Royals vs. Padres
Prediction, Odds & Props
Jun 22 | MLB AI Picks

Updated: 2025-06-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Kansas City Royals (38–38) take on the San Diego Padres (40–35) at Petco Park on Sunday, June 22, 2025. San Diego enters as a slight underdog (+105 ML, +1.5 run line), while the Royals are slight favorites (–114 ML, –1.5 RL), and the total sits at 8.5 runs—suggesting a competitive, mid-range scoring affair.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 22, 2025

Start Time: 4:10 PM EST​

Venue: Petco Park​

Padres Record: (41-35)

Royals Record: (38-39)

OPENING ODDS

KC Moneyline: -114

SD Moneyline: -105

KC Spread: -1.5

SD Spread: +1.5

Over/Under: 8.5

KC
Betting Trends

  • Kansas City has gone 5–5 ATS over their last ten games and is 14–16 as moneyline favorites of –114 or shorter. They’ve covered in 7 of 10 games when favored, showing a solid performance under pressure.

SD
Betting Trends

  • San Diego, at 17–20 when underdogs this season, has shown resilience but remains just below .500 ATS. They won 5 of 10 games as home underdogs and have covered a few times in close-picture contests.

MATCHUP TRENDS

  • Four of the Royals’ last ten games have gone over the total, indicating a balanced scoring trend. The Padres and Royals have veered under recently, making the mid‑8.5 total intriguing for swing-driven gameplay.

KC vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Caglianone over 0.5 Total Bases.

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Kansas City vs San Diego Prediction & Odds:
Free MLB Betting Insights for 6/22/25

Sunday’s matchup between the Kansas City Royals and the San Diego Padres at Petco Park brings together two teams hovering around playoff contention, each hoping to close the series with momentum heading into the final week of June. The Royals enter the game sitting at 38–38, riding a wave of inconsistency that’s seen them flash both resilience and regression over the past two weeks, while the Padres come in slightly better at 40–35, still searching for identity amid a turbulent rotation and uneven offensive output. Kansas City sends Seth Lugo to the mound in what was originally supposed to be Cole Ragans’ turn in the rotation, but Ragans has been placed on the IL with shoulder inflammation, forcing the Royals to dig into their depth to stay competitive. Lugo, who has experience in both starting and relief roles, faces the challenge of navigating a Padres lineup that mixes pop and patience with the likes of Manny Machado, Fernando Tatis Jr., and Jake Cronenworth, all of whom have driven in key runs in recent games. Meanwhile, San Diego counters with Randy Vásquez, a mid-rotation right-hander who’s been solid if unspectacular, posting a 3.70 ERA with decent command and an ability to induce weak contact when ahead in the count.

Offensively, Kansas City leans heavily on Bobby Witt Jr., who continues to make a strong All-Star case, batting over .290 with power and speed, while Salvador Pérez adds clutch hitting and leadership from behind the plate. San Diego’s advantage may come late in the game, as their bullpen, anchored by closer Robert Suárez and set-up man Jason Adam, has shown the ability to shut opponents down in high-leverage situations. The Royals bullpen, though serviceable, has been prone to mid-inning lapses that could haunt them if Lugo exits early and the Padres find themselves in scoring position often. ATS trends show Kansas City slightly better when listed as a slight favorite, having covered in seven of ten such recent spots, while San Diego, as a small home underdog, has gone 5–5 in their last ten, performing just below break-even. The run total is set at 8.5, and with both pitchers capable of limiting damage early but vulnerable when fatigued, the scoring could hinge on one or two innings where base hits stack up quickly. Petco Park’s pitcher-friendly conditions may keep the power down, shifting the focus to situational execution—bunting, sac flies, and clutch two-out singles could be the difference. Expect a tight contest with both teams struggling to create separation until the later innings, and the bullpen edge likely tilting the game in San Diego’s favor if they hold serve. A final score of 5–4 in favor of the Padres or a 4–3 Royals victory both feel plausible depending on early command and mid-game management, making this one of Sunday’s more nuanced and tactical MLB matchups with significant implications for both team trajectories.

Kansas City Royals MLB Preview

The Kansas City Royals approach Sunday’s game at Petco Park looking to regain momentum and push above the .500 mark after an uneven stretch that has highlighted both their promise and growing pains. Sitting at 38–38, the Royals continue to rely heavily on young cornerstone Bobby Witt Jr., whose blend of power, speed, and defensive excellence has made him one of the most exciting players in the American League. Witt enters Sunday batting just above .290 with 15 home runs and 20 stolen bases, a true engine atop a lineup that also includes veteran backstop Salvador Pérez, still producing at the plate with clutch RBIs, and middle infielder Jonathan India, whose plate discipline and occasional pop add balance in the middle innings. With Cole Ragans sidelined due to a shoulder issue, Kansas City turns to Seth Lugo, a reliable swingman with a track record of stepping into pressure spots, though his command can waver against patient lineups. Lugo’s ability to mix speeds and avoid the long ball will be tested in Petco’s deep dimensions, where line drives and hustle doubles become more frequent scoring threats.

Offensively, the Royals have had success generating runs through small ball and contact hitting, ranking among the league leaders in advancing runners and producing with two outs, but they’ve struggled when relying on home runs to carry the offense. The bullpen remains a key variable, especially with mid-relievers often tasked with bridging gaps earlier than desired, and manager Matt Quatraro has been aggressive with matchups to avoid late collapses. ATS-wise, Kansas City has gone 5–5 in its last ten overall and tends to cover when listed as narrow favorites, which they are here at –114, suggesting oddsmakers believe in their ability to hang with a comparable roster. Against the Padres, the Royals will aim to score early off Randy Vásquez, who’s shown flashes of promise but is still vulnerable to patient lineups that can foul off pitches and force mistakes. Witt Jr. and Pérez will be the primary catalysts for run creation, but Kansas City will need contributions from their bottom third to manufacture enough offense to keep pace. If Lugo delivers a solid five-inning start and the bullpen avoids issuing free passes, the Royals have a path to a low-scoring, one-run victory. A 4–3 or 5–4 win isn’t out of the question if the team stays clean defensively and remains aggressive on the basepaths, exploiting the Padres’ occasional lapses in catcher pop times and corner coverage. For Kansas City, Sunday’s contest is not just another game—it’s a chance to make a statement that they’re more than a .500 team coasting through the middle of the season, and that starts with their best players setting the tone from the first pitch onward.

The Kansas City Royals (38–38) take on the San Diego Padres (40–35) at Petco Park on Sunday, June 22, 2025. San Diego enters as a slight underdog (+105 ML, +1.5 run line), while the Royals are slight favorites (–114 ML, –1.5 RL), and the total sits at 8.5 runs—suggesting a competitive, mid-range scoring affair. Kansas City vs San Diego AI Prediction: Free MLB Betting Insights for Jun 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres enter Sunday’s matchup against the Kansas City Royals looking to solidify their hold on a National League Wild Card position while continuing to build momentum in what has been a streaky but promising season. At 40–35, the Padres have hovered above .500 thanks to timely hitting, resilient pitching performances, and a bullpen that has come through in late-game scenarios more often than not. They’ll send Randy Vásquez to the mound in this one, a right-hander who has started to find his rhythm in the rotation amid the continued absences of Yu Darvish and Joe Musgrove. Vásquez, armed with a mid-90s fastball and a sharp curve, has posted a 3.70 ERA this season and has shown improved poise in recent starts, especially when working with a lead. San Diego’s lineup continues to be anchored by Fernando Tatis Jr. and Manny Machado, with Tatis providing power and speed at the top and Machado offering consistency and veteran savvy in run-producing spots. Jake Cronenworth has also contributed with key hits, and Luis Campusano has offered a solid bat from behind the plate. While the Padres’ offense can occasionally run cold when overly reliant on home runs, they’ve fared better at Petco Park when they embrace a contact-oriented approach that keeps pressure on opposing defenses.

One of their biggest assets has been their bullpen, which features Robert Suárez closing games and Jason Adam setting up late innings with high-leverage precision. The unit has a collective ERA under 3.50 at home and has been instrumental in preserving narrow leads, especially in games with lower run totals. ATS-wise, the Padres have gone 5–5 in their last ten games and have been slightly below .500 as home underdogs this season, though they’ve covered frequently in games decided by two runs or fewer. Facing a Royals team with a vulnerable bullpen and a fill-in starter in Seth Lugo, the Padres will look to work deep counts early, forcing Lugo into long innings and attacking the Kansas City pen by the fifth or sixth frame. With Machado and Tatis setting the tone, San Diego could manufacture an early lead and then turn the game over to their dominant relief corps to close it out. Defensively, the Padres have been reliable, ranking in the top third of the league in fielding percentage and double plays turned, which could be critical in preventing the Royals from extending innings with speed or situational bunts. A 5–3 or 6–4 win is within reach if Vásquez delivers five solid frames and the bats generate timely offense against a Royals team still trying to piece together pitching consistency. Sunday’s game represents an opportunity for San Diego to finish the series with confidence, sharpen their execution against a comparable opponent, and position themselves for a strong finish to June.

Kansas City vs. San Diego Prop Picks (AI)

Remi is pouring through mountains of data on each team. In fact, anytime the Royals and Padres play there’s always several intriguing angles to key in on. Not to mention games played at Petco Park in Jun rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Caglianone over 0.5 Total Bases.

Kansas City vs. San Diego Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Royals and Padres and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

Interestingly enough, the data has been most watching on the linear correlation of factor emotional bettors tend to put on player performance factors between a Royals team going up against a possibly unhealthy Padres team. It appears the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Kansas City vs San Diego picks, computer picks Royals vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Royals Betting Trends

Kansas City has gone 5–5 ATS over their last ten games and is 14–16 as moneyline favorites of –114 or shorter. They’ve covered in 7 of 10 games when favored, showing a solid performance under pressure.

Padres Betting Trends

San Diego, at 17–20 when underdogs this season, has shown resilience but remains just below .500 ATS. They won 5 of 10 games as home underdogs and have covered a few times in close-picture contests.

Royals vs. Padres Matchup Trends

Four of the Royals’ last ten games have gone over the total, indicating a balanced scoring trend. The Padres and Royals have veered under recently, making the mid‑8.5 total intriguing for swing-driven gameplay.

Kansas City vs. San Diego Game Info

Kansas City vs San Diego starts on June 22, 2025 at 4:10 PM EST.

Spread: San Diego +1.5
Moneyline: Kansas City -114, San Diego -105
Over/Under: 8.5

Kansas City: (38-39)  |  San Diego: (41-35)

Remi's searched hard and found the best prop for this matchup: J. Caglianone over 0.5 Total Bases.. Prices move—always shop for the best number.

Four of the Royals’ last ten games have gone over the total, indicating a balanced scoring trend. The Padres and Royals have veered under recently, making the mid‑8.5 total intriguing for swing-driven gameplay.

KC trend: Kansas City has gone 5–5 ATS over their last ten games and is 14–16 as moneyline favorites of –114 or shorter. They’ve covered in 7 of 10 games when favored, showing a solid performance under pressure.

SD trend: San Diego, at 17–20 when underdogs this season, has shown resilience but remains just below .500 ATS. They won 5 of 10 games as home underdogs and have covered a few times in close-picture contests.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Kansas City vs. San Diego Odds

AI algorithm Remi is pouring through tons of data points on each team. In fact, anytime the Kansas City vs San Diego trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable patterns.

Kansas City vs San Diego Opening Odds

KC Moneyline: -114
SD Moneyline: -105
KC Spread: -1.5
SD Spread: +1.5
Over/Under: 8.5

Kansas City vs San Diego Live Odds

Games PTS ML SPR O/U
In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
3
7
 
-10000
 
-3.5 (-650)
O 10.5 (+425)
U 10.5 (-650)
In Progress
Tampa Bay Rays
Toronto Blue Jays
In Progress
Rays
Blue Jays
1
4
+1100
-3000
+3.5 (-155)
-3.5 (+120)
O 7.5 (+115)
U 7.5 (-150)
In Progress
Colorado Rockies
San Francisco Giants
In Progress
Rockies
Giants
2
3
+270
-350
+1.5 (+105)
-1.5 (-135)
O 10.5 (+105)
U 10.5 (-135)
In Progress
New York Mets
Miami Marlins
In Progress
Mets
Marlins
2
0
-350
+270
-2.5 (-102)
+2.5 (-125)
O 7.5 (-130)
U 7.5 (+100)
In Progress
Detroit Tigers
Boston Red Sox
In Progress
Tigers
Red Sox
0
1
+195
-250
+1.5 (-135)
-1.5 (+105)
O 6.5 (-150)
U 6.5 (+115)
In Progress
Chicago White Sox
Washington Nationals
In Progress
White Sox
Nationals
0
0
+130
-160
+1.5 (-160)
-1.5 (+125)
O 8.5 (-110)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+193
-215
+1.5 (-110)
-1.5 (-110)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-200)
-1.5 (+165)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-166
+1.5 (-143)
-1.5 (+123)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+125
-150
+1.5 (-190)
-1.5 (+155)
O 7 (-125)
U 7 (+105)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+136
-150
+1.5 (-165)
-1.5 (+145)
O 7.5 (-105)
U 7.5 (-115)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-150
+125
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-210)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+106
-117
+1.5 (-190)
-1.5 (+165)
O 10 (-116)
U 10 (-104)
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+144
-172
+1.5 (-146)
-1.5 (+122)
O 9 (-122)
U 9 (+100)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Kansas City Royals vs. San Diego Padres on June 22, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS