Guardians vs. Athletics
Prediction, Odds & Props
Jun 22 | MLB AI Picks
Updated: 2025-06-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cleveland Guardians (38–37) wrap up their weekend series with the Oakland Athletics (32–47) at Sutter Health Park on June 22, 2025, with the first pitch scheduled for 4:05 p.m. ET. Cleveland enters as a slight favorite (–135 ML, –1.5 run line), and the total sits at 9.5 runs—suggesting a moderately high-scoring, closely-contested afternoon.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 22, 2025
Start Time: 4:05 PM EST
Venue: Sutter Health Park
Athletics Record: (32-47)
Guardians Record: (38-37)
OPENING ODDS
CLE Moneyline: -129
ATH Moneyline: +107
CLE Spread: -1.5
ATH Spread: +1.5
Over/Under: 9.5
CLE
Betting Trends
- Cleveland has been solid against the spread of late, going 7–3 ATS in their past ten games—even with mixed results—they’ve shown up strong in close contests.
ATH
Betting Trends
- Oakland has been a tough underdog, covering several times recently as + odds, and sit at a strong 23–18 ATS on the year despite their losing record.
MATCHUP TRENDS
- Over the Guardians’ last ten games, only two have gone over the total, indicating games trend low — but Oakland’s streak of nine strikeouts in a recent game suggests potential inconsistency that could tilt scoring.
CLE vs. ATH
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Ramirez under 9.5 Fantasy Score.
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Cleveland vs Athletics Prediction & Odds:
Free MLB Betting Insights for 6/22/25
On the other side, J.P. Sears will likely take the mound for Oakland, owning a 5–6 record with a bloated 5.45 ERA and struggles with command that have led to early exits and bullpen overuse. The Athletics’ bullpen remains one of the shakiest in the league, which puts pressure on Sears to go deep into the game against a Guardians team that capitalizes on late-inning mistakes. Oakland’s offense, while limited, does feature Luis Urías, who’s shown flashes of power and could be a key factor if the game stays close. However, the A’s have struck out frequently in recent games and lack the situational hitting required to execute in tight contests. Defensively, Cleveland holds an edge, committing fewer errors and generally supporting their pitchers with more consistent fielding. The Guardians’ bullpen, headlined by closer Emmanuel Clase, offers a considerable advantage in a game projected to be close, with a 9.5 run total signaling a balanced scoring outlook. Cleveland’s experience in winning tight games and their ability to play small ball should tilt the odds in their favor, particularly if they can get to Sears early and force the A’s into their bullpen by the fifth inning. If Cecconi delivers a solid five-to-six-inning outing and Clase is available to lock things down, the Guardians are well-positioned to come away with a series-clinching win. A final score of 5–4 or 6–5 in favor of Cleveland seems likely, with the potential for a run-line cover if their offense shows early aggression and Ramírez continues his hot streak. While Oakland has shown some fight, especially when playing spoiler at home, their inconsistency, lack of depth, and bullpen volatility make them longshots to close out the series with a win unless everything breaks their way early.
Good morning to most of you.#GuardsBall | #GuardiWins pic.twitter.com/LePo79ibH5
— Cleveland Guardians (@CleGuardians) June 22, 2025
Cleveland Guardians MLB Preview
The Cleveland Guardians enter Sunday’s series finale against the Oakland Athletics aiming to continue their upward trajectory and push further above the .500 mark as they remain in the thick of the American League playoff hunt. Riding a recent 7–3 stretch against the spread, Cleveland has combined strong starting pitching, timely hitting, and dependable defense to consistently win close games, a formula that has paid dividends in the heart of the season. Leading the way is star third baseman José Ramírez, who has been a force both at the plate and in the field, batting .324 with 13 home runs and 36 RBIs while offering veteran leadership and clutch production when it matters most. Alongside Ramírez, Steven Kwan has been a sparkplug at the top of the order, getting on base at an elite rate and setting the tone for an offense that doesn’t rely solely on power but instead thrives on contact hitting, aggressive baserunning, and smart situational execution. Slade Cecconi will take the mound for the Guardians, bringing a 2–3 record and 4.15 ERA into a favorable matchup against an Athletics lineup that ranks among the league’s worst in run production, strikeouts, and extra-base hits.
Cecconi’s strength lies in limiting hard contact and working efficiently through the strike zone, and if he can establish his fastball early while mixing in his breaking pitches, he should be able to navigate through five or six quality innings with limited damage. The Guardians’ bullpen has also been a reliable weapon, anchored by Emmanuel Clase, who has been nearly automatic in the closer role and gives Cleveland a significant edge in any late-game scenario. Offensively, Cleveland has taken advantage of weaker pitching staffs like Oakland’s throughout the season, and they’ll look to jump on J.P. Sears early, who enters with a 5–6 record and a 5.45 ERA, plagued by command issues and susceptibility to big innings. The Guardians’ ability to wear down starters and punish bullpens could prove crucial here, especially if they can extend at-bats and force Sears into early trouble. From an ATS standpoint, Cleveland’s 7–3 recent record is a testament to their ability to not just win games but cover spreads even in tight contests, making them a solid play in close road matchups. Their disciplined approach and sound fundamentals make them dangerous against teams that struggle to execute consistently, and in a stadium like Sutter Health Park where conditions are neutral, their superior roster and sharper execution should shine. If Ramírez and Kwan continue to lead the charge and Cecconi delivers another poised performance, the Guardians should be in position to close out the series with a win and head into their next stretch with momentum. A 6–4 or 5–3 victory for Cleveland seems like a reasonable projection given their form, matchup edge, and overall consistency, especially against a rebuilding team like the Athletics that has struggled to hold leads and close games effectively.

Credit: USA TODAY/IMAGN
Athletics Athletics MLB Preview
The Oakland Athletics wrap up their weekend series at Sutter Health Park on Sunday afternoon looking to bounce back and avoid another series loss, as their 32–47 record continues to reflect a rebuilding season riddled with inconsistency, underperformance, and thin margins for error. While they have been one of the league’s most frequent underdogs, the A’s have quietly delivered some value to bettors, particularly at home, where they hold a solid 23–18 ATS record despite their losing overall mark. J.P. Sears is expected to take the ball for Oakland and while he enters with a 5–6 record and a bloated 5.45 ERA, the left-hander has shown occasional flashes of effectiveness when he’s able to command his sinker and generate weak contact, a skill that will be crucial against a Cleveland offense that thrives on stringing together base hits. Sears’ margin for error, however, is razor thin, especially against the likes of José Ramírez and Steven Kwan, who can both flip the momentum quickly with line drives and speed on the basepaths. If Sears can give the A’s five competitive innings and avoid issuing free passes, there’s a slim but plausible path for Oakland to remain competitive into the late frames, though it will also require solid defensive support—something the A’s have struggled to provide consistently this season.
Offensively, Oakland has shown signs of life through players like Luis Urías, who delivered a key homer earlier this week, and Zack Gelof, who continues to be a workhorse at second base, but the lineup overall has lacked power and failed to deliver in key scoring opportunities, especially against quality pitching. Facing Cleveland’s Slade Cecconi, who boasts a solid 4.15 ERA and mixes speeds well, the A’s will need to focus on situational hitting, making productive outs, and trying to manufacture runs through stolen bases or groundball advancement, tactics they have used sporadically but never consistently. Bullpen depth continues to be a sore spot, with late-inning leads often evaporating due to walks, hit batters, or lack of swing-and-miss stuff, and unless Sears can go deep, Oakland may once again find themselves vulnerable in the sixth inning or later. That said, the A’s have occasionally thrived in spoiler roles, particularly when underestimated, and with a total set at 9.5, there is a chance for the game to shift if their bats can deliver timely hits early. A win will likely require not only a standout start from Sears but also opportunistic scoring, crisp defense, and perhaps a bit of luck—conditions that haven’t aligned often this season. If they manage to keep the game low-scoring and within reach, a 5–4 or 6–5 upset is conceivable, but more realistically, a strong early effort followed by bullpen regression could result in another narrow defeat. Still, in a rebuilding year, every competitive game serves as a developmental opportunity, and the A’s will look to leave the field Sunday with both lessons learned and optimism for the growth of their young core.
You could see more catches like these by voting Law to the All-Star game 😎#VoteAthletics ⭐️ https://t.co/SBezYOtGtG pic.twitter.com/apwWCCVUU5
— Athletics (@Athletics) June 22, 2025
Cleveland vs. Athletics Prop Picks (AI)
Cleveland vs. Athletics Prediction (AI)

Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Guardians and Athletics and using recursive machine learning and impressive AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned weight knucklehead sportsbettors often put on Cleveland’s strength factors between a Guardians team going up against a possibly strong Athletics team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cleveland vs Athletics picks, computer picks Guardians vs Athletics, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Guardians Betting Trends
Cleveland has been solid against the spread of late, going 7–3 ATS in their past ten games—even with mixed results—they’ve shown up strong in close contests.
Athletics Betting Trends
Oakland has been a tough underdog, covering several times recently as + odds, and sit at a strong 23–18 ATS on the year despite their losing record.
Guardians vs. Athletics Matchup Trends
Over the Guardians’ last ten games, only two have gone over the total, indicating games trend low — but Oakland’s streak of nine strikeouts in a recent game suggests potential inconsistency that could tilt scoring.
Cleveland vs. Athletics Game Info
What time does Cleveland vs Athletics start on June 22, 2025?
Cleveland vs Athletics starts on June 22, 2025 at 4:05 PM EST.
Where is Cleveland vs Athletics being played?
Venue: Sutter Health Park.
What are the opening odds for Cleveland vs Athletics?
Spread: Athletics +1.5
Moneyline: Cleveland -129, Athletics +107
Over/Under: 9.5
What are the records for Cleveland vs Athletics?
Cleveland: (38-37) | Athletics: (32-47)
What is the AI best bet for Cleveland vs Athletics?
Remi's searched hard and found the best prop for this matchup: J. Ramirez under 9.5 Fantasy Score.. Prices move—always shop for the best number.
What are Cleveland vs Athletics trending bets?
Over the Guardians’ last ten games, only two have gone over the total, indicating games trend low — but Oakland’s streak of nine strikeouts in a recent game suggests potential inconsistency that could tilt scoring.
What are Cleveland trending bets?
CLE trend: Cleveland has been solid against the spread of late, going 7–3 ATS in their past ten games—even with mixed results—they’ve shown up strong in close contests.
What are Athletics trending bets?
ATH trend: Oakland has been a tough underdog, covering several times recently as + odds, and sit at a strong 23–18 ATS on the year despite their losing record.
Where can I find AI Picks for Cleveland vs Athletics?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. Athletics Odds
Remi is pouring through mountains of stats on each team. In fact, anytime the Cleveland vs Athletics trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.
Cleveland vs Athletics Opening Odds
CLE Moneyline:
-129 ATH Moneyline: +107
CLE Spread: -1.5
ATH Spread: +1.5
Over/Under: 9.5
Cleveland vs Athletics Live Odds
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Baltimore Orioles
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Sep 27, 2025 3:09PM EDT
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Toronto Blue Jays
9/27/25 3:09PM
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Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
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Nationals
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-105
-115
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+1.5 (-190)
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O 8.5 (-115)
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Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
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–
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+190
-235
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+1.5 (-105)
-1.5 (-115)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
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-140
+115
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+1.5 (-150)
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O 8 (-105)
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
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–
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+105
-125
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-1.5 (+165)
+1.5 (-200)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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+185
-225
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+1.5 (-110)
-1.5 (-110)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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+110
-130
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+1.5 (-190)
-1.5 (+155)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
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+145
-175
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+1.5 (-150)
-1.5 (+125)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
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+120
-145
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+1.5 (-190)
-1.5 (+155)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
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+115
-140
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+1.5 (-180)
-1.5 (+150)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
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–
–
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-145
+120
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-1.5 (+110)
+1.5 (-130)
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O 9 (-110)
U 9 (-110)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
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+100
-120
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-1.5 (+175)
+1.5 (-215)
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O 7 (-115)
U 7 (-105)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
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–
–
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+100
-120
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-1.5 (+155)
+1.5 (-190)
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O 10 (-115)
U 10 (-105)
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MLB Past Picks
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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Guardians vs. Athletics Athletics on June 22, 2025 at Sutter Health Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |