Cubs vs Astros Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 29)

Updated: 2025-06-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs and Houston Astros will conclude their three-game series on Sunday, June 29, 2025, at Daikin Park, with both teams holding identical 49–34 records. The Cubs will send right-hander Jameson Taillon (7–5, 4.47 ERA) to the mound, while the Astros counter with left-hander Framber Valdez (8–4, 2.88 ERA).

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 29, 2025

Start Time: 2:10 PM EST​

Venue: Daikin Park​

Astros Record: (49-34)

Cubs Record: (49-34)

OPENING ODDS

CHC Moneyline: +131

HOU Moneyline: -157

CHC Spread: +1.5

HOU Spread: -1.5

Over/Under: 7.5

CHC
Betting Trends

  • The Cubs have covered the run line in 24 of their 43 road games this season, demonstrating strong performance against the spread on the road.

HOU
Betting Trends

  • The Astros have covered the run line in 31 of their 45 home games, indicating a solid home-field advantage.

MATCHUP TRENDS

  • The Astros have hit the moneyline in 29 of their last 41 home games, yielding a 25% return on investment.

CHC vs. HOU
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.

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Chicago Cubs vs Houston Prediction & Odds:
Free MLB Betting Insights for 6/29/25

The Sunday showdown between the Chicago Cubs and Houston Astros at Daikin Park is shaping up to be one of the more anticipated matchups of the day, featuring two 49–34 teams both looking to establish a strong finish to June and gain a valuable series win in interleague play. The Cubs come into this contest having split the first two games of the series and will hand the ball to Jameson Taillon, who brings a 7–5 record and 4.47 ERA into the start. Taillon has had an up-and-down season, but when his command is on, he can eat innings and limit big innings with his mix of fastball, curve, and cutter. His challenge will be to navigate a Houston lineup that doesn’t strike out much and is anchored by the incredibly consistent Jeremy Peña and the resurgent Jake Meyers. Peña’s .322 average and smart plate discipline allow him to drive the offense from the two-hole, while Meyers has been punishing mistakes with a .307 average and sneaky power. The Astros will counter with ace Framber Valdez, who holds an 8–4 record with a 2.88 ERA and has been one of the most dominant left-handers in the American League this season, generating ground balls at one of the highest rates in MLB. His sweeping curve and effective sinker will be tough for a Cubs lineup that relies heavily on the lefty bat of Pete Crow-Armstrong and the versatile Kyle Tucker.

Crow-Armstrong is hitting .268 with a .549 slugging percentage and continues to develop into a dynamic offensive player, while Tucker remains one of the most complete hitters on the Cubs roster with his .283 average and .520 slugging percentage. Defensively, both clubs are sound, with the Astros infield excelling behind Valdez’s ground-ball heavy style and the Cubs boasting one of the best outfield arms in Tucker. Bullpen-wise, the Astros hold a slight edge, ranking second in bullpen ERA in the majors and demonstrating a reliable late-inning setup anchored by Bryan Abreu and Ryan Pressly. The Cubs’ pen has been more volatile, but they’ve found stability lately, and Pressly himself has posted a .216 opponent batting average despite a middling 3.90 ERA. With both lineups capable of producing runs, the difference could come down to who executes better in tight moments, whether it’s a timely double play, clutch two-out RBI, or clean ninth inning. Betting markets reflect how evenly matched this contest is, with both teams strong against the spread — the Cubs have covered in 24 of 43 road games while the Astros have hit the moneyline in 29 of their last 41 home games, yielding consistent returns. Ultimately, this game could hinge on Valdez’s ability to dominate through six or seven innings and whether Taillon can hold off the Astros’ top of the order long enough for the Cubs offense to do damage. It’s a classic high-stakes rubber match between two playoff-caliber clubs, and every pitch will matter as both look to claim bragging rights and momentum heading into July.

Chicago Cubs Cubs MLB Preview

The Chicago Cubs come into Sunday’s series finale at Daikin Park with a 49–34 record and a growing confidence that they can take the series against one of the American League’s premier teams in the Houston Astros. The Cubs have shown resilience and improvement throughout June, and they will turn to veteran right-hander Jameson Taillon to lead the charge on the mound. Taillon has had stretches of inconsistency this year, but his 7–5 record and 4.47 ERA show that he’s capable of grinding through outings and keeping his team in games with solid command and a mature pitch mix. His key to success on Sunday will be keeping the ball down and avoiding barrels against a Houston lineup that punishes mistakes. The Cubs offense will counter with a blend of emerging talent and reliable veterans, led by Pete Crow-Armstrong and Kyle Tucker. Crow-Armstrong has turned heads with his breakout campaign, hitting .268 with a .549 slugging percentage, using his speed and compact swing to impact games in multiple ways. Tucker has been one of the most reliable offensive pieces all season long, batting .283 with a .520 slugging percentage, and offers elite baserunning and defensive contributions in the outfield to match his production at the plate. The Cubs’ lineup has shown balance and the ability to string together rallies, and they will need to be opportunistic against Astros ace Framber Valdez, who rarely gives up extended innings or walks.

Patience at the plate, aggressive baserunning, and clutch hitting will be essential if they hope to crack Valdez early. The Cubs’ bullpen has improved in recent weeks, with Ryan Pressly beginning to return to form and posting a .216 opponent batting average despite a 3.90 ERA, though inconsistency remains a concern late in games. If the Cubs can keep the game close into the sixth or seventh inning, manager Craig Counsell has options to piece together the late frames, especially if his offense can provide timely run support. Defensively, Chicago has been steady, particularly in the outfield where Crow-Armstrong and Tucker offer elite range and arm strength, which should help suppress extra-base hits in a park like Daikin that plays fair to both hitters and pitchers. A series win on the road in Houston would send a loud message across the National League that this Cubs team is not just a nice story but a legitimate postseason contender with depth, youth, and veteran poise. Their road ATS record of 24 covers in 43 games speaks to their ability to stay competitive away from home, and if Taillon can provide quality innings while the lineup pressures Valdez early, the Cubs could very well head into July with one of the more impressive series wins of the season. This finale provides an opportunity to show they can go toe-to-toe with an elite club, and all eyes will be on whether the Cubs’ mix of energy, execution, and endurance will be enough to earn a hard-fought series win.

The Chicago Cubs and Houston Astros will conclude their three-game series on Sunday, June 29, 2025, at Daikin Park, with both teams holding identical 49–34 records. The Cubs will send right-hander Jameson Taillon (7–5, 4.47 ERA) to the mound, while the Astros counter with left-hander Framber Valdez (8–4, 2.88 ERA). Chicago Cubs vs Houston AI Prediction: Free MLB Betting Insights for Jun 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Houston Astros MLB Preview

The Houston Astros enter Sunday’s series finale at Daikin Park with a 49–34 record and a chance to assert their dominance at home by securing a critical series win over the surging Chicago Cubs, who have matched them stride for stride in the standings. The Astros will turn to their ace Framber Valdez, who has once again delivered a stellar season with an 8–4 record and a 2.88 ERA, relying on his signature sinker and exceptional command to keep hitters off balance and generate ground balls in crucial moments. Valdez has been nearly untouchable at home this year, and the Astros will look to him to set the tone against a Cubs lineup that brings power from both sides of the plate. Offensively, the Astros remain led by the red-hot Jeremy Peña, who is batting .322 with a .489 slugging percentage and continues to deliver in key spots, whether with a clutch hit or sharp base running, making him the motor of Houston’s offense. Jake Meyers has also stepped into a bigger role this season, batting .307 and providing an additional layer of consistency and speed that has taken pressure off other sluggers like Yordan Alvarez and Alex Bregman. The Astros lineup has found ways to win both with the long ball and through timely contact hitting, and they’ll aim to force Cubs starter Jameson Taillon into early trouble by capitalizing on pitches left up in the zone.

The Astros’ ability to score first has been a major contributor to their success, and if they can plate early runs, they’ll set themselves up to control the pace of the game and take advantage of their elite bullpen. Houston’s relievers have combined for the second-best bullpen ERA in the majors, a testament to their depth and versatility in closing out close games, and manager Joe Espada has used his late-inning arms with confidence and precision. With the likes of Ryan Pressly and Bryan Abreu waiting in the wings, the Astros have the luxury of shortening the game when given a lead, which has been key in preserving wins at home. Defensively, Houston has been sharp, particularly on the infield where Peña, Bregman, and Jose Altuve continue to form one of the more cohesive and sure-handed trios in the game, ideal for backing up Valdez’s ground-ball-heavy approach. The Astros have covered the run line in 31 of their 45 home games this year, showing their ability to not only win at home but do so convincingly. Sunday’s contest is more than just another June game; it’s a measuring stick for a Houston team that continues to contend at the highest level and has its sights set on another deep postseason run. If Valdez delivers as expected and the lineup capitalizes on Taillon’s early count tendencies, the Astros could close the month with a series win that reinforces their place among the league’s elite. Their mix of veteran savvy, pitching dominance, and offensive versatility makes them a dangerous opponent, and Sunday provides another chance to remind the rest of baseball just how complete and poised this Houston squad remains.

Chicago Cubs vs. Houston Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each line. In fact, anytime the Cubs and Astros play there’s always several intriguing trends to key in on. Not to mention games played at Daikin Park in Jun rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.

Chicago Cubs vs. Houston Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every past game between the Cubs and Astros and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Remi has been most watching on the growing emphasis human bettors often put on Chicago Cubs’s strength factors between a Cubs team going up against a possibly strong Astros team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago Cubs vs Houston picks, computer picks Cubs vs Astros, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

The Cubs have covered the run line in 24 of their 43 road games this season, demonstrating strong performance against the spread on the road.

Astros Betting Trends

The Astros have covered the run line in 31 of their 45 home games, indicating a solid home-field advantage.

Cubs vs. Astros Matchup Trends

The Astros have hit the moneyline in 29 of their last 41 home games, yielding a 25% return on investment.

Chicago Cubs vs. Houston Game Info

Chicago Cubs vs Houston starts on June 29, 2025 at 2:10 PM EST.

Spread: Houston -1.5
Moneyline: Chicago Cubs +131, Houston -157
Over/Under: 7.5

Chicago Cubs: (49-34)  |  Houston: (49-34)

Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 4.5 Fantasy Score.. Prices move—always shop for the best number.

The Astros have hit the moneyline in 29 of their last 41 home games, yielding a 25% return on investment.

CHC trend: The Cubs have covered the run line in 24 of their 43 road games this season, demonstrating strong performance against the spread on the road.

HOU trend: The Astros have covered the run line in 31 of their 45 home games, indicating a solid home-field advantage.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago Cubs vs. Houston Odds

Remi is pouring through tons of data points on each player. In fact, anytime the Chicago Cubs vs Houston trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.

Chicago Cubs vs Houston Opening Odds

CHC Moneyline: +131
HOU Moneyline: -157
CHC Spread: +1.5
HOU Spread: -1.5
Over/Under: 7.5

Chicago Cubs vs Houston Live Odds

Games PTS ML SPR O/U
Oct 24, 2025 9:08PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 9:08PM
Dodgers
Blue Jays
-149
+122
-1.5 (+119)
+1.5 (-145)
O 7 (-125)
U 7 (+103)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs Cubs vs. Houston Astros on June 29, 2025 at Daikin Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN