Astros vs. Angels
Prediction, Odds & Props
Jun 22 | MLB AI Picks

Updated: 2025-06-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Houston Astros (44–32) head to Angel Stadium on June 22, 2025, to face the Los Angeles Angels (36–39) in the rubber game of their three‑game set. The Angels come in as slight favorites (–125 ML, –1.5 run line), with the total at 8 runs—suggesting a close contest where pitching and timely hitting will be critical.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 22, 2025

Start Time: 4:07 PM EST​

Venue: Angel Stadium of Anaheim​

Angels Record: (37-39)

Astros Record: (44-33)

OPENING ODDS

HOU Moneyline: -130

LAA Moneyline: +109

HOU Spread: -1.5

LAA Spread: +1.5

Over/Under: 9

HOU
Betting Trends

  • Houston has gone 38–34 ATS overall, covering 7 of their last 10 games when playing as moneyline underdogs, showing resilience when not favored.

LAA
Betting Trends

  • Los Angeles has been solid at home as favorites, going 8–5 when listed at –125 or better, and has maintained a 6–4 spread record in their last ten games overall.

MATCHUP TRENDS

  • Seven of Houston’s last ten games have stayed under the total, while four of the Angels’ last ten ended with overs—highlighting a contrast that makes the 8‑run line intriguing depending on scoring trends.

HOU vs. LAA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: Y. Diaz under 7.5 Fantasy Score.

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Houston vs Los Angeles Angels Prediction & Odds:
Free MLB Betting Insights for 6/22/25

The Houston Astros and Los Angeles Angels meet Sunday, June 22, 2025, at Angel Stadium for the rubber match of their three-game series, with both clubs looking to build momentum as the season edges toward mid-summer. The Angels enter the finale after a dominant 9–1 win on Saturday that featured two-run homers from Luis Rengifo and Logan O’Hoppe, as well as an electric 10-strikeout performance from José Soriano, who held the Houston offense in check through 6.2 innings. That statement win sets up Sunday’s matchup where veteran Kyle Hendricks (5–6, 4.79 ERA) will try to keep the Astros’ lineup off balance using his trademark command and soft contact approach, while Houston hands the ball to rookie Brandon Walter, who will look to bounce back from a rough outing in which he gave up seven earned runs to this same Angels lineup earlier in the series. Walter’s potential is still evident in his strikeout-to-walk ratio and ability to generate ground balls when locating his cutter and sinker properly, but adjustments will be critical if he’s to give Houston a chance. The Astros’ offense was largely silenced on Saturday, managing just three hits and one run, but the lineup led by José Altuve, Yordan Álvarez, Alex Bregman, and dynamic rookie Joey Loperfido is capable of quick rebounds and scoring in bunches when they control the count.

Houston has thrived in the underdog role recently, covering in seven of their last ten games as moneyline dogs, and their 38–34 ATS record overall suggests they’ve found ways to stay competitive even in losses. The Angels, meanwhile, have shown more life at home and have gone 8–5 ATS when listed as –125 or better, supported by a bullpen that has held up well despite inconsistent starting pitching throughout the year. Offensively, they’ve leaned on O’Hoppe’s developing power, Zach Neto’s clutch hits, and Rengifo’s hot bat to piece together runs, particularly against lefties. The total for this game is set at eight, and while Houston games have skewed to the under in seven of their last ten, the Angels have been more variable, with power spikes like Saturday’s fueling the occasional over. If Walter can make the right adjustments and keep the ball down, this could turn into a 4–3 or 5–4 win for Houston, especially if the Astros’ bullpen can deliver in the later innings. On the other hand, if Hendricks locates well and the Angels get another burst of power early, they’re positioned to take the series with a low-scoring 4–2 type result. Ultimately, Sunday’s game could come down to which team capitalizes better on early opportunities, avoids defensive miscues, and gets steadier length from their starter. The Astros have the edge in upside, but the Angels have home field and current momentum, making this a tightly projected matchup that may not be decided until the final inning.

Houston Astros MLB Preview

The Houston Astros enter Sunday’s series finale at Angel Stadium with a sense of urgency after Saturday’s 9–1 blowout loss to the Angels exposed some of their most recent weaknesses—namely, a lack of timely hitting and a vulnerable starting rotation. At 44–32, the Astros remain squarely in postseason contention, but they have relied heavily on a core group of veterans, including José Altuve, Yordan Álvarez, and Alex Bregman, all of whom were held in check during Saturday’s defeat. The team’s offensive inconsistency has become more pronounced on the road, where they’ve struggled to deliver in high-leverage situations, despite showing value to bettors by covering in seven of their last ten games as moneyline underdogs. Sunday’s starting pitcher, rookie left-hander Brandon Walter, has the tall task of facing a lineup that roughed him up for seven earned runs earlier in the series. Walter does show potential, particularly with his strike-throwing ability and knack for inducing ground balls, but he’ll need better command of his cutter and a more effective changeup to neutralize the Angels’ right-handed bats. Houston’s bullpen, anchored by Bryan Abreu, Ryan Pressly, and Rafael Montero, has been reliable of late, but the workload could be stretched again if Walter fails to provide at least five competitive innings.

Defensively, the Astros remain steady, and their infield combination of Peña and Altuve continues to convert routine plays and turn double plays efficiently. What Houston needs most is early offensive pressure—they were out-hit 11–3 on Saturday and rarely threatened after falling behind early. J.P. France and Hunter Brown have recently helped stabilize the rotation, but Sunday is Walter’s stage to either step up or leave Houston scrambling. In terms of matchup, the Astros face Kyle Hendricks, a pitcher whose style—soft contact and pitch-to-contact—can work in Houston’s favor if their hitters stay patient and look for fastballs early in counts. Look for Álvarez and Bregman to set the tone with disciplined at-bats, while Jeremy Peña could play the hero if the game stays close late. Houston has a chance to bounce back, especially if Walter finds rhythm early and the Astros’ bats can break through by the middle innings. A narrow 5–4 win is realistic if they execute a cleaner, more focused game plan, particularly on offense and in run prevention. However, if Walter falters again, the Astros may be playing from behind quickly, and with a taxed bullpen, that could snowball. The key lies in better first-inning execution and a quicker offensive response if they fall behind, because while Houston has talent to win anywhere, execution—especially from their rookie starter—will dictate whether they return home with a series win or a frustrating missed opportunity.

The Houston Astros (44–32) head to Angel Stadium on June 22, 2025, to face the Los Angeles Angels (36–39) in the rubber game of their three‑game set. The Angels come in as slight favorites (–125 ML, –1.5 run line), with the total at 8 runs—suggesting a close contest where pitching and timely hitting will be critical. Houston vs Los Angeles Angels AI Prediction: Free MLB Betting Insights for Jun 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Los Angeles Angels Angels MLB Preview

The Los Angeles Angels approach Sunday’s series finale against the Houston Astros with confidence following a dominant 9–1 victory on Saturday that showcased their offensive potential and the continued development of their young arms. Now sitting at 36–39, the Angels are looking to claw back to .500 and build momentum during this home stand, where they’ve found more consistency both at the plate and on the mound. Saturday’s game featured explosive two-run homers from Luis Rengifo and Logan O’Hoppe, while José Soriano delivered one of his best starts of the year, striking out ten Astros in 6.2 innings and neutralizing Houston’s veteran lineup with a mix of velocity and command. On Sunday, the Angels will turn to veteran Kyle Hendricks (5–6, 4.79 ERA), whose value lies not in overpowering hitters but in inducing weak contact and working efficiently through lineups with his sinker-changeup mix. Hendricks will look to replicate Soriano’s early strike efficiency and avoid the big innings that have plagued some of his recent outings. The Angels’ lineup, boosted by Rengifo’s hot streak and O’Hoppe’s developing power, is beginning to coalesce, especially at home, where they have gone 8–5 ATS when listed as slight favorites like they are in this matchup.

Zach Neto and Mickey Moniak continue to play key supporting roles, offering speed and situational hitting that complements the middle-of-the-order threats. Defensively, the Angels were sharp on Saturday, turning in a clean performance behind Soriano and supporting their pitcher with strong infield play and smart outfield positioning. If Hendricks can get through five innings while limiting base runners, the Angels’ bullpen, led by Carlos Estévez and Adam Cimber, will have a chance to shut the door again against a Houston team that struggled to string together hits in Game 2 of the series. The total for Sunday’s game is set at eight runs, and the Angels’ improved offense makes the over a possibility if they jump on rookie lefty Brandon Walter early again. Walter surrendered seven earned runs to the Angels in his last start, and if the Angels’ hitters continue their patient, aggressive approach, they may not need to change much to replicate that success. The key for Los Angeles will be to score early, back Hendricks with clean defense, and hand the game over to a rested bullpen. If they can do that, a 4–2 or 5–3 win seems likely, especially considering the momentum generated by Saturday’s performance and the familiarity they now have with Walter’s tendencies. The Angels know they’re still playing catch-up in the standings, but with renewed energy at the plate, a reliable game plan for neutralizing Houston’s big bats, and the comfort of home-field advantage, they have a prime opportunity to win the series and inch closer to relevance in the AL West.

Houston vs. Los Angeles Angels Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Astros and Angels play there’s always several intriguing observations to key in on. Not to mention games played at Angel Stadium of Anaheim in Jun rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: Y. Diaz under 7.5 Fantasy Score.

Houston vs. Los Angeles Angels Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Astros and Angels and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Remi has been most keyed in on the linear correlation of weight human bettors often put on Houston’s strength factors between a Astros team going up against a possibly improved Angels team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Houston vs Los Angeles Angels picks, computer picks Astros vs Angels, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Astros Betting Trends

Houston has gone 38–34 ATS overall, covering 7 of their last 10 games when playing as moneyline underdogs, showing resilience when not favored.

Angels Betting Trends

Los Angeles has been solid at home as favorites, going 8–5 when listed at –125 or better, and has maintained a 6–4 spread record in their last ten games overall.

Astros vs. Angels Matchup Trends

Seven of Houston’s last ten games have stayed under the total, while four of the Angels’ last ten ended with overs—highlighting a contrast that makes the 8‑run line intriguing depending on scoring trends.

Houston vs. Los Angeles Angels Game Info

Houston vs Los Angeles Angels starts on June 22, 2025 at 4:07 PM EST.

Venue: Angel Stadium of Anaheim.

Spread: Los Angeles Angels +1.5
Moneyline: Houston -130, Los Angeles Angels +109
Over/Under: 9

Houston: (44-33)  |  Los Angeles Angels: (37-39)

Remi's searched hard and found the best prop for this matchup: Y. Diaz under 7.5 Fantasy Score.. Prices move—always shop for the best number.

Seven of Houston’s last ten games have stayed under the total, while four of the Angels’ last ten ended with overs—highlighting a contrast that makes the 8‑run line intriguing depending on scoring trends.

HOU trend: Houston has gone 38–34 ATS overall, covering 7 of their last 10 games when playing as moneyline underdogs, showing resilience when not favored.

LAA trend: Los Angeles has been solid at home as favorites, going 8–5 when listed at –125 or better, and has maintained a 6–4 spread record in their last ten games overall.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Houston vs. Los Angeles Angels Odds

AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Houston vs Los Angeles Angels trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable betting trends.

Houston vs Los Angeles Angels Opening Odds

HOU Moneyline: -130
LAA Moneyline: +109
HOU Spread: -1.5
LAA Spread: +1.5
Over/Under: 9

Houston vs Los Angeles Angels Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-105)
-1.5 (-115)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+160)
+1.5 (-195)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+155
-190
+1.5 (-152)
-1.5 (+120)
O 8 (-108)
U 8 (-117)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+125
-152
+1.5 (-186)
-1.5 (+145)
O 7.5 (-120)
U 7.5 (-107)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-155
+130
-1.5 (+105)
+1.5 (-125)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-115)
U 10 (-105)

MLB Past Picks

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Houston Astros vs. Los Angeles Angels Angels on June 22, 2025 at Angel Stadium of Anaheim.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN