Mariners vs. Cubs
Prediction, Odds & Props
Jun 21 | MLB AI Picks
Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Seattle Mariners head to Wrigley Field to take on the Chicago Cubs on June 21, 2025, with the Cubs firmly leading the National League Central and the Mariners chasing a Wild Card spot. With both pitching staffs healthy and key hitters back in the lineup, this interleague contest could hinge on one big inning at either park.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 21, 2025
Start Time: 2:20 PM EST
Venue: Wrigley Field
Cubs Record: (45-30)
Mariners Record: (38-36)
OPENING ODDS
SEA Moneyline: +141
CHC Moneyline: -169
SEA Spread: +1.5
CHC Spread: -1.5
Over/Under: 12
SEA
Betting Trends
- Seattle has struggled on the road recently, particularly when underdogs—they are just 1–4 ATS in their last five games as underdogs and carry a 17–16–3 ATS record at Wrigley this season.
CHC
Betting Trends
- Chicago has covered the spread in just four of their past ten games, though they maintain a solid 20–17 ATS at home and are 35–32–5 with the total at Wrigley this year.
MATCHUP TRENDS
- Five of the Cubs’ last ten home games have gone under the total, and Seattle has seen the under come in 12 of their last 35 road outings—setting up a likely low-to-mid scoring affair.
SEA vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: S. Suzuki under 9.5 Fantasy Score.
LIVE MLB ODDS
MLB ODDS COMPARISON
WANT MORE AI PICKS?
VS. SPREAD
308-221
NET UNITS
(INCL VIG)
+418
NET PROFIT
(INCL VIG)
$100/UNIT
$41,803
VS. SPREAD
1551-1329
NET UNITS
(INCL VIG)
+365.7
NET PROFIT
(INCL VIG)
$100/UNIT
$36,569
AI SPORTS PICK PRODUCTS
Create a Free Account

Remi Finds New Picks

Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Seattle vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 6/21/25
The pitching duel could prove pivotal: Chicago is expected to send Matthew Boyd to the mound, a lefty who has regained both velocity and command, while Seattle counters with George Kirby, fresh off back-to-back starts in which he struck out 19 batters combined with minimal walks. With two pitchers capable of limiting base runners and suppressing power, the flow of the game may hinge on infield execution and bullpen matchups in the sixth inning and beyond. Defensively, both clubs rank above average, and at a ballpark where wind and angles can influence outcomes dramatically, clean fielding and smart baserunning become critical. Historically, these teams haven’t faced each other often, but the Cubs have won every home series against Seattle at Wrigley, which adds psychological weight to Chicago’s advantage. The under has hit frequently in recent Cubs home games and Seattle road outings, pointing toward another controlled, low-to-mid scoring game. The Mariners will need to maximize every scoring opportunity they get—likely through base hits and aggressive running—while the Cubs can afford to lean on their deeper lineup and multi-inning bullpen structure to keep the game in check. If either starting pitcher gets hit early, the direction of the game could shift sharply, but if both settle in, this will turn into a battle of bullpen control and timely hitting. The Cubs’ ability to mix in left- and right-handed matchups late gives them a slight strategic edge, but Seattle’s high-upside arms keep them very much in this contest. Expect a game driven by strategy, fielding, and execution, where one big swing or defensive miscue may ultimately tip the balance in what figures to be a tense, tightly contested interleague showdown at the Friendly Confines.
Setting records. Making History.
— Seattle Mariners (@Mariners) June 20, 2025
⭐️ https://t.co/Q16mvWsAww ⭐️ pic.twitter.com/5etLDMyyuz
Seattle Mariners MLB Preview
The Seattle Mariners head into their June 21, 2025 matchup against the Chicago Cubs at Wrigley Field looking to snap out of an uneven stretch that has seen them falter in run production and against the spread, especially as road underdogs. With a recent 1–4 ATS record in their last five games as underdogs and a broader pattern of inconsistency in away games, the Mariners are in urgent need of a reset, and they’re hoping that begins with strong starting pitching. George Kirby is expected to take the mound, and his recent form offers optimism—he’s recorded 19 strikeouts over his last two starts, showcasing elite control, efficient sequencing, and the poise to keep high-powered lineups in check. Kirby’s ability to navigate deep into games without surrendering big innings will be key at Wrigley, where the unpredictable wind and fast outfield grass can quickly turn mistakes into momentum swings. Offensively, the Mariners have struggled to sustain rallies away from home, particularly against left-handed pitching, and they’ll need to be more aggressive early in counts if they want to put pressure on Cubs starter Matthew Boyd, who has been stingy with walks and successful in limiting slugging percentages against both sides of the plate.
The return of Luke Raley from injury offers a much-needed boost to a lineup that has relied too heavily on Cal Raleigh, whose league-leading home run total has not been enough to offset the club’s tendency to leave runners on base. Seattle’s approach at the plate must lean toward contact and pressure—their best path to runs is through singles, stolen bases, and exploiting defensive shifts rather than waiting for a long ball in a pitcher-friendly environment. Defensively, Seattle has performed well, with a solid infield and an outfield capable of covering the wide gaps at Wrigley, which will be crucial in preventing extra-base hits from Chicago’s aggressive baserunners. The Mariners’ bullpen has improved in recent weeks, showing signs of cohesion and reliability that had been missing earlier in the season, and manager Scott Servais will likely lean on his best arms early if Kirby encounters any turbulence. To win or cover in this contest, Seattle must control the pace of the game, limit free passes, and convert any scoring opportunity that arises—especially in the middle innings where they’ve too often gone silent. The pressure is on the offense to complement their strong pitching with timely hits, while the bullpen must protect any narrow margin afforded to them. If Seattle can execute their pitching-centric blueprint while avoiding the long scoring droughts that have plagued them, they are more than capable of challenging a Cubs team that has played well but remains vulnerable to disciplined teams with upside in the rotation. This game offers the Mariners a chance to prove they can win on the road against a playoff-caliber opponent and reestablish themselves as a force in the AL Wild Card race.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Oklahoma City Thunder enter Game 7 of the 2025 NBA Finals with home-court advantage, a 68–14 regular season behind them, and the league MVP Shai Gilgeous-Alexander poised to lead them to the franchise’s first title since 1979. Their campaign has been built on elite defense, selfless offensive flow, and a youth-driven identity that has matured into a dominant force under head coach Mark Daigneault. The Thunder have gone 9–2 at home this postseason and hold a 6.5-point spread in their favor for Game 7, reflecting the confidence oddsmakers and fans alike have in their ability to rise to the occasion. Gilgeous-Alexander has been brilliant, combining crafty isolation scoring with unflappable late-game poise, and he’ll be the focal point once again, supported by Jalen Williams’ all-around game and Chet Holmgren’s increasingly impactful two-way presence. The recent shift to placing Holmgren in a rebounding-centric role has paid dividends, as the rookie center has hauled in 26 boards across the last two games while anchoring OKC’s interior defense with more confidence and physicality. Offensively, the Thunder utilize dribble-drive action, corner spacing, and a steady diet of screen usage to create high-efficiency looks for their perimeter scorers and cutters. Jalen Williams and Lu Dort stretch opposing wings with slashing and catch-and-shoot opportunities, while Alex Caruso and Isaiah Joe offer defensive versatility and timely shotmaking that often swing momentum.
Oklahoma City’s greatest strength is its composure—despite its youth, this team rarely panics, having closed out tight games repeatedly throughout the season with controlled execution and excellent spacing. Defensively, Dort will again be tasked with disrupting Tyrese Haliburton’s rhythm, likely picking him up full-court to burn clock and limit Indiana’s offensive flow. Caruso may see increased minutes off the bench for situational defense and timely stops, especially if the game tightens late. OKC’s transition defense has also been exceptional in the Finals, helping slow Indiana’s breakneck pace and forcing them into a half-court game, where the Thunder’s length and switchability allow them to smother possessions. In Game 7, the Thunder will look to assert themselves early, control the tempo, and prevent the Pacers from dictating flow through full-court pressure or second-chance points. With Haliburton not fully healthy and the Pacers reliant on streaky perimeter shooting, OKC will be confident if they can build an early lead and control the boards. Managing foul trouble, avoiding complacency, and making timely substitutions will be crucial as the margin for error in a Game 7 is razor-thin. But with Gilgeous-Alexander locked in, Holmgren growing by the game, and a full-throttle OKC crowd behind them, the Thunder are in prime position to close the series with a statement win and begin what could be a new NBA dynasty. A controlled, balanced effort and one final MVP-level performance should be enough to deliver a 106–98 victory and a well-earned championship on their home floor.
reese homer! pic.twitter.com/WiHhDmrqDH
— Chicago Cubs (@Cubs) June 20, 2025
Seattle vs. Chicago Cubs Prop Picks (AI)
Seattle vs. Chicago Cubs Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Mariners and Cubs and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most watching on the trending weight knucklehead sportsbettors regularly put on player performance factors between a Mariners team going up against a possibly strong Cubs team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Seattle vs Chicago Cubs picks, computer picks Mariners vs Cubs, best bets, model edges, confidence ratings.
![]() |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
![]() |
|
MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
![]() |
|
MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
![]() |
|
MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
![]() |
|
MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
![]() |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Mariners Betting Trends
Seattle has struggled on the road recently, particularly when underdogs—they are just 1–4 ATS in their last five games as underdogs and carry a 17–16–3 ATS record at Wrigley this season.
Cubs Betting Trends
Chicago has covered the spread in just four of their past ten games, though they maintain a solid 20–17 ATS at home and are 35–32–5 with the total at Wrigley this year.
Mariners vs. Cubs Matchup Trends
Five of the Cubs’ last ten home games have gone under the total, and Seattle has seen the under come in 12 of their last 35 road outings—setting up a likely low-to-mid scoring affair.
Seattle vs. Chicago Cubs Game Info
What time does Seattle vs Chicago Cubs start on June 21, 2025?
Seattle vs Chicago Cubs starts on June 21, 2025 at 2:20 PM EST.
Where is Seattle vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for Seattle vs Chicago Cubs?
Spread: Chicago Cubs -1.5
Moneyline: Seattle +141, Chicago Cubs -169
Over/Under: 12
What are the records for Seattle vs Chicago Cubs?
Seattle: (38-36) | Chicago Cubs: (45-30)
What is the AI best bet for Seattle vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: S. Suzuki under 9.5 Fantasy Score.. Prices move—always shop for the best number.
What are Seattle vs Chicago Cubs trending bets?
Five of the Cubs’ last ten home games have gone under the total, and Seattle has seen the under come in 12 of their last 35 road outings—setting up a likely low-to-mid scoring affair.
What are Seattle trending bets?
SEA trend: Seattle has struggled on the road recently, particularly when underdogs—they are just 1–4 ATS in their last five games as underdogs and carry a 17–16–3 ATS record at Wrigley this season.
What are Chicago Cubs trending bets?
CHC trend: Chicago has covered the spread in just four of their past ten games, though they maintain a solid 20–17 ATS at home and are 35–32–5 with the total at Wrigley this year.
Where can I find AI Picks for Seattle vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Seattle vs. Chicago Cubs Odds
AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Seattle vs Chicago Cubs trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.
Seattle vs Chicago Cubs Opening Odds
SEA Moneyline:
+141 CHC Moneyline: -169
SEA Spread: +1.5
CHC Spread: -1.5
Over/Under: 12
Seattle vs Chicago Cubs Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+194
-235
|
+1.5 (-105)
-1.5 (-114)
|
O 8.5 (-122)
U 8.5 (+100)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-168
|
-1.5 (+118)
|
O 9 (-122)
U 9 (+100)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+132
-156
|
+1.5 (-154)
-1.5 (+128)
|
O 8.5 (-106)
U 8.5 (-114)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+102
-120
|
-1.5 (+162)
+1.5 (-196)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+198
-240
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-108)
U 8 (-112)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-124
+106
|
-1.5 (+130)
+1.5 (-156)
|
O 8.5 (-112)
U 8.5 (-108)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+177
-197
|
+1.5 (-118)
-1.5 (-102)
|
O 8.5 (-118)
U 8.5 (-102)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+128
-152
|
+1.5 (-178)
-1.5 (+146)
|
O 7.5 (-120)
U 7.5 (-102)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+143
-158
|
+1.5 (-150)
-1.5 (+130)
|
O 8.5 (+100)
U 8.5 (-120)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+132
-156
|
+1.5 (-172)
-1.5 (+142)
|
O 7 (-120)
U 7 (-102)
|
|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+120
-132
|
+1.5 (-180)
-1.5 (+157)
|
O 7.5 (-115)
U 7.5 (-105)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+102
-120
|
+1.5 (-215)
-1.5 (+180)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+104
-115
|
+1.5 (-185)
-1.5 (+161)
|
O 10 (-110)
U 10 (-110)
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Seattle Mariners vs. Chicago Cubs Cubs on June 21, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
![]() |
LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |