Royals vs. Padres
Prediction, Odds & Props
Jun 21 | MLB AI Picks

Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Kansas City Royals travel to Petco Park to face the San Diego Padres on June 21, 2025, with first pitch scheduled for 7:15 p.m. ET. The Padres open as solid favorites at −167 on the moneyline, with the total set at 7.5 runs, hinting at a moderately paced offensive contest.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 21, 2025

Start Time: 7:15 PM EST​

Venue: Petco Park​

Padres Record: (40-35)

Royals Record: (38-38)

OPENING ODDS

KC Moneyline: +136

SD Moneyline: -163

KC Spread: +1.5

SD Spread: -1.5

Over/Under: 7.5

KC
Betting Trends

  • The Royals have gone 5–5 against the run line in their last ten games and are 6–4 ATS over their past ten matchups overall, showing balanced performance as underdogs.

SD
Betting Trends

  • San Diego has struggled ATS of late, posting a 4–6 run line record in their previous ten games and a 5–5 ATS mark in the last ten, including a 5–5 record straight up.

MATCHUP TRENDS

  • Padres games have hit the over in five of their last ten outings, while Royals games have gone over seven of ten, suggesting the 7.5 total is well-placed and could lean toward the over tonight.

KC vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: V. Pasquantino over 5 Fantasy Score.

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Kansas City vs San Diego Prediction & Odds:
Free MLB Betting Insights for 6/21/25

Saturday’s interleague matchup at Petco Park between the Kansas City Royals and the San Diego Padres presents a compelling contrast in team identity and recent performance, as the Royals continue to surprise with above-average play while the Padres attempt to solidify their playoff footing amid streaky form. Kansas City enters the contest with a 37–38 record and is expected to send left-hander Noah Cameron to the mound, who has been a revelation in limited innings, carrying a 1.91 ERA and the ability to miss bats while limiting damage. The Royals took Game 1 of the series 6–5 in dramatic fashion, showcasing their offensive resilience and timely execution, and they’ve now won six of their last ten games overall with a 6–4 record against the spread in that span, giving bettors reason to trust them in underdog roles. Offensively, Kansas City has averaged 4.5 runs per game over its last ten, powered by a productive stretch from Salvador Perez and Bobby Witt Jr., who have anchored the middle of the order with extra-base hits and game-changing at-bats. The Padres, meanwhile, are 40–34 and will counter with Dylan Cease, a hard-throwing right-hander with high strikeout ability but a 2–6 record and a 4.69 ERA that reflects inconsistency and vulnerability to rallies when command falters.

Cease’s outings often hinge on early pitch efficiency, and against a contact-driven Royals lineup, his margin for error will be slim if the bullpen is asked to shoulder heavy innings early. San Diego’s offense has shown signs of life, with Xander Bogaerts recording a four-hit game earlier this week and Fernando Tatis Jr. continuing to flash power and speed, though the Padres’ 5–5 record in their last ten games, paired with a 4–6 ATS mark, signals that they haven’t fully clicked in all phases. Defensively, the Padres have been solid, and their late-inning relief group led by Robert Suarez and Yuki Matsui has been more dependable lately, though they’ll need to protect leads carefully against a Kansas City team that has stolen wins in the seventh inning or later with timely knocks. The betting total is set at 7.5, a figure that suggests confidence in the starters but could be tested if either team strings together innings with pressure on the basepaths or long-ball threats from the heart of each lineup. Matchup-wise, the Royals’ lefty-versus-righty edge may allow them to build early offense, while the Padres’ experience and depth give them the tools to close strong if Cease delivers at least five solid innings. In what projects to be a closely contested game, the outcome may come down to bullpen execution and which offense executes better with runners in scoring position, and given recent form, it wouldn’t be surprising to see a 5–4 or 6–5 final score either way with the total leaning slightly toward the over if both starters fail to last into the late innings.

Kansas City Royals MLB Preview

The Kansas City Royals enter Saturday’s game at Petco Park carrying positive momentum and a renewed sense of competitiveness as they aim to climb above .500 while continuing their impressive stretch of play that has delivered six wins in their last ten contests and a 6–4 mark against the spread during that run, which included a gritty 6–5 victory in Friday’s opener against the Padres. Expected to start for Kansas City is left-hander Noah Cameron, a rising arm who has posted a 1.91 ERA in limited major league action and offers poise, command, and a versatile pitch mix that should play well in a pitcher-friendly park like San Diego’s, particularly against a Padres lineup that tends to be more aggressive early in counts. Cameron’s ability to change speeds and work both sides of the plate will be critical in keeping hitters like Fernando Tatis Jr. and Manny Machado off balance, while minimizing damage in hitter-friendly counts. Offensively, the Royals have been on a steady scoring trend, averaging 4.5 runs per game over their last ten and leaning heavily on the leadership and bat of Salvador Perez, who continues to anchor the heart of the order with both power and clutch production, as well as the all-around excellence of Bobby Witt Jr., whose mix of speed, defense, and timely hitting has kept Kansas City competitive in tight games. Jonathan India has also been a sparkplug, extending innings and setting the table for the middle of the lineup, while the bottom third has contributed with opportunistic hits that have flipped the order over and added pressure to opposing pitchers.

Kansas City’s bullpen, though not elite, has been effective in recent outings, closing out late-inning leads and minimizing inherited runner scoring, with relievers like James McArthur and John Schreiber providing needed stability in close contests. Manager Matt Quatraro has shown confidence in his young arms, often trusting his staff to get through the sixth and seventh innings before turning to his most reliable back-end options. Defensively, the Royals have tightened up considerably from earlier in the season, playing sharp infield defense and limiting extra bases with accurate throws and good positional awareness, and they’ll need to maintain that standard to contain a Padres team that can turn singles into rallies when given extra chances. With Kansas City’s recent win and ATS record against quality opponents, they’re well positioned to keep the game close or potentially win outright if they can jump on Dylan Cease early and keep San Diego from getting a rhythm in the middle innings. If Cameron provides quality length and the Royals can force the Padres to use multiple bullpen arms before the seventh, they have the speed and situational hitting needed to tip the balance late, and while they remain underdogs, their form and confidence give them a strong opportunity to cover and possibly secure another narrow win in a 5–4 or 6–5 game.

The Kansas City Royals travel to Petco Park to face the San Diego Padres on June 21, 2025, with first pitch scheduled for 7:15 p.m. ET. The Padres open as solid favorites at −167 on the moneyline, with the total set at 7.5 runs, hinting at a moderately paced offensive contest. Kansas City vs San Diego AI Prediction: Free MLB Betting Insights for Jun 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres enter Saturday’s matchup at Petco Park looking to rebound after a narrow 6–5 loss in Friday’s opener to the Kansas City Royals, a game in which they showed offensive promise but were ultimately undone by missed opportunities and a few lapses in execution that have become familiar in their recent stretch of inconsistent play, resulting in a 5–5 record over their last ten games and a 4–6 mark against the spread during that time. Dylan Cease is expected to take the mound for San Diego, and while his record stands at 2–6 with a 4.69 ERA, he remains a high-upside starter capable of overpowering lineups with his fastball-slider combo and generating strikeouts at an elite clip when he’s in rhythm, although his command has wavered at times, especially when falling behind in counts or working from the stretch. The Padres’ offense has continued to flash potential, averaging just over four runs per game during their current stretch, with Fernando Tatis Jr. providing pop and energy at the top of the lineup, Manny Machado driving in runs when healthy, and Xander Bogaerts turning in one of his best performances of the season earlier this week with a four-hit game that helped propel a 5–3 win over the Dodgers.

Their top half of the order remains potent and fully capable of putting up crooked numbers when they string together at-bats, but they’ll need to be more efficient with runners in scoring position after leaving multiple chances on the table in Game 1 against Kansas City. Defensively, the Padres have played well at home, showing strong infield range and outfield coverage that has kept damage limited on bloopers and extra-base threats, and with an athletic roster, they’ve been effective in minimizing defensive breakdowns even in higher-scoring games. The bullpen continues to be a strength when called upon in manageable situations, with Robert Suarez and Yuki Matsui emerging as dependable late-inning options, though usage has been slightly elevated of late due to short outings from the rotation, placing added pressure on Cease to provide length in this one. Manager Mike Shildt has stressed the importance of sharper execution and timely hitting, knowing that the Royals have shown a knack for rallying late and stealing games in the seventh inning or later, and with a betting total set at 7.5, there’s a clear emphasis on pitching efficiency and controlling tempo to keep this from becoming another tight offensive battle. San Diego’s success hinges on Cease commanding the zone early, the offense delivering situational production with runners aboard, and the bullpen holding firm if called upon before the eighth inning, and if those boxes are checked, they are well positioned to respond with a win, cover the run line, and potentially keep the total under in a game that could finish in the neighborhood of 5–3 or 4–2 in favor of the home team.

Kansas City vs. San Diego Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each player. In fact, anytime the Royals and Padres play there’s always several intriguing trends to key in on. Not to mention games played at Petco Park in Jun can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: V. Pasquantino over 5 Fantasy Score.

Kansas City vs. San Diego Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Royals and Padres and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

The Algorithm has been most watching on the trending factor human bettors often put on Kansas City’s strength factors between a Royals team going up against a possibly healthy Padres team. In reality, the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Kansas City vs San Diego picks, computer picks Royals vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Royals Betting Trends

The Royals have gone 5–5 against the run line in their last ten games and are 6–4 ATS over their past ten matchups overall, showing balanced performance as underdogs.

Padres Betting Trends

San Diego has struggled ATS of late, posting a 4–6 run line record in their previous ten games and a 5–5 ATS mark in the last ten, including a 5–5 record straight up.

Royals vs. Padres Matchup Trends

Padres games have hit the over in five of their last ten outings, while Royals games have gone over seven of ten, suggesting the 7.5 total is well-placed and could lean toward the over tonight.

Kansas City vs. San Diego Game Info

Kansas City vs San Diego starts on June 21, 2025 at 7:15 PM EST.

Spread: San Diego -1.5
Moneyline: Kansas City +136, San Diego -163
Over/Under: 7.5

Kansas City: (38-38)  |  San Diego: (40-35)

Remi's searched hard and found the best prop for this matchup: V. Pasquantino over 5 Fantasy Score.. Prices move—always shop for the best number.

Padres games have hit the over in five of their last ten outings, while Royals games have gone over seven of ten, suggesting the 7.5 total is well-placed and could lean toward the over tonight.

KC trend: The Royals have gone 5–5 against the run line in their last ten games and are 6–4 ATS over their past ten matchups overall, showing balanced performance as underdogs.

SD trend: San Diego has struggled ATS of late, posting a 4–6 run line record in their previous ten games and a 5–5 ATS mark in the last ten, including a 5–5 record straight up.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Kansas City vs. San Diego Odds

AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the Kansas City vs San Diego trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.

Kansas City vs San Diego Opening Odds

KC Moneyline: +136
SD Moneyline: -163
KC Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5

Kansas City vs San Diego Live Odds

Games PTS ML SPR O/U
In Progress
Baltimore Orioles
New York Yankees
In Progress
Orioles
Yankees
0
0
+198
-240
+1.5 (-102)
-1.5 (-118)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+114)
O 9.5 (-110)
U 9.5 (-110)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+140
-166
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+102
-120
+1.5 (-196)
-1.5 (+162)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-144
+122
-1.5 (+115)
+1.5 (-138)
O 8 (-112)
U 8 (-108)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+108
-126
+1.5 (-196)
-1.5 (+162)
O 9 (+100)
U 9 (-122)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+180
-215
+1.5 (-118)
-1.5 (-102)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+116
-134
+1.5 (-184)
-1.5 (+152)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+144
-172
+1.5 (-142)
-1.5 (+118)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+126
-148
+1.5 (-188)
-1.5 (+155)
O 7.5 (-105)
U 7.5 (-115)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-142
+1.5 (-182)
-1.5 (+150)
O 7.5 (-118)
U 7.5 (-104)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-148
+126
-1.5 (+106)
+1.5 (-128)
O 9 (-108)
U 9 (-112)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-118
+1.5 (-210)
-1.5 (+172)
O 7.5 (+100)
U 7.5 (-122)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-118
-1.5 (+146)
+1.5 (-178)
O 10 (-114)
U 10 (-106)

MLB Past Picks

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Kansas City Royals vs. San Diego Padres on June 21, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS