Padres vs. Reds
Prediction, Odds & Props
Jun 28 | MLB AI Picks

Updated: 2025-06-26T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Diego Padres (44–36) face the Cincinnati Reds (42–39) on Saturday, June 28, 2025, at Great American Ball Park. The Reds are favored with a -156 moneyline, while the Padres are listed at +130.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 28, 2025

Start Time: 4:10 PM EST​

Venue: Great American Ball Park​

Reds Record: (43-39)

Padres Record: (44-37)

OPENING ODDS

SD Moneyline: =+130

CIN Moneyline: -156

SD Spread: =+1.5

CIN Spread: -1.5

Over/Under: 9.5

SD
Betting Trends

  • The Padres have a 41–39 record against the spread (ATS) this season.

CIN
Betting Trends

  • The Reds hold a 41–37 ATS record this season.

MATCHUP TRENDS

  • The Reds have a 6–3 record when favored by -156 or more this season.

SD vs. CIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Steer over 5.5 Fantasy Score.

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San Diego vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 6/28/25

Saturday’s matchup between the San Diego Padres and the Cincinnati Reds at Great American Ball Park brings together two playoff-hopeful National League squads looking to seize momentum as the calendar approaches July, with the Padres entering at 44–36 and third in the NL West, while the Reds stand at 42–39 and fourth in a competitive NL Central. The game features a compelling pitching duel, as the Padres send right-hander Randy Vásquez to the mound, who enters with a 3.60 ERA over 80 innings and has been a steady force with above-average control and the ability to generate ground balls, while the Reds counter with dominant left-hander Andrew Abbott, whose sensational 7–1 record and 1.79 ERA have made him one of the league’s most efficient starters, especially in home contests where his strikeout rate climbs noticeably. Offensively, both teams enter with nearly identical batting averages—San Diego and Cincinnati both sit at .248—but the Reds hold a notable edge in slugging percentage at .403 compared to the Padres’ .379, driven largely by the explosive Elly De La Cruz, who leads Cincinnati with 18 home runs, 86 hits, and electrifying base running that constantly applies pressure to opposing pitchers.

The Padres counter with star outfielder Fernando Tatis Jr., who has 13 home runs and remains a constant threat at the plate and in the field, along with Manny Machado, who has compiled a team-leading 89 hits and continues to deliver veteran leadership and production. In terms of team defense, the Reds slightly edge out the Padres with a .986 fielding percentage to San Diego’s .985, and both teams have kept defensive miscues to a minimum in 2025, suggesting that run prevention may hinge more on pitching execution than defensive breakdowns. The Reds also enter with a 22–18 home record and are 6–3 this season when favored at odds of -156 or greater, showing that they’ve largely handled expectations well in games like this, while San Diego’s 19–21 road record highlights some inconsistency away from Petco Park despite having the ninth-best team ERA in the majors at 3.61. With playoff implications subtly surfacing, this game may come down to which bullpen can maintain control in the later innings—Cincinnati’s relievers have shown resilience when protecting leads but have also been vulnerable when overextended, while San Diego’s bullpen has generally performed better than expected behind strong middle relief and effective matchups late. Both clubs also need to manage base paths wisely; the Reds are among the league leaders in steals and take the extra base aggressively, while the Padres rely more on situational hitting and big innings driven by extra-base hits. Given the tightly matched statistics and solid starting pitching on both sides, expect a competitive, low-scoring contest where one swing or one key defensive play could decide the outcome, with the Reds holding a slight edge due to Abbott’s dominance and home-field advantage, but the Padres are fully capable of flipping the script if Tatis or Machado can come through in a high-leverage situation.

San Diego Padres MLB Preview

The San Diego Padres enter Saturday’s game against the Cincinnati Reds looking to solidify their playoff standing in the crowded National League West as they sit at 44–36 and have shown flashes of becoming a well-rounded contender despite inconsistency in key areas. Randy Vásquez will take the mound for San Diego, bringing a 3–4 record with a 3.60 ERA across 80 innings of work, showcasing solid command and a calm presence under pressure that has earned him growing trust from the coaching staff. Vásquez has been particularly effective at inducing ground balls and limiting home runs, which will be critical in the hitter-friendly confines of Great American Ball Park. Offensively, the Padres are powered by Fernando Tatis Jr., who enters with 13 home runs and continues to be a dual threat both at the plate and on the base paths, while veteran third baseman Manny Machado has been San Diego’s most consistent bat, leading the team with 89 hits and showing steady production even in hostile environments. Their overall team batting average stands at .248, and while their slugging percentage of .379 lags behind other playoff hopefuls, they’ve shown the ability to string together timely hits and grind out runs against quality pitching. The Padres’ lineup is bolstered by contributions from players like Jake Cronenworth and Xander Bogaerts, who have struggled at times with consistency but remain capable of delivering big moments and helping turn over the lineup.

On defense, San Diego holds a .985 fielding percentage, a testament to their fundamentally sound infield anchored by Machado and Ha-Seong Kim, and behind the plate, Luis Campusano has emerged as a reliable receiver with a strong arm and game-calling aptitude that has aided the pitching staff. The bullpen has quietly been one of the team’s strengths, with Robert Suarez and Yuki Matsui delivering strong performances in the later innings and providing stability when the game is on the line. As a team, the Padres have a 41–39 record against the spread and sit slightly below .500 on the road at 19–21, indicating that while they’ve been competitive, they have room for improvement in tight road matchups against quality opponents. Saturday’s game poses a real challenge with Cincinnati starting lefty Andrew Abbott, who’s posted a 7–1 record with a microscopic 1.79 ERA and has dominated both righties and lefties with a deceptive fastball and strong offspeed mix. For San Diego to have success, they will need to work deep counts, elevate Abbott’s pitch count early, and hope that Tatis or Machado can come through with runners on base, while Vásquez must limit damage against a Reds lineup that thrives on momentum and aggressive base running. If the Padres can play a clean game defensively and their bullpen can hold its own in the later innings, they will have every opportunity to steal a tough road win and keep pace in a division race that continues to tighten with each passing series.

The San Diego Padres (44–36) face the Cincinnati Reds (42–39) on Saturday, June 28, 2025, at Great American Ball Park. The Reds are favored with a -156 moneyline, while the Padres are listed at +130. San Diego vs Cincinnati AI Prediction: Free MLB Betting Insights for Jun 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cincinnati Reds MLB Preview

The Cincinnati Reds enter Saturday’s home matchup against the San Diego Padres with a 42–39 record and find themselves firmly in the thick of the National League Central race as they aim to continue their winning ways behind one of the best young pitchers in baseball, left-hander Andrew Abbott, who brings a 7–1 record and sparkling 1.79 ERA into the contest. Abbott has been the Reds’ most consistent starter, using pinpoint control and an evolving pitch mix to keep hitters off balance, and his ability to dominate both sides of the plate has made him especially effective at Great American Ball Park, where he has been nearly untouchable in his last four home starts. Offensively, the Reds are led by the electric Elly De La Cruz, who enters the game with a team-high 18 home runs and 86 hits, adding elite speed and chaos creation on the base paths that has helped spark rallies and change the momentum of games in an instant. His emergence as an all-around superstar has been complemented by the steady bats of Spencer Steer and Christian Encarnacion-Strand, both of whom provide power and timely hitting in the middle of the order, while Jonathan India continues to contribute in key spots with solid on-base skills and leadership from the leadoff spot. The team as a whole owns a .248 batting average and an impressive .403 slugging percentage, showing their ability to do damage in bunches, particularly against pitchers who struggle to locate consistently, which will be a key matchup detail against Padres right-hander Randy Vásquez.

On defense, the Reds boast a .986 fielding percentage and have played crisp, clean baseball behind their starters, rarely giving away extra outs and executing well in late-inning situations when margins are slim. The bullpen has also held firm with Alexis Díaz serving as a reliable closer and Fernando Cruz emerging as a high-leverage option capable of bridging games from the starter to the ninth, giving manager David Bell the flexibility to manage matchups carefully in close contests. From a betting perspective, the Reds are 41–37 against the spread this season and are 6–3 when favored by -156 or more, reflecting a trend of performing well when expectations are higher, and their 22–18 home record underscores how much more comfortable they’ve been at Great American Ball Park compared to their road performances. To win Saturday’s game, Cincinnati will look to jump on Vásquez early and apply pressure through aggressive base running and disciplined at-bats, forcing the Padres’ pitching staff into uncomfortable situations and creating opportunities for De La Cruz and Steer to drive in runs. With Abbott on the mound and the offense clicking, the Reds are well-positioned to control the tempo and dictate terms, but they’ll need to maintain their composure and avoid the kind of defensive miscues or bullpen lapses that have cost them games in the past. If they execute their game plan effectively and continue riding the momentum from Abbott’s strong starts, Cincinnati should have a clear path to victory and a chance to tighten the division race even further with another key win over a solid NL West contender.

San Diego vs. Cincinnati Prop Picks (AI)

AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Padres and Reds play there’s always several intriguing angles to key in on. Not to mention games played at Great American Ball Park in Jun can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: S. Steer over 5.5 Fantasy Score.

San Diego vs. Cincinnati Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every past game between the Padres and Reds and using recursive machine learning and impressive AI to examine the data to a single cover probability.

The Algorithm has been most keyed in on the growing emphasis knucklehead sportsbettors often put on San Diego’s strength factors between a Padres team going up against a possibly tired Reds team. It appears the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Diego vs Cincinnati picks, computer picks Padres vs Reds, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Padres Betting Trends

The Padres have a 41–39 record against the spread (ATS) this season.

Reds Betting Trends

The Reds hold a 41–37 ATS record this season.

Padres vs. Reds Matchup Trends

The Reds have a 6–3 record when favored by -156 or more this season.

San Diego vs. Cincinnati Game Info

San Diego vs Cincinnati starts on June 28, 2025 at 4:10 PM EST.

Venue: Great American Ball Park.

Spread: Cincinnati -1.5
Moneyline: San Diego =+130, Cincinnati -156
Over/Under: 9.5

San Diego: (44-37)  |  Cincinnati: (43-39)

Remi's searched hard and found the best prop for this matchup: S. Steer over 5.5 Fantasy Score.. Prices move—always shop for the best number.

The Reds have a 6–3 record when favored by -156 or more this season.

SD trend: The Padres have a 41–39 record against the spread (ATS) this season.

CIN trend: The Reds hold a 41–37 ATS record this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Diego vs. Cincinnati Odds

Remi is pouring through tons of data on each team. In fact, anytime the San Diego vs Cincinnati trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.

San Diego vs Cincinnati Opening Odds

SD Moneyline: =+130
CIN Moneyline: -156
SD Spread: =+1.5
CIN Spread: -1.5
Over/Under: 9.5

San Diego vs Cincinnati Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+172
-205
+1.5 (-118)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+136
-162
+1.5 (-150)
-1.5 (+125)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+138
-164
+1.5 (-164)
-1.5 (+136)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-142
+1.5 (-182)
-1.5 (+150)
O 7.5 (-118)
U 7.5 (-104)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-162
+136
-1.5 (+100)
+1.5 (-120)
O 9 (+100)
U 9 (-122)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-118
-1.5 (+152)
+1.5 (-184)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Diego Padres vs. Cincinnati Reds on June 28, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN