Padres vs Giants Prediction — AI Finds CAN'T MISS MLB Lines & Props (Jun 04)
Updated: 2025-06-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Diego Padres travel to Oracle Park on Wednesday, June 4, 2025, to face the San Francisco Giants in the finale of their divisional series. San Francisco heads into the game looking to end a three-game skid, while the Padres aim to extend their strong road form.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Jun 04, 2025
Start Time: 9:45 PM EST
Venue: Oracle Park
Giants Record: (33-28)
Padres Record: (35-24)
OPENING ODDS
SD Moneyline: -110
SF Moneyline: -110
SD Spread: -1.5
SF Spread: +1.5
Over/Under: 7.5
SD
Betting Trends
- The Padres have been competitive as underdogs, winning 13 out of 24 games as underdogs and covering 3‑2 ATS in their last five games despite inconsistencies at home.
SF
Betting Trends
- San Francisco has struggled ATS on the road, going 14–19, and is just 1–4 ATS in their last five outings, though their overall current form shows they can bounce back quickly.
MATCHUP TRENDS
- Only three of the last ten Padres–Giants games have gone OVER, yet tonight’s total is set at 7, suggesting expectations for more offense than recent matchups have produced.
SD vs. SF
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: M. Chapman over 0.5 Total Bases.
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San Diego vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 6/4/25
The Giants have gone just 1–4 ATS over their last five games, reflecting a string of underwhelming offensive performances and late-inning breakdowns despite strong starts from Logan Webb, who remains a dominant presence at home with a 1.98 ERA in his most recent start. Offensively, the Giants continue to rely on Wilmer Flores and Heliot Ramos for production, both of whom have delivered power and run support in critical spots, but the overall lineup has lacked depth in recent matchups, failing to sustain rallies or capitalize on runners in scoring position. The total for this game is set at 7 runs, and while only three of the last ten games between these teams have gone over that mark, the current form of both offenses suggests the potential for more scoring than usual, especially if either bullpen is taxed early. The Padres’ edge in lineup depth and recent performance gives them a slight upper hand, but with Logan Webb on the hill, the Giants are always capable of flipping the narrative if they can provide enough early offense to support him. Ultimately, this game could hinge on which team breaks through first in a tight pitching duel and whether the late-inning bullpen units can hold serve, particularly if the game remains close into the seventh or eighth inning. A win for the Padres would mark another key step in their march toward the top of the division, while a victory for the Giants would stop the bleeding and keep them in the thick of the NL West race, making this rubber match a meaningful barometer for both squads.
The Wild Wild West pic.twitter.com/70KfK9Jsnr
— San Diego Padres (@Padres) June 4, 2025
San Diego Padres MLB Preview
The San Diego Padres enter Wednesday’s series finale against the San Francisco Giants with a 35–24 record and an increasingly confident posture as they continue to surge through their NL West schedule behind a revitalized offense, deep rotation, and timely execution that has led to a three-game road winning streak. This current run has been powered in large part by the elite play of Fernando Tatis Jr., who leads the team with 13 home runs and continues to showcase his range and arm in right field, while Manny Machado has emerged from an early-season funk to hit .302 and deliver several key RBI swings in the middle of the order. Complimenting the veteran duo are rising contributors like Jung Hoo Lee and Heliot Ramos, who have both played crucial roles in extending innings and applying pressure to opposing pitchers with disciplined plate approaches and smart baserunning. The Padres’ lineup has also benefited from improved situational hitting, converting opportunities with runners in scoring position at a higher clip and forcing opponents into defensive mistakes. On the mound, San Diego’s staff has been quietly among the league’s most effective, posting a 3.72 team ERA and ranking near the top of the NL in strikeout rate, with Nick Pivetta’s return from injury adding a steady presence to a rotation that already includes quality outings from Joe Musgrove and Dylan Cease.
While the bullpen has been prone to occasional volatility, closer Robert Suarez and setup man Wandy Peralta have delivered in recent outings, tightening up late-game execution and allowing the Padres to close out tight contests. Their 13–11 ATS road record reflects a team that battles in high-leverage environments and has grown more comfortable in hostile stadiums, using their speed, power, and depth to overwhelm opponents when they’re able to seize early momentum. Manager Mike Shildt has shown a deft touch with lineup flexibility and pitching changes, keeping arms fresh and finding ways to neutralize left-right splits during critical innings. Against San Francisco ace Logan Webb, the Padres will look to drive up pitch count early, stay patient with runners on base, and capitalize on any mistakes in the zone, especially if they can push Webb out of the game before the seventh. San Diego’s game plan will likely center around manufacturing early runs, protecting leads with middle relief, and relying on their superior lineup depth to wear down the Giants’ staff. With the team surging and health largely intact, the Padres are well-positioned to leave Oracle Park with a series win and keep the pressure on in the division, where every edge gained in June could prove vital in what promises to be a tightly contested NL West race. A win here wouldn’t just extend a strong road stretch—it would further confirm that San Diego’s high-end roster is finally executing at the level many envisioned before the season began.

Credit: USA TODAY/IMAGN
San Francisco Giants MLB Preview
The San Francisco Giants enter Wednesday’s series finale against the San Diego Padres at Oracle Park with a 32–25 record and a sense of urgency following a three-game losing streak that has dimmed some of the early momentum they built in the NL West, particularly after falling short in high-leverage moments in each of their recent matchups. Despite the skid, the Giants remain firmly in playoff contention and continue to benefit from the exceptional form of ace Logan Webb, who is expected to take the mound carrying a 1.98 ERA over his last start and a track record of dominance at home where his command and mound presence often set the tone for the team. Webb’s ability to induce ground balls, limit walks, and extend outings into the sixth and seventh innings has been pivotal, especially with a bullpen that has shown signs of fatigue and inconsistency, particularly in middle relief where inherited runners have become a growing problem. On the offensive side, the Giants have leaned on Wilmer Flores and Heliot Ramos, the latter of whom is in the midst of a breakout stretch featuring consistent power and run production from the heart of the lineup, while Flores remains the team’s most dependable RBI bat with 10 home runs and 47 RBIs to date. The rest of the lineup, however, has struggled to keep pace, with runners often stranded and rallies halted due to strikeouts and an overreliance on solo home runs instead of sustained offensive pressure.
San Francisco’s recent 1–4 ATS record reflects those offensive lulls and bullpen stumbles, and while the club is 14–11 at home overall, they’ve not consistently covered spreads at Oracle Park in part due to low-scoring, tightly contested games that don’t provide enough cushion. Manager Bob Melvin has pushed for sharper execution in two-strike situations and improved basepath decisions, and with a rival like San Diego in town, there’s added motivation to get back on track in front of a home crowd that has witnessed the team’s ups and downs throughout the first half. The key to securing a much-needed win will be Webb delivering a strong start and keeping the Padres’ dangerous top of the order in check while the Giants’ hitters must find ways to challenge San Diego’s bullpen by working deep counts and taking advantage of favorable matchups. With only three of the last ten meetings between these teams having gone over the total, and tonight’s line set at seven runs, this game has all the makings of another tight affair where one or two big moments could swing the result. If San Francisco can reassert their trademark formula—strong starting pitching, solid defense, and timely hits—they’ll be well-positioned to halt the Padres’ surge and remind the division that they’re still a serious threat when executing their brand of baseball effectively. A victory in this spot would not only end a frustrating slide but also restore some needed confidence as the Giants look to recapture early-season momentum and keep pace in an NL West race that remains wide open.
Another strong performance from Landen 😮💨
— SFGiants (@SFGiants) June 4, 2025
6.1 IP // 4 H // 0 R // 2 BB // 5 K pic.twitter.com/EtVuUXfi4t
San Diego vs. San Francisco Prop Picks (AI)
San Diego vs. San Francisco Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every facet between the Padres and Giants and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.
Remi has been most watching on the unproportionally assigned weight emotional bettors regularly put on player performance factors between a Padres team going up against a possibly deflated Giants team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Diego vs San Francisco picks, computer picks Padres vs Giants, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 2 |
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MLB | 10/20 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Padres Betting Trends
The Padres have been competitive as underdogs, winning 13 out of 24 games as underdogs and covering 3‑2 ATS in their last five games despite inconsistencies at home.
Giants Betting Trends
San Francisco has struggled ATS on the road, going 14–19, and is just 1–4 ATS in their last five outings, though their overall current form shows they can bounce back quickly.
Padres vs. Giants Matchup Trends
Only three of the last ten Padres–Giants games have gone OVER, yet tonight’s total is set at 7, suggesting expectations for more offense than recent matchups have produced.
San Diego vs. San Francisco Game Info
What time does San Diego vs San Francisco start on June 04, 2025?
San Diego vs San Francisco starts on June 04, 2025 at 9:45 PM EST.
Where is San Diego vs San Francisco being played?
Venue: Oracle Park.
What are the opening odds for San Diego vs San Francisco?
Spread: San Francisco +1.5
Moneyline: San Diego -110, San Francisco -110
Over/Under: 7.5
What are the records for San Diego vs San Francisco?
San Diego: (35-24) | San Francisco: (33-28)
What is the AI best bet for San Diego vs San Francisco?
Remi's searched hard and found the best prop for this matchup: M. Chapman over 0.5 Total Bases.. Prices move—always shop for the best number.
What are San Diego vs San Francisco trending bets?
Only three of the last ten Padres–Giants games have gone OVER, yet tonight’s total is set at 7, suggesting expectations for more offense than recent matchups have produced.
What are San Diego trending bets?
SD trend: The Padres have been competitive as underdogs, winning 13 out of 24 games as underdogs and covering 3‑2 ATS in their last five games despite inconsistencies at home.
What are San Francisco trending bets?
SF trend: San Francisco has struggled ATS on the road, going 14–19, and is just 1–4 ATS in their last five outings, though their overall current form shows they can bounce back quickly.
Where can I find AI Picks for San Diego vs San Francisco?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Diego vs. San Francisco Odds
Remi is pouring through mountains of data points on each player. In fact, anytime the San Diego vs San Francisco trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.
San Diego vs San Francisco Opening Odds
SD Moneyline:
-110 SF Moneyline: -110
SD Spread: -1.5
SF Spread: +1.5
Over/Under: 7.5
San Diego vs San Francisco Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 24, 2025 9:08PM EDT
Los Angeles Dodgers
Toronto Blue Jays
10/24/25 9:08PM
Dodgers
Blue Jays
|
–
–
|
-140
+127
|
-1.5 (+124)
+1.5 (-140)
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O 7.5 (+107)
U 7.5 (-123)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Diego Padres vs. San Francisco Giants on June 04, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |