in 31 of 93 games when listed at +126 or longer.

Cleveland vs. Chicago White Sox Game Info

Cleveland vs Chicago White Sox starts on July 12, 2025 at 4:10 PM EST.

Spread: Chicago White Sox +1.5
Moneyline: Cleveland -149, Chicago White Sox +124
Over/Under: 8.5

Cleveland: (44-49)  |  Chicago White Sox: (32-63)

Remi's searched hard and found the best prop for this matchup: A. Martinez over 0.5 Total Bases.. Prices move—always shop for the best number.

As a moneyline favorite this season, Cleveland has won 33 of 57 games (about 58%) and handled the –150 price well. Meanwhile, the White Sox have pulled off the upset in 31 of 93 games when listed at +126 or longer.

CLE trend: The Guardians have been strong ATS as favorites recently, covering the spread in 8 of their last 10 games.

CHW trend: Chicago has been just 3–5 ATS as underdogs in their last 8 games, showing inconsistency against the spread.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. Chicago White Sox Odds

Remi is pouring through loads of data on each player. In fact, anytime the Cleveland vs Chicago White Sox trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.

Cleveland vs Chicago White Sox Opening Odds

CLE Moneyline: -149
CHW Moneyline: +124
CLE Spread: -1.5
CHW Spread: +1.5
Over/Under: 8.5

Cleveland vs Chicago White Sox Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. Chicago White Sox White Sox on July 12, 2025 at Rate Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN