Blue Jays vs. Guardians
Prediction, Odds & Props
Jun 25 | MLB AI Picks

Updated: 2025-06-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Toronto Blue Jays and Cleveland Guardians square off in the second game of their three-game series on Wednesday, June 25, 2025, at Progressive Field. Toronto aims to build on their recent success, while Cleveland looks to even the series on their home turf.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 25, 2025

Start Time: 6:40 PM EST​

Venue: Progressive Field​

Guardians Record: (39-38)

Blue Jays Record: (42-36)

OPENING ODDS

TOR Moneyline: -110

CLE Moneyline: -109

TOR Spread: -1.5

CLE Spread: +1.5

Over/Under: 8

TOR
Betting Trends

  • The Blue Jays have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.

CLE
Betting Trends

  • The Guardians have covered the run line in 5 of their last 7 home games, showcasing their strength at Progressive Field.

MATCHUP TRENDS

  • The total has gone OVER in 4 of the Blue Jays’ last 10 games, while the Guardians have seen the total go UNDER in 3 of their last 5 home games, suggesting a potential for a low-scoring affair.

TOR vs. CLE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Santana over 0.5 Total Bases.

LIVE MLB ODDS

MLB ODDS COMPARISON

WANT MORE AI PICKS?

VAULT
VS. SPREAD
308-221
VAULT
NET UNITS
(INCL VIG)
+418
VAULT
NET PROFIT
(INCL VIG)
$100/UNIT
$41,803
EXECUTIVE
VS. SPREAD
1551-1329
EXECUTIVE
NET UNITS
(INCL VIG)
+365.7
EXECUTIVE
NET PROFIT
(INCL VIG)
$100/UNIT
$36,569

AI SPORTS PICK PRODUCTS

Create a Free Account

‘Create an Account’ to Get Remi’s Picks Today.

Remi Finds New Picks

Remi calculates the probability a team will cover the line.

Remi Works 24/7

Remi uses this probability to assign units to each pick.

Get Remi's AI Picks

Get Remi’s Top AI Sports Picks sent direct to your inbox.

Toronto vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 6/25/25

The June 25, 2025 matchup between the Toronto Blue Jays and the Cleveland Guardians at Progressive Field presents a compelling midseason clash between two American League clubs with postseason ambitions and evolving rosters. One of the headline storylines entering this game is the anticipated return of future Hall-of-Famer Max Scherzer, who will be making his 2025 season debut for the Blue Jays after recovering from a lingering thumb injury. Signed to a one-year, $15.5 million deal in the offseason, Scherzer brings not only veteran presence and experience but also the potential to dramatically reshape the Blue Jays’ rotation moving forward. Toronto arrives in Cleveland with a 42–36 record and riding the momentum of a solid recent stretch, having gone 6–4 in its last 10 contests. The Guardians, standing at 39–38, are very much in the thick of the AL Central race and have been a scrappy, competitive team with strong home performances, even if their offense has been a bit inconsistent at times. The Blue Jays’ offensive engine continues to be led by Vladimir Guerrero Jr., who has picked up his pace after a slow start to the year, while Bo Bichette and Davis Schneider provide steady contributions at the top and middle of the order.

Meanwhile, Cleveland counters with José Ramírez, one of the most consistent and productive third basemen in the league, and Steven Kwan, a relentless leadoff hitter who sets the tone with his contact hitting and plate discipline. Pitching will be the focal point of this game as Scherzer’s return adds a level of uncertainty and excitement, while Cleveland will need a strong start from its rotation to neutralize Toronto’s big bats. The Blue Jays are also among the most efficient teams in extra-inning contests this season, boasting a 5–2 record in such games, and have one of the top run line marks in all of baseball. On the flip side, the Guardians have gone exactly .500 against the spread, showing some volatility from game to game. Both clubs understand the implications of this matchup as they try to stay afloat in tightly contested divisions, and the outcome could hinge on bullpen execution and timely hitting, two areas that have made the difference for both teams in many of their victories this year. With Max Scherzer toeing the rubber, the Blue Jays look to send a message that they are gearing up for a serious playoff push, while the Guardians aim to defend their home turf and stay within striking distance in the standings. The game sets up as a fascinating showdown between experience and grit, where pitching command, situational hitting, and bullpen sharpness could all play pivotal roles. This one could go down to the wire and figures to be one of the more intriguing matchups on the Wednesday slate.

Toronto Blue Jays MLB Preview

The Toronto Blue Jays enter Wednesday’s contest against the Cleveland Guardians with momentum and renewed confidence, largely thanks to the highly anticipated season debut of Max Scherzer, who brings elite pedigree and experience back to the rotation after recovering from a nagging thumb injury. With a 42–36 record, Toronto has found a rhythm in recent weeks, going 6–4 over their last 10 games and benefiting from a more consistent offensive effort that’s starting to resemble the production expected of their talented core. Vladimir Guerrero Jr. is heating up at the plate, showing improved plate discipline and power numbers that had dipped early in the season, while Bo Bichette’s return to form as a reliable contact hitter and leadoff presence has steadied the offense. Davis Schneider has quietly provided clutch hits and versatility in the lineup, contributing to a balanced run-scoring attack. The Blue Jays have been one of MLB’s more effective teams on the run line in 2025, especially in road games, and they’ve performed well in close contests, highlighted by their impressive 5–2 record in extra-inning games. This resilience has been supported by a solid bullpen, with Jordan Romano and Yimi García providing late-inning stability when the Jays have a lead.

Toronto’s biggest question mark entering the second half of the season had been their starting rotation, but Scherzer’s return could be a game-changer. If the veteran right-hander can stay healthy and replicate even a portion of his previous dominance, the Jays could position themselves as legitimate contenders in the AL. Facing a Guardians team that has played well at home, Toronto will rely on Scherzer to set the tone and give the bullpen a lighter load. The defense, anchored by Kevin Kiermaier in center field and Matt Chapman at third, continues to prevent runs at a high level, complementing the club’s pitching efforts. Manager John Schneider has managed workloads carefully and will look to ease Scherzer into action with a manageable pitch count, though the intensity and stakes of the game may necessitate flexibility depending on how things unfold. The Jays will aim to be aggressive early against Cleveland’s starter, hoping to jump out in front and let their bullpen protect the advantage rather than having to play from behind. Toronto has also been above average in batting with runners in scoring position, and if they can continue to execute in those moments, they should be in a strong position to secure a win. Ultimately, the return of a legend, the upward trends of key bats, and the team’s overall resilience make the Blue Jays a dangerous opponent heading into this midweek showdown. As long as the offense avoids extended slumps and Scherzer’s outing doesn’t get derailed early, Toronto has the tools to make a statement and potentially begin a sustained run toward the top of the American League standings.

The Toronto Blue Jays and Cleveland Guardians square off in the second game of their three-game series on Wednesday, June 25, 2025, at Progressive Field. Toronto aims to build on their recent success, while Cleveland looks to even the series on their home turf. Toronto vs Cleveland AI Prediction: Free MLB Betting Insights for Jun 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cleveland Guardians MLB Preview

The Cleveland Guardians return home on June 25, 2025, to host the Toronto Blue Jays in what promises to be an electric midweek matchup between two postseason hopefuls trending in the right direction. The Guardians have been one of the American League’s most consistent and well-rounded teams this season, currently boasting a strong record and an especially impressive home performance at Progressive Field, where they’ve been a dominant 25–11. Manager Stephen Vogt’s club continues to thrive with a combination of elite pitching, timely hitting, and sound defense—traits that have helped them stay in the mix for the AL Central title and beyond. Cleveland’s offense, which was considered a concern earlier in the year, has emerged thanks to breakout campaigns from Andrés Giménez and Josh Naylor, who have been clutch in the heart of the order. José Ramírez remains the engine of the lineup, providing both power and on-base prowess, while Steven Kwan has delivered stability atop the order with his contact-heavy approach. On the mound, the Guardians continue to impress with Tanner Bibee scheduled to start Wednesday’s contest. The right-hander has shown exceptional command and poise in his second MLB season, thriving in big moments and minimizing damage when runners are aboard. His ability to induce ground balls has been a perfect fit for Cleveland’s airtight infield defense, which has helped turn one of the highest double-play rates in baseball.

The bullpen, anchored by Emmanuel Clase and supported by hard-throwing arms like Hunter Gaddis and Tim Herrin, remains one of the best in the American League, particularly in close games. With Toronto expected to activate Max Scherzer and potentially bring postseason-level intensity to the matchup, the Guardians will need to counter with plate discipline and situational hitting to wear down the veteran pitcher early. Expect Cleveland to challenge Scherzer with a patient approach, looking to raise his pitch count and force the Blue Jays into their middle relief corps. The Guardians have been exceptionally effective at home against right-handed pitching, and their balance between lefty and righty bats makes them hard to match up against late in games. They’ve also been excellent in one-run games, which speaks to their maturity and ability to execute under pressure. With playoff implications beginning to loom, Cleveland knows how important these interleague contests are—not just for standings, but also as measuring sticks against top-tier competition. Their defensive sharpness, particularly on the left side of the infield, along with aggressive baserunning, often gives them small but meaningful edges that turn into wins. If the Guardians can get to Scherzer early and give Bibee a lead to work with, they’ll be in a strong position to lock down another statement win at home and continue to build momentum into the summer stretch. The mixture of experienced leadership and youthful production makes this Cleveland team uniquely dangerous, and they’ll look to put it all together once again under the lights at Progressive Field.

Toronto vs. Cleveland Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each team. In fact, anytime the Blue Jays and Guardians play there’s always several intriguing angles to key in on. Not to mention games played at Progressive Field in Jun seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: C. Santana over 0.5 Total Bases.

Toronto vs. Cleveland Prediction (AI)

Remi Robot Icon

Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Blue Jays and Guardians and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the growing factor emotional bettors tend to put on coaching factors between a Blue Jays team going up against a possibly healthy Guardians team. It appears the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Toronto vs Cleveland picks, computer picks Blue Jays vs Guardians, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Blue Jays Betting Trends

The Blue Jays have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.

Guardians Betting Trends

The Guardians have covered the run line in 5 of their last 7 home games, showcasing their strength at Progressive Field.

Blue Jays vs. Guardians Matchup Trends

The total has gone OVER in 4 of the Blue Jays’ last 10 games, while the Guardians have seen the total go UNDER in 3 of their last 5 home games, suggesting a potential for a low-scoring affair.

Toronto vs. Cleveland Game Info

Toronto vs Cleveland starts on June 25, 2025 at 6:40 PM EST.

Spread: Cleveland +1.5
Moneyline: Toronto -110, Cleveland -109
Over/Under: 8

Toronto: (42-36)  |  Cleveland: (39-38)

Remi's searched hard and found the best prop for this matchup: C. Santana over 0.5 Total Bases.. Prices move—always shop for the best number.

The total has gone OVER in 4 of the Blue Jays’ last 10 games, while the Guardians have seen the total go UNDER in 3 of their last 5 home games, suggesting a potential for a low-scoring affair.

TOR trend: The Blue Jays have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.

CLE trend: The Guardians have covered the run line in 5 of their last 7 home games, showcasing their strength at Progressive Field.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Toronto vs. Cleveland Odds

Remi is pouring through tons of stats on each line. In fact, anytime the Toronto vs Cleveland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable patterns.

Toronto vs Cleveland Opening Odds

TOR Moneyline: -110
CLE Moneyline: -109
TOR Spread: -1.5
CLE Spread: +1.5
Over/Under: 8

Toronto vs Cleveland Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Toronto Blue Jays vs. Cleveland Guardians on June 25, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN