The Boston Red Sox and San Francisco Giants close out their interleague series at Oracle Park on Sunday, June 22, 2025, in a matchup rich with narratives and playoff implications for both clubs. Boston, hovering just above .500, is trying to stay relevant in the AL Wild Card race, while San Francisco, riding momentum from their acquisition of former Red Sox slugger Rafael Devers, continues its push to keep pace in the NL West. Sunday’s pitching matchup features Lucas Giolito for the Red Sox and Robbie Ray for the Giants, two veterans with drastically different seasons thus far—Giolito sporting a 4.73 ERA marked by inconsistency and control lapses, while Ray has been solid since returning from injury with a tidy 2.68 ERA and sharp strikeout numbers. The Red Sox offense is keyed by Jarren Duran’s leadoff spark and the return of Wilyer Abreu and Trevor Story, providing much-needed lineup balance and clutch hitting against left-handers. Meanwhile, San Francisco’s lineup is now anchored by Devers, whose presence has already paid dividends with a home run against his former team on Saturday, and Heliot Ramos, who’s been consistent in run production.

Both teams have leaned on reliable bullpen arms lately—Garrett Whitlock and Kenley Jansen for Boston, and the Giants with a mix of veterans and emerging middle relievers—but the overall edge might go to San Francisco given their ability to hand the ball to Ray and avoid overtaxing the bullpen early. Boston’s defense and base-running have been aggressive and effective in tight games, giving them an edge in one-run contests, especially if the game comes down to late-inning execution. However, playing at Oracle Park—where run production is often stifled by spacious dimensions and wind conditions—the game could hinge on which team executes better in situational hitting. With the total set at 7.5 runs, oddsmakers expect a lower-scoring game, and both teams’ recent trends—Boston hitting the under in eight of its last ten games—reinforce that expectation. The Red Sox will need Giolito to work efficiently and limit traffic to stay competitive, especially considering their inconsistent performance as road underdogs this season. San Francisco, favored at home where they are 10–7 when listed at –159 or shorter, may have just enough firepower, especially with Devers swinging a hot bat and Robbie Ray’s strikeout ability neutralizing Boston’s lefty-heavy lineup. A 4–3 final score favoring the Giants feels likely if the game follows expected trends, though the Red Sox could steal a win if their bullpen holds and they capitalize on a big inning against Ray or a mid-relief misstep. Ultimately, this game could turn on one or two swing moments—an error, a bloop single, or a clutch two-out RBI—underscoring just how narrow the margins are between two teams trying to stay in the hunt as summer baseball intensifies.