Padres vs Reds Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 28)
Updated: 2025-06-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Diego Padres (44–36) face the Cincinnati Reds (42–39) on Saturday, June 28, 2025, at Great American Ball Park. The Reds are favored with a -156 moneyline, while the Padres are listed at +130.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 28, 2025
Start Time: 4:10 PM EST
Venue: Great American Ball Park
Reds Record: (43-39)
Padres Record: (44-37)
OPENING ODDS
SD Moneyline: =+130
CIN Moneyline: -156
SD Spread: =+1.5
CIN Spread: -1.5
Over/Under: 9.5
SD
Betting Trends
- The Padres have a 41–39 record against the spread (ATS) this season.
CIN
Betting Trends
- The Reds hold a 41–37 ATS record this season.
MATCHUP TRENDS
- The Reds have a 6–3 record when favored by -156 or more this season.
SD vs. CIN
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: S. Steer over 5.5 Fantasy Score.
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San Diego vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 6/28/25
The Padres counter with star outfielder Fernando Tatis Jr., who has 13 home runs and remains a constant threat at the plate and in the field, along with Manny Machado, who has compiled a team-leading 89 hits and continues to deliver veteran leadership and production. In terms of team defense, the Reds slightly edge out the Padres with a .986 fielding percentage to San Diego’s .985, and both teams have kept defensive miscues to a minimum in 2025, suggesting that run prevention may hinge more on pitching execution than defensive breakdowns. The Reds also enter with a 22–18 home record and are 6–3 this season when favored at odds of -156 or greater, showing that they’ve largely handled expectations well in games like this, while San Diego’s 19–21 road record highlights some inconsistency away from Petco Park despite having the ninth-best team ERA in the majors at 3.61. With playoff implications subtly surfacing, this game may come down to which bullpen can maintain control in the later innings—Cincinnati’s relievers have shown resilience when protecting leads but have also been vulnerable when overextended, while San Diego’s bullpen has generally performed better than expected behind strong middle relief and effective matchups late. Both clubs also need to manage base paths wisely; the Reds are among the league leaders in steals and take the extra base aggressively, while the Padres rely more on situational hitting and big innings driven by extra-base hits. Given the tightly matched statistics and solid starting pitching on both sides, expect a competitive, low-scoring contest where one swing or one key defensive play could decide the outcome, with the Reds holding a slight edge due to Abbott’s dominance and home-field advantage, but the Padres are fully capable of flipping the script if Tatis or Machado can come through in a high-leverage situation.
Final. pic.twitter.com/opHyAU1H9M
— San Diego Padres (@Padres) June 28, 2025
San Diego Padres MLB Preview
The San Diego Padres enter Saturday’s game against the Cincinnati Reds looking to solidify their playoff standing in the crowded National League West as they sit at 44–36 and have shown flashes of becoming a well-rounded contender despite inconsistency in key areas. Randy Vásquez will take the mound for San Diego, bringing a 3–4 record with a 3.60 ERA across 80 innings of work, showcasing solid command and a calm presence under pressure that has earned him growing trust from the coaching staff. Vásquez has been particularly effective at inducing ground balls and limiting home runs, which will be critical in the hitter-friendly confines of Great American Ball Park. Offensively, the Padres are powered by Fernando Tatis Jr., who enters with 13 home runs and continues to be a dual threat both at the plate and on the base paths, while veteran third baseman Manny Machado has been San Diego’s most consistent bat, leading the team with 89 hits and showing steady production even in hostile environments. Their overall team batting average stands at .248, and while their slugging percentage of .379 lags behind other playoff hopefuls, they’ve shown the ability to string together timely hits and grind out runs against quality pitching. The Padres’ lineup is bolstered by contributions from players like Jake Cronenworth and Xander Bogaerts, who have struggled at times with consistency but remain capable of delivering big moments and helping turn over the lineup.
On defense, San Diego holds a .985 fielding percentage, a testament to their fundamentally sound infield anchored by Machado and Ha-Seong Kim, and behind the plate, Luis Campusano has emerged as a reliable receiver with a strong arm and game-calling aptitude that has aided the pitching staff. The bullpen has quietly been one of the team’s strengths, with Robert Suarez and Yuki Matsui delivering strong performances in the later innings and providing stability when the game is on the line. As a team, the Padres have a 41–39 record against the spread and sit slightly below .500 on the road at 19–21, indicating that while they’ve been competitive, they have room for improvement in tight road matchups against quality opponents. Saturday’s game poses a real challenge with Cincinnati starting lefty Andrew Abbott, who’s posted a 7–1 record with a microscopic 1.79 ERA and has dominated both righties and lefties with a deceptive fastball and strong offspeed mix. For San Diego to have success, they will need to work deep counts, elevate Abbott’s pitch count early, and hope that Tatis or Machado can come through with runners on base, while Vásquez must limit damage against a Reds lineup that thrives on momentum and aggressive base running. If the Padres can play a clean game defensively and their bullpen can hold its own in the later innings, they will have every opportunity to steal a tough road win and keep pace in a division race that continues to tighten with each passing series.

Credit: USA TODAY/IMAGN
Cincinnati Reds MLB Preview
The Cincinnati Reds enter Saturday’s home matchup against the San Diego Padres with a 42–39 record and find themselves firmly in the thick of the National League Central race as they aim to continue their winning ways behind one of the best young pitchers in baseball, left-hander Andrew Abbott, who brings a 7–1 record and sparkling 1.79 ERA into the contest. Abbott has been the Reds’ most consistent starter, using pinpoint control and an evolving pitch mix to keep hitters off balance, and his ability to dominate both sides of the plate has made him especially effective at Great American Ball Park, where he has been nearly untouchable in his last four home starts. Offensively, the Reds are led by the electric Elly De La Cruz, who enters the game with a team-high 18 home runs and 86 hits, adding elite speed and chaos creation on the base paths that has helped spark rallies and change the momentum of games in an instant. His emergence as an all-around superstar has been complemented by the steady bats of Spencer Steer and Christian Encarnacion-Strand, both of whom provide power and timely hitting in the middle of the order, while Jonathan India continues to contribute in key spots with solid on-base skills and leadership from the leadoff spot. The team as a whole owns a .248 batting average and an impressive .403 slugging percentage, showing their ability to do damage in bunches, particularly against pitchers who struggle to locate consistently, which will be a key matchup detail against Padres right-hander Randy Vásquez.
On defense, the Reds boast a .986 fielding percentage and have played crisp, clean baseball behind their starters, rarely giving away extra outs and executing well in late-inning situations when margins are slim. The bullpen has also held firm with Alexis Díaz serving as a reliable closer and Fernando Cruz emerging as a high-leverage option capable of bridging games from the starter to the ninth, giving manager David Bell the flexibility to manage matchups carefully in close contests. From a betting perspective, the Reds are 41–37 against the spread this season and are 6–3 when favored by -156 or more, reflecting a trend of performing well when expectations are higher, and their 22–18 home record underscores how much more comfortable they’ve been at Great American Ball Park compared to their road performances. To win Saturday’s game, Cincinnati will look to jump on Vásquez early and apply pressure through aggressive base running and disciplined at-bats, forcing the Padres’ pitching staff into uncomfortable situations and creating opportunities for De La Cruz and Steer to drive in runs. With Abbott on the mound and the offense clicking, the Reds are well-positioned to control the tempo and dictate terms, but they’ll need to maintain their composure and avoid the kind of defensive miscues or bullpen lapses that have cost them games in the past. If they execute their game plan effectively and continue riding the momentum from Abbott’s strong starts, Cincinnati should have a clear path to victory and a chance to tighten the division race even further with another key win over a solid NL West contender.
Just an electric night at GABP#ATOBTTR pic.twitter.com/EqAzt09cnO
— Cincinnati Reds (@Reds) June 28, 2025
San Diego vs. Cincinnati Prop Picks (AI)
San Diego vs. Cincinnati Prediction (AI)

Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Padres and Reds and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Remi has been most watching on the growing emphasis knucklehead sportsbettors regularly put on San Diego’s strength factors between a Padres team going up against a possibly rested Reds team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Diego vs Cincinnati picks, computer picks Padres vs Reds, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Padres Betting Trends
The Padres have a 41–39 record against the spread (ATS) this season.
Reds Betting Trends
The Reds hold a 41–37 ATS record this season.
Padres vs. Reds Matchup Trends
The Reds have a 6–3 record when favored by -156 or more this season.
San Diego vs. Cincinnati Game Info
What time does San Diego vs Cincinnati start on June 28, 2025?
San Diego vs Cincinnati starts on June 28, 2025 at 4:10 PM EST.
Where is San Diego vs Cincinnati being played?
Venue: Great American Ball Park.
What are the opening odds for San Diego vs Cincinnati?
Spread: Cincinnati -1.5
Moneyline: San Diego =+130, Cincinnati -156
Over/Under: 9.5
What are the records for San Diego vs Cincinnati?
San Diego: (44-37) | Cincinnati: (43-39)
What is the AI best bet for San Diego vs Cincinnati?
Remi's searched hard and found the best prop for this matchup: S. Steer over 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are San Diego vs Cincinnati trending bets?
The Reds have a 6–3 record when favored by -156 or more this season.
What are San Diego trending bets?
SD trend: The Padres have a 41–39 record against the spread (ATS) this season.
What are Cincinnati trending bets?
CIN trend: The Reds hold a 41–37 ATS record this season.
Where can I find AI Picks for San Diego vs Cincinnati?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Diego vs. Cincinnati Odds
AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the San Diego vs Cincinnati trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.
San Diego vs Cincinnati Opening Odds
SD Moneyline:
=+130 CIN Moneyline: -156
SD Spread: =+1.5
CIN Spread: -1.5
Over/Under: 9.5
San Diego vs Cincinnati Live Odds
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Diego Padres vs. Cincinnati Reds on June 28, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |