Astros vs. Angels
Prediction, Odds & Props
Jun 21 | MLB AI Picks
Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Houston Astros head to Angel Stadium to take on the Los Angeles Angels on June 21, 2025, with first pitch scheduled for 9:38 p.m. ET. Houston opens as a slight favorite, while the total is set at 8.5 runs, suggesting a competitive matchup with moderate scoring potential.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 21, 2025
Start Time: 9:38 PM EST
Venue: Angel Stadium of Anaheim
Angels Record: (36-39)
Astros Record: (44-32)
OPENING ODDS
HOU Moneyline: -119
LAA Moneyline: -100
HOU Spread: -1.5
LAA Spread: +1.5
Over/Under: 8.5
HOU
Betting Trends
- The Astros have been solid when favored, going 6–2 in their last eight games as moneyline favorites and sitting at a 5–5 ATS record over their past ten matchups, signaling consistent value in spread betting.
LAA
Betting Trends
- The Angels have been tough to predict, posting a 4–1 ATS record in their last five games overall but an even 21–21 mark in road games as underdogs. Their home performances have leaned toward the over, with 14 of their last 31 home games pushing past the total.
MATCHUP TRENDS
- Astros games have hit the over in 4 of their last 10, while Angels games have cleared the total in 2 of their last 5—making the 8.5-run line a reasonable candidate for an over play in a matchup defined by strong pitching and streaking offense.
HOU vs. LAA
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Soriano under 18.5 Outs.
LIVE MLB ODDS
MLB ODDS COMPARISON
WANT MORE AI PICKS?
VS. SPREAD
308-221
NET UNITS
(INCL VIG)
+418
NET PROFIT
(INCL VIG)
$100/UNIT
$41,803
VS. SPREAD
1554-1329
NET UNITS
(INCL VIG)
+376.6
NET PROFIT
(INCL VIG)
$100/UNIT
$37,661
AI SPORTS PICK PRODUCTS
Create a Free Account

Remi Finds New Picks

Remi Works 24/7
Remi uses this probability to assign units to each pick.
Get Remi's AI Picks
Get Remi’s Top AI Sports Picks sent direct to your inbox.
Hedge Meaning in Betting | 4 Obvious Times to Hedge
Learn about hedge betting to manage risk and secure profits. Understand...
What is a Push in Betting? | 3 Ways To Use To Your Advantage
Understand what a push in betting means, how it happens in...
What Does the + and – Mean in Sports Betting? | 5 Easy Tips
Learn the basics of sports betting odds, what the plus (+)...
Houston vs Los Angeles Angels Prediction & Odds:
Free MLB Betting Insights for 6/21/25
Houston’s offense remains headlined by Alex Bregman, Kyle Tucker, and Yordan Álvarez, who provide a dangerous mix of power and patience, and if they can get into Brown’s secondary pitches early, the Astros are well-equipped to push runs across and force the Angels into early bullpen decisions. Defensively, both clubs have been competent, though Houston holds the edge in infield efficiency and outfield arm strength, which could be important in preventing extra bases in a park where doubles can quickly turn into momentum-shifting innings. The Astros’ bullpen, featuring quality arms like Bryan Abreu and Ryan Pressly, gives them a late-inning advantage, particularly if they enter the seventh with a lead, as Houston has closed out tight games effectively over the past few weeks. The Angels’ bullpen has shown improvement recently, but still lacks the depth and high-leverage experience of Houston’s relief corps, making it critical for their starter to work at least six innings to reduce exposure. With the betting total set at 8.5 runs, there’s an expectation that the game will feature steady offensive production without becoming an all-out slugfest, and given both teams’ recent run trends, the over is a realistic outcome if the starters falter early or either lineup takes advantage of long at-bats and error-prone defense. Ultimately, the game may hinge on which pitcher establishes command first and which offense executes with runners in scoring position, and while the Angels have played close games at home lately, the Astros’ overall form, lineup depth, and bullpen strength make them slight favorites in what could be a 5–4 or 6–5 road victory that delivers late drama and tests each team’s bullpen in the final frames.
Held down the halos. #VoteStros x @MethodistHosp pic.twitter.com/85UjOzCb7M
— Houston Astros (@astros) June 21, 2025
Houston Astros MLB Preview
The Houston Astros enter Saturday’s matchup against the Los Angeles Angels with momentum on their side, having won 10 of their last 14 games in June and covering the run line in six of their last eight as moneyline favorites, a trend that underscores their resurgence after a slower start to the season. Houston’s projected starter Brandon Walter, a young left-hander, brings fresh energy and a developing pitch mix that emphasizes ground ball contact and deception, and although still gaining major league experience, he has been dependable in recent outings by limiting walks and inducing weak contact early in counts. His role will be to set the tone against an Angels lineup that thrives on working counts and generating pressure through situational hitting, and his success will hinge on avoiding the middle of the zone and maintaining efficiency through the first two times through the order. Offensively, the Astros continue to get significant production from their core, with Kyle Tucker and Yordan Álvarez driving in runs at an elite rate while Alex Bregman and Jeremy Peña provide strong contact and RBI opportunities from the middle and lower parts of the lineup.
The Astros have averaged just over five runs per game in their last ten, and their ability to score in multiple ways—via home runs, walks, or two-out rallies—makes them especially dangerous against pitchers like Hunter Brown who have struggled with consistency and command in early innings. Houston’s bullpen is one of its key advantages, featuring a trio of dependable arms in Bryan Abreu, Ryan Pressly, and Rafael Montero who have all shown the ability to protect leads and limit baserunners in high-leverage moments, and if Walter can hand the ball off with a lead, the Astros should feel confident in shutting the door. Defensively, the Astros remain sharp across the board, particularly in the infield where Peña and Jose Altuve continue to form one of the most efficient middle infield duos in the American League, and their ability to convert double plays and prevent extra bases should be a factor in keeping the Angels’ aggressive approach in check. Houston’s approach to this game will be simple but effective: establish early offense, work deep into counts against Brown, take advantage of any bullpen fatigue, and execute cleanly on defense to limit the Angels’ scoring windows. If Walter delivers a solid five innings and the lineup can get into the Los Angeles bullpen before the seventh, the Astros will be in prime position to cover and pull out another close win on the road, with a likely final score in the range of 5–4 or 6–5 and the total pushing just past the 8.5 mark depending on how both teams capitalize with runners in scoring position.

Credit: USA TODAY/IMAGN
Los Angeles Angels Angels MLB Preview
The Los Angeles Angels return to Angel Stadium on Saturday night looking to build on their recent stretch of competitive play, having gone 4–1 ATS in their last five games and playing with more confidence at home, where they’ve shown the ability to hang tough against stronger opponents despite their underdog status. Hunter Brown is expected to take the mound for Los Angeles, and while the right-hander has flashed top-tier stuff in prior outings, his 2025 campaign has been marked by inconsistency, with control issues and early pitch-count climbs limiting his efficiency and putting extra pressure on the bullpen. The key for Brown will be commanding his fastball early and mixing in his breaking pitches effectively against a Houston Astros lineup that thrives on patient at-bats and power threats throughout the order, and if he can keep the walks down and avoid the long ball, he gives the Angels a realistic chance to remain within striking distance deep into the game. Offensively, the Angels are led by leadoff hitter Zach Neto, who has continued to provide spark with both his speed and ability to work counts, while Taylor Ward and Nolan Schanuel have each stepped up recently with timely hitting and situational execution that has kept the Angels competitive even when trailing early.
Los Angeles has averaged a steady four runs per game over their last ten outings and shown a tendency to score late, particularly against middle-relief arms, which could be a factor if they can chase Astros starter Brandon Walter by the fifth or sixth inning. The bullpen, though not elite, has stabilized in recent appearances, with improved outings from Matt Moore and Carlos Estévez giving manager Ron Washington more flexibility in navigating high-leverage innings without immediately turning to overused arms. Defensively, the Angels have also shown better fundamentals, cutting down on errors and improving their outfield alignment and communication, which will be crucial against a Houston team that looks to stretch singles into doubles and capitalize on any extra-base opportunities. The game script for the Angels likely involves a strong first three innings from Brown, opportunistic hitting with runners in scoring position, and continued late-inning pressure to exploit any lapses from the Astros’ bullpen or defensive positioning. If the Angels can keep the score within a run by the seventh, their improved execution and home energy could swing the momentum their way, potentially leading to a 5–4 upset win or at least a close-run game that results in another ATS cover. Much will depend on their ability to stay mentally sharp, take advantage of any Houston miscues, and not allow the game to get away from them early, and while the Astros enter as the favorite, the Angels’ current form, lineup resilience, and ability to play well as underdogs at home make this a game that could go either way in the late innings.
FINAL: Astros 3, Angels 2 pic.twitter.com/2S7AhPunhz
— Los Angeles Angels (@Angels) June 21, 2025
Houston vs. Los Angeles Angels Prop Picks (AI)
Houston vs. Los Angeles Angels Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Astros and Angels and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
The Algorithm has been most watching on the trending emphasis human bettors tend to put on coaching factors between a Astros team going up against a possibly healthy Angels team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Houston vs Los Angeles Angels picks, computer picks Astros vs Angels, best bets, model edges, confidence ratings.
![]() |
DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
ACTIVE PICKS LOCKED - SEE NOW |
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Astros Betting Trends
The Astros have been solid when favored, going 6–2 in their last eight games as moneyline favorites and sitting at a 5–5 ATS record over their past ten matchups, signaling consistent value in spread betting.
Angels Betting Trends
The Angels have been tough to predict, posting a 4–1 ATS record in their last five games overall but an even 21–21 mark in road games as underdogs. Their home performances have leaned toward the over, with 14 of their last 31 home games pushing past the total.
Astros vs. Angels Matchup Trends
Astros games have hit the over in 4 of their last 10, while Angels games have cleared the total in 2 of their last 5—making the 8.5-run line a reasonable candidate for an over play in a matchup defined by strong pitching and streaking offense.
Houston vs. Los Angeles Angels Game Info
What time does Houston vs Los Angeles Angels start on June 21, 2025?
Houston vs Los Angeles Angels starts on June 21, 2025 at 9:38 PM EST.
Where is Houston vs Los Angeles Angels being played?
Venue: Angel Stadium of Anaheim.
What are the opening odds for Houston vs Los Angeles Angels?
Spread: Los Angeles Angels +1.5
Moneyline: Houston -119, Los Angeles Angels -100
Over/Under: 8.5
What are the records for Houston vs Los Angeles Angels?
Houston: (44-32) | Los Angeles Angels: (36-39)
What is the AI best bet for Houston vs Los Angeles Angels?
Remi's searched hard and found the best prop for this matchup: J. Soriano under 18.5 Outs.. Prices move—always shop for the best number.
What are Houston vs Los Angeles Angels trending bets?
Astros games have hit the over in 4 of their last 10, while Angels games have cleared the total in 2 of their last 5—making the 8.5-run line a reasonable candidate for an over play in a matchup defined by strong pitching and streaking offense.
What are Houston trending bets?
HOU trend: The Astros have been solid when favored, going 6–2 in their last eight games as moneyline favorites and sitting at a 5–5 ATS record over their past ten matchups, signaling consistent value in spread betting.
What are Los Angeles Angels trending bets?
LAA trend: The Angels have been tough to predict, posting a 4–1 ATS record in their last five games overall but an even 21–21 mark in road games as underdogs. Their home performances have leaned toward the over, with 14 of their last 31 home games pushing past the total.
Where can I find AI Picks for Houston vs Los Angeles Angels?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Houston vs. Los Angeles Angels Odds
Remi is pouring through loads of data on each line. In fact, anytime the Houston vs Los Angeles Angels trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.
Houston vs Los Angeles Angels Opening Odds
HOU Moneyline:
-119 LAA Moneyline: -100
HOU Spread: -1.5
LAA Spread: +1.5
Over/Under: 8.5
Houston vs Los Angeles Angels Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
|
–
–
|
+158
-194
|
+1.5 (-126)
-1.5 (+104)
|
O 9 (-101)
U 9 (-120)
|
|
Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
|
–
–
|
+237
-301
|
+1.5 (+118)
-1.5 (-144)
|
O 7.5 (-112)
U 7.5 (-108)
|
|
Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
|
–
–
|
+168
-208
|
+1.5 (-119)
-1.5 (-102)
|
O 8 (-120)
U 8 (-102)
|
|
Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
|
–
–
|
-102
-119
|
-1.5 (+157)
+1.5 (-192)
|
O 8.5 (-121)
U 8.5 (-101)
|
|
Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
|
–
–
|
+162
-200
|
+1.5 (-126)
-1.5 (+104)
|
O 7.5 (-115)
U 7.5 (-105)
|
|
Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
|
–
–
|
-105
-115
|
-1.5 (+163)
+1.5 (-201)
|
O 8 (-108)
U 8 (-112)
|
|
Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
|
–
–
|
+123
-150
|
+1.5 (-157)
-1.5 (+128)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Sep 28, 2025 3:11PM EDT
New York Mets
Miami Marlins
9/28/25 3:11PM
Mets
Marlins
|
–
–
|
-121
-101
|
-1.5 (+128)
+1.5 (-157)
|
O 8 (-116)
U 8 (-105)
|
|
Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
Braves
|
–
–
|
+168
-208
|
+1.5 (-123)
-1.5 (+101)
|
O 7.5 (-108)
U 7.5 (-112)
|
|
Sep 28, 2025 3:20PM EDT
St Louis Cardinals
Chicago Cubs
9/28/25 3:20PM
Cardinals
Cubs
|
–
–
|
-164
|
-1.5 (+127)
|
O 8.5 (-105)
U 8.5 (-116)
|
|
Sep 30, 2025 2:30PM EDT
San Diego Padres
Chicago Cubs
9/30/25 2:30PM
Padres
Cubs
|
–
–
|
+101
-123
|
pk
pk
|
|
MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Houston Astros vs. Los Angeles Angels Angels on June 21, 2025 at Angel Stadium of Anaheim.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
![]() |
LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |