Padres vs. Giants
Prediction, Odds & Props
Jun 05 | MLB AI Picks

Updated: 2025-06-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Diego Padres travel to Oracle Park to face the San Francisco Giants on Thursday, June 5, 2025. After splitting the first two games of the series, both teams are fighting for momentum in the tight NL West race.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 05, 2025

Start Time: 3:45 PM EST​

Venue: Oracle Park​

Giants Record: (33-28)

Padres Record: (35-24)

OPENING ODDS

SD Moneyline: +106

SF Moneyline: -126

SD Spread: +1.5

SF Spread: -1.5

Over/Under: 7.5

SD
Betting Trends

  • San Diego has been competitive as road underdogs, covering 7 of their last 12 away games, and has a 4–2 ATS record as favorites in their last 10 outings.

SF
Betting Trends

  • San Francisco is 27–32 ATS on the season and just 1–4 ATS in their last five home games, despite playing well in front of their fans.

MATCHUP TRENDS

  • Only 3 of the last 10 Padres–Giants matchups hit the Over, yet the total is set at 7 runs, suggesting oddsmakers expect more offense than recent history would indicate.

SD vs. SF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Machado over 6.5 Fantasy Score.

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San Diego vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 6/5/25

The San Diego Padres and San Francisco Giants conclude their NL West clash at Oracle Park on Thursday, June 5, 2025, in what promises to be a tightly contested rubber match between two teams separated by only a few games in the division standings. The Padres enter at 35–24 and will send right-hander Dylan Cease to the mound, who has been stellar all season with elite strikeout numbers, a sharp slider, and the ability to pitch deep into games while neutralizing power bats from both sides of the plate. Cease’s command and poise will be tested by a Giants lineup that, while not flashy, executes well situationally and has leaned on timely hits from players like Heliot Ramos and Wilmer Flores to stay afloat in low-scoring battles. The Giants, sitting at 33–27, counter with left-hander Robbie Ray, who brings a veteran presence and a sinker-slider arsenal capable of inducing ground balls and working around hard contact, particularly in Oracle Park’s pitcher-friendly dimensions. Both teams have top-five bullpens by ERA, and each has recently relied heavily on those relief arms in back-to-back close contests, meaning the success of the starters in getting through six innings could be the key to preserving the best bullpen options for the late game.

The Padres’ offense, built around Manny Machado (.315 average) and Fernando Tatis Jr. (13 HR), thrives on high-leverage situations and disciplined at-bats, whereas San Francisco lacks power depth but compensates with contact hitting and opportunistic base running, especially in the lower half of their order. San Diego has performed well on the road, including a 7–6 ATS record as underdogs in away games, while the Giants are just 1–4 ATS over their last five at home, reflecting late-inning breakdowns or missed scoring chances. Defensively, both clubs are fundamentally sound, and with the game’s total set at a modest 7 runs, oddsmakers expect a classic pitcher’s duel—though both lineups are capable of changing the game with one timely rally. The Padres will likely look to strike early and play add-on baseball through the middle innings while the Giants will need to lean on Ray to keep the game within reach and hand it over to a rested back-end bullpen. Ultimately, the team that executes better with runners in scoring position, controls the tempo on the mound, and avoids costly defensive lapses will walk away with a critical series win that could help define the trajectory of their division race in June. Both managers, Bob Melvin for San Francisco and Mike Shildt for San Diego, will likely manage aggressively with substitutions and bullpen matchups, knowing that this game could set the tone for a pivotal stretch of the season.

San Diego Padres MLB Preview

The San Diego Padres enter Thursday’s series finale at Oracle Park with a 35–24 record and a growing sense of momentum following a narrow extra-inning win that showcased the team’s resilience, deep pitching, and timely hitting—all traits that have kept them near the top of the NL West standings throughout the first half of the season. Manager Mike Shildt will hand the ball to right-hander Dylan Cease, who has emerged as one of the most effective strikeout pitchers in the National League thanks to his electric fastball, devastating slider, and an ability to miss bats in high-leverage spots, making him the ideal tone-setter in a critical division matchup. Cease enters with confidence and composure, and his ability to work through the middle of San Francisco’s order will be a crucial element if the Padres hope to neutralize the home crowd and avoid relying too heavily on their bullpen, which has been sharp but used frequently in recent games. Offensively, San Diego continues to be powered by the dynamic duo of Manny Machado and Fernando Tatis Jr., with Machado hitting over .315 and Tatis supplying power and speed with 13 home runs and aggressive base running that creates chaos for defenses and scoring opportunities for the Padres.

This lineup has depth and versatility, with hitters like Ha-Seong Kim, Jake Cronenworth, and Luis Campusano all contributing quality at-bats and defensive stability, helping San Diego thrive in close games and maintain a strong run differential against tough pitching. The Padres have also proven themselves on the road, going 7–6 ATS as away underdogs, and they’ve shown the mental toughness to win one-run games, grind out late-inning rallies, and absorb pressure in hostile environments like San Francisco. Their bullpen, anchored by closer Robert Suárez and late-inning specialist Jason Adam, remains a key strength, and if Cease can hand over a lead after six innings, the Padres are well-positioned to seal the win. One area of emphasis for San Diego will be avoiding prolonged offensive droughts, particularly against left-hander Robbie Ray, who has a tendency to induce weak contact if hitters become overly aggressive early in counts. If the Padres stay disciplined, take advantage of early scoring opportunities, and continue playing crisp defense behind Cease, they’ll have an excellent shot to claim the series and solidify their position as a legitimate division threat heading into a tough June schedule. Thursday’s game is a chance not just for another win, but for San Diego to send a clear message that they are capable of closing out tight series on the road against quality opponents—exactly the kind of resolve that defines contenders by the All-Star break.

The San Diego Padres travel to Oracle Park to face the San Francisco Giants on Thursday, June 5, 2025. After splitting the first two games of the series, both teams are fighting for momentum in the tight NL West race. San Diego vs San Francisco AI Prediction: Free MLB Betting Insights for Jun 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco Giants MLB Preview

The San Francisco Giants return to Oracle Park for Thursday’s series finale against the San Diego Padres looking to bounce back from a narrow loss and assert their presence in the competitive NL West where every series win carries weight, particularly against a divisional rival like the Padres. Holding a 33–27 record, the Giants will turn to left-hander Robbie Ray, whose midseason form has stabilized their rotation by providing length, efficiency, and a proven ability to induce weak contact with his effective sinker-slider combination. Ray’s main challenge will be navigating the heart of San Diego’s order, which features high-contact and power hitters like Manny Machado and Fernando Tatis Jr., and his ability to command the inside part of the plate while avoiding elevated fastballs will be critical if he’s to keep the Padres from gaining early momentum. The Giants’ offense has not overwhelmed anyone in terms of power numbers this season, but it has been timely and situationally smart, led by Heliot Ramos and Wilmer Flores who have consistently come through in RBI situations and kept the lineup productive despite broader inconsistencies.

San Francisco has struggled to cover the run line at home recently, going just 1–4 ATS in their last five games at Oracle Park, a trend they’re eager to reverse by executing more cleanly in late-inning scenarios and converting more runners in scoring position into actual runs. The bullpen, while ranked top five in ERA, has shown signs of fatigue after a grueling stretch of tight games, and manager Bob Melvin will likely need to manage his relief corps closely to ensure the most effective matchups in the seventh and eighth innings, especially if the game stays tight. Defensively, the Giants remain reliable, turning double plays with consistency and benefiting from strong fundamentals, but any lapses—especially against a Padres team that thrives on aggressive base running—could quickly tilt the momentum. For San Francisco to emerge victorious, they’ll need Ray to give them at least six strong innings, the offense to produce a few multi-hit innings rather than relying solely on the long ball, and the bullpen to deliver clean frames under pressure. With the series on the line and the potential to climb closer to the division lead, the Giants will need to execute in every phase—pitching, fielding, and situational hitting—to overcome a well-rounded San Diego team and reestablish Oracle Park as a place where they can consistently lock down wins. This game is more than just a series closer—it’s a measuring stick for whether the Giants can consistently hang with the top-tier teams in the National League and build the kind of momentum that fuels legitimate postseason runs.

San Diego vs. San Francisco Prop Picks (AI)

Remi is pouring through mountains of data on each player. In fact, anytime the Padres and Giants play there’s always several intriguing angles to key in on. Not to mention games played at Oracle Park in Jun almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: M. Machado over 6.5 Fantasy Score.

San Diego vs. San Francisco Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Padres and Giants and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the growing emphasis emotional bettors tend to put on coaching factors between a Padres team going up against a possibly tired Giants team. It appears the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Diego vs San Francisco picks, computer picks Padres vs Giants, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Padres Betting Trends

San Diego has been competitive as road underdogs, covering 7 of their last 12 away games, and has a 4–2 ATS record as favorites in their last 10 outings.

Giants Betting Trends

San Francisco is 27–32 ATS on the season and just 1–4 ATS in their last five home games, despite playing well in front of their fans.

Padres vs. Giants Matchup Trends

Only 3 of the last 10 Padres–Giants matchups hit the Over, yet the total is set at 7 runs, suggesting oddsmakers expect more offense than recent history would indicate.

San Diego vs. San Francisco Game Info

San Diego vs San Francisco starts on June 05, 2025 at 3:45 PM EST.

Spread: San Francisco -1.5
Moneyline: San Diego +106, San Francisco -126
Over/Under: 7.5

San Diego: (35-24)  |  San Francisco: (33-28)

Remi's searched hard and found the best prop for this matchup: M. Machado over 6.5 Fantasy Score.. Prices move—always shop for the best number.

Only 3 of the last 10 Padres–Giants matchups hit the Over, yet the total is set at 7 runs, suggesting oddsmakers expect more offense than recent history would indicate.

SD trend: San Diego has been competitive as road underdogs, covering 7 of their last 12 away games, and has a 4–2 ATS record as favorites in their last 10 outings.

SF trend: San Francisco is 27–32 ATS on the season and just 1–4 ATS in their last five home games, despite playing well in front of their fans.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Diego vs. San Francisco Odds

AI algorithm Remi is pouring through mountains of stats on each player. In fact, anytime the San Diego vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.

San Diego vs San Francisco Opening Odds

SD Moneyline: +106
SF Moneyline: -126
SD Spread: +1.5
SF Spread: -1.5
Over/Under: 7.5

San Diego vs San Francisco Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+194
-235
+1.5 (-105)
-1.5 (-114)
O 8.5 (-122)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-168
 
-1.5 (+118)
O 9 (-122)
U 9 (+100)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+132
-156
+1.5 (-154)
-1.5 (+128)
O 8.5 (-106)
U 8.5 (-114)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+102
-120
-1.5 (+162)
+1.5 (-196)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+198
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-108)
U 8 (-112)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-124
+106
-1.5 (+130)
+1.5 (-156)
O 8.5 (-112)
U 8.5 (-108)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+177
-197
+1.5 (-118)
-1.5 (-102)
O 8.5 (-118)
U 8.5 (-102)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+128
-152
+1.5 (-178)
-1.5 (+146)
O 7.5 (-120)
U 7.5 (-102)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+143
-158
+1.5 (-150)
-1.5 (+130)
O 8.5 (+100)
U 8.5 (-120)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+132
-156
+1.5 (-172)
-1.5 (+142)
O 7 (-120)
U 7 (-102)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+120
-132
+1.5 (-180)
-1.5 (+157)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+102
-120
+1.5 (-215)
-1.5 (+180)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+104
-115
+1.5 (-185)
-1.5 (+161)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Diego Padres vs. San Francisco Giants on June 05, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN