Giants vs. White Sox
Prediction, Odds & Props
Jun 28 | MLB AI Picks

Updated: 2025-06-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco Giants (44–37) face the Chicago White Sox (26–55) on Saturday, June 28, 2025, at Guaranteed Rate Field. The Giants aim to capitalize on their recent momentum, while the White Sox look to rebound from a challenging season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 28, 2025

Start Time: 4:10 PM EST​

Venue: Rate Field​

White Sox Record: (26-56)

Giants Record: (45-37)

OPENING ODDS

SF Moneyline: -169

CHW Moneyline: =+141

SF Spread: -1.5

CHW Spread: =+1.5

Over/Under: 8

SF
Betting Trends

  • The Giants have a 34–42 record against the spread (ATS) this season, covering in 44.7% of their games.

CHW
Betting Trends

  • The White Sox have a 45–35 ATS record in 2025, covering in 56.3% of their games.

MATCHUP TRENDS

  • The Giants have been favored in 53 games this season, winning 30 of them (56.6%), and have a 50% win rate when favored by at least -167 on the moneyline. Conversely, the White Sox have been underdogs in 82 games, winning 26 (31.7%) of those contests.

SF vs. CHW
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Schmitt over 0.5 Total Bases.

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San Francisco vs Chicago White Sox Prediction & Odds:
Free MLB Betting Insights for 6/28/25

Saturday’s interleague clash between the San Francisco Giants and the Chicago White Sox at Guaranteed Rate Field features two teams headed in drastically different directions, as the Giants enter the contest with a 44–37 record and in firm playoff contention, while the White Sox continue to endure a difficult rebuilding year at 26–55. San Francisco has been steadily building momentum in the National League, bolstered by a well-rounded offensive attack and consistent contributions from a pitching staff that has quietly exceeded expectations. The addition of Rafael Devers has proven pivotal for the Giants, with the veteran third baseman leading the team in OPS at .836 while providing clutch hits and stabilizing the heart of the order. Heliot Ramos has also emerged as a breakout performer, leading the team with 13 home runs and pairing power with patience to stretch opposing pitchers and force deeper counts. Landen Roupp, who is expected to take the mound Saturday, has delivered consistent results with a 3.67 ERA over 76 innings, but more impressively has tightened up his command over his last seven outings, lowering his ERA to 2.50 during that span. Roupp’s sinker-heavy arsenal and late-breaking curveball have been particularly effective at inducing soft contact and getting out of jams, traits that should serve him well against a White Sox lineup struggling to sustain offense.

Chicago, meanwhile, continues to search for answers offensively, hitting just .218 as a team over the last 30 days and ranking 29th in the majors in that category, with a thin lineup that has been further weakened by injuries to key players like Luis Robert Jr. While the White Sox have gotten some recent production from Lenyn Sosa, who has posted a .977 OPS over the past couple of weeks, and Mike Tauchman, who leads the team with an .850 OPS, these performances have been the exception rather than the norm. Aaron Civale will make his third start since joining the White Sox and enters with a 5.25 ERA over 12 innings pitched, still trying to find his rhythm after an uneven start to the season. Civale’s control and pitch sequencing will be tested against a Giants lineup that does not strike out much and has shown the ability to score in bunches, especially when it gets contributions from the bottom of the order. While the White Sox have shown flashes at home—most notably a surprising 5–0 record on recent Friday home games—their season-long trends remain troubling, particularly their 31.7% win rate when listed as underdogs, which has applied in 82 games so far. The Giants, conversely, have won 56.6% of their games as favorites and appear well-positioned to take advantage of a matchup where they hold significant edges in rotation stability, offensive production, and team health. Saturday’s contest offers San Francisco a valuable opportunity to bank another win against a team in flux, while the White Sox will need a rare complete performance to halt their slide. Unless their offense can break out and Civale can outperform expectations, the edge remains clearly with a Giants team that is executing confidently across all phases.

San Francisco Giants MLB Preview

The San Francisco Giants come into Saturday’s game against the Chicago White Sox with a 44–37 record and a growing sense of momentum as they push toward the National League playoff race, powered by a roster that’s delivering in all facets of the game and finding consistency both at the plate and on the mound. Offensively, the Giants are led by Rafael Devers, whose presence since joining the team has sparked production throughout the lineup; his .836 OPS and timely hitting have elevated the club’s offensive ceiling while allowing young breakout star Heliot Ramos to shine with 13 home runs and an .825 OPS of his own. With Thairo Estrada, Michael Conforto, and Mike Yastrzemski offering quality at-bats and dependable defense, San Francisco has maintained the kind of offensive balance that makes them dangerous in any park, and they’ve shown the ability to win both low-scoring grind-it-out games and high-octane slugfests. On the mound, the Giants will rely on Landen Roupp, who’s been excellent in recent weeks, compiling a 3.67 ERA across 76 innings and tightening things up considerably over his last seven starts with a 2.50 ERA in that span, showing better command and sequencing to complement his sinker-heavy repertoire.

Roupp’s ability to work deep into games and limit hard contact has taken pressure off a bullpen that has had to carry heavy innings earlier in the season, and with Chicago’s offense sputtering at the bottom of the league in most statistical categories—including a .218 team average over the past 30 days—he should be able to control the tempo and attack the zone early. San Francisco’s 34–42 ATS record doesn’t fully reflect how competitive they’ve been, particularly when favored; they’ve won 30 of 53 games as the betting favorite and have a 50% win rate when favored by -167 or more, proving reliable in situations like the one they face Saturday. The Giants have also found ways to manufacture runs even when their power goes quiet, whether it’s via base-stealing threats, bunts, or clutch two-out hits, and that kind of tactical flexibility gives them an edge against a White Sox team that ranks among the league’s worst in run differential and starting pitcher ERA. With Chicago likely turning to Aaron Civale, who has allowed 7 earned runs in 12 innings since joining the Sox, the Giants’ lineup will look to jump on early mistakes and force the White Sox bullpen into extended action once again. The stakes are growing each week for San Francisco, and these are the games that playoff-caliber teams are expected to win—not just because of talent disparities, but because of execution, poise, and the ability to capitalize on mismatches—and as it stands, the Giants appear fully capable of doing just that, especially if Roupp stays sharp and the offense keeps applying pressure from the first pitch onward.

The San Francisco Giants (44–37) face the Chicago White Sox (26–55) on Saturday, June 28, 2025, at Guaranteed Rate Field. The Giants aim to capitalize on their recent momentum, while the White Sox look to rebound from a challenging season. San Francisco vs Chicago White Sox AI Prediction: Free MLB Betting Insights for Jun 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago White Sox White Sox MLB Preview

The Chicago White Sox enter Saturday’s game against the San Francisco Giants with a 26–55 record that reflects a season of transition, inconsistency, and developmental growing pains as the organization tries to lay the groundwork for a future resurgence while dealing with the harsh reality of another last-place campaign. Offensively, the team has been mired in a prolonged slump, hitting just .218 over the past 30 days and ranking 29th in Major League Baseball in overall production, a troubling sign for a club that has seen very few bright spots in the lineup outside of the occasional breakout game from players like Mike Tauchman, Lenyn Sosa, or Miguel Vargas. Tauchman leads the team with an .850 OPS and has been one of the few consistent contributors from both sides of the plate, while Sosa has surged recently with a .977 OPS over the last couple of weeks, showing improved approach and contact quality, but the rest of the lineup remains patchy and prone to extended dry spells. The absence of Luis Robert Jr. continues to leave a gaping hole in the middle of the order, and his power-speed combination has been sorely missed on both offense and defense. Aaron Civale is set to make his third start for the White Sox since being acquired, and while he’s managed to complete 12 innings in two starts, his 5.25 ERA and early command issues suggest he’s still adjusting to new surroundings and trying to rediscover the form that once made him a promising rotation piece in Cleveland.

Civale will face a tough Giants lineup anchored by Rafael Devers and Heliot Ramos, and he’ll need to be sharp from the outset to prevent the game from getting away early—especially given the lack of run support behind him. Defensively, the White Sox have not been fundamentally sound, and their bullpen has been overworked, often thrust into high-stress situations as a result of short outings from starters and an offense that frequently falls behind early. Despite a solid 45–35 ATS record that indicates they’ve occasionally played closer than expected, they’ve won just 31.7% of their games as underdogs, which they have been in 82 contests so far this season, and those odds reflect the kind of uphill battle they’re facing again Saturday. One odd silver lining is their bizarrely strong 5–0 home record on Fridays, though that trend won’t help them this time as they look to avoid another series loss on a Saturday afternoon where they’ll need nearly flawless execution to compete. Manager Pedro Grifol continues to mix the lineup and rotate younger players into prominent roles to see who can be part of the long-term solution, and while those opportunities are important for development, they’ve yet to produce wins. Unless Civale can somehow silence a surging San Francisco offense and the White Sox bats break out against Landen Roupp, a pitcher who’s been lights-out in his last seven starts, the White Sox are once again in danger of being outmatched in every phase of the game. For a team looking to give its home fans something to cheer about and avoid a sweep, Saturday’s task is steep, and success may depend more on individual flashes of potential than cohesive, competitive baseball.

San Francisco vs. Chicago White Sox Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each team. In fact, anytime the Giants and White Sox play there’s always several intriguing trends to key in on. Not to mention games played at Rate Field in Jun seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Schmitt over 0.5 Total Bases.

San Francisco vs. Chicago White Sox Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Giants and White Sox and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

The Algorithm has been most fixated on the linear correlation of weight emotional bettors often put on San Francisco’s strength factors between a Giants team going up against a possibly improved White Sox team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Chicago White Sox picks, computer picks Giants vs White Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Giants Betting Trends

The Giants have a 34–42 record against the spread (ATS) this season, covering in 44.7% of their games.

White Sox Betting Trends

The White Sox have a 45–35 ATS record in 2025, covering in 56.3% of their games.

Giants vs. White Sox Matchup Trends

The Giants have been favored in 53 games this season, winning 30 of them (56.6%), and have a 50% win rate when favored by at least -167 on the moneyline. Conversely, the White Sox have been underdogs in 82 games, winning 26 (31.7%) of those contests.

San Francisco vs. Chicago White Sox Game Info

San Francisco vs Chicago White Sox starts on June 28, 2025 at 4:10 PM EST.

Spread: Chicago White Sox =+1.5
Moneyline: San Francisco -169, Chicago White Sox =+141
Over/Under: 8

San Francisco: (45-37)  |  Chicago White Sox: (26-56)

Remi's searched hard and found the best prop for this matchup: C. Schmitt over 0.5 Total Bases.. Prices move—always shop for the best number.

The Giants have been favored in 53 games this season, winning 30 of them (56.6%), and have a 50% win rate when favored by at least -167 on the moneyline. Conversely, the White Sox have been underdogs in 82 games, winning 26 (31.7%) of those contests.

SF trend: The Giants have a 34–42 record against the spread (ATS) this season, covering in 44.7% of their games.

CHW trend: The White Sox have a 45–35 ATS record in 2025, covering in 56.3% of their games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Chicago White Sox Odds

AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the San Francisco vs Chicago White Sox trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable betting trends.

San Francisco vs Chicago White Sox Opening Odds

SF Moneyline: -169
CHW Moneyline: =+141
SF Spread: -1.5
CHW Spread: =+1.5
Over/Under: 8

San Francisco vs Chicago White Sox Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Chicago White Sox White Sox on June 28, 2025 at Rate Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN