Cardinals vs. Cubs
Prediction, Odds & Props
Jul 06 | MLB AI Picks
Updated: 2025-07-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals (70–69) and Chicago Cubs (46–32) are set to clash in the final game of their series at Wrigley Field on Sunday, July 6, 2025, at 2:20 PM ET. With both teams vying for divisional supremacy, this matchup carries significant implications for the National League Central standings.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jul 06, 2025
Start Time: 6:10 PM EST
Venue: Wrigley Field
Cubs Record: (53-36)
Cardinals Record: (48-42)
OPENING ODDS
STL Moneyline: +171
CHC Moneyline: -208
STL Spread: +1.5
CHC Spread: -1.5
Over/Under: 7.5
STL
Betting Trends
- The Cardinals have a 5–5 record against the spread in their last 10 games.
CHC
Betting Trends
- The Cubs are 30–35 against the run line this season.
MATCHUP TRENDS
- In their last 10 head-to-head matchups, the Cardinals and Cubs have each secured 5 wins, reflecting the evenly matched nature of this rivalry.
STL vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.
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St. Louis vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 7/6/25
Offensively, St. Louis is getting more consistent production from players like Willson Contreras and Masyn Winn, both of whom have added timely hits and improved plate discipline. With both teams capable of manufacturing runs and applying pressure on the basepaths, the game could hinge on execution in late innings, particularly as both clubs’ bullpens are trending in opposite directions—Chicago’s relief unit has held up well under pressure, while the Cardinals’ recent improvements will be put to the test in a hostile road environment. The rivalry backdrop only amplifies the drama; the Cubs and Cardinals have split their last 10 meetings evenly, and every game in the season series has felt like it could swing either way based on a single mistake or clutch at-bat. Betting trends suggest this could be another tight contest, with both teams going 5–5 ATS in their last 10 and neither establishing dominant momentum in the matchup. Wrigley Field’s unique elements—changing winds, the ivy, and unpredictable bounces—could also play a role in shaping the game’s narrative. As the final game before the break, expect managers to approach this with urgency, possibly extending starting pitchers deeper than usual or deploying high-leverage relievers earlier if the situation demands it. With postseason implications already looming and pride on the line between two of the league’s most passionate fanbases, this series finale has all the makings of a summer classic—a hard-fought, high-intensity battle that could serve as a tone-setter for both teams as they brace for the stretch run.
THAT'S A WINNER!! pic.twitter.com/PrujFQCBjr
— St. Louis Cardinals (@Cardinals) July 5, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals enter Sunday’s rivalry finale against the Chicago Cubs at Wrigley Field with a 70–69 record and a clear sense of urgency as they look to gain ground in a tightly contested NL Central race before the All-Star break. After a rocky start to the season, the Cardinals have clawed their way back to respectability with improved pitching, more consistent run production, and a much-needed stretch of better defensive play. The resurgence has been spearheaded by veteran right-hander Sonny Gray, who leads the rotation with a 3.91 ERA and 168 strikeouts, giving the club a reliable presence at the top of the staff in every fifth-day matchup. Gray’s ability to command the zone, attack hitters with a sharp breaking ball, and minimize big innings has helped stabilize what was once a shaky staff, and he’ll be instrumental if the Cardinals want to steal a road win in one of the league’s toughest environments. At the plate, St. Louis has leaned on Alec Burleson, whose team-best 21 home runs and 70 RBIs have provided crucial power in the middle of the order. Burleson’s emergence as a legitimate run producer has taken some pressure off aging veterans like Paul Goldschmidt and Nolan Arenado, who’ve both endured inconsistent stretches, and given manager Oliver Marmol some lineup flexibility. Masyn Winn and Willson Contreras have also chipped in with quality at-bats and timely hits, helping the Cardinals generate more runs even in low-scoring, pitching-heavy contests.
But what’s most impressed during their recent uptick has been the team’s ability to hang in close games—a byproduct of better bullpen performance and smarter situational baseball. Giovanny Gallegos and JoJo Romero have given the Cardinals some breathing room in late innings, and Ryan Helsley has found his groove again as the closer, flashing elite strikeout stuff and better command. Even so, inconsistency remains a concern, particularly on the road where the Cardinals have struggled to maintain offensive momentum and capitalize with runners in scoring position. Defensively, they’ve cleaned up the errors that plagued them earlier in the year, but playing at Wrigley—where wild hops and unpredictable wind conditions are always a factor—will test their composure. The Cardinals have split their last ten meetings with the Cubs, suggesting this series finale could go either way, and with both teams evenly matched in many respects, the margin for error will be razor thin. For St. Louis, the key to success will be jumping on Shota Imanaga early before he settles into a rhythm, and then turning the game over to a bullpen that has been far more effective in the past three weeks than it was in April or May. A win on Sunday wouldn’t just take the series—it would give the Cardinals an emotional lift heading into the break and reinforce their status as a legitimate second-half threat in the division. In a rivalry steeped in history and intensity, Sunday’s game will be less about records and more about who can execute in the spotlight, and the Cardinals are showing signs that they’re ready for that challenge.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Chicago Cubs enter Sunday’s series finale against the St. Louis Cardinals with a 46–32 record and a firm grip on the National League Central lead, aiming to cap off a strong first half of the season with a statement win over their longtime division rivals. This 2025 campaign has been defined by a potent blend of consistent starting pitching, timely offense, and solid team defense, and manager Craig Counsell’s squad has displayed the poise and execution of a club built for October. Ian Happ has been the offensive catalyst for the Cubs all season, leading the team with 25 home runs and 86 RBIs, and providing crucial middle-of-the-lineup production when it matters most. His combination of power, discipline, and clutch hitting has been instrumental in breaking open tight games, while Seiya Suzuki’s .283 batting average and quality at-bats from Nico Hoerner and Christopher Morel have given the Cubs a balanced, opportunistic offense. But perhaps the biggest story in Chicago’s rise this season has been the dominance of left-hander Shota Imanaga, who takes the mound Sunday with a 2.91 ERA and 174 strikeouts, giving the Cubs a true ace who has stymied opposing lineups with a devastating splitter and pinpoint command. Imanaga’s emergence has provided stability atop the rotation, allowing the rest of the staff to settle into clearly defined roles and putting less pressure on the bullpen to cover excessive innings.
Speaking of the bullpen, the Cubs have leaned on a late-inning trio that includes Adbert Alzolay, Mark Leiter Jr., and Julian Merryweather, each of whom has delivered in high-leverage spots with a combination of swing-and-miss stuff and improved control. Defensively, Chicago has been sharp across the diamond, with Dansby Swanson and Hoerner forming one of the league’s best double-play tandems and Cody Bellinger continuing to play gold-glove caliber defense in the outfield. That kind of consistency and versatility has allowed the Cubs to navigate slumps and injuries without losing traction in the standings, and they’ve maintained a strong home-field advantage at Wrigley Field, where the team’s energy and crowd support create a unique and often difficult environment for visiting teams. Sunday’s game will test their ability to close out a tense rivalry series, but with Imanaga on the mound and their bats heating up again after a few quiet games, the Cubs appear well-positioned to handle the pressure. The Cardinals, despite hovering near .500, always play the Cubs tough, and with Sonny Gray expected to start for St. Louis, Chicago will need to work counts and capitalize on any scoring chances early before he can settle in. The key for the Cubs will be keeping the ball in play, avoiding wasted at-bats with runners on base, and letting Imanaga control the game’s tempo with his elite command and movement. A win on Sunday would not only seal a critical series win over a division opponent but also set a confident tone heading into the All-Star break, reaffirming that this Cubs team isn’t just a first-half surprise—they’re built to compete deep into the season.
within two. pic.twitter.com/CpSM25WhLA
— Chicago Cubs (@Cubs) July 5, 2025
St. Louis vs. Chicago Cubs Prop Picks (AI)
St. Louis vs. Chicago Cubs Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Cardinals and Cubs and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Interestingly enough, the data has been most watching on the unproportionally assigned emphasis knucklehead sportsbettors tend to put on coaching factors between a Cardinals team going up against a possibly deflated Cubs team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Chicago Cubs picks, computer picks Cardinals vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals have a 5–5 record against the spread in their last 10 games.
Cubs Betting Trends
The Cubs are 30–35 against the run line this season.
Cardinals vs. Cubs Matchup Trends
In their last 10 head-to-head matchups, the Cardinals and Cubs have each secured 5 wins, reflecting the evenly matched nature of this rivalry.
St. Louis vs. Chicago Cubs Game Info
What time does St. Louis vs Chicago Cubs start on July 06, 2025?
St. Louis vs Chicago Cubs starts on July 06, 2025 at 6:10 PM EST.
Where is St. Louis vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for St. Louis vs Chicago Cubs?
Spread: Chicago Cubs -1.5
Moneyline: St. Louis +171, Chicago Cubs -208
Over/Under: 7.5
What are the records for St. Louis vs Chicago Cubs?
St. Louis: (48-42) | Chicago Cubs: (53-36)
What is the AI best bet for St. Louis vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.. Prices move—always shop for the best number.
What are St. Louis vs Chicago Cubs trending bets?
In their last 10 head-to-head matchups, the Cardinals and Cubs have each secured 5 wins, reflecting the evenly matched nature of this rivalry.
What are St. Louis trending bets?
STL trend: The Cardinals have a 5–5 record against the spread in their last 10 games.
What are Chicago Cubs trending bets?
CHC trend: The Cubs are 30–35 against the run line this season.
Where can I find AI Picks for St. Louis vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Chicago Cubs Odds
Remi is pouring through mountains of data on each team. In fact, anytime the St. Louis vs Chicago Cubs trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.
St. Louis vs Chicago Cubs Opening Odds
STL Moneyline:
+171 CHC Moneyline: -208
STL Spread: +1.5
CHC Spread: -1.5
Over/Under: 7.5
St. Louis vs Chicago Cubs Live Odds
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Baltimore Orioles
New York Yankees
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Orioles
Yankees
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Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
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-178
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O 9.5 (-110)
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Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
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Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
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+102
-120
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-1.5 (+162)
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O 8.5 (-122)
U 8.5 (+100)
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Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
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+198
-240
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+1.5 (-110)
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O 8 (-108)
U 8 (-112)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
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+122
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
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+108
-126
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+1.5 (-196)
-1.5 (+162)
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O 9 (+100)
U 9 (-122)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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+180
-215
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+1.5 (-118)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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-134
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+1.5 (-184)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
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+144
-172
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+1.5 (-142)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
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+126
-148
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+1.5 (-188)
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O 7.5 (-105)
U 7.5 (-115)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
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+120
-142
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+1.5 (-182)
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O 7.5 (-118)
U 7.5 (-104)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
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-148
+126
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+1.5 (-128)
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O 9 (-108)
U 9 (-112)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
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+100
-118
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+1.5 (-210)
-1.5 (+172)
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O 7.5 (+100)
U 7.5 (-122)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
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+100
-118
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-1.5 (+146)
+1.5 (-178)
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O 10 (-114)
U 10 (-106)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Chicago Cubs Cubs on July 06, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |