Guardians vs. Giants
Prediction, Odds & Props
Jun 19 | MLB AI Picks
Updated: 2025-06-17T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cleveland Guardians visit Oracle Park on June 19, 2025, to take on the San Francisco Giants in a pivotal interleague matchup where Cleveland seeks to balance the series and San Francisco looks to overcome recent struggles. Both teams are searching for momentum—Cleveland after a gritty win yesterday, San Francisco aiming to bounce back following a four-game skid.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 19, 2025
Start Time: 4:05 PM EST
Venue: Oracle Park
Giants Record: (41-33)
Guardians Record: (37-35)
OPENING ODDS
CLE Moneyline: +144
SF Moneyline: -172
CLE Spread: +1.5
SF Spread: -1.5
Over/Under: 7
CLE
Betting Trends
- Cleveland is 56–55 against the run line this season and has gone 23–22 ATS as underdogs, displaying modest resilience in tight matchups.
SF
Betting Trends
- San Francisco is 24–21 ATS overall and performs better at home, going 12–7 ATS when favored by –1.5 in recent games—though they’re 1–4 ATS over their last five outings.
MATCHUP TRENDS
- The Giants are posting around –153 on the moneyline and –1.5 run line, with an 8-run total; they’ve lost four straight, while the Guardians have shown strength in underdog roles. Both teams trend toward low-scoring affairs, setting up a clash where pitching and defense could tilt the result.
CLE vs. SF
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.
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Cleveland vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 6/19/25
Offensively, Cleveland counters San Francisco’s big bats with contact-first threats like José Ramírez, Steven Kwan, and Brayan Rocchio, while Schneemann has become an unlikely spark plug with several timely hits this past week. On the Giants’ side, the addition of Rafael Devers to a lineup already featuring Heliot Ramos and Jung Hoo Lee gives them explosive potential, though their recent skid has been defined more by lack of situational hitting than power outages. From a betting angle, San Francisco enters as –153 favorites with a –1.5 run line, while Cleveland comes in at around +128, and the Over/Under set at 8 runs reflects both teams’ tendencies to trend Under due to inconsistent offensive stretches and quality bullpen work. Defensively, San Francisco has been shaky at times, which cost them in close games, whereas Cleveland has played cleaner baseball overall. The key matchup will revolve around how sharp Verlander is in his return—if he can command his fastball and stay ahead in counts, San Francisco has a clear edge. If not, Cleveland’s pesky lineup and dangerous bullpen could capitalize and steal a second straight win. Expect a game dictated by tempo, with early scoring opportunities possibly defining the pace, and one swing—like Schneemann’s last night—having the potential to flip the momentum in what should be a tightly contested, low-scoring affair between two teams trying to solidify their playoff positioning heading into the final weeks of June.
Back-to-back!#GuardsBall | #GuardiWWins pic.twitter.com/4QkWLxprLl
— Cleveland Guardians (@CleGuardians) June 19, 2025
Cleveland Guardians MLB Preview
The Cleveland Guardians enter Thursday’s matchup against the San Francisco Giants looking to extend their momentum following a 4–2 victory on Wednesday night that showcased their signature formula—clutch hitting, clean defense, and a rock-solid bullpen. Sitting at 36–36 on the season and 56–55 against the spread, the Guardians have performed admirably in underdog spots, winning nearly half their games when closing at +128 or worse and covering in over 50% of those contests. Much of their recent success has stemmed from timely offensive contributions by players like José Ramírez and Steven Kwan, but it was Daniel Schneemann who provided the latest spark, blasting a three-run homer that proved decisive in the series opener. Schneemann has quickly become one of Cleveland’s most surprising contributors, blending power with versatility, and his emergence has added depth to a lineup that often relies more on contact and situational execution than raw slugging. Defensively, the Guardians have remained crisp, ranking in the top half of the league in fielding percentage and avoiding the kinds of errors that often swing close games—particularly on the road, where their margin for error is thinner. The Guardians are expected to use a mix of starting pitching and bullpen depth to keep Thursday’s contest close, likely relying on a mid-rotation arm to go four to five innings before turning things over to trusted late-inning arms like Matt Festa and All-Star closer Emmanuel Clase.
This relief corps has been dominant in tight contests, locking down games with a blend of velocity and deception that has stifled opposing offenses in one-run and two-run situations. Offensively, Cleveland’s game plan will center on pressuring Justin Verlander early, looking to force deep counts and capitalize on any rust in his first start back from the injured list. If they can push across a run or two in the opening frames and turn the game over to their bullpen with a lead or even a tie, their odds of pulling off a second straight road win rise considerably. Though not known for home-run power, the Guardians have demonstrated a knack for clutch hitting and two-out production—traits that are particularly valuable in low-scoring games at pitcher-friendly Oracle Park. With the total sitting at 8 runs and both teams trending Under in recent matchups, the Guardians will look to win through control, execution, and capitalizing on mistakes, rather than overwhelming their opponent. Ultimately, Cleveland’s blend of gritty offense, efficient bullpen work, and reliable fielding gives them a legitimate chance to take the series lead if they can once again neutralize the middle of the Giants’ order and avoid falling behind early. Their betting value lies not just in their underdog price, but in their ability to hang around, force mistakes, and finish strong—qualities that make them a serious threat to any team struggling to find rhythm, as the Giants are now.

Credit: USA TODAY/IMAGN
San Francisco Giants MLB Preview
The San Francisco Giants return to Oracle Park on Thursday, June 19, looking to snap a four-game losing streak and reclaim control of their home field as they face the visiting Cleveland Guardians in the rubber match of their interleague set. At 24–21 ATS this season and 12–7 when favored by –1.5 at home, the Giants have been solid in front of their fans but have shown signs of vulnerability in recent games, particularly when their bats fall silent or starting pitching falters early. Thursday brings an added layer of anticipation with the return of veteran ace Justin Verlander, who will make his first start back from the injured list following a pectoral strain. Verlander, though still seeking his first win of 2025, carries the weight of a Hall of Fame career and is expected to provide stability and leadership for a rotation that has struggled in his absence. While his season stat line—0–3 with a 4.33 ERA across 10 starts—is underwhelming, the Giants are banking on his experience and pitch mix to contain a Cleveland lineup that rarely strikes out and thrives on contact hitting. At the plate, the Giants need a reset.
Their recent struggles haven’t been for lack of star power—Rafael Devers has provided pop, and Heliot Ramos continues to flash power and athleticism—but the team has struggled with runners in scoring position, leaving far too many on base in winnable games. Jung Hoo Lee’s ability to set the table will be critical against Cleveland’s sharp bullpen, as San Francisco will need to build leads early to avoid facing All-Star closer Emmanuel Clase with the game on the line. The defense also needs to clean up, as mental errors and misplays have cost them dearly in recent one-run losses. Still, this is a team capable of flipping momentum quickly, particularly if Verlander is able to navigate the first few innings without damage and the offense can execute in key spots. With a betting line currently sitting at –153 moneyline and –1.5 run line, oddsmakers remain optimistic about the Giants’ potential bounce-back, especially considering Cleveland’s tendency to play tight, low-scoring games. San Francisco’s success Thursday hinges on three key elements: Verlander’s command and durability, situational hitting in the middle innings, and mistake-free defense late in the game. If they can hit on all three, they’re more than capable of evening the series and ending the losing streak. However, failure in even one of those areas—particularly allowing Cleveland’s bullpen to take over early—could leave the door open for yet another frustrating loss. For a team with postseason aspirations and a freshly bolstered roster, this game offers a timely opportunity to recalibrate and get back on track in front of a home crowd eager to see their club return to winning ways.
Patrick Bailey wasted no time re-introducing himself 💪 pic.twitter.com/HKg7i2wL7G
— SFGiants (@SFGiants) June 19, 2025
Cleveland vs. San Francisco Prop Picks (AI)
Cleveland vs. San Francisco Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Guardians and Giants and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most focused on the trending weight knucklehead sportsbettors regularly put on coaching factors between a Guardians team going up against a possibly unhealthy Giants team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cleveland vs San Francisco picks, computer picks Guardians vs Giants, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Guardians Betting Trends
Cleveland is 56–55 against the run line this season and has gone 23–22 ATS as underdogs, displaying modest resilience in tight matchups.
Giants Betting Trends
San Francisco is 24–21 ATS overall and performs better at home, going 12–7 ATS when favored by –1.5 in recent games—though they’re 1–4 ATS over their last five outings.
Guardians vs. Giants Matchup Trends
The Giants are posting around –153 on the moneyline and –1.5 run line, with an 8-run total; they’ve lost four straight, while the Guardians have shown strength in underdog roles. Both teams trend toward low-scoring affairs, setting up a clash where pitching and defense could tilt the result.
Cleveland vs. San Francisco Game Info
What time does Cleveland vs San Francisco start on June 19, 2025?
Cleveland vs San Francisco starts on June 19, 2025 at 4:05 PM EST.
Where is Cleveland vs San Francisco being played?
Venue: Oracle Park.
What are the opening odds for Cleveland vs San Francisco?
Spread: San Francisco -1.5
Moneyline: Cleveland +144, San Francisco -172
Over/Under: 7
What are the records for Cleveland vs San Francisco?
Cleveland: (37-35) | San Francisco: (41-33)
What is the AI best bet for Cleveland vs San Francisco?
Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Cleveland vs San Francisco trending bets?
The Giants are posting around –153 on the moneyline and –1.5 run line, with an 8-run total; they’ve lost four straight, while the Guardians have shown strength in underdog roles. Both teams trend toward low-scoring affairs, setting up a clash where pitching and defense could tilt the result.
What are Cleveland trending bets?
CLE trend: Cleveland is 56–55 against the run line this season and has gone 23–22 ATS as underdogs, displaying modest resilience in tight matchups.
What are San Francisco trending bets?
SF trend: San Francisco is 24–21 ATS overall and performs better at home, going 12–7 ATS when favored by –1.5 in recent games—though they’re 1–4 ATS over their last five outings.
Where can I find AI Picks for Cleveland vs San Francisco?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. San Francisco Odds
AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the Cleveland vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.
Cleveland vs San Francisco Opening Odds
CLE Moneyline:
+144 SF Moneyline: -172
CLE Spread: +1.5
SF Spread: -1.5
Over/Under: 7
Cleveland vs San Francisco Live Odds
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U 9 (+100)
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U 8.5 (-114)
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O 8.5 (-110)
U 8.5 (-110)
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O 8 (-108)
U 8 (-112)
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Sep 27, 2025 4:11PM EDT
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-124
+106
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-1.5 (+130)
+1.5 (-156)
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O 8.5 (-112)
U 8.5 (-108)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
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–
–
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+177
-197
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+1.5 (-118)
-1.5 (-102)
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O 8.5 (-118)
U 8.5 (-102)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
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–
–
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+128
-152
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+1.5 (-178)
-1.5 (+146)
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O 7.5 (-120)
U 7.5 (-102)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
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+143
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+1.5 (-150)
-1.5 (+130)
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O 8.5 (+100)
U 8.5 (-120)
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Sep 27, 2025 7:16PM EDT
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+132
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-1.5 (+142)
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O 7 (-120)
U 7 (-102)
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Sep 27, 2025 8:40PM EDT
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+120
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O 7.5 (-115)
U 7.5 (-105)
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Sep 27, 2025 9:41PM EDT
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9/27/25 9:41PM
Dodgers
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–
–
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+102
-120
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+1.5 (-215)
-1.5 (+180)
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O 7.5 (-110)
U 7.5 (-110)
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
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–
–
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+104
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+1.5 (-185)
-1.5 (+161)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Guardians vs. San Francisco Giants on June 19, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |