Mariners vs Cubs Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 22)
Updated: 2025-06-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Seattle Mariners (38–36) visit Wrigley Field to take on the Chicago Cubs (45–28) on June 22, 2025, in the final game of their weekend series. Chicago is a modest favorite, with the total around 9 runs—setting the stage for a balanced contest between offensive potential and pitching strength.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 22, 2025
Start Time: 2:20 PM EST
Venue: Wrigley Field
Cubs Record: (46-30)
Mariners Record: (38-37)
OPENING ODDS
SEA Moneyline: -114
CHC Moneyline: -105
SEA Spread: -1.5
CHC Spread: +1.5
Over/Under: 11.5
SEA
Betting Trends
- The Mariners are 31–41 ATS this season and have gone 4–6 ATS in their last ten road games, reflecting a team that’s hovered around .500 both SU and against the spread.
CHC
Betting Trends
- Chicago has a strong 35–34 ATS record this year and is 6–6 ATS over its last twelve games, showing consistency in covering expectations as favorites at Wrigley Field.
MATCHUP TRENDS
- Series history and venue trends favor low-scoring affairs: Cubs have won 8 of 11 matchups at home and 10 of 13 head-to-head overall. Additionally, recent Mariners–Cubs games have leaned under, and both teams’ recent games show moderate scoring, making the under on 9 a compelling angle.
SEA vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Kelly under 5.5 Fantasy Score.
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Seattle vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 6/22/25
Their offense has been heavily dependent on power, particularly from catcher Cal Raleigh, and while rookies like Cole Young and Ben Williamson have started to find their footing, the lineup remains prone to strikeouts and missed opportunities with runners in scoring position. Both teams’ recent totals have hovered near the betting line of 9, with the Cubs’ pitching tending to suppress big innings and the Mariners’ inconsistency lending itself to mixed scoring results, although Seattle’s recent games have skewed over more often. From a betting angle, the Cubs are 35–34 ATS and have covered in six of their last twelve contests, a reflection of their ability to handle expectations, especially when favored at home, while Seattle sits at 31–41 ATS and has covered just four times in their last ten road games, underscoring their volatility as underdogs. Defensively, the Cubs have the clear advantage, committing fewer errors and executing in tight spots with poise, whereas the Mariners have been prone to lapses that extend innings and cost runs. If Gilbert can provide length and the Mariners manage to jump on Rea early, they have the pieces to keep the game close, but if the Cubs strike first and settle into their offensive rhythm, the game could easily tilt their way by the middle innings. Ultimately, Chicago’s depth, home-field comfort, and current momentum suggest a 5–3 or 6–4 outcome in their favor, barring an unexpectedly dominant performance from Gilbert and a surge from Seattle’s streaky offense. This matchup promises competitive baseball with playoff implications for the Cubs and urgency for the Mariners, and both teams will look to close the series strong with postseason positioning in mind.
Logan Gilbert gets the start in tomorrow's rubber match. pic.twitter.com/mikh7ZQEsO
— Seattle Mariners (@Mariners) June 21, 2025
Seattle Mariners MLB Preview
The Seattle Mariners head into Sunday’s series finale against the Chicago Cubs hoping to reverse their troubling road trajectory and avoid another missed opportunity in a season that has thus far lacked offensive consistency and depth from their starting rotation. The team has fallen to 38–36 after enduring a stretch of seven losses in their last eight road games, a slide that has been particularly frustrating given the talent present in the lineup and the flashes of dominance shown by their pitching staff when healthy. Logan Gilbert is expected to make his return from a minor injury and start Sunday’s contest, bringing a strong 2.55 ERA and excellent command numbers to the mound, which could prove pivotal in neutralizing a potent Cubs offense if he can settle in early and establish his fastball. Seattle’s bullpen, although talented, has been heavily used during this stretch and may be tested again if Gilbert cannot go deep into the game, making it critical that the Mariners minimize early-inning damage and avoid high-leverage scenarios before the sixth. Offensively, Seattle continues to lean heavily on Cal Raleigh, whose power from the catcher spot has been a rare constant in an otherwise streaky lineup that has failed to consistently string together quality at-bats.
The Mariners have seen modest contributions from younger players like Cole Young and Ben Williamson, but the lack of timely hitting and poor numbers with runners in scoring position have haunted them all season, particularly on the road where pressure mounts quickly. Their 31–41 ATS record and 4–6 mark in their last ten road games reflect those struggles, often coming up just short of covering spreads due to late-game breakdowns or offensive droughts. The team’s path to success on Sunday will likely involve aggressive early plate appearances against Colin Rea, trying to get into the Cubs’ bullpen by the fourth or fifth inning, and using their speed and athleticism to create chaos on the basepaths, something that has worked in spurts this season when the top of the order gets on. If Gilbert can limit the Cubs to one or two early runs and the Mariners can capitalize on one or two big swings—likely from Raleigh or a fastball-sitting J.P. Crawford—then they could find themselves in a position to steal a 5–4 or 4–3 win late. However, given their form and offensive imbalance, it will require a near-perfect pitching performance and clutch hitting in key spots, something that has eluded them often during this difficult road stretch. Still, with Gilbert on the hill and the potential for power in their lineup, the Mariners remain a dangerous underdog capable of punching above their weight if they can execute cleanly and capitalize on early opportunities against a Cubs team that has dominated at home this season.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Chicago Cubs enter Sunday’s finale against the Seattle Mariners at Wrigley Field with momentum firmly on their side, holding a 45–28 record and aiming to finish off the series strong behind right-hander Colin Rea, who has found a groove in recent starts and offers solid mid-rotation stability with improved fastball command and sequencing. Rea, who’s emerged as a dependable option while the rotation endures some injury absences, will be backed by one of the most complete and dynamic lineups in the National League, featuring Seiya Suzuki’s high contact rate, Kyle Tucker’s power and OBP skills, and Pete Crow-Armstrong’s blend of speed and situational hitting, all contributing to a Cubs offense that has punished mediocre pitching and excelled in tight late-game situations. The Cubs’ defense has been steady, especially on the infield where Nico Hoerner and Dansby Swanson continue to turn key double plays and limit big innings, while the bullpen—anchored by a committee of effective arms—has been a quiet strength, rarely blowing leads and often shutting the door when handed a late advantage. From a betting standpoint, Chicago enters this matchup with a 35–34 ATS record overall, having gone 6–6 ATS over their last twelve games, suggesting dependable performance without being overvalued by the market, especially at home where they’ve covered more consistently than on the road.
The Cubs have dominated Seattle at Wrigley in recent years, winning eight of the last eleven meetings there, and their game plan should once again emphasize patience at the plate, driving pitch counts against Logan Gilbert, and pressuring Seattle’s bullpen early to tilt the leverage in their favor by the middle innings. Even if Gilbert performs well early, the Cubs’ ability to work deep counts and produce clutch two-out RBIs makes them dangerous every time through the order, and their overall balance between lefty and righty bats allows manager Craig Counsell to adapt fluidly depending on the situation. With Wrigley expected to favor pitchers due to cooler June winds and Gilbert’s ground-ball tendencies, the Cubs may lean on contact hitting and aggressive base running to generate runs, rather than relying on the long ball as they sometimes do on the road. If Rea can provide five or six strong innings and limit the Mariners’ power threats like Cal Raleigh and J.P. Crawford, the Cubs’ deeper lineup and superior bullpen give them a clear path to a 5–3 or 4–2 victory, especially with their home-field advantage and track record of execution in close games. The key will be early offense and clean defensive play, both of which Chicago has delivered consistently this month, and if they continue to dictate the pace and protect leads late, the Cubs will have positioned themselves perfectly to secure another series win and keep building momentum toward the All-Star break.
— Chicago Cubs (@Cubs) June 21, 2025
Seattle vs. Chicago Cubs Prop Picks (AI)
Seattle vs. Chicago Cubs Prediction (AI)

Remi, our AI sports genius, has been pouring over mountains of data from every angle between the Mariners and Cubs and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the unproportionally assigned weight human bettors regularly put on player performance factors between a Mariners team going up against a possibly deflated Cubs team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Seattle vs Chicago Cubs picks, computer picks Mariners vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Mariners Betting Trends
The Mariners are 31–41 ATS this season and have gone 4–6 ATS in their last ten road games, reflecting a team that’s hovered around .500 both SU and against the spread.
Cubs Betting Trends
Chicago has a strong 35–34 ATS record this year and is 6–6 ATS over its last twelve games, showing consistency in covering expectations as favorites at Wrigley Field.
Mariners vs. Cubs Matchup Trends
Series history and venue trends favor low-scoring affairs: Cubs have won 8 of 11 matchups at home and 10 of 13 head-to-head overall. Additionally, recent Mariners–Cubs games have leaned under, and both teams’ recent games show moderate scoring, making the under on 9 a compelling angle.
Seattle vs. Chicago Cubs Game Info
What time does Seattle vs Chicago Cubs start on June 22, 2025?
Seattle vs Chicago Cubs starts on June 22, 2025 at 2:20 PM EST.
Where is Seattle vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for Seattle vs Chicago Cubs?
Spread: Chicago Cubs +1.5
Moneyline: Seattle -114, Chicago Cubs -105
Over/Under: 11.5
What are the records for Seattle vs Chicago Cubs?
Seattle: (38-37) | Chicago Cubs: (46-30)
What is the AI best bet for Seattle vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: C. Kelly under 5.5 Fantasy Score.. Prices move—always shop for the best number.
What are Seattle vs Chicago Cubs trending bets?
Series history and venue trends favor low-scoring affairs: Cubs have won 8 of 11 matchups at home and 10 of 13 head-to-head overall. Additionally, recent Mariners–Cubs games have leaned under, and both teams’ recent games show moderate scoring, making the under on 9 a compelling angle.
What are Seattle trending bets?
SEA trend: The Mariners are 31–41 ATS this season and have gone 4–6 ATS in their last ten road games, reflecting a team that’s hovered around .500 both SU and against the spread.
What are Chicago Cubs trending bets?
CHC trend: Chicago has a strong 35–34 ATS record this year and is 6–6 ATS over its last twelve games, showing consistency in covering expectations as favorites at Wrigley Field.
Where can I find AI Picks for Seattle vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Seattle vs. Chicago Cubs Odds
AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Seattle vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.
Seattle vs Chicago Cubs Opening Odds
SEA Moneyline:
-114 CHC Moneyline: -105
SEA Spread: -1.5
CHC Spread: +1.5
Over/Under: 11.5
Seattle vs Chicago Cubs Live Odds
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Seattle Mariners
Toronto Blue Jays
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Blue Jays
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O 7.5 (+126)
U 7.5 (-168)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Seattle Mariners vs. Chicago Cubs Cubs on June 22, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |