Cardinals vs. Guardians
Prediction, Odds & Props
Jun 29 | MLB AI Picks

Updated: 2025-06-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (46–38) conclude their three-game series against the Cleveland Guardians (40–41) on Sunday, June 29, 2025, at Progressive Field. The Cardinals are slight favorites with a -125 moneyline, while the Guardians are listed at +105.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 29, 2025

Start Time: 12:05 PM EST​

Venue: Progressive Field​

Guardians Record: (40-41)

Cardinals Record: (46-38)

OPENING ODDS

STL Moneyline: -125

CLE Moneyline: +105

STL Spread: -1.5

CLE Spread: +1.5

Over/Under: 8.5

STL
Betting Trends

  • The Cardinals have a 44–40 record against the spread (ATS) this season.

CLE
Betting Trends

  • The Guardians hold a 39–42 ATS record this season.

MATCHUP TRENDS

  • The Cardinals have covered the spread in 6 of their last 8 games against the Guardians.

STL vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Burleson over 5.5 Fantasy Score.

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St. Louis vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 6/29/25

Sunday’s series finale between the St. Louis Cardinals and the Cleveland Guardians at Progressive Field offers a competitive and compelling matchup between two teams with playoff aspirations and a desire to enter July on the right foot. The Cardinals come into the game at 46–38, having already taken the first two games of the series and seeking a sweep to solidify their spot in the upper tier of the National League Central. The Guardians sit just below .500 at 40–41 and are looking to avoid a costly sweep at home as they continue to navigate an up-and-down AL Central race. On the mound, left-hander Matthew Liberatore will start for St. Louis, bringing a 5–6 record with a 3.96 ERA over 86.1 innings, showing notable growth in command and poise, particularly with runners on base, and increasingly trusting his curveball in tight spots. For Cleveland, it’ll be fellow lefty Logan Allen, who enters with a 5–5 record and 4.25 ERA across 72 innings, relying on a three-pitch mix that includes a deceptive changeup and a sweeping slider that can be effective when he’s ahead in counts. Offensively, the Cardinals have found success through balance and consistency, with Brendan Donovan and Alec Burleson both batting .300, and Burleson adding a strong .477 slugging percentage that has helped generate timely extra-base hits. Cleveland leans heavily on José Ramírez, the club’s most consistent offensive threat with a .312 batting average, 13 home runs, and a knack for clutch performances, while Steven Kwan provides top-of-the-order stability and speed with a .300 average and strong on-base skills.

Both teams have comparable team ERAs—St. Louis at 3.96 and Cleveland at 3.99—which speaks to how evenly matched they are in terms of run prevention, although St. Louis may hold the edge in bullpen performance and late-game execution, having closed out tight wins effectively throughout the series. In the field, both clubs have played clean baseball, but the Cardinals have shown sharper execution during this series, particularly in turning double plays and managing pressure situations with runners aboard. The ATS trends also favor St. Louis, who has covered the spread in six of their last eight matchups against Cleveland, and their 44–40 ATS record on the season reflects a team that consistently meets or exceeds betting expectations. For Cleveland, their 39–42 ATS mark illustrates the inconsistency that has dogged them, and unless they can get a strong start from Allen and timely production beyond Ramírez and Kwan, they may find it difficult to generate enough offense to break through against a Cardinals pitching staff that has been executing its game plan effectively all weekend. Ultimately, this game could come down to which team’s left-hander better handles the opposing lineup and whether Cleveland’s offense can finally get going against a St. Louis club that seems to have found its rhythm at the perfect time. A sweep would further cement the Cardinals as a legitimate postseason contender, while a Guardians win would serve as both a morale boost and a much-needed step toward stability in an increasingly volatile division race.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter Sunday’s contest at Progressive Field with a 46–38 record and a growing sense of confidence as they aim to complete a three-game sweep of the Cleveland Guardians and continue their push toward the top of the National League Central standings, driven by strong starting pitching, timely hitting, and improved consistency both at the plate and in the field. Starting for the Cardinals is left-hander Matthew Liberatore, who brings a 5–6 record and a 3.96 ERA into the game across 86.1 innings pitched, and while his win-loss record may not stand out, his increased ability to command his curveball and keep hitters off balance has allowed him to pitch deeper into games and limit big innings, especially when paired with sharp defensive support behind him. Liberatore’s maturity on the mound has become more evident in recent outings, as he’s demonstrated greater efficiency and composure, often getting key outs with runners in scoring position and avoiding the blow-up innings that plagued his earlier starts. Offensively, the Cardinals are finding rhythm thanks to a lineup that offers production from multiple spots, including Brendan Donovan, who is hitting .300 and doing an excellent job of setting the table from the top of the order, and Alec Burleson, also hitting .300 with a .477 slugging percentage that has provided much-needed power in the middle of the lineup.

Contributions from Paul Goldschmidt, Nolan Gorman, and Masyn Winn have added further depth to a lineup that’s begun executing situational hitting with more regularity, allowing the team to capitalize on scoring chances even when the long ball isn’t the primary weapon. Defensively, St. Louis has been sound during the series, turning critical double plays and showing sharp instincts, particularly on the infield where players like Nolan Arenado continue to make challenging plays look routine and set the tone for a team that understands the value of limiting extra outs. The bullpen has been another strength for the Cardinals during this stretch, with closer Ryan Helsley locking down games efficiently and setup options like JoJo Romero and Andrew Kittredge showing versatility in getting out of jams and maintaining leads. St. Louis has also been strong against the spread this season, currently sitting at 44–40 ATS, and they’ve covered in six of their last eight meetings with the Guardians, which suggests they’ve been not only winning games in this matchup but often doing so convincingly. The Cardinals will look to attack Logan Allen early, forcing him to pitch from behind in counts and ideally getting into Cleveland’s middle relief before the late innings, where their bullpen advantage becomes even more apparent. If Liberatore can keep José Ramírez and Steven Kwan from doing damage and the Cardinals can string together quality at-bats in the middle innings, there’s every reason to believe they can close out the series sweep, head home with momentum, and continue to solidify their status as a dangerous and playoff-caliber team heading into the second half of the season.

The St. Louis Cardinals (46–38) conclude their three-game series against the Cleveland Guardians (40–41) on Sunday, June 29, 2025, at Progressive Field. The Cardinals are slight favorites with a -125 moneyline, while the Guardians are listed at +105. St. Louis vs Cleveland AI Prediction: Free MLB Betting Insights for Jun 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians return to Progressive Field on Sunday aiming to avoid a sweep at the hands of the St. Louis Cardinals and salvage the final game of their three-game series, entering with a 40–41 record and searching for the spark that could propel them back into the upper tier of the American League Central. Cleveland will send left-hander Logan Allen to the mound, a pitcher with a 5–5 record and 4.25 ERA across 72 innings who has had stretches of effectiveness this season by relying on his fading changeup and well-tunneled slider to induce soft contact and stay out of the big inning, but his success often hinges on his ability to get ahead in counts early and avoid nibbling at the corners. Allen faces a Cardinals lineup that has hit lefties well in recent games, so his ability to neutralize the top of the order—particularly Brendan Donovan and Alec Burleson—will be critical if the Guardians hope to keep the game within reach. Offensively, Cleveland continues to ride the production of superstar third baseman José Ramírez, whose .312 batting average, 13 home runs, and strong RBI totals have made him the engine of the Guardians’ attack, while Steven Kwan complements him well at the top of the lineup with a .300 average and an excellent approach at the plate that sets the table for the heart of the order. However, the supporting cast has been inconsistent, particularly the bottom half of the order, which has struggled to generate offense and capitalize on the opportunities created by Ramírez and Kwan, often stalling potential rallies.

The Guardians’ inability to string together multi-run innings has left them vulnerable in close games, and their 39–42 record against the spread reflects a team that has been competitive but not consistently effective in beating expectations. Defensively, the Guardians have remained steady with a 3.99 team ERA and above-average fielding metrics, and their ability to limit mistakes in the field has kept them in games even when the offense sputters, though the bullpen has had difficulty protecting narrow leads or keeping deficits manageable. Key relievers like Emmanuel Clase and Hunter Gaddis have had strong moments, but the setup corps has shown signs of fatigue, making it critical for Allen to go at least six innings and limit the bullpen’s exposure against a Cardinals team that has shown excellent late-game execution. For Cleveland to take this game, they’ll need to put pressure on Cardinals starter Matthew Liberatore early by being aggressive on fastballs in hitter’s counts and forcing him to pitch from the stretch, a situation where he’s been less effective. Generating offense from sources beyond just Ramírez and Kwan—such as Will Brennan or David Fry—could be the difference between another frustrating offensive showing and a breakout that helps them end the series on a high note. With the Guardians hovering near .500 and the division race still wide open, a win on Sunday would not only stop the bleeding from the past two games but also give them a psychological edge heading into their next stretch of games, reinforcing their resilience and ability to respond to adversity when it matters most.

St. Louis vs. Cleveland Prop Picks (AI)

AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Cardinals and Guardians play there’s always several intriguing trends to key in on. Not to mention games played at Progressive Field in Jun can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: A. Burleson over 5.5 Fantasy Score.

St. Louis vs. Cleveland Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every angle between the Cardinals and Guardians and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

The Algorithm has been most keyed in on the linear correlation of factor emotional bettors often put on player performance factors between a Cardinals team going up against a possibly unhealthy Guardians team. In reality, the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Cleveland picks, computer picks Cardinals vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have a 44–40 record against the spread (ATS) this season.

Guardians Betting Trends

The Guardians hold a 39–42 ATS record this season.

Cardinals vs. Guardians Matchup Trends

The Cardinals have covered the spread in 6 of their last 8 games against the Guardians.

St. Louis vs. Cleveland Game Info

St. Louis vs Cleveland starts on June 29, 2025 at 12:05 PM EST.

Spread: Cleveland +1.5
Moneyline: St. Louis -125, Cleveland +105
Over/Under: 8.5

St. Louis: (46-38)  |  Cleveland: (40-41)

Remi's searched hard and found the best prop for this matchup: A. Burleson over 5.5 Fantasy Score.. Prices move—always shop for the best number.

The Cardinals have covered the spread in 6 of their last 8 games against the Guardians.

STL trend: The Cardinals have a 44–40 record against the spread (ATS) this season.

CLE trend: The Guardians hold a 39–42 ATS record this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Cleveland Odds

Remi is pouring through loads of stats on each team. In fact, anytime the St. Louis vs Cleveland trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.

St. Louis vs Cleveland Opening Odds

STL Moneyline: -125
CLE Moneyline: +105
STL Spread: -1.5
CLE Spread: +1.5
Over/Under: 8.5

St. Louis vs Cleveland Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Cleveland Guardians on June 29, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN