Reds vs. Cardinals
Prediction, Odds & Props
Jun 22 | MLB AI Picks
Updated: 2025-06-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cincinnati Reds (38–35) head to Busch Stadium to face the St. Louis Cardinals (41–35) on June 22, 2025, with first pitch at 2:15 p.m. ET. St. Louis is a modest favorite (-142 moneyline, –1.5 run line), and the total is 9.0–9.5, implying expectations for a competitive and moderately high-scoring game.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 22, 2025
Start Time: 2:15 PM EST
Venue: Busch Stadium
Cardinals Record: (42-35)
Reds Record: (39-38)
OPENING ODDS
CIN Moneyline: -114
STL Moneyline: -105
CIN Spread: -1.5
STL Spread: +1.5
Over/Under: 9.5
CIN
Betting Trends
- Cincinnati has performed well as underdogs, going 6–11 as + odds but covering in 5 of those games. They’ve been 5–5 ATS in their last ten overall and have hit the over in 6 of their last 7 games.
STL
Betting Trends
- St. Louis has been strong as favorites, going 6–3 SU and covering 6 of 9 times at -142 or shorter. Their overall ATS record is solid (around 42–33), though they’ve dropped 4 of their last 5 at home—most of those as odds-on favorites.
MATCHUP TRENDS
- This series has recently leaned under: 4 of their last 5 matchups were under the total. Additionally, St. Louis is 40–31 on the Over this season, while Cincinnati is 32–38; but head-to-head trends at Busch favor unders, suggesting a nuanced lean.
CIN vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: A. Burleson over 0.5 Total Bases.
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Cincinnati vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 6/22/25
Offensively, the Reds have exploded for 34 runs in their last five games, led by De La Cruz, TJ Friedl, and Christian Encarnacion-Strand, forming a young, energetic core that thrives on speed and pressure. Meanwhile, St. Louis counters with the veteran bats of Nolan Arenado and Paul Goldschmidt, supported by breakout players like Masyn Winn and Lars Nootbaar who have kept the offense steady but have not shown the same explosive potential. Defensively, both teams are sharp in the infield and athletic in the outfield, but the Reds’ aggression on the basepaths gives them a potential edge in manufacturing runs. From a betting perspective, Cincinnati has been hitting the over consistently—six of their last seven games have gone over the total—while the Cardinals’ recent home games have skewed under, including four of their last five at Busch. This creates a betting crossroads, with the total around 9.0 and both lineups capable of putting up crooked numbers when pitchers falter. If Singer can keep the ball on the ground and avoid the long ball, and if Cincinnati can scratch a couple of early runs off Pallante, they’re well-positioned to put pressure on a Cardinals team that has been uneven in close games. On the flip side, if Pallante continues his mastery over Reds hitters and the St. Louis bullpen holds strong, a 5–3 or 6–4 home win feels entirely possible. This game figures to be a close, tactical battle with playoff implications and betting intrigue, and the result may come down to late-inning execution and the ability of each club’s bullpen to handle the pressure of a rubber match in a tight division.
ELLY FROM THE RIGHT SIDE⚡️@ellylacocoa18 x https://t.co/HKf2mrrBht pic.twitter.com/NmRmMtEnHp
— Cincinnati Reds (@Reds) June 21, 2025
Cincinnati Reds MLB Preview
The Cincinnati Reds enter Sunday’s finale against the Cardinals on a high note offensively, having scored 34 runs over their last five games while showcasing one of the league’s most dynamic young cores centered around Elly De La Cruz, who is in the midst of a torrid stretch that has included a four-game home run streak and elite base-stealing pace that continues to rattle opposing pitchers and defenses. He’s been complemented by consistent contributions from TJ Friedl and Christian Encarnacion-Strand, giving the Reds a top-to-bottom lineup that applies pressure from both power and speed angles, which has translated to recent over results—six of their last seven games have gone over the total, and the offense seems to be clicking at just the right time. On the mound, Cincinnati turns to right-hander Brady Singer, who at 7–4 with a 4.34 ERA represents a solid, if at times volatile, arm in the rotation capable of inducing weak contact and ground balls when he commands the zone, though occasional struggles with location can lead to early trouble if hitters sit on fastballs or hangers. Singer’s ability to navigate St. Louis’s disciplined lineup in the first two times through the order will be key to setting up the bullpen, which has held leads effectively in recent weeks and shown resilience in high-leverage situations despite heavy usage.
Defensively, the Reds are aggressive and athletic, particularly in the infield, and have used their range and glove work to support their pitchers, keeping games within reach even when runs start to pile up. While Cincinnati’s ATS record isn’t elite, they’ve performed admirably as underdogs this season, going 5–4 ATS in recent games when listed at longer odds, and they’ve consistently found value in road matchups thanks to their ability to score in bunches. Their base-running aggression often forces errors and quick decisions from opposing fielders, which has led to extra opportunities and extended innings—especially valuable in tight contests like this. If Singer can pitch efficiently into the sixth and the offense can replicate the early-game pressure it applied in the last few outings, Cincinnati is in position to capitalize on a Cardinals team that’s faltered at home recently, including a 1–4 ATS run at Busch Stadium. A 6–5 or 7–4 victory is not out of reach for a Reds squad that enters the game with confidence, offensive rhythm, and the kind of energy that often decides tight divisional matchups down the stretch. Expect Cincinnati to remain aggressive from the first pitch, try to take the extra base, and challenge Pallante early in the count before turning the game over to a bullpen that’s been quietly effective, looking to complete a statement series win on the road.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
The St. Louis Cardinals return to Busch Stadium on Sunday looking to close out their series against the division-rival Cincinnati Reds with a crucial win behind right-hander Andre Pallante, who dazzled earlier in the series with six scoreless innings against these same Reds and now looks to repeat that performance as he builds on his 5–3 record and seeks to continue his stretch of consistency. Pallante is at his best when working quickly and inducing ground balls, and his recent success against Cincinnati gives manager Oliver Marmol confidence that he can once again neutralize the Reds’ high-energy lineup, which has been on fire in recent games but was largely stymied when Pallante last faced them. Offensively, the Cardinals bring a mix of veteran presence and youthful spark, with Nolan Arenado and Paul Goldschmidt continuing to serve as foundational cornerstones while Masyn Winn and Lars Nootbaar provide athleticism, situational hitting, and speed at the top and middle of the order. This balance has allowed the Cardinals to stay competitive even in tight, low-scoring games, and their ability to manufacture runs rather than rely solely on power has been key, especially at pitcher-friendly Busch Stadium, where the ball doesn’t fly out as easily as in other National League parks.
St. Louis also boasts one of the league’s most efficient bullpens, with closer Ryan Helsley leading all of baseball in saves and showing a remarkable ability to escape jams with strikeouts and weak contact, while set-up men like Giovanny Gallegos and JoJo Romero have helped bridge the gap effectively in the late innings. From a betting perspective, the Cardinals have been strong this season overall, posting an ATS record of 42–33, and while they’ve recently stumbled at home—dropping four of their last five games ATS at Busch—many of those losses have been by razor-thin margins, often hinging on late-game execution. The team has also leaned toward the under in recent home games, with four of their last five at Busch Stadium staying below the total, largely due to strong pitching and the nature of the park itself favoring pitchers and solid defensive play. St. Louis will look to apply early pressure on Brady Singer, who has been serviceable but occasionally vulnerable to patient lineups like theirs, and if they can draw deep counts and get into Cincinnati’s bullpen by the fifth or sixth inning, their offensive depth and bullpen strength could become deciding factors. The Cardinals will rely heavily on clean fielding, timely hitting, and minimizing extra-base damage from Elly De La Cruz and the Reds’ young sluggers, and if they execute their game plan, a 5–3 or 6–4 home win is well within reach, particularly with the crowd behind them and a pitcher on the mound who’s already shown he can dominate this opponent. Sunday’s finale offers a chance for St. Louis to both defend home turf and keep pace in a crowded NL Central race, where every series win and every well-played game can mean the difference between postseason hopes and disappointment come September.
THAT'S A WALKOFF & THAT'S A SERIES WINNER!! pic.twitter.com/RPcS6gACXQ
— St. Louis Cardinals (@Cardinals) June 21, 2025
Cincinnati vs. St. Louis Prop Picks (AI)
Cincinnati vs. St. Louis Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every angle between the Reds and Cardinals and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.
Remi has been most keyed in on the trending emphasis human bettors tend to put on player performance factors between a Reds team going up against a possibly healthy Cardinals team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cincinnati vs St. Louis picks, computer picks Reds vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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Reds Betting Trends
Cincinnati has performed well as underdogs, going 6–11 as + odds but covering in 5 of those games. They’ve been 5–5 ATS in their last ten overall and have hit the over in 6 of their last 7 games.
Cardinals Betting Trends
St. Louis has been strong as favorites, going 6–3 SU and covering 6 of 9 times at -142 or shorter. Their overall ATS record is solid (around 42–33), though they’ve dropped 4 of their last 5 at home—most of those as odds-on favorites.
Reds vs. Cardinals Matchup Trends
This series has recently leaned under: 4 of their last 5 matchups were under the total. Additionally, St. Louis is 40–31 on the Over this season, while Cincinnati is 32–38; but head-to-head trends at Busch favor unders, suggesting a nuanced lean.
Cincinnati vs. St. Louis Game Info
What time does Cincinnati vs St. Louis start on June 22, 2025?
Cincinnati vs St. Louis starts on June 22, 2025 at 2:15 PM EST.
Where is Cincinnati vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for Cincinnati vs St. Louis?
Spread: St. Louis +1.5
Moneyline: Cincinnati -114, St. Louis -105
Over/Under: 9.5
What are the records for Cincinnati vs St. Louis?
Cincinnati: (39-38) | St. Louis: (42-35)
What is the AI best bet for Cincinnati vs St. Louis?
Remi's searched hard and found the best prop for this matchup: A. Burleson over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Cincinnati vs St. Louis trending bets?
This series has recently leaned under: 4 of their last 5 matchups were under the total. Additionally, St. Louis is 40–31 on the Over this season, while Cincinnati is 32–38; but head-to-head trends at Busch favor unders, suggesting a nuanced lean.
What are Cincinnati trending bets?
CIN trend: Cincinnati has performed well as underdogs, going 6–11 as + odds but covering in 5 of those games. They’ve been 5–5 ATS in their last ten overall and have hit the over in 6 of their last 7 games.
What are St. Louis trending bets?
STL trend: St. Louis has been strong as favorites, going 6–3 SU and covering 6 of 9 times at -142 or shorter. Their overall ATS record is solid (around 42–33), though they’ve dropped 4 of their last 5 at home—most of those as odds-on favorites.
Where can I find AI Picks for Cincinnati vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cincinnati vs. St. Louis Odds
AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Cincinnati vs St. Louis trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.
Cincinnati vs St. Louis Opening Odds
CIN Moneyline:
-114 STL Moneyline: -105
CIN Spread: -1.5
STL Spread: +1.5
Over/Under: 9.5
Cincinnati vs St. Louis Live Odds
Games | PTS | ML | SPR | O/U | |
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O 8.5 (-110)
U 8.5 (-110)
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2
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-250
+185
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-1.5 (+150)
+1.5 (-200)
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O 5.5 (-105)
U 5.5 (-125)
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Chicago White Sox
Washington Nationals
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Nationals
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4
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+101
-121
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U 8.5 (+100)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
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+169
-208
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+1.5 (-120)
-1.5 (+100)
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O 8.5 (-105)
U 8.5 (-115)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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–
–
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+129
-154
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+1.5 (-175)
-1.5 (+145)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
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–
–
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+148
-180
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+1.5 (-145)
-1.5 (+125)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
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–
–
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+138
-164
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+1.5 (-170)
-1.5 (+145)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
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–
–
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+119
-142
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+1.5 (-180)
-1.5 (+155)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
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–
–
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-162
+136
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-1.5 (+100)
+1.5 (-120)
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O 9 (+100)
U 9 (-120)
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
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–
–
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+101
-121
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-1.5 (+170)
+1.5 (-200)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
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–
–
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+100
-120
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+1.5 (-195)
-1.5 (+165)
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O 10 (-105)
U 10 (-115)
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Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
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–
–
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+140
-170
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+1.5 (-125)
-1.5 (+105)
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O 9.5 (+100)
U 9.5 (-120)
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Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
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–
–
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+240
-300
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+1.5 (+110)
-1.5 (-130)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
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–
–
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+180
-220
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+1.5 (-115)
-1.5 (-105)
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O 8 (-115)
U 8 (-105)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cincinnati Reds vs. St. Louis Cardinals on June 22, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |