Royals vs Cardinals Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 05)
Updated: 2025-06-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Kansas City Royals travel to Busch Stadium to face the St. Louis Cardinals on Thursday, June 5, 2025, with KC looking to keep their recent form rolling and STL eager to rebound after falling short in earlier games this week. Both teams hover near .550, making this finale a pivotal divisional showdown.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 05, 2025
Start Time: 1:45 PM EST
Venue: Busch Stadium
Cardinals Record: (33-27)
Royals Record: (32-29)
OPENING ODDS
KC Moneyline: +110
STL Moneyline: -131
KC Spread: +1.5
STL Spread: -1.5
Over/Under: 8.5
KC
Betting Trends
- Kansas City has excelled as road underdogs, covering the spread in 12 of their last 26 away games and carrying solid value despite modest records.
STL
Betting Trends
- St. Louis has gone just 3–7 ATS over their last ten home starts. However, they hold a 19–8 record at Busch Stadium this season, making them tough to beat straight-up even while underperforming against the spread.
MATCHUP TRENDS
- Only 3 of the last 10 Royals–Cardinals matchups have gone over the total. Today’s line is set at 8.5, signaling expectations for more offense than history suggests.
KC vs. STL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: B. Witt over 1,5 Total Bases.
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Kansas City vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 6/5/25
Kansas City is likely to send left-hander Noah Cameron (1.05 ERA) to the mound, who has been excellent at inducing soft contact and giving the Royals a chance to control pace early, while St. Louis will likely counter with Mikolas, who has performed well at home but must avoid the big inning against a Kansas City team that capitalizes on mistakes. The total is set at 8.5, higher than recent head-to-head trends would suggest, with only three of the last ten matchups between these two having gone over, but the volatility in both bullpens and the capacity for sudden scoring spikes makes the over a viable possibility. The Royals’ offense has shown more balance lately, with Witt Jr., Vinnie Pasquantino, and Salvador Perez contributing up and down the lineup, while the Cardinals continue to lean on veterans like Nolan Arenado, Willson Contreras, and Lars Nootbaar to provide clutch hits. Ultimately, the game is likely to come down to situational execution—whichever team avoids defensive lapses, strings together base hits with runners on, and manages the middle innings effectively will emerge with a win that could carry meaningful implications as both clubs look to stay in the thick of the playoff chase. This isn’t just about salvaging a split or winning a series; it’s about setting a tone for June and building confidence heading into tougher stretches of the schedule.
Game two in St. Lou. pic.twitter.com/dPO1mDUTGs
— Kansas City Royals (@Royals) June 4, 2025
Kansas City Royals MLB Preview
The Kansas City Royals enter Thursday’s series finale at Busch Stadium with a 32–29 record and the kind of momentum that can shift a season, fueled by a stunning 10–7 comeback win in the opener that featured a four-RBI performance from Bobby Witt Jr. and a bullpen that shut down the Cardinals after early trouble. Witt Jr. continues to be the catalyst for the Royals’ offense, showcasing power, speed, and a growing ability to deliver in high-leverage moments, while Vinnie Pasquantino and Salvador Perez offer middle-of-the-lineup experience and timely production. The Royals’ offense, while not always explosive, thrives on situational execution—stringing together productive at-bats, aggressive but smart baserunning, and capitalizing on opponent mistakes. Kansas City’s pitching, once a weakness, has stabilized thanks to the emergence of left-hander Noah Cameron, who enters with a sparkling 1.05 ERA and a calm demeanor on the mound that has earned the trust of manager Matt Quatraro. Cameron doesn’t rely on overpowering stuff but instead mixes his pitches well, changes speeds effectively, and lets his defense work behind him, which has led to several efficient outings even against stronger lineups.
The bullpen, with key arms like Daniel Lynch IV and John Schreiber, has become a legitimate asset, capable of holding leads and extinguishing rallies with strike-throwing consistency. On the road, the Royals have been a gritty, resilient group, going 12–13 ATS but frequently outperforming expectations in tight games, especially when installed as underdogs. Their defense has been solid, limiting extra bases and converting key outs, while the coaching staff has emphasized tempo and consistency in fielding execution. Quatraro has leaned into a hybrid offensive strategy—small ball supported by selective power—and it has begun to yield positive results as Kansas City climbs the standings. With a chance to take another road series from a quality opponent, the Royals will rely on Cameron to establish rhythm early, Witt Jr. to lead the offensive attack, and the bullpen to continue its string of strong showings. If those three elements align, Kansas City is in a prime position to come out of St. Louis with a critical win, further cementing its role as a rising factor in the AL Wild Card race and proving that their early-season form wasn’t a fluke but rather the foundation of a scrappy, capable playoff contender.

Credit: USA TODAY/IMAGN
St. Louis Cardinals MLB Preview
The St. Louis Cardinals return to Busch Stadium for Thursday’s series finale against the Kansas City Royals with a 33–27 record and a sense of urgency after letting a five-run lead slip away in Tuesday’s 10–7 loss, a game that exposed cracks in both their starting rotation and middle relief corps. Andre Pallante struggled mightily in that outing, allowing seven earned runs over just 4⅓ innings, and while the offense provided early support, the inability to shut the door underscored a recurring theme for St. Louis—getting strong starts from the front end of the rotation while struggling to maintain leads once the bullpen takes over. That inconsistency has led to a disappointing 3–7 ATS record over their last ten home games despite boasting an impressive 19–8 straight-up mark at Busch Stadium, where they’ve historically played well. Miles Mikolas is expected to take the mound and will be counted on to restore order after recent volatility, using his sinker-slider combo to generate ground balls and limit the Royals’ ability to string together extra-base hits. Offensively, the Cardinals continue to lean on Nolan Arenado, Lars Nootbaar, and Willson Contreras, all of whom have produced in clutch moments but haven’t been able to consistently carry the load when facing quality bullpens or in late-game scenarios.
The return of Brendan Donovan has provided some spark and lineup flexibility, but the team overall has been slow to capitalize on scoring opportunities with runners in scoring position, something they’ll need to correct quickly if they want to avoid losing this series. Defensively, St. Louis remains sharp, anchored by one of the best infields in baseball, yet lapses in late-inning execution—from both the mound and the plate—have negated what would otherwise be a strong foundation for victory. Manager Oliver Marmol has emphasized sharper situational play and improved tempo, particularly in the early innings, to avoid chasing late in games against a Royals team that has proven capable of manufacturing pressure from minimal base traffic. If Mikolas can get through five or six innings clean and set up the back end of the bullpen for Ryan Helsley and JoJo Romero, the Cardinals will be in good shape, but any slip in command could open the door for Kansas City’s opportunistic lineup. St. Louis needs to reassert control, slow down Bobby Witt Jr., and take advantage of Noah Cameron’s inexperience on the mound by applying offensive pressure early. A win would allow them to avoid a series loss at home, keep pace in the tightly packed NL Central, and reestablish Busch Stadium as a place where the Cardinals don’t just win—they dominate.
Game 2 vs. KC pic.twitter.com/E00Ieb4fpI
— St. Louis Cardinals (@Cardinals) June 4, 2025
Kansas City vs. St. Louis Prop Picks (AI)
Kansas City vs. St. Louis Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every facet between the Royals and Cardinals and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
The Algorithm has been most focused on the unproportionally assigned emphasis emotional bettors tend to put on coaching factors between a Royals team going up against a possibly improved Cardinals team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Kansas City vs St. Louis picks, computer picks Royals vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Royals Betting Trends
Kansas City has excelled as road underdogs, covering the spread in 12 of their last 26 away games and carrying solid value despite modest records.
Cardinals Betting Trends
St. Louis has gone just 3–7 ATS over their last ten home starts. However, they hold a 19–8 record at Busch Stadium this season, making them tough to beat straight-up even while underperforming against the spread.
Royals vs. Cardinals Matchup Trends
Only 3 of the last 10 Royals–Cardinals matchups have gone over the total. Today’s line is set at 8.5, signaling expectations for more offense than history suggests.
Kansas City vs. St. Louis Game Info
What time does Kansas City vs St. Louis start on June 05, 2025?
Kansas City vs St. Louis starts on June 05, 2025 at 1:45 PM EST.
Where is Kansas City vs St. Louis being played?
Venue: Busch Stadium.
What are the opening odds for Kansas City vs St. Louis?
Spread: St. Louis -1.5
Moneyline: Kansas City +110, St. Louis -131
Over/Under: 8.5
What are the records for Kansas City vs St. Louis?
Kansas City: (32-29) | St. Louis: (33-27)
What is the AI best bet for Kansas City vs St. Louis?
Remi's searched hard and found the best prop for this matchup: B. Witt over 1,5 Total Bases.. Prices move—always shop for the best number.
What are Kansas City vs St. Louis trending bets?
Only 3 of the last 10 Royals–Cardinals matchups have gone over the total. Today’s line is set at 8.5, signaling expectations for more offense than history suggests.
What are Kansas City trending bets?
KC trend: Kansas City has excelled as road underdogs, covering the spread in 12 of their last 26 away games and carrying solid value despite modest records.
What are St. Louis trending bets?
STL trend: St. Louis has gone just 3–7 ATS over their last ten home starts. However, they hold a 19–8 record at Busch Stadium this season, making them tough to beat straight-up even while underperforming against the spread.
Where can I find AI Picks for Kansas City vs St. Louis?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Kansas City vs. St. Louis Odds
Remi is pouring through mountains of data on each line. In fact, anytime the Kansas City vs St. Louis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable betting trends.
Kansas City vs St. Louis Opening Odds
KC Moneyline:
+110 STL Moneyline: -131
KC Spread: +1.5
STL Spread: -1.5
Over/Under: 8.5
Kansas City vs St. Louis Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 8:00PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 8PM
Dodgers
Blue Jays
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–
–
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-143
+130
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-1.5 (+120)
+1.5 (-140)
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O 7.5 (+105)
U 7.5 (-125)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Kansas City Royals vs. St. Louis Cardinals on June 05, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |