Astros vs. Angels
Prediction, Odds & Props
Jun 21 | MLB AI Picks

Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Houston Astros head to Angel Stadium to take on the Los Angeles Angels on June 21, 2025, with first pitch scheduled for 9:38 p.m. ET. Houston opens as a slight favorite, while the total is set at 8.5 runs, suggesting a competitive matchup with moderate scoring potential.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 21, 2025

Start Time: 9:38 PM EST​

Venue: Angel Stadium of Anaheim​

Angels Record: (36-39)

Astros Record: (44-32)

OPENING ODDS

HOU Moneyline: -119

LAA Moneyline: -100

HOU Spread: -1.5

LAA Spread: +1.5

Over/Under: 8.5

HOU
Betting Trends

  • The Astros have been solid when favored, going 6–2 in their last eight games as moneyline favorites and sitting at a 5–5 ATS record over their past ten matchups, signaling consistent value in spread betting.

LAA
Betting Trends

  • The Angels have been tough to predict, posting a 4–1 ATS record in their last five games overall but an even 21–21 mark in road games as underdogs. Their home performances have leaned toward the over, with 14 of their last 31 home games pushing past the total.

MATCHUP TRENDS

  • Astros games have hit the over in 4 of their last 10, while Angels games have cleared the total in 2 of their last 5—making the 8.5-run line a reasonable candidate for an over play in a matchup defined by strong pitching and streaking offense.

HOU vs. LAA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Soriano under 18.5 Outs.

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Houston vs Los Angeles Angels Prediction & Odds:
Free MLB Betting Insights for 6/21/25

Saturday’s matchup between the Houston Astros and Los Angeles Angels at Angel Stadium is expected to be a competitive, moderately high-scoring affair between two clubs trending in different but compelling directions, with the Astros entering on a hot streak and the Angels showing flashes of sharp underdog resilience. Houston comes into the contest with a 10–4 record in June and 6–2 as a moneyline favorite over the past few weeks, buoyed by consistent offensive production and improved pitching depth, and they’ll send left-hander Brandon Walter to the mound, a young arm whose recent outings have shown promise, particularly with his ability to induce ground balls and limit big innings through soft contact. Walter’s job will be to navigate an Angels lineup that has looked more confident lately, anchored by leadoff spark Zach Neto, the slugging presence of Taylor Ward, and steady contributions from Nolan Schanuel, all of whom have helped Los Angeles post a 4–1 ATS record in their last five games, keeping them competitive in tighter contests. The Angels will counter with Hunter Brown, a right-hander who has shown flashes of brilliance but has been inconsistent this season, and his ability to command the zone early and avoid deep pitch counts will be critical to limiting Houston’s rhythm, especially with the Astros’ lineup finding success in working walks and stringing together productive at-bats in the middle innings.

Houston’s offense remains headlined by Alex Bregman, Kyle Tucker, and Yordan Álvarez, who provide a dangerous mix of power and patience, and if they can get into Brown’s secondary pitches early, the Astros are well-equipped to push runs across and force the Angels into early bullpen decisions. Defensively, both clubs have been competent, though Houston holds the edge in infield efficiency and outfield arm strength, which could be important in preventing extra bases in a park where doubles can quickly turn into momentum-shifting innings. The Astros’ bullpen, featuring quality arms like Bryan Abreu and Ryan Pressly, gives them a late-inning advantage, particularly if they enter the seventh with a lead, as Houston has closed out tight games effectively over the past few weeks. The Angels’ bullpen has shown improvement recently, but still lacks the depth and high-leverage experience of Houston’s relief corps, making it critical for their starter to work at least six innings to reduce exposure. With the betting total set at 8.5 runs, there’s an expectation that the game will feature steady offensive production without becoming an all-out slugfest, and given both teams’ recent run trends, the over is a realistic outcome if the starters falter early or either lineup takes advantage of long at-bats and error-prone defense. Ultimately, the game may hinge on which pitcher establishes command first and which offense executes with runners in scoring position, and while the Angels have played close games at home lately, the Astros’ overall form, lineup depth, and bullpen strength make them slight favorites in what could be a 5–4 or 6–5 road victory that delivers late drama and tests each team’s bullpen in the final frames.

Houston Astros MLB Preview

The Houston Astros enter Saturday’s matchup against the Los Angeles Angels with momentum on their side, having won 10 of their last 14 games in June and covering the run line in six of their last eight as moneyline favorites, a trend that underscores their resurgence after a slower start to the season. Houston’s projected starter Brandon Walter, a young left-hander, brings fresh energy and a developing pitch mix that emphasizes ground ball contact and deception, and although still gaining major league experience, he has been dependable in recent outings by limiting walks and inducing weak contact early in counts. His role will be to set the tone against an Angels lineup that thrives on working counts and generating pressure through situational hitting, and his success will hinge on avoiding the middle of the zone and maintaining efficiency through the first two times through the order. Offensively, the Astros continue to get significant production from their core, with Kyle Tucker and Yordan Álvarez driving in runs at an elite rate while Alex Bregman and Jeremy Peña provide strong contact and RBI opportunities from the middle and lower parts of the lineup.

The Astros have averaged just over five runs per game in their last ten, and their ability to score in multiple ways—via home runs, walks, or two-out rallies—makes them especially dangerous against pitchers like Hunter Brown who have struggled with consistency and command in early innings. Houston’s bullpen is one of its key advantages, featuring a trio of dependable arms in Bryan Abreu, Ryan Pressly, and Rafael Montero who have all shown the ability to protect leads and limit baserunners in high-leverage moments, and if Walter can hand the ball off with a lead, the Astros should feel confident in shutting the door. Defensively, the Astros remain sharp across the board, particularly in the infield where Peña and Jose Altuve continue to form one of the most efficient middle infield duos in the American League, and their ability to convert double plays and prevent extra bases should be a factor in keeping the Angels’ aggressive approach in check. Houston’s approach to this game will be simple but effective: establish early offense, work deep into counts against Brown, take advantage of any bullpen fatigue, and execute cleanly on defense to limit the Angels’ scoring windows. If Walter delivers a solid five innings and the lineup can get into the Los Angeles bullpen before the seventh, the Astros will be in prime position to cover and pull out another close win on the road, with a likely final score in the range of 5–4 or 6–5 and the total pushing just past the 8.5 mark depending on how both teams capitalize with runners in scoring position.

The Houston Astros head to Angel Stadium to take on the Los Angeles Angels on June 21, 2025, with first pitch scheduled for 9:38 p.m. ET. Houston opens as a slight favorite, while the total is set at 8.5 runs, suggesting a competitive matchup with moderate scoring potential. Houston vs Los Angeles Angels AI Prediction: Free MLB Betting Insights for Jun 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Los Angeles Angels Angels MLB Preview

The Los Angeles Angels return to Angel Stadium on Saturday night looking to build on their recent stretch of competitive play, having gone 4–1 ATS in their last five games and playing with more confidence at home, where they’ve shown the ability to hang tough against stronger opponents despite their underdog status. Hunter Brown is expected to take the mound for Los Angeles, and while the right-hander has flashed top-tier stuff in prior outings, his 2025 campaign has been marked by inconsistency, with control issues and early pitch-count climbs limiting his efficiency and putting extra pressure on the bullpen. The key for Brown will be commanding his fastball early and mixing in his breaking pitches effectively against a Houston Astros lineup that thrives on patient at-bats and power threats throughout the order, and if he can keep the walks down and avoid the long ball, he gives the Angels a realistic chance to remain within striking distance deep into the game. Offensively, the Angels are led by leadoff hitter Zach Neto, who has continued to provide spark with both his speed and ability to work counts, while Taylor Ward and Nolan Schanuel have each stepped up recently with timely hitting and situational execution that has kept the Angels competitive even when trailing early.

Los Angeles has averaged a steady four runs per game over their last ten outings and shown a tendency to score late, particularly against middle-relief arms, which could be a factor if they can chase Astros starter Brandon Walter by the fifth or sixth inning. The bullpen, though not elite, has stabilized in recent appearances, with improved outings from Matt Moore and Carlos Estévez giving manager Ron Washington more flexibility in navigating high-leverage innings without immediately turning to overused arms. Defensively, the Angels have also shown better fundamentals, cutting down on errors and improving their outfield alignment and communication, which will be crucial against a Houston team that looks to stretch singles into doubles and capitalize on any extra-base opportunities. The game script for the Angels likely involves a strong first three innings from Brown, opportunistic hitting with runners in scoring position, and continued late-inning pressure to exploit any lapses from the Astros’ bullpen or defensive positioning. If the Angels can keep the score within a run by the seventh, their improved execution and home energy could swing the momentum their way, potentially leading to a 5–4 upset win or at least a close-run game that results in another ATS cover. Much will depend on their ability to stay mentally sharp, take advantage of any Houston miscues, and not allow the game to get away from them early, and while the Astros enter as the favorite, the Angels’ current form, lineup resilience, and ability to play well as underdogs at home make this a game that could go either way in the late innings.

Houston vs. Los Angeles Angels Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each player. In fact, anytime the Astros and Angels play there’s always several intriguing observations to key in on. Not to mention games played at Angel Stadium of Anaheim in Jun can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Soriano under 18.5 Outs.

Houston vs. Los Angeles Angels Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Astros and Angels and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

The Algorithm has been most watching on the trending emphasis human bettors tend to put on coaching factors between a Astros team going up against a possibly healthy Angels team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Houston vs Los Angeles Angels picks, computer picks Astros vs Angels, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Astros Betting Trends

The Astros have been solid when favored, going 6–2 in their last eight games as moneyline favorites and sitting at a 5–5 ATS record over their past ten matchups, signaling consistent value in spread betting.

Angels Betting Trends

The Angels have been tough to predict, posting a 4–1 ATS record in their last five games overall but an even 21–21 mark in road games as underdogs. Their home performances have leaned toward the over, with 14 of their last 31 home games pushing past the total.

Astros vs. Angels Matchup Trends

Astros games have hit the over in 4 of their last 10, while Angels games have cleared the total in 2 of their last 5—making the 8.5-run line a reasonable candidate for an over play in a matchup defined by strong pitching and streaking offense.

Houston vs. Los Angeles Angels Game Info

Houston vs Los Angeles Angels starts on June 21, 2025 at 9:38 PM EST.

Venue: Angel Stadium of Anaheim.

Spread: Los Angeles Angels +1.5
Moneyline: Houston -119, Los Angeles Angels -100
Over/Under: 8.5

Houston: (44-32)  |  Los Angeles Angels: (36-39)

Remi's searched hard and found the best prop for this matchup: J. Soriano under 18.5 Outs.. Prices move—always shop for the best number.

Astros games have hit the over in 4 of their last 10, while Angels games have cleared the total in 2 of their last 5—making the 8.5-run line a reasonable candidate for an over play in a matchup defined by strong pitching and streaking offense.

HOU trend: The Astros have been solid when favored, going 6–2 in their last eight games as moneyline favorites and sitting at a 5–5 ATS record over their past ten matchups, signaling consistent value in spread betting.

LAA trend: The Angels have been tough to predict, posting a 4–1 ATS record in their last five games overall but an even 21–21 mark in road games as underdogs. Their home performances have leaned toward the over, with 14 of their last 31 home games pushing past the total.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Houston vs. Los Angeles Angels Odds

Remi is pouring through loads of data on each line. In fact, anytime the Houston vs Los Angeles Angels trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

Houston vs Los Angeles Angels Opening Odds

HOU Moneyline: -119
LAA Moneyline: -100
HOU Spread: -1.5
LAA Spread: +1.5
Over/Under: 8.5

Houston vs Los Angeles Angels Live Odds

Games PTS ML SPR O/U
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+158
-194
+1.5 (-126)
-1.5 (+104)
O 9 (-101)
U 9 (-120)
Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
+237
-301
+1.5 (+118)
-1.5 (-144)
O 7.5 (-112)
U 7.5 (-108)
Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
+168
-208
+1.5 (-119)
-1.5 (-102)
O 8 (-120)
U 8 (-102)
Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
-102
-119
-1.5 (+157)
+1.5 (-192)
O 8.5 (-121)
U 8.5 (-101)
Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
+162
-200
+1.5 (-126)
-1.5 (+104)
O 7.5 (-115)
U 7.5 (-105)
Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
-105
-115
-1.5 (+163)
+1.5 (-201)
O 8 (-108)
U 8 (-112)
Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
+123
-150
+1.5 (-157)
-1.5 (+128)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:11PM EDT
New York Mets
Miami Marlins
9/28/25 3:11PM
Mets
Marlins
-121
-101
-1.5 (+128)
+1.5 (-157)
O 8 (-116)
U 8 (-105)
Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
Braves
+168
-208
+1.5 (-123)
-1.5 (+101)
O 7.5 (-108)
U 7.5 (-112)
Sep 28, 2025 3:20PM EDT
St Louis Cardinals
Chicago Cubs
9/28/25 3:20PM
Cardinals
Cubs
 
-164
 
-1.5 (+127)
O 8.5 (-105)
U 8.5 (-116)
Sep 30, 2025 2:30PM EDT
San Diego Padres
Chicago Cubs
9/30/25 2:30PM
Padres
Cubs
+101
-123
pk
pk

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Houston Astros vs. Los Angeles Angels Angels on June 21, 2025 at Angel Stadium of Anaheim.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS