Orioles vs. Yankees
Prediction, Odds & Props
Jun 21 | MLB AI Picks

Updated: 2025-06-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Baltimore Orioles travel to face the New York Yankees on June 21, 2025, in a clash between third-in-the-division Orioles and a resurging Yankees squad trying to build on recent momentum. With Max Fried expected to counter Zach Eflin, pitching will be the key storyline in what looks to be a pitcher’s duel.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 21, 2025

Start Time: 1:05 PM EST​

Venue: Yankee Stadium​

Yankees Record: (43-32)

Orioles Record: (33-42)

OPENING ODDS

BAL Moneyline: +142

NYY Moneyline: -169

BAL Spread: +1.5

NYY Spread: -1.5

Over/Under: 9.5

BAL
Betting Trends

  • The Orioles are 32–43 against the spread (ATS) this season, but are 7–3 over their last ten games straight up, showing they’ve been competitive despite being underdogs.

NYY
Betting Trends

  • The Yankees have struggled ATS overall with a roughly .440 record, including 16–17 as home favorites, but have started to rebound, covering in recent home matchups.

MATCHUP TRENDS

  • This marks an intriguing contrast: Baltimore has played well overall recently, while New York is stronger as a home favorite, which could create a tight line scenario in this inter-divisional tilt.

BAL vs. NYY
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Cowser over 0.5 Total Bases.

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Baltimore vs New York Yankees Prediction & Odds:
Free MLB Betting Insights for 6/21/25

The June 21, 2025 matchup between the Baltimore Orioles and the New York Yankees sets the stage for an intense AL East showdown featuring two teams with distinctly different identities but similar urgency. The Yankees, playing at home in Yankee Stadium, will lean heavily on ace Max Fried, whose elite command, sub-2.00 ERA, and innings-eating efficiency have given the Bronx Bombers a consistent chance to win nearly every time he takes the mound. Fried’s ability to induce weak contact and control the game’s pace makes him a formidable opponent for a Baltimore offense that has often struggled with high-end left-handed pitching. On the other side, the Orioles send out Zach Eflin, who brings a 4.81 ERA but has shown glimpses of dominance in past outings, including strong early-season appearances against Tampa Bay and the Yankees themselves. While Eflin’s recent performance has fluctuated, he remains capable of shutting down good lineups when his command is crisp and his sinker-slider combo is on point. Offensively, New York holds the power edge with sluggers like Aaron Judge, Cody Bellinger, and Giancarlo Stanton in the lineup, each capable of shifting the game’s momentum with one swing. However, Baltimore counters with scrappy, balanced contributors like Adley Rutschman and Gunnar Henderson, who excel at putting balls in play and pressuring defenses with smart baserunning.

Recent form favors both teams in their own ways—the Yankees have been gaining traction at home with improved bullpen outings and a disciplined lineup approach, while Baltimore has gone 7–3 in its last ten games and appears to be responding well under interim manager Tony Mansolino. Statistically, the Yankees have been stronger as home favorites, although their season ATS record is mediocre, while the Orioles continue to outperform straight up but struggle to cover spreads. This contrast suggests a tightly contested affair where the run line may be determined by one key inning or bullpen performance. Both teams’ bullpens have been question marks at times, though the Yankees have shown more late-game poise of late, and that could prove pivotal if Fried hands them a lead after six innings. If Baltimore keeps the game close into the eighth, their offensive discipline and improved defense give them a shot to steal a win. However, the Yankees’ top-end talent, home-field familiarity, and ability to strike quickly give them the edge in high-leverage moments. Expect a low-scoring affair where the outcome hinges on which starter blinks first and whose bullpen better absorbs pressure in the final frames.

Baltimore Orioles MLB Preview

The Baltimore Orioles arrive at Yankee Stadium on June 21, 2025, with renewed confidence and a stronger sense of purpose than their overall record might suggest. Despite sitting at 33–42 entering this contest, the Orioles have surged recently with a 7–3 mark in their last ten games and an 11–6 record since interim manager Tony Mansolino took over in early June. This upswing reflects a team finding its identity after a tumultuous start to the season. Baltimore’s offense has been key to this turnaround, led by rising stars Gunnar Henderson and Adley Rutschman, who have delivered clutch hits and provided steady production in the heart of the lineup. Complemented by Cedric Mullins’ speed and contact approach, the Orioles have built a lineup that doesn’t rely on power alone but rather excels in manufacturing runs and extending innings through patience and baserunning aggression. Starting pitcher Zach Eflin gets the nod against the Yankees, carrying a 4.81 ERA that masks his potential when he’s locked in. Eflin has struggled with consistency this season, but his track record includes impressive outings against AL East opponents and a prior scoreless appearance versus New York, which should provide some confidence heading into this high-stakes divisional matchup.

Baltimore’s challenge will be twofold: supporting Eflin early with run support and navigating a Yankees bullpen that has recently rediscovered its sharpness. Defensively, the Orioles have improved, limiting costly mistakes that plagued them earlier in the season, and they’ll need to be sharp to contain the likes of Aaron Judge and Cody Bellinger in high-leverage moments. The Orioles’ bullpen has been hit-or-miss throughout the season, but with closer Craig Kimbrel and setup men showing flashes of dominance, they possess the pieces to hold leads if the starters can hand them over with an advantage. ATS-wise, Baltimore has underperformed this year, holding a sub-.450 record, yet their recent straight-up wins suggest they are closing the gap between potential and execution. The key for Baltimore will be maintaining discipline at the plate and executing fundamentally sound baseball—something they’ve excelled at in recent road games despite their 14–22 overall away record. Against an ace like Max Fried, the Orioles must make every base runner count and stay mentally tough through the middle innings, when the Yankees often shift momentum. If Eflin can navigate through Judge, Bellinger, and Stanton without early damage, and if the offense can scratch out a few timely runs, Baltimore could be in position to pull off an upset or at least stay well within the run line. The Orioles are underdogs on paper but have the talent, confidence, and recent performance to make this a highly competitive game against a division rival fighting to climb back into postseason relevance.

The Baltimore Orioles travel to face the New York Yankees on June 21, 2025, in a clash between third-in-the-division Orioles and a resurging Yankees squad trying to build on recent momentum. With Max Fried expected to counter Zach Eflin, pitching will be the key storyline in what looks to be a pitcher’s duel. Baltimore vs New York Yankees AI Prediction: Free MLB Betting Insights for Jun 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Yankees Yankees MLB Preview

The New York Yankees host the Baltimore Orioles on June 21, 2025, with a growing sense of urgency and determination to reassert themselves as a force in the AL East. Coming into this matchup with a record hovering above .500 and a recent uptick in form at Yankee Stadium, the Yankees aim to build momentum on the back of elite starting pitching and a gradually stabilizing bullpen. The centerpiece of their strategy will be ace Max Fried, who has emerged as the clear leader of the rotation with a sparkling 1.89 ERA and pinpoint command that consistently shuts down top-tier offenses. Fried’s ability to work deep into games, limit walks, and suppress power makes him an ideal matchup against a Baltimore team that relies on contact and movement rather than slugging. Offensively, the Yankees are beginning to rediscover their identity with Aaron Judge leading the charge, supported by the left-handed power of Cody Bellinger and the versatile bats of Giancarlo Stanton and Jazz Chisholm Jr. While the offense has been streaky, it has shown signs of improved patience and production in key situations, particularly during recent home games where the team has covered the spread more reliably. Defensively, the Yankees are sound across the board, anchored by a sure-handed infield and an athletic outfield that can erase would-be extra-base hits.

Their bullpen, which had been a source of concern earlier in the season, has started to deliver more consistent results thanks to refined roles and fewer late-inning implosions, giving manager Aaron Boone confidence in matchups beyond the sixth inning. Against a surging Orioles club, the Yankees’ approach will be to strike early behind Fried’s dominance and force Baltimore to play catch-up, a scenario in which New York tends to thrive. Their ability to manufacture runs in the early innings and protect leads with strategic bullpen usage has defined their recent success, particularly at home where the comfort of their surroundings seems to enhance execution. The team has also responded well to high-pressure divisional games, which adds another layer of motivation heading into this one. While their overall against-the-spread record has been underwhelming, especially in broader season context, the Yankees have shown they can cover and win convincingly when their starting pitching is sharp and the bats are timely. If Fried can hold Baltimore scoreless through the early frames and Judge or Bellinger deliver a big hit to break the game open, the Yankees will be in prime position to not only win but cover the run line. With a well-rounded roster beginning to click and the advantage of home field, New York enters this contest poised to contain a hot Orioles squad and continue their pursuit of division leaders with a statement performance.

Baltimore vs. New York Yankees Prop Picks (AI)

Remi is pouring through tons of datapoints on each team. In fact, anytime the Orioles and Yankees play there’s always several intriguing observations to key in on. Not to mention games played at Yankee Stadium in Jun almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Cowser over 0.5 Total Bases.

Baltimore vs. New York Yankees Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every angle between the Orioles and Yankees and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Remi has been most focused on the linear correlation of factor knucklehead sportsbettors often put on coaching factors between a Orioles team going up against a possibly tired Yankees team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Baltimore vs New York Yankees picks, computer picks Orioles vs Yankees, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Orioles Betting Trends

The Orioles are 32–43 against the spread (ATS) this season, but are 7–3 over their last ten games straight up, showing they’ve been competitive despite being underdogs.

Yankees Betting Trends

The Yankees have struggled ATS overall with a roughly .440 record, including 16–17 as home favorites, but have started to rebound, covering in recent home matchups.

Orioles vs. Yankees Matchup Trends

This marks an intriguing contrast: Baltimore has played well overall recently, while New York is stronger as a home favorite, which could create a tight line scenario in this inter-divisional tilt.

Baltimore vs. New York Yankees Game Info

Baltimore vs New York Yankees starts on June 21, 2025 at 1:05 PM EST.

Spread: New York Yankees -1.5
Moneyline: Baltimore +142, New York Yankees -169
Over/Under: 9.5

Baltimore: (33-42)  |  New York Yankees: (43-32)

Remi's searched hard and found the best prop for this matchup: C. Cowser over 0.5 Total Bases.. Prices move—always shop for the best number.

This marks an intriguing contrast: Baltimore has played well overall recently, while New York is stronger as a home favorite, which could create a tight line scenario in this inter-divisional tilt.

BAL trend: The Orioles are 32–43 against the spread (ATS) this season, but are 7–3 over their last ten games straight up, showing they’ve been competitive despite being underdogs.

NYY trend: The Yankees have struggled ATS overall with a roughly .440 record, including 16–17 as home favorites, but have started to rebound, covering in recent home matchups.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Baltimore vs. New York Yankees Odds

AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Baltimore vs New York Yankees trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.

Baltimore vs New York Yankees Opening Odds

BAL Moneyline: +142
NYY Moneyline: -169
BAL Spread: +1.5
NYY Spread: -1.5
Over/Under: 9.5

Baltimore vs New York Yankees Live Odds

Games PTS ML SPR O/U
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Cincinnati Reds
Milwaukee Brewers
In Progress
Reds
Brewers
7
4
-6000
+1800
-2.5 (-400)
+2.5 (+290)
O 11.5 (+150)
U 11.5 (-190)
In Progress
Texas Rangers
Cleveland Guardians
In Progress
Rangers
Guardians
2
2
+125
-167
-1.5 (+475)
+1.5 (-1000)
O 7 (-120)
U 7 (+100)
In Progress
Arizona Diamondbacks
San Diego Padres
In Progress
Diamondbacks
Padres
1
5
+850
-1800
+3.5 (+120)
-3.5 (-150)
O 9.5 (+100)
U 9.5 (-130)
In Progress
Houston Astros
Los Angeles Angels
In Progress
Astros
Angels
2
0
-280
+215
-2.5 (-105)
+2.5 (-125)
O 9.5 (-105)
U 9.5 (-125)
In Progress
Los Angeles Dodgers
Seattle Mariners
In Progress
Dodgers
Mariners
0
0
+115
-145
+1.5 (-200)
-1.5 (+160)
O 5.5 (-125)
U 5.5 (-105)
In Progress
Kansas City Royals
Oakland Athletics
In Progress
Royals
Athletics
0
0
-105
-125
+1.5 (-180)
-1.5 (+145)
O 10.5 (+100)
U 10.5 (-130)
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+158
-190
+1.5 (-125)
-1.5 (+105)
O 8.5 (-120)
U 8.5 (+100)
Sep 28, 2025 3:06PM EDT
Colorado Rockies
San Francisco Giants
9/28/25 3:06PM
Rockies
Giants
+240
-305
+1.5 (+118)
-1.5 (-140)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:06PM EDT
Minnesota Twins
Philadelphia Phillies
9/28/25 3:06PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8 (-120)
U 8 (+100)
Sep 28, 2025 3:06PM EDT
Chicago White Sox
Washington Nationals
9/28/25 3:06PM
White Sox
Nationals
+100
-120
+1.5 (-190)
-1.5 (+158)
O 8.5 (-120)
U 8.5 (+100)
Sep 28, 2025 3:08PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/28/25 3:08PM
Rays
Blue Jays
+170
-205
+1.5 (-120)
-1.5 (+100)
O 7.5 (-115)
U 7.5 (-105)
Sep 28, 2025 3:10PM EDT
Los Angeles Dodgers
Seattle Mariners
9/28/25 3:10PM
Dodgers
Mariners
-110
-110
-1.5 (+150)
+1.5 (-178)
O 8 (-120)
U 8 (+100)
Sep 28, 2025 3:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/28/25 3:11PM
Reds
Brewers
+110
-130
+1.5 (-170)
-1.5 (+140)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:16PM EDT
Pittsburgh Pirates
Atlanta Braves
9/28/25 3:16PM
Pirates
Braves
+175
-210
+1.5 (-120)
-1.5 (+100)
O 7.5 (-110)
U 7.5 (-110)
Sep 28, 2025 3:20PM EDT
St Louis Cardinals
Chicago Cubs
9/28/25 3:20PM
Cardinals
Cubs
 
-165
pk
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MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Baltimore Orioles vs. New York Yankees Yankees on June 21, 2025 at Yankee Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS