Phillies vs Astros Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 25)
Updated: 2025-06-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Philadelphia Phillies and Houston Astros are set to face off on Wednesday, June 25, 2025, at Daikin Park in Houston, Texas, with the first pitch scheduled for 8:10 p.m. ET. This matchup features two division leaders: the Phillies atop the NL East at 47–32 and the Astros leading the AL West at 46–33, both aiming to solidify their standings as the season progresses.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 25, 2025
Start Time: 8:10 PM EST
Venue: Daikin Park
Astros Record: (46-33)
Phillies Record: (47-32)
OPENING ODDS
PHI Moneyline: -160
HOU Moneyline: +135
PHI Spread: -1.5
HOU Spread: +1.5
Over/Under: 7.5
PHI
Betting Trends
- The Phillies have a 35–37 record against the spread (ATS) this season.
HOU
Betting Trends
- The Astros have a 6–4 record against the spread (ATS) over their past 10 games.
MATCHUP TRENDS
- The Astros have a 28–13 home record this season and are currently on a six-game home winning streak.
PHI vs. HOU
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Altuve over 4.5 Fantasy Score.
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Philadelphia vs Houston Prediction & Odds:
Free MLB Betting Insights for 6/25/25
Philadelphia’s offense, meanwhile, relies on the top-of-the-order trio of Trea Turner, Nick Castellanos, and Alec Bohm, all batting near .300 and capable of stringing together rallies. Kyle Schwarber adds the long ball potential, and his career success against Houston should keep Astros pitchers wary. Despite the low-scoring loss in the series opener, the Phillies had several opportunities to break through and will look to capitalize this time around, particularly against a less-experienced arm in Gordon. The Phillies boast one of the league’s better road records and are likely eager to avoid a series loss as they fend off a surging Mets team in their own division. Defensively, both clubs are solid, and the bullpen depth on each side should make scoring in the late innings difficult. Ultimately, this game comes down to execution and timely hitting, with Wheeler providing the edge on the mound if he receives enough run support. However, Houston’s recent home dominance and ability to hit in clutch moments make them a tough out. With the playoffs inching closer each week, this interleague clash could have long-term implications for seeding and momentum, and it features just enough star power and narrative intrigue to make it a highlight of the Wednesday slate. Whether it’s a pitcher’s duel or a late-inning offensive burst that defines the outcome, expect both dugouts to approach this contest with postseason-like intensity.
Howdy from Houston#RingTheBell pic.twitter.com/0ewPMnLhnh
— Philadelphia Phillies (@Phillies) June 24, 2025
Philadelphia Phillies MLB Preview
The Philadelphia Phillies enter Wednesday’s matchup against the Houston Astros determined to rebound from a tough 1–0 shutout loss in the series opener and reassert themselves as one of baseball’s most balanced and complete teams. They currently lead the NL East thanks to a deep roster featuring a strong mix of veterans and emerging talent, and with ace Zack Wheeler on the mound, they’ll look to lean on his dominance to even the series. Wheeler, who holds a 7–2 record and a 2.61 ERA, has been exceptional in 2025, consistently pitching deep into games and neutralizing top-tier offenses with elite command and strikeout ability. His presence should be a major asset as the Phillies face a dangerous Astros lineup that’s been red-hot at home. Offensively, Philadelphia will need more production from its core group after being blanked in Game 1 despite multiple opportunities. Trea Turner and Nick Castellanos continue to hit over .290 and serve as key table-setters, while Alec Bohm and Kyle Schwarber bring run-producing power from the middle of the order. Schwarber in particular will be relied upon to get to lefty Colton Gordon early, especially given his ability to change the game with one swing.
Though the Phillies have been strong on the road with a top-tier away record, they’ve shown some inconsistency against southpaws, making the matchup with Gordon one that could go either way. In the bullpen, Philadelphia has leaned on Jose Alvarado and Seranthony Dominguez for late-game support, though the offense will need to deliver with runners in scoring position to avoid a repeat of their Game 1 struggles. One key for the Phillies is getting production from the bottom third of the lineup, which has lagged behind the elite top half, and they may need a spark from someone like Bryson Stott or Brandon Marsh. With the Braves and Mets staying competitive in the division, the Phillies can’t afford to let games slip away, especially when their ace is on the hill. Their defense, usually reliable, will be tested against an aggressive Houston team that puts pressure on opponents with contact hitting and smart baserunning. This matchup also serves as a good litmus test for Philadelphia’s ability to perform in a hostile environment, and Wednesday presents an opportunity to flip the narrative of the series before heading back home. Wheeler’s ability to silence the crowd early with strikeouts and weak contact could prove pivotal, as could the offense’s need to jump ahead and avoid chasing late. If the Phillies can generate offense early and maintain their bullpen’s rhythm late, they’ll be well positioned to earn a series split and keep their divisional rivals at bay.

Credit: USA TODAY/IMAGN
Houston Astros MLB Preview
The Houston Astros head into Wednesday’s contest against the Philadelphia Phillies with confidence after securing a tight 1–0 win in the series opener, relying on timely pitching and defensive execution to hold off one of the National League’s best teams. With left-hander Colton Gordon slated to start, the Astros aim to build on their recent momentum and take the series from a Phillies team currently sitting atop the NL East standings. Gordon has been serviceable in his rookie campaign, showing poise and good command while navigating tough lineups, and he’ll be tasked with limiting damage from Philadelphia’s power-heavy offense. While he may not be a household name yet, Gordon has given Houston stability on the mound during stretches when the rotation has battled injuries and inconsistencies, and the team’s offense will look to provide early run support to ease pressure on the young lefty. Offensively, the Astros are beginning to round into form after a slow start to the season, with Jose Altuve and Kyle Tucker continuing to lead the way in both batting average and on-base production. Tucker has quietly pieced together an MVP-caliber season with over 20 home runs and an OPS near .950, making him a focal point of the Astros’ offensive attack. Yordan Alvarez, though still working back to full strength, has shown flashes of his elite hitting talent and adds another layer of danger in the middle of the lineup.
Houston’s overall record at Minute Maid Park has been solid, and they’ve performed particularly well in close games and late-inning situations, thanks in large part to a bullpen anchored by Ryan Pressly and Bryan Abreu. The Astros have also improved their defensive consistency in recent weeks, helping to prevent extended rallies and giving their pitchers more confidence to pitch to contact. As they prepare for this key interleague showdown, manager Joe Espada will be looking for his team to stay aggressive on the basepaths and apply pressure to a Phillies defense that has occasionally faltered under duress. Key contributors like Alex Bregman and Jeremy Peña have been trending upward at the plate, giving Houston a more complete lineup that doesn’t rely solely on a few stars to carry the offensive load. With the AL West race tightening and the Mariners and Rangers remaining close in the standings, the Astros are well aware of the importance of stringing together wins during their home stand. A series win over the Phillies would provide a morale boost and reinforce the belief that this team can compete at a high level even as it balances a blend of veteran leadership and younger contributors. While Zack Wheeler presents a significant challenge, Houston’s success against elite right-handers this season suggests they have the tools to grind out at-bats, manufacture runs, and push across just enough offense to win. If they continue to execute in the field and maintain the bullpen’s recent dominance, the Astros could be poised to take full control of this mini-series and continue their climb in the American League playoff picture.
Built For Shutout Ball.https://t.co/W06pfHRkGz⭐️@MethodistHosp pic.twitter.com/5rVSnQLmrs
— Houston Astros (@astros) June 25, 2025
Philadelphia vs. Houston Prop Picks (AI)
Philadelphia vs. Houston Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Phillies and Astros and using recursive machine learning and impressive AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the growing weight human bettors often put on coaching factors between a Phillies team going up against a possibly improved Astros team. We’ve found the true game analytics might reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Philadelphia vs Houston picks, computer picks Phillies vs Astros, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Phillies Betting Trends
The Phillies have a 35–37 record against the spread (ATS) this season.
Astros Betting Trends
The Astros have a 6–4 record against the spread (ATS) over their past 10 games.
Phillies vs. Astros Matchup Trends
The Astros have a 28–13 home record this season and are currently on a six-game home winning streak.
Philadelphia vs. Houston Game Info
What time does Philadelphia vs Houston start on June 25, 2025?
Philadelphia vs Houston starts on June 25, 2025 at 8:10 PM EST.
Where is Philadelphia vs Houston being played?
Venue: Daikin Park.
What are the opening odds for Philadelphia vs Houston?
Spread: Houston +1.5
Moneyline: Philadelphia -160, Houston +135
Over/Under: 7.5
What are the records for Philadelphia vs Houston?
Philadelphia: (47-32) | Houston: (46-33)
What is the AI best bet for Philadelphia vs Houston?
Remi's searched hard and found the best prop for this matchup: J. Altuve over 4.5 Fantasy Score.. Prices move—always shop for the best number.
What are Philadelphia vs Houston trending bets?
The Astros have a 28–13 home record this season and are currently on a six-game home winning streak.
What are Philadelphia trending bets?
PHI trend: The Phillies have a 35–37 record against the spread (ATS) this season.
What are Houston trending bets?
HOU trend: The Astros have a 6–4 record against the spread (ATS) over their past 10 games.
Where can I find AI Picks for Philadelphia vs Houston?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Philadelphia vs. Houston Odds
Remi is pouring through loads of data on each line. In fact, anytime the Philadelphia vs Houston trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.
Philadelphia vs Houston Opening Odds
PHI Moneyline:
-160 HOU Moneyline: +135
PHI Spread: -1.5
HOU Spread: +1.5
Over/Under: 7.5
Philadelphia vs Houston Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 9:08PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 9:08PM
Dodgers
Blue Jays
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–
–
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-149
+122
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-1.5 (+119)
+1.5 (-145)
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O 7 (-125)
U 7 (+103)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Philadelphia Phillies vs. Houston Astros on June 25, 2025 at Daikin Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |