Cardinals vs. Cubs
Prediction, Odds & Props
Jul 04 | MLB AI Picks

Updated: 2025-07-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (43–42) and Chicago Cubs (48–37) renew their storied rivalry on Friday, July 4, 2025, at Wrigley Field. First pitch is scheduled for 2:20 p.m. ET, with Miles Mikolas (4–5, 4.76 ERA) starting for the Cardinals and Colin Rea (5–3, 4.37 ERA) taking the mound for the Cubs.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jul 04, 2025

Start Time: 2:20 PM EST​

Venue: Wrigley Field​

Cubs Record: (52-35)

Cardinals Record: (47-41)

OPENING ODDS

STL Moneyline: +131

CHC Moneyline: -157

STL Spread: +1.5

CHC Spread: -1.5

Over/Under: 10

STL
Betting Trends

  • The Cardinals have covered the spread in 5 of their last 6 road games, indicating strong performance against the spread when playing away.

CHC
Betting Trends

  • The Cubs are 4–1 against the spread in their last 5 home games, showcasing their dominance at Wrigley Field.

MATCHUP TRENDS

  • The total has gone OVER in 7 of the last 8 meetings between the Cardinals and Cubs, suggesting a trend toward high-scoring games in this rivalry.

STL vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Kelly over 3.5 Fantasy Score.

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St. Louis vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 7/4/25

The Chicago Cubs and St. Louis Cardinals meet on July 4, 2025, at Wrigley Field in a crucial divisional battle that carries playoff implications for both historic rivals. The Cubs come in with a 48–37 record, leading the National League Central and playing some of their best baseball of the season, including a recent sweep of the Cleveland Guardians that featured a 1–0 walk-off win. The Cardinals, at 43–42, are trying to stay afloat in both the divisional and wild card races but arrive in Chicago after a rough three-game sweep at the hands of the Pittsburgh Pirates in which they failed to score a single run. The contrast in momentum between these two teams is sharp, but rivalry games tend to defy trends, and the holiday setting at Wrigley Field promises a charged atmosphere for a series that could swing the trajectory of the Cardinals’ season. Friday’s pitching matchup features Colin Rea for the Cubs, who has been solid with a 5–3 record and 4.37 ERA, while the Cardinals send out veteran righty Miles Mikolas, who has struggled at times this year but still brings experience and familiarity with the Cubs’ lineup. Offensively, the Cubs have been far more consistent of late, getting contributions from a balanced group including Nico Hoerner, Seiya Suzuki, and Christopher Morel, while the Cardinals have leaned on Brendan Donovan’s steady bat and the power of Willson Contreras and Nolan Arenado, though the latter has cooled off recently.

The betting trends suggest a potentially high-scoring affair, as the total has gone OVER in seven of the last eight meetings between these two clubs, and both teams have been covering the spread well—St. Louis in five of their last six road games and the Cubs in four of their last five home outings. Chicago’s bullpen, led by closer Adbert Alzolay, has been quietly effective and may give them the late-inning edge, particularly against a Cardinals lineup that has struggled mightily over the last few games. Defensively, both teams rank in the upper half of the league, though the Cubs have been slightly better at limiting unearned runs and turning key double plays. With just one game separating multiple teams in the NL Wild Card chase, every game in this series holds weight, and the Cardinals know a poor showing could knock them below .500 and dampen their postseason hopes. For the Cubs, this is a golden opportunity to create distance at the top of the division and reinforce their status as legitimate contenders heading into the All-Star break. The Fourth of July setting, combined with a tight divisional race and the always fiery rivalry between Chicago and St. Louis, sets the stage for what should be a high-intensity series opener where every pitch, at-bat, and defensive play will matter. Expect fireworks not just after the game, but during it—on the scoreboard, in the dugouts, and likely from a few emotional moments as these bitter rivals battle for momentum in one of the league’s most iconic matchups.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals head into their July 4 matchup at Wrigley Field with a 43–42 record and considerable urgency after a disastrous series against the Pittsburgh Pirates in which they were shut out in all three games, marking one of their lowest offensive stretches of the season. Despite their recent woes, the Cardinals remain in the thick of the NL Wild Card race and only 5.5 games behind the division-leading Cubs, making this holiday weekend series a vital opportunity to close the gap and regain momentum. Manager Oliver Marmol has been under pressure to ignite a more consistent offense, as the team’s production has fluctuated dramatically throughout the season. Brendan Donovan remains the club’s most reliable hitter, leading the team with a .293 batting average while showing his usual versatility both at the plate and in the field. Willson Contreras has provided the power with 11 home runs and 51 RBIs, while Nolan Arenado, though not as dominant as in prior years, has added 10 home runs and 13 doubles. The supporting cast, however, has lacked timely hitting, and the Cardinals have stranded far too many runners in scoring position, a trend they cannot afford to continue against a Cubs team that has been thriving in clutch moments.

Miles Mikolas will get the ball to open the series, entering with a 4–5 record and a 4.76 ERA, numbers that reflect a season filled with inconsistencies, particularly against teams with strong top-of-the-lineup hitters like Chicago. Mikolas must find a way to navigate early innings without damage, especially with the Cubs’ offense clicking and Wrigley Field likely to be lively on the holiday. St. Louis has been sharper on the road than at home in recent weeks, covering the spread in five of their last six away games, and they’ll need to rely on clean defense, timely pitching changes, and improved situational hitting to keep pace with the Cubs. The bullpen, anchored by Ryan Helsley, has been a strength when given a lead to protect, but that hasn’t been a luxury of late with the bats falling silent. The Cardinals’ defensive unit, while not flashy, has been reliable, especially infielders like Paul Goldschmidt and Tommy Edman, who continue to make routine plays look easy. If the Cardinals are going to make a serious push toward the postseason, this series may be a pivotal point in their season—not only because of the standings implications but because it provides a chance to correct recent flaws against their most familiar rival. A series win would restore confidence, while another poor showing could push them toward seller status ahead of the trade deadline. The Fourth of July setting only raises the stakes, and the Cardinals know they must come out focused, aggressive, and energized to avoid falling further behind and to prove that their playoff chase is still a credible one heading into the final stretch of the first half.

The St. Louis Cardinals (43–42) and Chicago Cubs (48–37) renew their storied rivalry on Friday, July 4, 2025, at Wrigley Field. First pitch is scheduled for 2:20 p.m. ET, with Miles Mikolas (4–5, 4.76 ERA) starting for the Cardinals and Colin Rea (5–3, 4.37 ERA) taking the mound for the Cubs. St. Louis vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Jul 04. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs return home to Wrigley Field on July 4, 2025, with a 48–37 record and a four-game lead in the National League Central, entering this rivalry series against the St. Louis Cardinals with momentum, confidence, and a clear opportunity to solidify their division lead. Fresh off a three-game sweep of the Cleveland Guardians that included a dramatic 1–0 walk-off win, the Cubs have now won six of their last eight games and are playing their most consistent baseball of the season. Much of their recent success can be attributed to their balanced offensive approach, deep pitching staff, and ability to execute in tight games—traits that have made them a tough out whether at home or on the road. Wrigley Field has become a reliable haven for the Cubs, where they’ve gone 22–18 and covered the spread in four of their last five games. Colin Rea gets the start in Friday’s opener, entering with a 5–3 record and a 4.37 ERA, offering steady mid-rotation value and the ability to give the team five or six competitive innings. Chicago’s bullpen has done its part when called upon, with Adbert Alzolay converting 18 of 21 save chances and the rest of the relief corps consistently bridging late innings with limited damage. Offensively, the Cubs have had no shortage of contributors. Nico Hoerner has been a catalyst at the top of the order, mixing contact hitting with intelligent baserunning, while Seiya Suzuki continues to drive in key runs with a controlled swing and disciplined approach.

Christopher Morel, with his energy and power, has added flair to a lineup that’s built to grind out at-bats and capitalize on pitcher mistakes. The Cubs aren’t just relying on a few stars—they’re getting production throughout the order, which gives them a major edge against opponents like the Cardinals, who have been much more top-heavy and inconsistent. Defensively, Chicago has been above average, turning double plays effectively and minimizing unforced errors, which is critical in rivalry games where mistakes often decide the outcome. Manager Craig Counsell has been instrumental in keeping the club steady, employing smart bullpen management and maximizing matchups on both sides of the ball. Against the Cardinals, the Cubs know they’ll face a motivated team desperate to get back on track, but they also recognize the opportunity to not only win the series but potentially bury a divisional challenger before the All-Star break. Historically, games between these two teams are unpredictable and emotionally charged, especially on a holiday like the Fourth of July with a packed Wrigley crowd. For the Cubs, however, the formula for success remains clear—limit free passes, play clean defense, execute with runners in scoring position, and hand the ball off to a rested bullpen with the lead. If they stick to that blueprint, they’ll be in position to take another meaningful step toward a playoff return and send a strong message to the rest of the National League that the North Siders are no longer a pleasant surprise—they’re a serious threat.

St. Louis vs. Chicago Cubs Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Cardinals and Cubs play there’s always several intriguing angles to key in on. Not to mention games played at Wrigley Field in Jul can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: C. Kelly over 3.5 Fantasy Score.

St. Louis vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every facet between the Cardinals and Cubs and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the trending factor human bettors tend to put on Chicago Cubs’s strength factors between a Cardinals team going up against a possibly improved Cubs team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Chicago Cubs picks, computer picks Cardinals vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Cardinals Betting Trends

The Cardinals have covered the spread in 5 of their last 6 road games, indicating strong performance against the spread when playing away.

Cubs Betting Trends

The Cubs are 4–1 against the spread in their last 5 home games, showcasing their dominance at Wrigley Field.

Cardinals vs. Cubs Matchup Trends

The total has gone OVER in 7 of the last 8 meetings between the Cardinals and Cubs, suggesting a trend toward high-scoring games in this rivalry.

St. Louis vs. Chicago Cubs Game Info

St. Louis vs Chicago Cubs starts on July 04, 2025 at 2:20 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: St. Louis +131, Chicago Cubs -157
Over/Under: 10

St. Louis: (47-41)  |  Chicago Cubs: (52-35)

Remi's searched hard and found the best prop for this matchup: C. Kelly over 3.5 Fantasy Score.. Prices move—always shop for the best number.

The total has gone OVER in 7 of the last 8 meetings between the Cardinals and Cubs, suggesting a trend toward high-scoring games in this rivalry.

STL trend: The Cardinals have covered the spread in 5 of their last 6 road games, indicating strong performance against the spread when playing away.

CHC trend: The Cubs are 4–1 against the spread in their last 5 home games, showcasing their dominance at Wrigley Field.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Chicago Cubs Odds

AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the St. Louis vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.

St. Louis vs Chicago Cubs Opening Odds

STL Moneyline: +131
CHC Moneyline: -157
STL Spread: +1.5
CHC Spread: -1.5
Over/Under: 10

St. Louis vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
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-1667
+750
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O 7.5 (-110)
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9/28/25 3:06PM
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+160
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O 8.5 (-122)
U 8.5 (+100)
Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
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+240
-295
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U 7.5 (-110)
Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
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+180
-215
+1.5 (-125)
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O 8 (-122)
U 8 (+100)
Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
-102
-116
-1.5 (+164)
+1.5 (-200)
O 8.5 (-115)
U 8.5 (-105)
Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
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+166
-198
+1.5 (-134)
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O 7.5 (-122)
U 7.5 (+100)
Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
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-106
-110
-1.5 (+155)
+1.5 (-188)
O 8 (-104)
U 8 (-118)
Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
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+124
-146
+1.5 (-162)
-1.5 (+134)
O 7.5 (-115)
U 7.5 (-105)
Sep 28, 2025 3:11PM EDT
New York Mets
Miami Marlins
9/28/25 3:11PM
Mets
Marlins
-132
+112
-1.5 (+128)
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O 8 (-122)
U 8 (+100)
Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
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+184
-220
+1.5 (-120)
-1.5 (+100)
O 7.5 (-105)
U 7.5 (-115)
Sep 28, 2025 3:20PM EDT
St Louis Cardinals
Chicago Cubs
9/28/25 3:20PM
Cardinals
Cubs
 
-170
 
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 30, 2025 2:30PM EDT
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Chicago Cubs
9/30/25 2:30PM
Padres
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+101
-123
pk
pk

MLB Past Picks

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Chicago Cubs Cubs on July 04, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS