Brewers vs Twins Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 21)
Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Milwaukee Brewers visit the Minnesota Twins at Target Field on June 21, 2025, with both teams looking to fine-tune their midseason form. With pitching matchups and recent run-line trends in play, this interleague duel promises to hinge on key innings and bullpen execution.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 21, 2025
Start Time: 2:10 PM EST
Venue: Target Field
Twins Record: (37-38)
Brewers Record: (41-35)
OPENING ODDS
MIL Moneyline: +110
MIN Moneyline: -131
MIL Spread: +1.5
MIN Spread: -1.5
Over/Under: 9.5
MIL
Betting Trends
- The Brewers are 2–6 against the run line in their last eight games at home, and they’ve struggled ATS as underdogs against Minnesota, going 3–6 in their past ten interleague meetings at Target Field.
MIN
Betting Trends
- Minnesota has been a runaway ATS favorite of late, going 10–1 in its last 11 games overall, including a dominant 8–2 ATS mark in interleague road contests against the Brewers.
MATCHUP TRENDS
- The Brewers have combined with the Twins to hit the “under” in six of the last seven interleague games at Target Field, while Minnesota has covered the run line in 23 of their last 34 contests—suggesting a downward trend in both total scoring and run-line blowouts.
MIL vs. MIN
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Quintana over 16.5 Fantasy Score.
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Milwaukee vs Minnesota Prediction & Odds:
Free MLB Betting Insights for 6/21/25
Offensively, both teams lean toward the situational end of the spectrum rather than depending on home run barrages, with Minnesota showing better patience and contact skills in high-leverage moments. The Twins’ pitching staff, led by a mix of control-focused starters and a bullpen that’s peaking at the right time, has made a habit of suppressing late rallies, particularly in one-run games. Milwaukee’s challenge will be twofold: keeping the game close early against a lineup that doesn’t give away at-bats, and avoiding bullpen breakdowns that have cost them several tight games in recent weeks. Historically, these teams have combined for the under in six of their last seven matchups at Target Field, and both enter this game with rosters built to suppress scoring rather than inflate it, particularly with two starters capable of missing bats and keeping hitters honest. The Brewers will need to manufacture offense early or create pressure through base running and extended at-bats to give themselves a shot against a Twins team that rarely beats itself. In the end, while the Twins are deserved favorites given their recent form and home dominance, the unpredictability of a rookie flamethrower on the mound for Milwaukee keeps the game interesting from both a betting and competitive standpoint. The most likely outcome is a close, low-scoring battle decided by which bullpen blinks first and which offense seizes a scoring opportunity late—an area where Minnesota currently holds the edge.
We are witnessing the beginning of something very, very special@Jmisiorowski9 pic.twitter.com/tIVuhnFO89
— Milwaukee Brewers (@Brewers) June 21, 2025
Milwaukee Brewers MLB Preview
The Milwaukee Brewers head into their June 21, 2025 matchup against the Minnesota Twins with the hope that electric rookie Jacob Misiorowski can help stabilize a team that’s been inconsistent both offensively and against the spread in recent weeks. Despite being in the thick of the National League Central race earlier this season, the Brewers have struggled mightily to cover the run line recently, going just 2–6 ATS in their last eight games and showing particular vulnerability as underdogs. Their visit to Target Field brings additional challenges, as Milwaukee has dropped six of their last nine matchups at the Twins’ home park and has failed to consistently generate offense against Minnesota’s pitching staff in those contests. However, the addition of Misiorowski to the rotation offers a potential spark. The right-hander flashed elite stuff in his debut, throwing five no-hit innings and topping out at 102 mph, which gives Milwaukee a high-ceiling weapon to potentially shut down Minnesota’s methodical offense. Offensively, the Brewers are led by a resurgent Christian Yelich, who appears to be rounding into form with improved contact rates and timely hitting. William Contreras and rookie Jackson Chourio offer additional threats in a lineup that, while lacking explosive power, is capable of stringing together productive innings when executing small-ball fundamentals.
The issue for Milwaukee has been consistency, both at the plate and in late-game execution, where bullpen lapses and defensive miscues have cost them several close contests. Their bullpen, once a strength, has been unpredictable of late, particularly when tasked with protecting narrow leads or keeping deficits within reach. Defensively, the Brewers can be sharp, especially with Willy Adames anchoring the infield, but they’ve also committed untimely errors that have extended innings and allowed opponents to pull away. If Misiorowski can replicate his debut performance and hold Minnesota to minimal damage over five or six innings, the Brewers have a chance to keep this game within striking distance, particularly if their offense can capitalize on early scoring chances. However, if the bullpen is called upon too early or the bats go cold—as they have in several interleague matchups—Milwaukee could again find itself unable to cover the run line. ATS trends suggest caution for bettors favoring the Brewers, but their upside remains tied to how well their young starter handles the moment and whether their veterans can step up against a disciplined Twins club. A tight, low-scoring affair would be ideal for Milwaukee’s chances, but they’ll need to be sharper across the board than they’ve been in recent weeks to pull off a road upset or even stay within a single run at Target Field.

Credit: USA TODAY/IMAGN
Minnesota Twins MLB Preview
The Minnesota Twins welcome the Milwaukee Brewers to Target Field on June 21, 2025, riding an impressive wave of momentum and standing as one of the most reliable teams in baseball against the spread over the past month. Winners of 10 of their last 11 ATS and playing disciplined, low-risk baseball, the Twins have constructed a winning formula centered on pitching depth, defensive precision, and consistent contact hitting. Their recent run-line dominance isn’t a coincidence—it reflects their ability to control tempo, limit big innings, and close out games with poise, especially at home where they’ve consistently outperformed opponents both straight up and against the line. The rotation has found its rhythm, offering quality starts across the board, while the bullpen has emerged as a legitimate weapon, protecting narrow leads with sharp execution and situational awareness. Although Minnesota may lack the flashy offensive firepower of other American League contenders, their batting order, led by Byron Buxton, Carlos Correa, and Edouard Julien, excels in grinding out at-bats, moving runners, and pressuring opposing pitchers into mistakes. That relentless approach has kept them competitive even in low-scoring games and has proven especially effective against erratic or inexperienced starters—a situation they’ll look to exploit against Brewers rookie Jacob Misiorowski.
Defensively, the Twins have been sharp, minimizing errors and turning key double plays in tight innings, which has helped suppress scoring and sustain their under-trend tendencies in betting markets. Their fielders are athletic and well-positioned, and their pitchers trust the defense behind them, allowing for efficient pitch-to-contact strategies that keep games moving quickly and opponents frustrated. From a managerial standpoint, Rocco Baldelli has shown a masterful command of in-game tactics, particularly with bullpen usage and lineup adjustments late in contests. The Twins often win close games by executing the little things—pinch hits, stolen bases, bunt placement—which has made them a nightmare to close out even for elite bullpens. Against Milwaukee, the Twins will likely look to wear down the young starter early, extend at-bats, and build scoring threats through situational hitting. Their bullpen, having excelled at neutralizing threats in the seventh inning and beyond, gives them a strategic advantage if the game stays within a one- or two-run margin. The overall profile of the Twins heading into this matchup suggests a team fully in control of its identity, playing with confidence, and thriving under structure. Their recent run-line trends, combined with home-field consistency and opponent volatility, position them as the clear side to back in this interleague tilt. If they stick to their formula—early pressure, clean defense, and late-inning shutdowns—they are well-equipped not only to win but to cover yet again against a Brewers squad still searching for balance and reliability.
The force is strong with this one pic.twitter.com/goEKYE2lXy
— Minnesota Twins (@Twins) June 20, 2025
Milwaukee vs. Minnesota Prop Picks (AI)
Milwaukee vs. Minnesota Prediction (AI)

Remi, our AI sports wizard, has been pouring over tons of data from every angle between the Brewers and Twins and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.
Remi has been most keyed in on the linear correlation of emphasis knucklehead sportsbettors regularly put on coaching factors between a Brewers team going up against a possibly tired Twins team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Milwaukee vs Minnesota picks, computer picks Brewers vs Twins, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Brewers Betting Trends
The Brewers are 2–6 against the run line in their last eight games at home, and they’ve struggled ATS as underdogs against Minnesota, going 3–6 in their past ten interleague meetings at Target Field.
Twins Betting Trends
Minnesota has been a runaway ATS favorite of late, going 10–1 in its last 11 games overall, including a dominant 8–2 ATS mark in interleague road contests against the Brewers.
Brewers vs. Twins Matchup Trends
The Brewers have combined with the Twins to hit the “under” in six of the last seven interleague games at Target Field, while Minnesota has covered the run line in 23 of their last 34 contests—suggesting a downward trend in both total scoring and run-line blowouts.
Milwaukee vs. Minnesota Game Info
What time does Milwaukee vs Minnesota start on June 21, 2025?
Milwaukee vs Minnesota starts on June 21, 2025 at 2:10 PM EST.
Where is Milwaukee vs Minnesota being played?
Venue: Target Field.
What are the opening odds for Milwaukee vs Minnesota?
Spread: Minnesota -1.5
Moneyline: Milwaukee +110, Minnesota -131
Over/Under: 9.5
What are the records for Milwaukee vs Minnesota?
Milwaukee: (41-35) | Minnesota: (37-38)
What is the AI best bet for Milwaukee vs Minnesota?
Remi's searched hard and found the best prop for this matchup: J. Quintana over 16.5 Fantasy Score.. Prices move—always shop for the best number.
What are Milwaukee vs Minnesota trending bets?
The Brewers have combined with the Twins to hit the “under” in six of the last seven interleague games at Target Field, while Minnesota has covered the run line in 23 of their last 34 contests—suggesting a downward trend in both total scoring and run-line blowouts.
What are Milwaukee trending bets?
MIL trend: The Brewers are 2–6 against the run line in their last eight games at home, and they’ve struggled ATS as underdogs against Minnesota, going 3–6 in their past ten interleague meetings at Target Field.
What are Minnesota trending bets?
MIN trend: Minnesota has been a runaway ATS favorite of late, going 10–1 in its last 11 games overall, including a dominant 8–2 ATS mark in interleague road contests against the Brewers.
Where can I find AI Picks for Milwaukee vs Minnesota?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Milwaukee vs. Minnesota Odds
Remi is pouring through tons of data points on each player. In fact, anytime the Milwaukee vs Minnesota trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.
Milwaukee vs Minnesota Opening Odds
MIL Moneyline:
+110 MIN Moneyline: -131
MIL Spread: +1.5
MIN Spread: -1.5
Over/Under: 9.5
Milwaukee vs Minnesota Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 9:08PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 9:08PM
Dodgers
Blue Jays
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–
–
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-140
+127
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-1.5 (+124)
+1.5 (-140)
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O 7.5 (+107)
U 7.5 (-123)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Milwaukee Brewers vs. Minnesota Twins on June 21, 2025 at Target Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |