Cubs vs. Cardinals
Prediction, Odds & Props
Jun 25 | MLB AI Picks

Updated: 2025-06-23T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs and St. Louis Cardinals renew their storied rivalry on Wednesday, June 25, 2025, at Busch Stadium in St. Louis, with first pitch scheduled for 7:45 p.m. CT. This midseason clash carries significant weight in the National League Central standings, as both teams vie for divisional supremacy.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 25, 2025

Start Time: 7:45 PM EST​

Venue: Busch Stadium​

Cardinals Record: (44-36)

Cubs Record: (46-33)

OPENING ODDS

CHC Moneyline: -136

STL Moneyline: +113

CHC Spread: -1.5

STL Spread: +1.5

Over/Under: 9

CHC
Betting Trends

  • The Cubs have a 38–38 record against the spread (ATS) this season.

STL
Betting Trends

  • The Cardinals have a 43–36 record against the spread (ATS) this season.

MATCHUP TRENDS

  • The Cubs have covered the spread in 5 of their last 7 road games.

CHC vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Boyd over 20.5 Fantasy Score.

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Chicago Cubs vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 6/25/25

The Chicago Cubs and St. Louis Cardinals are set to clash once again in their fierce divisional rivalry on June 25, 2025, at Busch Stadium in a game with real implications for the National League Central standings. The Cubs enter the matchup leading the division at 46–32, while the Cardinals, hot on their heels at 43–36, are looking to build on recent momentum and make up ground in the standings. Chicago has found consistency offensively, led by Seiya Suzuki’s 20 home runs and 57 RBIs, while Pete Crow-Armstrong has nearly matched his production with 19 homers and 50 RBIs. On the mound, Ben Brown’s 88 strikeouts reflect his value in the rotation, but the team’s pitching depth has been inconsistent, especially in high-leverage late-game scenarios, as shown in a lopsided 14–6 defeat against the Mariners earlier in the week. The Cubs’ road performance has improved recently, with the team covering the spread in five of their last seven away games, and their overall road record sits at a solid 22–17.

St. Louis counters with a team that has built momentum through balance and solid play at home, as the Cardinals have gone 24–15 in their own ballpark while boasting a collective team ERA of 3.93 and a WHIP of 1.26. Brendan Donovan continues to lead the club in hits with 85, and Nolan Arenado leads in home runs with 10, providing the Cardinals with a mixture of contact and power. A recent 1–4 setback to the Reds was a blemish on an otherwise strong stretch of play that included a five-game winning streak. This game could be a pivotal one in shaping the division race, with both teams bringing playoff-level intensity into the series. The Cubs will need a cleaner bullpen performance and sharper execution on the road to keep the Cardinals at bay, while St. Louis must continue leaning on their dependable pitching and capitalize on scoring opportunities against a sometimes vulnerable Cubs staff. The Cubs have split their last ten games and have been just average ATS overall (38–38), while the Cardinals have been more consistent against the spread (43–36), especially at home. Given how tightly contested the NL Central has been throughout the season, this matchup offers a measuring stick for both teams heading into the summer stretch, where depth and momentum begin to separate contenders from pretenders. With stars like Suzuki, Crow-Armstrong, and Arenado on display, expect fireworks on both sides in what should be an exciting, high-stakes battle between two historic franchises still jockeying for early supremacy in one of baseball’s most competitive divisions.

Chicago Cubs Cubs MLB Preview

The Chicago Cubs come into this matchup against the St. Louis Cardinals with a strong overall record of 46–32 and currently sit atop the National League Central, looking to tighten their grip on the division as the season nears its midpoint. Despite a tough 14–6 loss to the Mariners earlier this week, the Cubs have displayed potent offensive firepower, most notably from Seiya Suzuki, who leads the team with 20 home runs and 57 RBIs, and Pete Crow-Armstrong, who continues to impress with 19 homers and 50 RBIs of his own. Their lineup has been a well-balanced mix of veteran power and young energy, and they have shown a growing ability to manufacture runs in key moments, which has helped them stay competitive in close games. On the mound, Ben Brown has emerged as a standout contributor with 88 strikeouts and a 6–3 record, anchoring a pitching staff that, while inconsistent at times, has been serviceable enough to keep the Cubs winning more often than not.

Their bullpen, however, remains a concern, especially after allowing a large number of runs in their most recent blowout loss, suggesting that late-inning stability could be a deciding factor in upcoming games. On the road, the Cubs have been effective, posting a 22–17 record away from Wrigley Field and covering the spread in five of their last seven away contests, indicating resilience in hostile environments. Their 38–38 record ATS for the season suggests they’ve been a fairly neutral bet overall, but their recent road trend is a positive sign heading into this critical division matchup. Manager Craig Counsell will be relying on his hitters to set the tone early, especially with Suzuki and Crow-Armstrong leading the offensive charge, while also hoping for a bounce-back pitching performance from his rotation and bullpen. This series against St. Louis is more than just another set of games—it’s a chance for the Cubs to maintain their position atop a tightly contested division and send a message that they’re the team to beat in the Central. With key divisional games like this, execution in all phases—starting pitching, timely hitting, and bullpen reliability—becomes crucial, and the Cubs will need to play with both urgency and precision to fend off a surging Cardinals squad. If they can manage to tighten their defense and hold their composure in high-leverage spots, the Cubs have the talent to come out of this series with an even firmer grip on first place and a psychological edge over a familiar rival.

The Chicago Cubs and St. Louis Cardinals renew their storied rivalry on Wednesday, June 25, 2025, at Busch Stadium in St. Louis, with first pitch scheduled for 7:45 p.m. CT. This midseason clash carries significant weight in the National League Central standings, as both teams vie for divisional supremacy. Chicago Cubs vs St. Louis AI Prediction: Free MLB Betting Insights for Jun 25. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals return to Busch Stadium looking to continue their recent surge as they prepare to host the division-leading Chicago Cubs in a pivotal National League Central showdown. Entering this matchup with a 40–37 record, the Cardinals have gained valuable momentum, winning six of their last ten games and steadily climbing in the standings as the race tightens in the Central. Nolan Gorman has been the biggest story for St. Louis lately, leading the team with 18 home runs and 44 RBIs, while Masyn Winn provides a steady on-base presence with a team-high .303 batting average and 42 runs scored. The lineup has started to click as a unit, showing more consistency in putting together scoring innings, and Paul Goldschmidt’s veteran leadership remains a stabilizing factor, even as his numbers dip slightly from previous years. On the mound, Lance Lynn and Sonny Gray have been key to the recent turnaround, combining for over 160 strikeouts and providing the type of veteran presence that keeps games close. Gray, with a 3.52 ERA, has shown he can be counted on in big moments, and if the bullpen can hold firm, the Cardinals could be primed to take a few games off their division rivals.

At home, St. Louis has played solid baseball, sporting a 20–15 record and showing a knack for late-game dramatics and walk-off wins, making Busch Stadium a tough environment for opponents. Their 39–38 mark against the spread reflects a team that is competitive, though sometimes unpredictable, but their recent 4–2 ATS stretch at home suggests they’ve been finding ways to outperform betting expectations. Manager Oliver Marmol has emphasized fundamentals and better situational hitting, and the team’s improved defensive execution has limited big innings by opponents—a crucial component when facing a powerful Cubs lineup. The Cardinals know that this series carries more than just statistical weight; it’s a statement opportunity against their longtime rival, with playoff implications already looming over every divisional matchup. To win, St. Louis will need continued production from the heart of the order, smart baserunning, and clean defensive innings, particularly in the later stages when bullpen management becomes a chess match. The fans in St. Louis will be loud and energized, knowing what’s at stake, and that home-field edge could provide the final boost in what promises to be a tightly contested series. If the Cardinals can continue to build on their recent momentum and play up to their potential in all facets of the game, they could walk away from this series not just with wins, but with a renewed belief that they are legitimate contenders to dethrone the Cubs atop the division.

Chicago Cubs vs. St. Louis Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each team. In fact, anytime the Cubs and Cardinals play there’s always several intriguing angles to key in on. Not to mention games played at Busch Stadium in Jun can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Boyd over 20.5 Fantasy Score.

Chicago Cubs vs. St. Louis Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every past game between the Cubs and Cardinals and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Remi has been most focused on the linear correlation of emphasis emotional bettors regularly put on Chicago Cubs’s strength factors between a Cubs team going up against a possibly deflated Cardinals team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago Cubs vs St. Louis picks, computer picks Cubs vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
ACTIVE PICKS LOCKED - SEE NOW

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

The Cubs have a 38–38 record against the spread (ATS) this season.

Cardinals Betting Trends

The Cardinals have a 43–36 record against the spread (ATS) this season.

Cubs vs. Cardinals Matchup Trends

The Cubs have covered the spread in 5 of their last 7 road games.

Chicago Cubs vs. St. Louis Game Info

Chicago Cubs vs St. Louis starts on June 25, 2025 at 7:45 PM EST.

Spread: St. Louis +1.5
Moneyline: Chicago Cubs -136, St. Louis +113
Over/Under: 9

Chicago Cubs: (46-33)  |  St. Louis: (44-36)

Remi's searched hard and found the best prop for this matchup: M. Boyd over 20.5 Fantasy Score.. Prices move—always shop for the best number.

The Cubs have covered the spread in 5 of their last 7 road games.

CHC trend: The Cubs have a 38–38 record against the spread (ATS) this season.

STL trend: The Cardinals have a 43–36 record against the spread (ATS) this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago Cubs vs. St. Louis Odds

AI algorithm Remi is pouring through mountains of data points on each line. In fact, anytime the Chicago Cubs vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable betting trends.

Chicago Cubs vs St. Louis Opening Odds

CHC Moneyline: -136
STL Moneyline: +113
CHC Spread: -1.5
STL Spread: +1.5
Over/Under: 9

Chicago Cubs vs St. Louis Live Odds

Games PTS ML SPR O/U
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Philadelphia Phillies
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5
0
-375
+260
-4.5 (+265)
+4.5 (-375)
O 5.5 (-115)
U 5.5 (-115)
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Cincinnati Reds
Milwaukee Brewers
In Progress
Reds
Brewers
6
1
-850
+510
-4.5 (+105)
+4.5 (-140)
O 13.5 (+105)
U 13.5 (-140)
In Progress
Texas Rangers
Cleveland Guardians
In Progress
Rangers
Guardians
2
2
+125
-165
+1.5 (-300)
-1.5 (+215)
O 7.5 (+110)
U 7.5 (-145)
In Progress
Pittsburgh Pirates
Atlanta Braves
In Progress
Pirates
Braves
1
1
+120
-160
+1.5 (-245)
-1.5 (+180)
O 6.5 (-110)
U 6.5 (-120)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+130
-155
+1.5 (-170)
-1.5 (+140)
O 7.5 (-105)
U 7.5 (-115)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+120
-1.5 (+115)
+1.5 (-140)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-200)
-1.5 (+165)
O 7 (+100)
U 7 (-120)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+155)
+1.5 (-190)
O 10 (-115)
U 10 (-105)
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+140
-170
+1.5 (-125)
-1.5 (+105)
O 9.5 (+100)
U 9.5 (-120)
Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
+240
-300
+1.5 (+115)
-1.5 (-140)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
+165
-200
+1.5 (-120)
-1.5 (+100)
O 8.5 (+100)
U 8.5 (-120)
Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
-105
-115
-1.5 (+155)
+1.5 (-190)
O 8.5 (-120)
U 8.5 (+100)
Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
+160
-195
+1.5 (-120)
-1.5 (+100)
O 8 (-105)
U 8 (-115)
Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
-110
-110
-1.5 (+155)
+1.5 (-190)
O 8.5 (+100)
U 8.5 (-120)
Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
+130
-155
+1.5 (-150)
-1.5 (+125)
O 7.5 (-110)
U 7.5 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs Cubs vs. St. Louis Cardinals on June 25, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS