Reds vs. Cubs
Prediction, Odds & Props
Jun 01 | MLB AI Picks

Updated: 2025-05-30T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On June 1, 2025, the Cincinnati Reds (29–30) will face the Chicago Cubs (36–22) at Wrigley Field in the final game of their three-game series. The Cubs aim to secure the series win and maintain their lead in the NL Central, while the Reds look to even the series and improve their standings.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Jun 01, 2025

Start Time: 2:20 PM EST​

Venue: Wrigley Field​

Cubs Record: (36-22)

Reds Record: (29-30)

OPENING ODDS

CIN Moneyline: +137

CHC Moneyline: -162

CIN Spread: +1.5

CHC Spread: -1.5

Over/Under: 7.5

CIN
Betting Trends

  • The Reds have covered the run line in 20 of their 30 road games this season, reflecting a 66.7% success rate against the spread.

CHC
Betting Trends

  • The Cubs have covered the run line in 19 of their 30 home games this season, indicating a 63.3% success rate against the spread.

MATCHUP TRENDS

  • The Cubs are favored at -1.5 on the run line, with odds of +140, while the Reds are +1.5 underdogs on the run line. The total is set at 7.5 runs for this matchup.

CIN vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: T. Friedl over 0.5 Total Bases.

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Cincinnati vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 6/1/25

The June 1, 2025 matchup between the Cincinnati Reds and the Chicago Cubs at Wrigley Field sets the stage for a tightly contested NL Central showdown between two teams with very different season trajectories to date, as the first-place Cubs aim to close out a home series win while the Reds look to even their record and make a statement on the road. The Cubs enter the finale at 36–22, riding the momentum of eight wins in their last nine home games and thriving behind an explosive offense that averages nearly six runs per game, powered by the dynamic combination of Pete Crow-Armstrong’s 15 home runs and Seiya Suzuki’s 52 RBIs, both of whom have consistently come through in big moments. Chicago’s lineup has shown balance and depth, with contributions coming from throughout the order, and manager Craig Counsell’s disciplined, matchup-oriented approach has paid dividends, especially at Wrigley where the Cubs have been excellent at applying pressure early and forcing mistakes from opposing pitchers. Jameson Taillon (4–3, 3.86 ERA) gets the start for the Cubs and brings stability to a rotation that has improved steadily, and while he’s not overpowering, his ability to limit hard contact and pitch deep into games has been critical to preserving bullpen depth and holding narrow leads.

On the other side, the Reds come into the game at 29–30, just below .500 but far from out of contention, especially given their resilience on the road where they’ve gone 15–16 and covered the run line in two-thirds of those games—a mark of their scrappiness and tendency to hang around late into contests. Elly De La Cruz remains the focal point of Cincinnati’s offense with 11 home runs and 40 RBIs, and his combination of power and speed makes him a constant threat to flip a game with one swing or one stolen base, but the Reds need more consistent support around him to capitalize on scoring opportunities and match teams like Chicago inning for inning. Nick Martinez (3–5, 3.48 ERA) will start for Cincinnati and enters with a respectable ERA but has been victimized by poor run support and late-game breakdowns, so he’ll need to work efficiently and limit walks against a Cubs lineup that thrives on grinding out at-bats. Defensively, both teams have been sharp, but the Reds have been particularly opportunistic on the bases and in high-leverage defensive situations, making clean execution a must if the Cubs want to avoid late-inning drama. The total is set at 7.5 runs, and the Cubs are favored at -1.5, but given Cincinnati’s ATS success and the presence of capable arms on both sides, this game could hinge on one or two timely hits or defensive plays. With first-place implications for Chicago and momentum-shifting potential for Cincinnati, Sunday’s series finale is poised to be a high-stakes contest full of playoff energy, divisional pride, and the kind of intensity that defines June baseball between longtime rivals.

Cincinnati Reds MLB Preview

The Cincinnati Reds enter their June 1, 2025 matchup against the Chicago Cubs at Wrigley Field with a 29–30 record and the clear objective of evening both the series and their season mark by leaning on the road-tested resilience that’s allowed them to cover the run line in 66.7% of their away games, including several against playoff-caliber teams. While the Reds haven’t been dominant, they’ve found ways to stay competitive thanks to the explosive talent of Elly De La Cruz, who leads the team with 11 home runs and 40 RBIs and continues to be a nightmare for opposing pitchers and catchers with his combination of power, speed, and aggressive baserunning. Alongside him, the Reds have gotten timely hitting from a rotating cast of contributors, and while the offense has occasionally run cold, it remains capable of putting up crooked numbers when De La Cruz sets the tone early in the game. Cincinnati’s biggest challenge has been consistency from the rest of the lineup and the rotation, but they’ll turn to Nick Martinez on Sunday, whose 3–5 record doesn’t fully reflect his solid 3.48 ERA and ability to navigate lineups with a mix of off-speed pitches and a strong sense of pitch sequencing that often keeps batters guessing through the middle innings.

Martinez will need to be especially sharp against a Cubs lineup averaging nearly six runs per game and led by Seiya Suzuki and Pete Crow-Armstrong, both of whom have punished mistakes all season and are particularly dangerous in the friendly confines of Wrigley Field. For the Reds to keep this one close and potentially steal the game, they’ll need Martinez to go at least six innings while avoiding the one big blow that has occasionally doomed his outings, and the bullpen must be ready to hold the line if the game stays tight. Defensively, Cincinnati has held its own, and their ability to turn double plays and make clean throws has helped offset the inconsistencies in their run prevention efforts, especially on the road where one error can shift momentum quickly. Manager David Bell has continued to instill a fight-until-the-end mentality, and while the Reds remain a team in development, their upside is evident in stretches where their youth plays fast and fearless rather than overly cautious. Sunday’s game gives Cincinnati a valuable opportunity not just to earn a tough road win but to measure themselves against one of the division’s best and prove they can go toe-to-toe when the pressure is on, and if De La Cruz can ignite the offense early and Martinez keeps the ball down in the zone, the Reds have a real shot at heading home with a critical series split and a boost of confidence heading into June.

On June 1, 2025, the Cincinnati Reds (29–30) will face the Chicago Cubs (36–22) at Wrigley Field in the final game of their three-game series. The Cubs aim to secure the series win and maintain their lead in the NL Central, while the Reds look to even the series and improve their standings. Cincinnati vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Jun 01. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs enter their June 1, 2025 matchup against the Cincinnati Reds with a 36–22 record, fueled by one of the most consistent offenses in the National League and a dominant stretch at Wrigley Field where they’ve won eight of their last nine games, continuing to assert themselves as a serious contender atop the NL Central. The Cubs have covered the run line in 63.3% of their home games this season, and much of that success stems from a lineup that combines power, patience, and situational execution, led by Seiya Suzuki, who has driven in 52 runs, and Pete Crow-Armstrong, who leads the team with 15 home runs while also providing elite defense and baserunning. Chicago’s offense has been firing on all cylinders, averaging 5.89 runs per game, and consistently applying pressure early in games by working deep counts and forcing pitchers into high-stress innings, which will be their game plan again against Reds starter Nick Martinez, a right-hander with a 3–5 record and a respectable 3.48 ERA who has occasionally struggled when facing lineups that can extend at-bats and capitalize on mistakes.

On the mound for the Cubs, Jameson Taillon (4–3, 3.86 ERA) brings a veteran presence and a command-first approach that has helped him limit damage and provide quality starts, and with the Cubs’ bullpen performing efficiently behind him, manager Craig Counsell will look to his starter to go at least six innings and hand over a lead to a relief corps that has closed out games with consistency. Defensively, the Cubs have been sharp, with sound infield play and a strong outfield alignment that helps minimize extra-base hits, and they’ve excelled at preventing innings from unraveling thanks to smart shifts and clean execution, particularly when playing in front of a home crowd that’s been a real factor this season. Counsell’s leadership and tactical flexibility have also allowed the team to exploit platoon advantages and make game-time adjustments that neutralize opponents’ strengths, and that chess-match mentality has worked well against younger or less experienced clubs like the Reds. The key for Chicago in this matchup will be to strike early, forcing Martinez into stressful innings while taking advantage of any missed locations with runners in scoring position, and then letting Taillon pitch with a lead and control the game’s tempo. The Cubs enter the contest as -1.5 favorites on the run line, and with their potent offense, sharp pitching, and home-field momentum, they are well-positioned to close out the series with a statement win that would not only maintain their lead in the division but also continue to solidify their reputation as one of the most complete and confident teams in the National League through the first two months of the season.

Cincinnati vs. Chicago Cubs Prop Picks (AI)

Remi is pouring through tons of stats on each player. In fact, anytime the Reds and Cubs play there’s always several intriguing trends to key in on. Not to mention games played at Wrigley Field in Jun can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: T. Friedl over 0.5 Total Bases.

Cincinnati vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every angle between the Reds and Cubs and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

The Algorithm has been most fixated on the linear correlation of factor knucklehead sportsbettors regularly put on player performance factors between a Reds team going up against a possibly strong Cubs team. It appears the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cincinnati vs Chicago Cubs picks, computer picks Reds vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Reds Betting Trends

The Reds have covered the run line in 20 of their 30 road games this season, reflecting a 66.7% success rate against the spread.

Cubs Betting Trends

The Cubs have covered the run line in 19 of their 30 home games this season, indicating a 63.3% success rate against the spread.

Reds vs. Cubs Matchup Trends

The Cubs are favored at -1.5 on the run line, with odds of +140, while the Reds are +1.5 underdogs on the run line. The total is set at 7.5 runs for this matchup.

Cincinnati vs. Chicago Cubs Game Info

Cincinnati vs Chicago Cubs starts on June 01, 2025 at 2:20 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: Cincinnati +137, Chicago Cubs -162
Over/Under: 7.5

Cincinnati: (29-30)  |  Chicago Cubs: (36-22)

Remi's searched hard and found the best prop for this matchup: T. Friedl over 0.5 Total Bases.. Prices move—always shop for the best number.

The Cubs are favored at -1.5 on the run line, with odds of +140, while the Reds are +1.5 underdogs on the run line. The total is set at 7.5 runs for this matchup.

CIN trend: The Reds have covered the run line in 20 of their 30 road games this season, reflecting a 66.7% success rate against the spread.

CHC trend: The Cubs have covered the run line in 19 of their 30 home games this season, indicating a 63.3% success rate against the spread.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cincinnati vs. Chicago Cubs Odds

AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Cincinnati vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

Cincinnati vs Chicago Cubs Opening Odds

CIN Moneyline: +137
CHC Moneyline: -162
CIN Spread: +1.5
CHC Spread: -1.5
Over/Under: 7.5

Cincinnati vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cincinnati Reds vs. Chicago Cubs Cubs on June 01, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN