Mariners vs. Cubs
Prediction, Odds & Props
Jun 21 | MLB AI Picks

Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Seattle Mariners head to Wrigley Field to take on the Chicago Cubs on June 21, 2025, with the Cubs firmly leading the National League Central and the Mariners chasing a Wild Card spot. With both pitching staffs healthy and key hitters back in the lineup, this interleague contest could hinge on one big inning at either park.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 21, 2025

Start Time: 2:20 PM EST​

Venue: Wrigley Field​

Cubs Record: (45-30)

Mariners Record: (38-36)

OPENING ODDS

SEA Moneyline: +141

CHC Moneyline: -169

SEA Spread: +1.5

CHC Spread: -1.5

Over/Under: 12

SEA
Betting Trends

  • Seattle has struggled on the road recently, particularly when underdogs—they are just 1–4 ATS in their last five games as underdogs and carry a 17–16–3 ATS record at Wrigley this season.

CHC
Betting Trends

  • Chicago has covered the spread in just four of their past ten games, though they maintain a solid 20–17 ATS at home and are 35–32–5 with the total at Wrigley this year.

MATCHUP TRENDS

  • Five of the Cubs’ last ten home games have gone under the total, and Seattle has seen the under come in 12 of their last 35 road outings—setting up a likely low-to-mid scoring affair.

SEA vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Suzuki under 9.5 Fantasy Score.

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Seattle vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 6/21/25

The June 21, 2025 matchup between the Seattle Mariners and Chicago Cubs at Wrigley Field pits two postseason hopefuls with contrasting momentum and identities in a game that may ultimately be decided by pitching command and timely execution. The Cubs enter the contest firmly atop the NL Central, thanks to a blend of elite outfield defense, reliable starting pitching, and a deep, balanced lineup anchored by Kyle Tucker, Seiya Suzuki, and the electric Pete Crow-Armstrong, whose speed and glove have made him a breakout force. Chicago has found stability at home, building a solid 20–17 record against the spread at Wrigley, though recent trends show inconsistency in run-line outcomes with a 4–6 ATS mark over their last ten games. On the other side, Seattle is in a tight American League Wild Card race but has struggled to produce consistent offense on the road, especially when cast as underdogs. Their 1–4 ATS record in their last five as road underdogs reflects those offensive lulls, but they bring back Luke Raley to rejoin a lineup that has leaned heavily on the power of Cal Raleigh, who currently leads the majors in home runs.

The pitching duel could prove pivotal: Chicago is expected to send Matthew Boyd to the mound, a lefty who has regained both velocity and command, while Seattle counters with George Kirby, fresh off back-to-back starts in which he struck out 19 batters combined with minimal walks. With two pitchers capable of limiting base runners and suppressing power, the flow of the game may hinge on infield execution and bullpen matchups in the sixth inning and beyond. Defensively, both clubs rank above average, and at a ballpark where wind and angles can influence outcomes dramatically, clean fielding and smart baserunning become critical. Historically, these teams haven’t faced each other often, but the Cubs have won every home series against Seattle at Wrigley, which adds psychological weight to Chicago’s advantage. The under has hit frequently in recent Cubs home games and Seattle road outings, pointing toward another controlled, low-to-mid scoring game. The Mariners will need to maximize every scoring opportunity they get—likely through base hits and aggressive running—while the Cubs can afford to lean on their deeper lineup and multi-inning bullpen structure to keep the game in check. If either starting pitcher gets hit early, the direction of the game could shift sharply, but if both settle in, this will turn into a battle of bullpen control and timely hitting. The Cubs’ ability to mix in left- and right-handed matchups late gives them a slight strategic edge, but Seattle’s high-upside arms keep them very much in this contest. Expect a game driven by strategy, fielding, and execution, where one big swing or defensive miscue may ultimately tip the balance in what figures to be a tense, tightly contested interleague showdown at the Friendly Confines.

Seattle Mariners MLB Preview

The Seattle Mariners head into their June 21, 2025 matchup against the Chicago Cubs at Wrigley Field looking to snap out of an uneven stretch that has seen them falter in run production and against the spread, especially as road underdogs. With a recent 1–4 ATS record in their last five games as underdogs and a broader pattern of inconsistency in away games, the Mariners are in urgent need of a reset, and they’re hoping that begins with strong starting pitching. George Kirby is expected to take the mound, and his recent form offers optimism—he’s recorded 19 strikeouts over his last two starts, showcasing elite control, efficient sequencing, and the poise to keep high-powered lineups in check. Kirby’s ability to navigate deep into games without surrendering big innings will be key at Wrigley, where the unpredictable wind and fast outfield grass can quickly turn mistakes into momentum swings. Offensively, the Mariners have struggled to sustain rallies away from home, particularly against left-handed pitching, and they’ll need to be more aggressive early in counts if they want to put pressure on Cubs starter Matthew Boyd, who has been stingy with walks and successful in limiting slugging percentages against both sides of the plate.

The return of Luke Raley from injury offers a much-needed boost to a lineup that has relied too heavily on Cal Raleigh, whose league-leading home run total has not been enough to offset the club’s tendency to leave runners on base. Seattle’s approach at the plate must lean toward contact and pressure—their best path to runs is through singles, stolen bases, and exploiting defensive shifts rather than waiting for a long ball in a pitcher-friendly environment. Defensively, Seattle has performed well, with a solid infield and an outfield capable of covering the wide gaps at Wrigley, which will be crucial in preventing extra-base hits from Chicago’s aggressive baserunners. The Mariners’ bullpen has improved in recent weeks, showing signs of cohesion and reliability that had been missing earlier in the season, and manager Scott Servais will likely lean on his best arms early if Kirby encounters any turbulence. To win or cover in this contest, Seattle must control the pace of the game, limit free passes, and convert any scoring opportunity that arises—especially in the middle innings where they’ve too often gone silent. The pressure is on the offense to complement their strong pitching with timely hits, while the bullpen must protect any narrow margin afforded to them. If Seattle can execute their pitching-centric blueprint while avoiding the long scoring droughts that have plagued them, they are more than capable of challenging a Cubs team that has played well but remains vulnerable to disciplined teams with upside in the rotation. This game offers the Mariners a chance to prove they can win on the road against a playoff-caliber opponent and reestablish themselves as a force in the AL Wild Card race.

The Seattle Mariners head to Wrigley Field to take on the Chicago Cubs on June 21, 2025, with the Cubs firmly leading the National League Central and the Mariners chasing a Wild Card spot. With both pitching staffs healthy and key hitters back in the lineup, this interleague contest could hinge on one big inning at either park. Seattle vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Jun 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Oklahoma City Thunder enter Game 7 of the 2025 NBA Finals with home-court advantage, a 68–14 regular season behind them, and the league MVP Shai Gilgeous-Alexander poised to lead them to the franchise’s first title since 1979. Their campaign has been built on elite defense, selfless offensive flow, and a youth-driven identity that has matured into a dominant force under head coach Mark Daigneault. The Thunder have gone 9–2 at home this postseason and hold a 6.5-point spread in their favor for Game 7, reflecting the confidence oddsmakers and fans alike have in their ability to rise to the occasion. Gilgeous-Alexander has been brilliant, combining crafty isolation scoring with unflappable late-game poise, and he’ll be the focal point once again, supported by Jalen Williams’ all-around game and Chet Holmgren’s increasingly impactful two-way presence. The recent shift to placing Holmgren in a rebounding-centric role has paid dividends, as the rookie center has hauled in 26 boards across the last two games while anchoring OKC’s interior defense with more confidence and physicality. Offensively, the Thunder utilize dribble-drive action, corner spacing, and a steady diet of screen usage to create high-efficiency looks for their perimeter scorers and cutters. Jalen Williams and Lu Dort stretch opposing wings with slashing and catch-and-shoot opportunities, while Alex Caruso and Isaiah Joe offer defensive versatility and timely shotmaking that often swing momentum.

Oklahoma City’s greatest strength is its composure—despite its youth, this team rarely panics, having closed out tight games repeatedly throughout the season with controlled execution and excellent spacing. Defensively, Dort will again be tasked with disrupting Tyrese Haliburton’s rhythm, likely picking him up full-court to burn clock and limit Indiana’s offensive flow. Caruso may see increased minutes off the bench for situational defense and timely stops, especially if the game tightens late. OKC’s transition defense has also been exceptional in the Finals, helping slow Indiana’s breakneck pace and forcing them into a half-court game, where the Thunder’s length and switchability allow them to smother possessions. In Game 7, the Thunder will look to assert themselves early, control the tempo, and prevent the Pacers from dictating flow through full-court pressure or second-chance points. With Haliburton not fully healthy and the Pacers reliant on streaky perimeter shooting, OKC will be confident if they can build an early lead and control the boards. Managing foul trouble, avoiding complacency, and making timely substitutions will be crucial as the margin for error in a Game 7 is razor-thin. But with Gilgeous-Alexander locked in, Holmgren growing by the game, and a full-throttle OKC crowd behind them, the Thunder are in prime position to close the series with a statement win and begin what could be a new NBA dynasty. A controlled, balanced effort and one final MVP-level performance should be enough to deliver a 106–98 victory and a well-earned championship on their home floor.

Seattle vs. Chicago Cubs Prop Picks (AI)

AI algorithm Remi is pouring through mountains of stats on each line. In fact, anytime the Mariners and Cubs play there’s always several intriguing angles to key in on. Not to mention games played at Wrigley Field in Jun rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: S. Suzuki under 9.5 Fantasy Score.

Seattle vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every simulation between the Mariners and Cubs and using recursive machine learning and impressive AI to analyze the data to a single cover probability.

Interestingly enough, the data has been most watching on the trending weight knucklehead sportsbettors regularly put on player performance factors between a Mariners team going up against a possibly strong Cubs team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Seattle vs Chicago Cubs picks, computer picks Mariners vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Mariners Betting Trends

Seattle has struggled on the road recently, particularly when underdogs—they are just 1–4 ATS in their last five games as underdogs and carry a 17–16–3 ATS record at Wrigley this season.

Cubs Betting Trends

Chicago has covered the spread in just four of their past ten games, though they maintain a solid 20–17 ATS at home and are 35–32–5 with the total at Wrigley this year.

Mariners vs. Cubs Matchup Trends

Five of the Cubs’ last ten home games have gone under the total, and Seattle has seen the under come in 12 of their last 35 road outings—setting up a likely low-to-mid scoring affair.

Seattle vs. Chicago Cubs Game Info

Seattle vs Chicago Cubs starts on June 21, 2025 at 2:20 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: Seattle +141, Chicago Cubs -169
Over/Under: 12

Seattle: (38-36)  |  Chicago Cubs: (45-30)

Remi's searched hard and found the best prop for this matchup: S. Suzuki under 9.5 Fantasy Score.. Prices move—always shop for the best number.

Five of the Cubs’ last ten home games have gone under the total, and Seattle has seen the under come in 12 of their last 35 road outings—setting up a likely low-to-mid scoring affair.

SEA trend: Seattle has struggled on the road recently, particularly when underdogs—they are just 1–4 ATS in their last five games as underdogs and carry a 17–16–3 ATS record at Wrigley this season.

CHC trend: Chicago has covered the spread in just four of their past ten games, though they maintain a solid 20–17 ATS at home and are 35–32–5 with the total at Wrigley this year.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. Chicago Cubs Odds

AI algorithm Remi is pouring through loads of stats on each team. In fact, anytime the Seattle vs Chicago Cubs trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.

Seattle vs Chicago Cubs Opening Odds

SEA Moneyline: +141
CHC Moneyline: -169
SEA Spread: +1.5
CHC Spread: -1.5
Over/Under: 12

Seattle vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. Chicago Cubs Cubs on June 21, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN