Blue Jays vs. Guardians
Prediction, Odds & Props
Jun 25 | MLB AI Picks
Updated: 2025-06-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Toronto Blue Jays and Cleveland Guardians square off in the second game of their three-game series on Wednesday, June 25, 2025, at Progressive Field. Toronto aims to build on their recent success, while Cleveland looks to even the series on their home turf.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 25, 2025
Start Time: 6:40 PM EST
Venue: Progressive Field
Guardians Record: (39-38)
Blue Jays Record: (42-36)
OPENING ODDS
TOR Moneyline: -110
CLE Moneyline: -109
TOR Spread: -1.5
CLE Spread: +1.5
Over/Under: 8
TOR
Betting Trends
- The Blue Jays have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.
CLE
Betting Trends
- The Guardians have covered the run line in 5 of their last 7 home games, showcasing their strength at Progressive Field.
MATCHUP TRENDS
- The total has gone OVER in 4 of the Blue Jays’ last 10 games, while the Guardians have seen the total go UNDER in 3 of their last 5 home games, suggesting a potential for a low-scoring affair.
TOR vs. CLE
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Santana over 0.5 Total Bases.
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Toronto vs Cleveland Prediction & Odds:
Free MLB Betting Insights for 6/25/25
Meanwhile, Cleveland counters with José Ramírez, one of the most consistent and productive third basemen in the league, and Steven Kwan, a relentless leadoff hitter who sets the tone with his contact hitting and plate discipline. Pitching will be the focal point of this game as Scherzer’s return adds a level of uncertainty and excitement, while Cleveland will need a strong start from its rotation to neutralize Toronto’s big bats. The Blue Jays are also among the most efficient teams in extra-inning contests this season, boasting a 5–2 record in such games, and have one of the top run line marks in all of baseball. On the flip side, the Guardians have gone exactly .500 against the spread, showing some volatility from game to game. Both clubs understand the implications of this matchup as they try to stay afloat in tightly contested divisions, and the outcome could hinge on bullpen execution and timely hitting, two areas that have made the difference for both teams in many of their victories this year. With Max Scherzer toeing the rubber, the Blue Jays look to send a message that they are gearing up for a serious playoff push, while the Guardians aim to defend their home turf and stay within striking distance in the standings. The game sets up as a fascinating showdown between experience and grit, where pitching command, situational hitting, and bullpen sharpness could all play pivotal roles. This one could go down to the wire and figures to be one of the more intriguing matchups on the Wednesday slate.
A picture is worth a thousand words.
— Toronto Blue Jays (@BlueJays) June 25, 2025
This one just needs two: GAME. OVER 🤫 pic.twitter.com/TysbABUMwR
Toronto Blue Jays MLB Preview
The Toronto Blue Jays enter Wednesday’s contest against the Cleveland Guardians with momentum and renewed confidence, largely thanks to the highly anticipated season debut of Max Scherzer, who brings elite pedigree and experience back to the rotation after recovering from a nagging thumb injury. With a 42–36 record, Toronto has found a rhythm in recent weeks, going 6–4 over their last 10 games and benefiting from a more consistent offensive effort that’s starting to resemble the production expected of their talented core. Vladimir Guerrero Jr. is heating up at the plate, showing improved plate discipline and power numbers that had dipped early in the season, while Bo Bichette’s return to form as a reliable contact hitter and leadoff presence has steadied the offense. Davis Schneider has quietly provided clutch hits and versatility in the lineup, contributing to a balanced run-scoring attack. The Blue Jays have been one of MLB’s more effective teams on the run line in 2025, especially in road games, and they’ve performed well in close contests, highlighted by their impressive 5–2 record in extra-inning games. This resilience has been supported by a solid bullpen, with Jordan Romano and Yimi García providing late-inning stability when the Jays have a lead.
Toronto’s biggest question mark entering the second half of the season had been their starting rotation, but Scherzer’s return could be a game-changer. If the veteran right-hander can stay healthy and replicate even a portion of his previous dominance, the Jays could position themselves as legitimate contenders in the AL. Facing a Guardians team that has played well at home, Toronto will rely on Scherzer to set the tone and give the bullpen a lighter load. The defense, anchored by Kevin Kiermaier in center field and Matt Chapman at third, continues to prevent runs at a high level, complementing the club’s pitching efforts. Manager John Schneider has managed workloads carefully and will look to ease Scherzer into action with a manageable pitch count, though the intensity and stakes of the game may necessitate flexibility depending on how things unfold. The Jays will aim to be aggressive early against Cleveland’s starter, hoping to jump out in front and let their bullpen protect the advantage rather than having to play from behind. Toronto has also been above average in batting with runners in scoring position, and if they can continue to execute in those moments, they should be in a strong position to secure a win. Ultimately, the return of a legend, the upward trends of key bats, and the team’s overall resilience make the Blue Jays a dangerous opponent heading into this midweek showdown. As long as the offense avoids extended slumps and Scherzer’s outing doesn’t get derailed early, Toronto has the tools to make a statement and potentially begin a sustained run toward the top of the American League standings.

Credit: USA TODAY/IMAGN
Cleveland Guardians MLB Preview
The Cleveland Guardians return home on June 25, 2025, to host the Toronto Blue Jays in what promises to be an electric midweek matchup between two postseason hopefuls trending in the right direction. The Guardians have been one of the American League’s most consistent and well-rounded teams this season, currently boasting a strong record and an especially impressive home performance at Progressive Field, where they’ve been a dominant 25–11. Manager Stephen Vogt’s club continues to thrive with a combination of elite pitching, timely hitting, and sound defense—traits that have helped them stay in the mix for the AL Central title and beyond. Cleveland’s offense, which was considered a concern earlier in the year, has emerged thanks to breakout campaigns from Andrés Giménez and Josh Naylor, who have been clutch in the heart of the order. José Ramírez remains the engine of the lineup, providing both power and on-base prowess, while Steven Kwan has delivered stability atop the order with his contact-heavy approach. On the mound, the Guardians continue to impress with Tanner Bibee scheduled to start Wednesday’s contest. The right-hander has shown exceptional command and poise in his second MLB season, thriving in big moments and minimizing damage when runners are aboard. His ability to induce ground balls has been a perfect fit for Cleveland’s airtight infield defense, which has helped turn one of the highest double-play rates in baseball.
The bullpen, anchored by Emmanuel Clase and supported by hard-throwing arms like Hunter Gaddis and Tim Herrin, remains one of the best in the American League, particularly in close games. With Toronto expected to activate Max Scherzer and potentially bring postseason-level intensity to the matchup, the Guardians will need to counter with plate discipline and situational hitting to wear down the veteran pitcher early. Expect Cleveland to challenge Scherzer with a patient approach, looking to raise his pitch count and force the Blue Jays into their middle relief corps. The Guardians have been exceptionally effective at home against right-handed pitching, and their balance between lefty and righty bats makes them hard to match up against late in games. They’ve also been excellent in one-run games, which speaks to their maturity and ability to execute under pressure. With playoff implications beginning to loom, Cleveland knows how important these interleague contests are—not just for standings, but also as measuring sticks against top-tier competition. Their defensive sharpness, particularly on the left side of the infield, along with aggressive baserunning, often gives them small but meaningful edges that turn into wins. If the Guardians can get to Scherzer early and give Bibee a lead to work with, they’ll be in a strong position to lock down another statement win at home and continue to build momentum into the summer stretch. The mixture of experienced leadership and youthful production makes this Cleveland team uniquely dangerous, and they’ll look to put it all together once again under the lights at Progressive Field.
Another one tomorrow.#GuardsBall pic.twitter.com/tcRcOtWoEE
— Cleveland Guardians (@CleGuardians) June 25, 2025
Toronto vs. Cleveland Prop Picks (AI)
Toronto vs. Cleveland Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Blue Jays and Guardians and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the growing factor emotional bettors tend to put on coaching factors between a Blue Jays team going up against a possibly healthy Guardians team. It appears the true game analytics might reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Toronto vs Cleveland picks, computer picks Blue Jays vs Guardians, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Blue Jays Betting Trends
The Blue Jays have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.
Guardians Betting Trends
The Guardians have covered the run line in 5 of their last 7 home games, showcasing their strength at Progressive Field.
Blue Jays vs. Guardians Matchup Trends
The total has gone OVER in 4 of the Blue Jays’ last 10 games, while the Guardians have seen the total go UNDER in 3 of their last 5 home games, suggesting a potential for a low-scoring affair.
Toronto vs. Cleveland Game Info
What time does Toronto vs Cleveland start on June 25, 2025?
Toronto vs Cleveland starts on June 25, 2025 at 6:40 PM EST.
Where is Toronto vs Cleveland being played?
Venue: Progressive Field.
What are the opening odds for Toronto vs Cleveland?
Spread: Cleveland +1.5
Moneyline: Toronto -110, Cleveland -109
Over/Under: 8
What are the records for Toronto vs Cleveland?
Toronto: (42-36) | Cleveland: (39-38)
What is the AI best bet for Toronto vs Cleveland?
Remi's searched hard and found the best prop for this matchup: C. Santana over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Toronto vs Cleveland trending bets?
The total has gone OVER in 4 of the Blue Jays’ last 10 games, while the Guardians have seen the total go UNDER in 3 of their last 5 home games, suggesting a potential for a low-scoring affair.
What are Toronto trending bets?
TOR trend: The Blue Jays have covered the run line in 4 of their last 10 games, indicating a recent trend of close contests.
What are Cleveland trending bets?
CLE trend: The Guardians have covered the run line in 5 of their last 7 home games, showcasing their strength at Progressive Field.
Where can I find AI Picks for Toronto vs Cleveland?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Toronto vs. Cleveland Odds
Remi is pouring through tons of stats on each line. In fact, anytime the Toronto vs Cleveland trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable patterns.
Toronto vs Cleveland Opening Odds
TOR Moneyline:
-110 CLE Moneyline: -109
TOR Spread: -1.5
CLE Spread: +1.5
Over/Under: 8
Toronto vs Cleveland Live Odds
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–
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+194
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O 8.5 (-122)
U 8.5 (+100)
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U 9 (+100)
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U 8.5 (-114)
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–
–
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+102
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O 8.5 (-110)
U 8.5 (-110)
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–
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+198
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+1.5 (-110)
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O 8 (-108)
U 8 (-112)
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Sep 27, 2025 4:11PM EDT
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-124
+106
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-1.5 (+130)
+1.5 (-156)
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O 8.5 (-112)
U 8.5 (-108)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
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+177
-197
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+1.5 (-118)
-1.5 (-102)
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O 8.5 (-118)
U 8.5 (-102)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
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–
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+128
-152
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+1.5 (-178)
-1.5 (+146)
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O 7.5 (-120)
U 7.5 (-102)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
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Pirates
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–
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+143
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+1.5 (-150)
-1.5 (+130)
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O 8.5 (+100)
U 8.5 (-120)
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Sep 27, 2025 7:16PM EDT
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Cleveland Guardians
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–
–
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+132
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+1.5 (-172)
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O 7 (-120)
U 7 (-102)
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+120
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+1.5 (-180)
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O 7.5 (-115)
U 7.5 (-105)
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–
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+102
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+1.5 (-215)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
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Royals
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–
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+104
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Toronto Blue Jays vs. Cleveland Guardians on June 25, 2025 at Progressive Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |