Guardians vs Giants Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 17)
Updated: 2025-06-15T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cleveland Guardians (35–34) take on the San Francisco Giants (41–30) at Oracle Park on June 17, 2025, in a pivotal interleague matchup. With both teams vying for playoff positions, this game could have significant implications for their respective postseason aspirations.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 17, 2025
Start Time: 9:45 PM EST
Venue: Oracle Park
Giants Record: (41-31)
Guardians Record: (35-35)
OPENING ODDS
CLE Moneyline: +136
SF Moneyline: -163
CLE Spread: +1.5
SF Spread: -1.5
Over/Under: 7
CLE
Betting Trends
- The Cleveland Guardians have covered the spread in 19 of their 43 games as underdogs this season, reflecting a 44.2% success rate.
SF
Betting Trends
- The San Francisco Giants have an ATS record of 41–30 this season, indicating consistent performance against the spread.
MATCHUP TRENDS
- The Giants are favored at -1.5 with an over/under set at 7 runs. The Guardians have a 4–9 record when listed as underdogs of +136 or longer, suggesting challenges in overcoming significant odds.
CLE vs. SF
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.
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Cleveland vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 6/17/25
The Guardians, by contrast, have struggled with offensive consistency and rely heavily on the production of José Ramírez, their all-everything third baseman who continues to lead the team in most offensive categories and remains the heart of the clubhouse both on and off the field. The rest of Cleveland’s lineup has shown flashes but lacks the depth or power to consistently compete with stronger rotations, meaning situational hitting and smart baserunning are essential for them to stay in games. Defensively, both teams have been sound, but San Francisco has the edge with more reliable infield play and fewer costly errors over the course of the season. From a betting perspective, the Giants enter as -1.5 favorites with an over/under set at just 7 runs—reflecting the strength of the starting pitching matchup and the expectation for a low-scoring, tightly contested game. San Francisco has covered the spread in 41 of 71 games this year, one of the best ATS records in MLB, while Cleveland has only managed to cover 44.2% of the time when listed as underdogs. For the Guardians to pull off the upset, Cecconi will need to deliver a career-best outing and keep the Giants off the scoreboard through the first five innings, giving Ramírez and the top half of the order a chance to scratch out enough runs. The Giants, on the other hand, will look to ride their ace, continue their aggressive early-inning approach, and let their dominant bullpen preserve a late lead. This game could be a litmus test for both teams—whether the Giants can keep rolling behind Robbie Ray’s Cy Young-caliber season, and whether the Guardians have enough resilience and timely offense to make noise on the road in a hostile environment.
Gotta get our heroes to ATL, Cleveland! 🦸♂️
— Cleveland Guardians (@CleGuardians) June 16, 2025
Here's a reminder to vote every day!https://t.co/twAxRaaPhX#GuardsBall | #VoteGuards pic.twitter.com/oA6KrabEhl
Cleveland Guardians MLB Preview
The Cleveland Guardians arrive at Oracle Park for their June 17, 2025 clash with the San Francisco Giants holding a 35–34 record and looking to gain traction in the AL Central, where parity has kept the race wide open despite Cleveland’s inconsistency throughout the season. After showing promise early, the Guardians have encountered turbulence in recent weeks due to a combination of underwhelming run support, defensive lapses, and a lack of consistency from the back end of their pitching staff. Manager Stephen Vogt turns to Slade Cecconi for this matchup, a 25-year-old right-hander who enters with a 1–3 record and a 4.26 ERA, still seeking to establish himself as a steady presence in the rotation. Cecconi has flashed moments of command and efficiency, particularly with his fastball-slider combination, but struggles to finish hitters with two strikes and has had difficulty navigating third-time-through-the-order situations. He’ll need pinpoint command against a Giants lineup that is aggressive early in counts and thrives on driving up pitch counts to get into opposing bullpens. Offensively, the Guardians rely heavily on the steady excellence of José Ramírez, whose ability to impact the game on both sides of the ball makes him the team’s clear catalyst. Ramírez leads the club in nearly every offensive category and continues to be one of MLB’s most underappreciated stars, combining power, contact, and elite baserunning with high-IQ play.
However, outside of Ramírez, Cleveland’s offense has lacked consistent firepower, with players like Josh Naylor and Steven Kwan showing stretches of productivity but not delivering at a level that puts pressure on elite rotations like San Francisco’s. Cleveland’s approach at the plate leans heavily on contact and base-to-base movement, which can be effective when backed by timely hitting and clean defense, but also leaves little margin for error when facing aces like Robbie Ray. On the defensive side, the Guardians have held their own in the infield but have been shaky in the outfield, with a few misreads and errant throws costing them extra bases and runs in tight contests. The bullpen, traditionally a Cleveland strength, has been more volatile in 2025, lacking a defined closer and struggling with inherited runners in high-leverage situations. From a betting standpoint, Cleveland has struggled to exceed expectations, posting a 44.2% success rate against the spread as underdogs, including a 4–9 mark in games where they were listed at +136 or longer. If the Guardians want to steal a win in San Francisco, they’ll need Cecconi to pitch to soft contact and avoid big innings, while the offense must capitalize on any scoring chances they get, particularly against Ray early in the count. Cleveland has shown resilience this season, often grinding out close wins despite being outslugged on paper, and they’ll need that same gritty identity to deliver in a tough road environment against one of the National League’s most complete teams. A win here could signal the beginning of a turning point in their season—but only if they play one of their most complete games to date.

Credit: USA TODAY/IMAGN
San Francisco Giants MLB Preview
The San Francisco Giants welcome the Cleveland Guardians to Oracle Park on June 17, 2025, with a 41–30 record that has them entrenched in the heart of the National League West race, driven by elite starting pitching, disciplined defense, and a well-balanced offense. Few pitchers in baseball have been as effective this season as Robbie Ray, who will start for the Giants with an 8–1 record and a 2.55 ERA, anchoring a staff that leads the league with a collective 3.12 ERA. Ray has been dominant at home, consistently neutralizing left-handed power and striking out hitters at a high rate, and his ability to work deep into games has relieved pressure from a bullpen that’s been excellent in late-game situations. Supporting Ray has been a Giants offense that might not feature many superstars but gets the job done with contributions throughout the order, including breakout outfielder Heliot Ramos, who leads the team with 77 hits, and veteran Wilmer Flores, who has driven in 51 runs and continues to deliver in clutch spots. Ramos has developed into one of the most reliable contact hitters on the roster, using a compact swing and great pitch recognition to extend at-bats and fuel rallies, while Flores remains a power threat who thrives in RBI situations.
Other key contributors include Thairo Estrada and Michael Conforto, giving manager Bob Melvin the flexibility to shift lineups depending on matchups while maintaining consistent run production. Defensively, the Giants have been efficient and fundamentally sound, rarely giving away extra outs and frequently bailing out their pitchers with timely double plays and solid positioning—attributes that will be critical against a Cleveland team that leans on contact and manufacturing runs. The bullpen, led by Camilo Doval and Taylor Rogers, has been one of the best in baseball in holding leads, and the Giants are particularly tough to beat when they enter the seventh inning with an advantage. From a betting standpoint, San Francisco has been among the most consistent teams in the league, with a 41–30 record against the spread (ATS), outperforming projections and regularly covering even as favorites. They enter this game as -1.5 favorites with the total set at 7 runs, a nod to the anticipated dominance of Ray and the low-scoring profile of many Giants home games. The formula for a San Francisco win is simple but effective: get six or seven strong innings from Ray, scratch out runs through patient at-bats and timely contact, and let the bullpen slam the door. The Giants are built for games like these—tight, methodical, and fundamentally sound—and will look to continue their efficient winning ways as they host a scrappy Guardians team. If Ray can establish rhythm early and Ramos and Flores produce at their usual levels, the Giants have a clear path to securing another key victory in their pursuit of a division title.
A crash course on the man they call Carita: pic.twitter.com/VhR17tgrgG
— SFGiants (@SFGiants) June 16, 2025
Cleveland vs. San Francisco Prop Picks (AI)
Cleveland vs. San Francisco Prediction (AI)

Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Guardians and Giants and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned emphasis knucklehead sportsbettors regularly put on coaching factors between a Guardians team going up against a possibly unhealthy Giants team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cleveland vs San Francisco picks, computer picks Guardians vs Giants, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Guardians Betting Trends
The Cleveland Guardians have covered the spread in 19 of their 43 games as underdogs this season, reflecting a 44.2% success rate.
Giants Betting Trends
The San Francisco Giants have an ATS record of 41–30 this season, indicating consistent performance against the spread.
Guardians vs. Giants Matchup Trends
The Giants are favored at -1.5 with an over/under set at 7 runs. The Guardians have a 4–9 record when listed as underdogs of +136 or longer, suggesting challenges in overcoming significant odds.
Cleveland vs. San Francisco Game Info
What time does Cleveland vs San Francisco start on June 17, 2025?
Cleveland vs San Francisco starts on June 17, 2025 at 9:45 PM EST.
Where is Cleveland vs San Francisco being played?
Venue: Oracle Park.
What are the opening odds for Cleveland vs San Francisco?
Spread: San Francisco -1.5
Moneyline: Cleveland +136, San Francisco -163
Over/Under: 7
What are the records for Cleveland vs San Francisco?
Cleveland: (35-35) | San Francisco: (41-31)
What is the AI best bet for Cleveland vs San Francisco?
Remi's searched hard and found the best prop for this matchup: M. Yastrzemski over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Cleveland vs San Francisco trending bets?
The Giants are favored at -1.5 with an over/under set at 7 runs. The Guardians have a 4–9 record when listed as underdogs of +136 or longer, suggesting challenges in overcoming significant odds.
What are Cleveland trending bets?
CLE trend: The Cleveland Guardians have covered the spread in 19 of their 43 games as underdogs this season, reflecting a 44.2% success rate.
What are San Francisco trending bets?
SF trend: The San Francisco Giants have an ATS record of 41–30 this season, indicating consistent performance against the spread.
Where can I find AI Picks for Cleveland vs San Francisco?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. San Francisco Odds
Remi is pouring through mountains of data points on each line. In fact, anytime the Cleveland vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.
Cleveland vs San Francisco Opening Odds
CLE Moneyline:
+136 SF Moneyline: -163
CLE Spread: +1.5
SF Spread: -1.5
Over/Under: 7
Cleveland vs San Francisco Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 9:08PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 9:08PM
Dodgers
Blue Jays
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–
–
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-140
+127
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-1.5 (+124)
+1.5 (-140)
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O 7.5 (+107)
U 7.5 (-123)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Guardians vs. San Francisco Giants on June 17, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |