Mariners vs Cubs Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 22)

Updated: 2025-06-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Seattle Mariners (38–36) visit Wrigley Field to take on the Chicago Cubs (45–28) on June 22, 2025, in the final game of their weekend series. Chicago is a modest favorite, with the total around 9 runs—setting the stage for a balanced contest between offensive potential and pitching strength.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 22, 2025

Start Time: 2:20 PM EST​

Venue: Wrigley Field​

Cubs Record: (46-30)

Mariners Record: (38-37)

OPENING ODDS

SEA Moneyline: -114

CHC Moneyline: -105

SEA Spread: -1.5

CHC Spread: +1.5

Over/Under: 11.5

SEA
Betting Trends

  • The Mariners are 31–41 ATS this season and have gone 4–6 ATS in their last ten road games, reflecting a team that’s hovered around .500 both SU and against the spread.

CHC
Betting Trends

  • Chicago has a strong 35–34 ATS record this year and is 6–6 ATS over its last twelve games, showing consistency in covering expectations as favorites at Wrigley Field.

MATCHUP TRENDS

  • Series history and venue trends favor low-scoring affairs: Cubs have won 8 of 11 matchups at home and 10 of 13 head-to-head overall. Additionally, recent Mariners–Cubs games have leaned under, and both teams’ recent games show moderate scoring, making the under on 9 a compelling angle.

SEA vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Kelly under 5.5 Fantasy Score.

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Seattle vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 6/22/25

Sunday’s finale between the Seattle Mariners and the Chicago Cubs at Wrigley Field brings together two clubs at different junctures of their season, with the Cubs riding high atop the NL Central and the Mariners still battling to find consistency as they linger near the .500 mark. The Cubs have won eight of their last eleven meetings against Seattle at Wrigley and currently own a commanding 45–28 record thanks to a combination of a deep lineup and strong pitching performances, including quality outings from starters like Colin Rea, who is expected to take the mound in this matchup. Rea has been effective in his recent starts, mixing velocity and control well, and benefits from excellent run support led by Kyle Tucker, Seiya Suzuki, and Pete Crow-Armstrong, who have powered the Cubs to one of the most balanced offenses in the National League. The Mariners, meanwhile, are likely to send Logan Gilbert to the mound, a right-hander with a stellar 2.55 ERA who returns from a short stint on the injured list and brings an elite strikeout-to-walk ratio that could keep Chicago’s bats at bay if he regains command quickly. However, Seattle has struggled on the road, dropping seven of their last eight away games and going just 3–15 in their last 18 road contests, which highlights their inability to maintain offensive momentum or shut down opponents consistently in hostile environments.

Their offense has been heavily dependent on power, particularly from catcher Cal Raleigh, and while rookies like Cole Young and Ben Williamson have started to find their footing, the lineup remains prone to strikeouts and missed opportunities with runners in scoring position. Both teams’ recent totals have hovered near the betting line of 9, with the Cubs’ pitching tending to suppress big innings and the Mariners’ inconsistency lending itself to mixed scoring results, although Seattle’s recent games have skewed over more often. From a betting angle, the Cubs are 35–34 ATS and have covered in six of their last twelve contests, a reflection of their ability to handle expectations, especially when favored at home, while Seattle sits at 31–41 ATS and has covered just four times in their last ten road games, underscoring their volatility as underdogs. Defensively, the Cubs have the clear advantage, committing fewer errors and executing in tight spots with poise, whereas the Mariners have been prone to lapses that extend innings and cost runs. If Gilbert can provide length and the Mariners manage to jump on Rea early, they have the pieces to keep the game close, but if the Cubs strike first and settle into their offensive rhythm, the game could easily tilt their way by the middle innings. Ultimately, Chicago’s depth, home-field comfort, and current momentum suggest a 5–3 or 6–4 outcome in their favor, barring an unexpectedly dominant performance from Gilbert and a surge from Seattle’s streaky offense. This matchup promises competitive baseball with playoff implications for the Cubs and urgency for the Mariners, and both teams will look to close the series strong with postseason positioning in mind.

Seattle Mariners MLB Preview

The Seattle Mariners head into Sunday’s series finale against the Chicago Cubs hoping to reverse their troubling road trajectory and avoid another missed opportunity in a season that has thus far lacked offensive consistency and depth from their starting rotation. The team has fallen to 38–36 after enduring a stretch of seven losses in their last eight road games, a slide that has been particularly frustrating given the talent present in the lineup and the flashes of dominance shown by their pitching staff when healthy. Logan Gilbert is expected to make his return from a minor injury and start Sunday’s contest, bringing a strong 2.55 ERA and excellent command numbers to the mound, which could prove pivotal in neutralizing a potent Cubs offense if he can settle in early and establish his fastball. Seattle’s bullpen, although talented, has been heavily used during this stretch and may be tested again if Gilbert cannot go deep into the game, making it critical that the Mariners minimize early-inning damage and avoid high-leverage scenarios before the sixth. Offensively, Seattle continues to lean heavily on Cal Raleigh, whose power from the catcher spot has been a rare constant in an otherwise streaky lineup that has failed to consistently string together quality at-bats.

The Mariners have seen modest contributions from younger players like Cole Young and Ben Williamson, but the lack of timely hitting and poor numbers with runners in scoring position have haunted them all season, particularly on the road where pressure mounts quickly. Their 31–41 ATS record and 4–6 mark in their last ten road games reflect those struggles, often coming up just short of covering spreads due to late-game breakdowns or offensive droughts. The team’s path to success on Sunday will likely involve aggressive early plate appearances against Colin Rea, trying to get into the Cubs’ bullpen by the fourth or fifth inning, and using their speed and athleticism to create chaos on the basepaths, something that has worked in spurts this season when the top of the order gets on. If Gilbert can limit the Cubs to one or two early runs and the Mariners can capitalize on one or two big swings—likely from Raleigh or a fastball-sitting J.P. Crawford—then they could find themselves in a position to steal a 5–4 or 4–3 win late. However, given their form and offensive imbalance, it will require a near-perfect pitching performance and clutch hitting in key spots, something that has eluded them often during this difficult road stretch. Still, with Gilbert on the hill and the potential for power in their lineup, the Mariners remain a dangerous underdog capable of punching above their weight if they can execute cleanly and capitalize on early opportunities against a Cubs team that has dominated at home this season.

The Seattle Mariners (38–36) visit Wrigley Field to take on the Chicago Cubs (45–28) on June 22, 2025, in the final game of their weekend series. Chicago is a modest favorite, with the total around 9 runs—setting the stage for a balanced contest between offensive potential and pitching strength. Seattle vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Jun 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs enter Sunday’s finale against the Seattle Mariners at Wrigley Field with momentum firmly on their side, holding a 45–28 record and aiming to finish off the series strong behind right-hander Colin Rea, who has found a groove in recent starts and offers solid mid-rotation stability with improved fastball command and sequencing. Rea, who’s emerged as a dependable option while the rotation endures some injury absences, will be backed by one of the most complete and dynamic lineups in the National League, featuring Seiya Suzuki’s high contact rate, Kyle Tucker’s power and OBP skills, and Pete Crow-Armstrong’s blend of speed and situational hitting, all contributing to a Cubs offense that has punished mediocre pitching and excelled in tight late-game situations. The Cubs’ defense has been steady, especially on the infield where Nico Hoerner and Dansby Swanson continue to turn key double plays and limit big innings, while the bullpen—anchored by a committee of effective arms—has been a quiet strength, rarely blowing leads and often shutting the door when handed a late advantage. From a betting standpoint, Chicago enters this matchup with a 35–34 ATS record overall, having gone 6–6 ATS over their last twelve games, suggesting dependable performance without being overvalued by the market, especially at home where they’ve covered more consistently than on the road.

The Cubs have dominated Seattle at Wrigley in recent years, winning eight of the last eleven meetings there, and their game plan should once again emphasize patience at the plate, driving pitch counts against Logan Gilbert, and pressuring Seattle’s bullpen early to tilt the leverage in their favor by the middle innings. Even if Gilbert performs well early, the Cubs’ ability to work deep counts and produce clutch two-out RBIs makes them dangerous every time through the order, and their overall balance between lefty and righty bats allows manager Craig Counsell to adapt fluidly depending on the situation. With Wrigley expected to favor pitchers due to cooler June winds and Gilbert’s ground-ball tendencies, the Cubs may lean on contact hitting and aggressive base running to generate runs, rather than relying on the long ball as they sometimes do on the road. If Rea can provide five or six strong innings and limit the Mariners’ power threats like Cal Raleigh and J.P. Crawford, the Cubs’ deeper lineup and superior bullpen give them a clear path to a 5–3 or 4–2 victory, especially with their home-field advantage and track record of execution in close games. The key will be early offense and clean defensive play, both of which Chicago has delivered consistently this month, and if they continue to dictate the pace and protect leads late, the Cubs will have positioned themselves perfectly to secure another series win and keep building momentum toward the All-Star break.

Seattle vs. Chicago Cubs Prop Picks (AI)

Remi is pouring through tons of datapoints on each player. In fact, anytime the Mariners and Cubs play there’s always several intriguing observations to key in on. Not to mention games played at Wrigley Field in Jun can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: C. Kelly under 5.5 Fantasy Score.

Seattle vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every angle between the Mariners and Cubs and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the unproportionally assigned weight human bettors regularly put on player performance factors between a Mariners team going up against a possibly deflated Cubs team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line in particular.

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Below is our current AI Seattle vs Chicago Cubs picks, computer picks Mariners vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 2 INTEL Locked INTEL
MLB 10/20 SEA@TOR UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Mariners Betting Trends

The Mariners are 31–41 ATS this season and have gone 4–6 ATS in their last ten road games, reflecting a team that’s hovered around .500 both SU and against the spread.

Cubs Betting Trends

Chicago has a strong 35–34 ATS record this year and is 6–6 ATS over its last twelve games, showing consistency in covering expectations as favorites at Wrigley Field.

Mariners vs. Cubs Matchup Trends

Series history and venue trends favor low-scoring affairs: Cubs have won 8 of 11 matchups at home and 10 of 13 head-to-head overall. Additionally, recent Mariners–Cubs games have leaned under, and both teams’ recent games show moderate scoring, making the under on 9 a compelling angle.

Seattle vs. Chicago Cubs Game Info

Seattle vs Chicago Cubs starts on June 22, 2025 at 2:20 PM EST.

Spread: Chicago Cubs +1.5
Moneyline: Seattle -114, Chicago Cubs -105
Over/Under: 11.5

Seattle: (38-37)  |  Chicago Cubs: (46-30)

Remi's searched hard and found the best prop for this matchup: C. Kelly under 5.5 Fantasy Score.. Prices move—always shop for the best number.

Series history and venue trends favor low-scoring affairs: Cubs have won 8 of 11 matchups at home and 10 of 13 head-to-head overall. Additionally, recent Mariners–Cubs games have leaned under, and both teams’ recent games show moderate scoring, making the under on 9 a compelling angle.

SEA trend: The Mariners are 31–41 ATS this season and have gone 4–6 ATS in their last ten road games, reflecting a team that’s hovered around .500 both SU and against the spread.

CHC trend: Chicago has a strong 35–34 ATS record this year and is 6–6 ATS over its last twelve games, showing consistency in covering expectations as favorites at Wrigley Field.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. Chicago Cubs Odds

AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Seattle vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

Seattle vs Chicago Cubs Opening Odds

SEA Moneyline: -114
CHC Moneyline: -105
SEA Spread: -1.5
CHC Spread: +1.5
Over/Under: 11.5

Seattle vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
In Progress
Seattle Mariners
Toronto Blue Jays
In Progress
Mariners
Blue Jays
3
1
-480
+330
-1.5 (-194)
+1.5 (+144)
O 7.5 (+126)
U 7.5 (-168)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. Chicago Cubs Cubs on June 22, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN