Nationals vs Padres Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 25)
Updated: 2025-06-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Washington Nationals and San Diego Padres are set to conclude their three-game series on Wednesday, June 25, 2025, at Petco Park in San Diego. The Padres, aiming to solidify their position in the National League West, will look to capitalize on their home-field advantage against the struggling Nationals.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 25, 2025
Start Time: 4:10 PM EST
Venue: Petco Park
Padres Record: (43-36)
Nationals Record: (33-47)
OPENING ODDS
WAS Moneyline: +128
SD Moneyline: -153
WAS Spread: +1.5
SD Spread: -1.5
Over/Under: 8
WAS
Betting Trends
- The Washington Nationals have covered the run line in 4 of their last 6 road games, indicating a slight improvement in their performance away from home.
SD
Betting Trends
- The San Diego Padres have covered the run line in 5 of their last 7 home games, showcasing their strength at Petco Park.
MATCHUP TRENDS
- The total has gone UNDER in 5 of the Nationals’ last 6 games, while the Padres have seen the total go UNDER in 4 of their last 5 games, suggesting a potential low-scoring affair.
WAS vs. SD
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Wood over 1.5 Hits+Runs+RBI.
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Washington vs San Diego Prediction & Odds:
Free MLB Betting Insights for 6/25/25
The Nationals, meanwhile, have shown resilience, with players like CJ Abrams and James Wood making significant contributions. Abrams, an All-Star in 2024, has been a spark plug for the Nationals, while Wood has provided power in the lineup. MacKenzie Gore, the Nationals’ probable starter, has demonstrated potential, including a franchise-record 13 strikeouts on Opening Day 2025. However, the Nationals’ bullpen has faced challenges, often struggling to maintain leads. Defensively, both teams have areas to improve, but the Padres have been more consistent in minimizing errors. Given the Padres’ home advantage and more balanced roster, they appear poised to take the series, but the Nationals have the talent to challenge and potentially upset.
eighty. pic.twitter.com/TqD2ABREpm
— Washington Nationals (@Nationals) June 24, 2025
Washington Nationals MLB Preview
The Washington Nationals come into this game against the San Diego Padres on June 25, 2025 with a 33-47 record that reflects the ups and downs of a young club still very much in the middle of its rebuilding process, but despite the challenges they’ve faced all season this is a team that continues to show grit and a focus on development as they look for pieces to build around in the future. The Nationals have relied heavily on their emerging core to lead the way, especially shortstop CJ Abrams, who has put together a breakout first half by hitting close to .290 with power and speed at the top of the order while demonstrating an improved ability to make contact and put pressure on opposing defenses with his legs. Abrams’ combination of gap-to-gap power and aggressive base running has given Washington a spark at the top of the lineup that they sorely needed, and his leadership by example is helping set a competitive tone for the rest of the team. Alongside Abrams, the Nationals also lean on the contributions of outfielders Lane Thomas and Jacob Young, who add athleticism and defense in the outfield as well as occasional pop at the plate. On the mound, left-hander MacKenzie Gore continues to show flashes of the dominant pitcher they hoped he’d become, entering this game with an ERA hovering in the low-threes and ranking among the National League leaders in strikeouts.
Gore’s mix of a lively fastball and a sharp breaking ball has kept him competitive in most of his starts, but like much of the Nationals’ rotation this year he has been prone to stretches of inconsistency and will need to control the strike zone and work ahead in counts if he wants to quiet a dangerous Padres lineup in their own ballpark. Beyond Gore, Washington’s bullpen has been a work in progress all season long, with a revolving cast of arms that has struggled to hold onto leads and keep games within reach, making it all the more important for the offense to jump out to an early lead and put pressure on San Diego from the opening innings. This Nationals team knows they face a daunting task in Petco Park against a Padres squad that has playoff aspirations and is comfortable playing at home, but if Washington can lean into its strengths — Abrams’ disruptive speed, Gore’s swing-and-miss stuff, and some timely hitting from the middle of their order — they can make this a competitive contest and take another small but meaningful step toward becoming the kind of team that can contend in the years to come. They may not yet have the depth or the established veteran presence to overpower the top teams, but they’ve got the youth, the hunger, and the drive to make life difficult for their opponents every time they take the field, and this game will be one more important test for a franchise committed to building something lasting.

Credit: USA TODAY/IMAGN
San Diego Padres MLB Preview
The San Diego Padres come into this matchup on June 25, 2025 with a 44-36 record that has them firmly in the hunt for a playoff spot in the competitive National League West, and they will look to use their home-field advantage at Petco Park to take care of business against a rebuilding Washington Nationals team that’s still trying to find its identity. This Padres club has built its success around a balanced offensive attack led by perennial star Manny Machado, who continues to anchor the middle of the order with his mix of power and situational hitting, routinely coming up with big hits when San Diego needs them most. Around him, Xander Bogaerts has been a model of consistency with a batting average well above .280, providing an experienced and professional bat at shortstop and setting the table for big innings with his patient approach at the plate. Luis Arraez, acquired in the offseason, has also been a catalyst at the top of the order, bringing his trademark contact skills and on-base prowess to ignite the offense and put pressure on opposing pitchers, allowing San Diego to manufacture runs even when the home run ball isn’t there.
On the mound, the Padres will lean on their deep rotation to control this game, and while they may not have the ace they once relied on in years past, arms like Nick Pivetta and Joe Musgrove have given them competitive innings all season long with Pivetta in particular using his lively fastball and sharp breaking pitches to keep hitters off balance. Musgrove’s veteran poise and big-game experience also help steady the rotation, especially in games like this where they’ll want to jump out to an early lead and then let their bullpen take over. The Padres’ bullpen, headlined by closer Robert Suarez and setup man Steven Wilson, has been one of the most effective in the National League when they have a lead late, and their ability to lock down the final outs will be key to avoiding any letdown against a feisty Washington team. Defensively, San Diego is sound up the middle with Bogaerts and Kim, and they rarely beat themselves with errors or sloppy fundamentals, which could make a big difference if this game stays close into the late innings. Playing at home also brings a certain energy to this Padres club that tends to elevate their performance, and they’ll look to jump on the Nationals early by being aggressive on the basepaths and putting their power bats in good spots to do damage. With a legitimate shot at making a serious run this postseason, San Diego knows that games like this — where they face a struggling opponent — are must-win opportunities that will go a long way toward cementing their status as a contender. If they can stick to their game plan, get a quality outing from their starter, and continue swinging the bats with confidence up and down the lineup, they’ll be well positioned to close this series on a high note and build some momentum heading into a tough stretch against divisional rivals.
Curly W. pic.twitter.com/u3vqYanBhF
— San Diego Padres (@Padres) June 25, 2025
Washington vs. San Diego Prop Picks (AI)
Washington vs. San Diego Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Nationals and Padres and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the unproportionally assigned factor human bettors tend to put on coaching factors between a Nationals team going up against a possibly unhealthy Padres team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Washington vs San Diego picks, computer picks Nationals vs Padres, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Nationals Betting Trends
The Washington Nationals have covered the run line in 4 of their last 6 road games, indicating a slight improvement in their performance away from home.
Padres Betting Trends
The San Diego Padres have covered the run line in 5 of their last 7 home games, showcasing their strength at Petco Park.
Nationals vs. Padres Matchup Trends
The total has gone UNDER in 5 of the Nationals’ last 6 games, while the Padres have seen the total go UNDER in 4 of their last 5 games, suggesting a potential low-scoring affair.
Washington vs. San Diego Game Info
What time does Washington vs San Diego start on June 25, 2025?
Washington vs San Diego starts on June 25, 2025 at 4:10 PM EST.
Where is Washington vs San Diego being played?
Venue: Petco Park.
What are the opening odds for Washington vs San Diego?
Spread: San Diego -1.5
Moneyline: Washington +128, San Diego -153
Over/Under: 8
What are the records for Washington vs San Diego?
Washington: (33-47) | San Diego: (43-36)
What is the AI best bet for Washington vs San Diego?
Remi's searched hard and found the best prop for this matchup: J. Wood over 1.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Washington vs San Diego trending bets?
The total has gone UNDER in 5 of the Nationals’ last 6 games, while the Padres have seen the total go UNDER in 4 of their last 5 games, suggesting a potential low-scoring affair.
What are Washington trending bets?
WAS trend: The Washington Nationals have covered the run line in 4 of their last 6 road games, indicating a slight improvement in their performance away from home.
What are San Diego trending bets?
SD trend: The San Diego Padres have covered the run line in 5 of their last 7 home games, showcasing their strength at Petco Park.
Where can I find AI Picks for Washington vs San Diego?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Washington vs. San Diego Odds
AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Washington vs San Diego trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.
Washington vs San Diego Opening Odds
WAS Moneyline:
+128 SD Moneyline: -153
WAS Spread: +1.5
SD Spread: -1.5
Over/Under: 8
Washington vs San Diego Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
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–
–
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-157
+129
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-1.5 (+118)
+1.5 (-144)
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O 7.5 (+102)
U 7.5 (-125)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Washington Nationals vs. San Diego Padres on June 25, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |