Padres vs Reds Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 29)
Updated: 2025-06-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Diego Padres and Cincinnati Reds will face off in the decisive game of their three-game series on Sunday, June 29, 2025, at Great American Ball Park. The series is currently tied 1-1, with both teams aiming to secure the series win.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 29, 2025
Start Time: 1:40 PM EST
Venue: Great American Ball Park
Reds Record: (43-40)
Padres Record: (45-37)
OPENING ODDS
SD Moneyline: +114
CIN Moneyline: -135
SD Spread: +1.5
CIN Spread: -1.5
Over/Under: 9
SD
Betting Trends
- The Padres have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.
CIN
Betting Trends
- The Reds have covered the run line in 6 of their last 10 games, showcasing their competitiveness in recent matchups.
MATCHUP TRENDS
- The total has gone under in 7 of the Padres’ last 10 games, suggesting a pattern of lower-scoring affairs.
SD vs. CIN
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: E. De La Cruz over 7.5 Fantasy Score.
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San Diego vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 6/29/25
Cincinnati’s offense, meanwhile, is powered by Elly De La Cruz and Spencer Steer, with De La Cruz emerging as a true multi-tool threat who can change a game with his legs, glove, or bat. Steer has heated up lately, including a three-home-run game earlier in the week, and he adds thump in the middle of the Reds’ order. The bullpens will play a crucial role in the outcome, with San Diego’s relievers, including Jason Adam and his 1.77 ERA, having the edge in late-inning reliability. The Reds have seen solid work from Emilio Pagan, but their bullpen has struggled to hold late leads, and defensive miscues have often compounded those issues. Betting trends suggest a tight, low-scoring affair, as the Padres have gone under the total in seven of their last ten games, while both teams have been competitive against the spread lately. For San Diego, the keys will be getting Kolek through five or six efficient innings, keeping De La Cruz off the bases, and pressuring Lodolo early in counts to avoid chasing his breaking pitches. For Cincinnati, finding early offense and playing clean defense behind Lodolo will be essential, as giving extra outs to the Padres has proven costly in prior matchups. This game could turn on a single misplay, missed location, or well-timed homer, and with both clubs jockeying for position in their divisions, every edge matters. Fans should expect a close contest where situational hitting and bullpen depth may ultimately determine who leaves the field with a series win and who heads into the new week facing more questions than answers.
Comeback W. pic.twitter.com/1ejPTIVNEl
— San Diego Padres (@Padres) June 28, 2025
San Diego Padres MLB Preview
The San Diego Padres arrive at Great American Ball Park on Sunday with a 44–37 record and a clear mission to close out their road series against the Cincinnati Reds with a win, leaning on their roster depth, improving rotation, and a lineup that features some of the league’s most recognizable names. The Padres will start Stephen Kolek, a right-hander who has held his own in a rotational role with a 3–3 record and a 3.95 ERA, relying on movement and location rather than overpowering stuff, often pitching to weak contact and letting his defense do the work. Kolek’s ability to navigate a lefty-heavy Reds lineup will be tested, especially against the red-hot Spencer Steer and the electrifying Elly De La Cruz, but if he can limit walks and keep his pitch count down, he’ll give San Diego a strong chance to control the early innings. Offensively, the Padres continue to be paced by Manny Machado and Fernando Tatis Jr., with Machado hitting close to .295 and continuing to be a reliable run producer and clubhouse leader, while Tatis provides elite athleticism, power, and outfield defense, often delivering in high-leverage moments. The presence of Luis Arraez at the top of the lineup gives the Padres a table-setter who rarely strikes out and frequently puts pressure on opposing pitchers with his high contact rate and savvy base running, while Jake Cronenworth and Xander Bogaerts have offered timely hits that add length to the batting order.
The Padres’ ability to manufacture runs without relying solely on the long ball makes them versatile offensively, especially in games where the ballpark or conditions don’t favor home runs. Their bullpen has become a significant asset, with Jason Adam emerging as a late-inning shutdown option thanks to his 1.77 ERA and calm presence in high-pressure spots, and the rest of the relief corps has largely avoided blowups, which has allowed San Diego to win close games more frequently. Manager Mike Shildt has shown confidence in his staff’s ability to mix and match late in games, which should serve them well if this finale plays out as a tight, low-scoring affair. Defensively, the Padres are among the most reliable infield units in the league, with Machado and Ha-Seong Kim flashing elite gloves and strong arms, and Arraez making the routine plays at second while also showing great instincts. To secure the win and the series, the Padres will need Kolek to provide five solid innings, the offense to scratch out runs early and often, and the bullpen to hold strong against a Reds team that can explode in spurts. A victory here would cap a productive road series and give the Padres momentum heading into July, while reinforcing their identity as a deep, balanced team capable of contending when all aspects of their game click. With the NL West race tightening, every win matters, and Sunday offers a prime opportunity to close the month with a strong statement.

Credit: USA TODAY/IMAGN
Cincinnati Reds MLB Preview
The Cincinnati Reds enter Sunday’s series finale against the San Diego Padres with a 43–39 record and a growing sense of urgency as they look to stay relevant in the competitive NL Central and defend their home turf with a series win. Nick Lodolo takes the mound for the Reds and brings with him a 5–5 record and a 3.63 ERA across his starts this season, serving as one of the club’s more reliable arms with good command and strikeout potential that will be key to neutralizing a dangerous Padres lineup featuring All-Star caliber bats. Lodolo’s success often hinges on his ability to get ahead early in counts and use his curveball to finish at-bats, especially against right-handed power threats like Fernando Tatis Jr. and Manny Machado. On offense, the Reds have been led by the dynamic Elly De La Cruz, whose .279 batting average and blend of speed and power make him one of the most exciting young players in the game, capable of turning the tide of a game with his legs or his bat. Spencer Steer has also stepped up lately, highlighted by a recent three-homer performance that showed his potential to carry the offense for stretches, while veteran Jonathan India provides steady production and leadership in the infield.
The Reds will look to capitalize early on Padres starter Stephen Kolek, who although solid, is not overpowering and can be vulnerable to aggressive lineups that make contact early in the count. Defensively, Cincinnati has been better this season but still battles occasional lapses that can prove costly in tight games, and Lodolo will benefit greatly if the infield can execute on ground balls to keep pitch counts low and innings short. The bullpen, anchored by Emilio Pagan and Alexis Díaz, has been serviceable in high-leverage spots, though control issues have occasionally surfaced, especially in back-to-back outings. The Reds have covered the run line in six of their last ten games, and they’ve shown an ability to rise to the occasion when playing at home, feeding off the energy of the Great American Ball Park crowd, which has remained supportive even through stretches of inconsistency. To win Sunday’s rubber match, the Reds need to continue executing their aggressive offensive identity by running the bases aggressively, putting balls in play with runners in scoring position, and applying pressure through situational hitting. If Lodolo can provide at least six innings of quality work and the offense can scratch out a couple of early runs, Cincinnati will be well positioned to hand the ball to the bullpen with a lead and close out the series on a high note. Manager Terry Francona will also likely lean on matchups in late innings, and his ability to manage the bullpen carousel will be critical. A win would not only give the Reds a meaningful series victory over a strong Padres club but would also signal to the rest of the division that Cincinnati intends to compete deep into the summer with its mix of emerging stars and resilient pitching.
Series finale tomorrow: pic.twitter.com/LHZ4VysTcz
— Cincinnati Reds (@Reds) June 28, 2025
San Diego vs. Cincinnati Prop Picks (AI)
San Diego vs. Cincinnati Prediction (AI)

Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every facet between the Padres and Reds and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Interestingly enough, the data has been most focused on the linear correlation of weight knucklehead sportsbettors tend to put on Cincinnati’s strength factors between a Padres team going up against a possibly improved Reds team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Diego vs Cincinnati picks, computer picks Padres vs Reds, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Padres Betting Trends
The Padres have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.
Reds Betting Trends
The Reds have covered the run line in 6 of their last 10 games, showcasing their competitiveness in recent matchups.
Padres vs. Reds Matchup Trends
The total has gone under in 7 of the Padres’ last 10 games, suggesting a pattern of lower-scoring affairs.
San Diego vs. Cincinnati Game Info
What time does San Diego vs Cincinnati start on June 29, 2025?
San Diego vs Cincinnati starts on June 29, 2025 at 1:40 PM EST.
Where is San Diego vs Cincinnati being played?
Venue: Great American Ball Park.
What are the opening odds for San Diego vs Cincinnati?
Spread: Cincinnati -1.5
Moneyline: San Diego +114, Cincinnati -135
Over/Under: 9
What are the records for San Diego vs Cincinnati?
San Diego: (45-37) | Cincinnati: (43-40)
What is the AI best bet for San Diego vs Cincinnati?
Remi's searched hard and found the best prop for this matchup: E. De La Cruz over 7.5 Fantasy Score.. Prices move—always shop for the best number.
What are San Diego vs Cincinnati trending bets?
The total has gone under in 7 of the Padres’ last 10 games, suggesting a pattern of lower-scoring affairs.
What are San Diego trending bets?
SD trend: The Padres have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.
What are Cincinnati trending bets?
CIN trend: The Reds have covered the run line in 6 of their last 10 games, showcasing their competitiveness in recent matchups.
Where can I find AI Picks for San Diego vs Cincinnati?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Diego vs. Cincinnati Odds
AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the San Diego vs Cincinnati trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.
San Diego vs Cincinnati Opening Odds
SD Moneyline:
+114 CIN Moneyline: -135
SD Spread: +1.5
CIN Spread: -1.5
Over/Under: 9
San Diego vs Cincinnati Live Odds
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Diego Padres vs. Cincinnati Reds on June 29, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |