The November 15, 2025, AAC matchup between the UTSA Roadrunners and the Charlotte 49ers sets up as a pivotal late-season contest between two programs heading in different directions but both desperate for momentum. UTSA enters at 4-5, still clinging to bowl eligibility hopes and seeking to rebound from a humbling road loss to South Florida, while Charlotte, at 1-7, continues to search for answers in a season marred by offensive inconsistency and defensive breakdowns. The Roadrunners, led by head coach Jeff Traylor, have built their identity around explosive offense, experience, and tempo, but their defense has been a glaring weakness on the road. In contrast, Charlotte’s head coach Biff Poggi continues to lay the foundation of a culture focused on discipline and toughness, even as the 49ers struggle to translate that mentality into wins. On paper, this matchup heavily favors UTSA’s offensive firepower, but conference road games have proven unpredictable, especially when motivation and pride come into play for a home underdog. UTSA’s offense remains its calling card. Quarterback Owen McCown has been the engine behind a balanced attack that averages more than 420 total yards and 32 points per game. McCown’s arm strength and field vision make him dangerous, particularly when targeting receivers Joshua Cephus and Devin McCuin, both capable of breaking games open with yards after the catch. The ground game, led by running back Robert Henry Jr., provides the perfect complement, averaging over 5 yards per carry behind a veteran offensive line that has steadily improved throughout the season. Expect the Roadrunners to use a mix of inside-zone and tempo-based passing to stretch Charlotte’s defense early and establish control. However, UTSA’s major concern remains its defense, which has given up over 30 points per game and struggled to defend both the pass and explosive plays. The unit’s lack of consistency, particularly in road environments, has put pressure on the offense to win shootouts.

Against Charlotte, UTSA’s defense must focus on discipline, gap integrity, and avoiding mental lapses on third down that have repeatedly extended drives. Charlotte, though heavily outmatched on paper, will look to take advantage of those defensive lapses by running the ball and controlling tempo. The 49ers’ offense has averaged just 18 points per game but has shown flashes when quarterback Trexler Ivey or Jalon Jones can find rhythm on quick, high-percentage passes. Running back Rod Gainey Jr. remains their most consistent offensive weapon, and establishing him early will be crucial to prevent UTSA from dictating pace. Defensively, Charlotte has struggled to stop the run and limit big plays, surrendering more than 410 yards per game. However, their front seven, led by Eyabi Okie-Anoma and defensive tackle Demon Clowney, has shown moments of promise when playing at home. For the 49ers, the key will be pressuring McCown without overcommitting blitzes that leave their secondary exposed. From a betting standpoint, UTSA opens as a sizable favorite, hovering around -17.5, while the total sits near 61 points. The Roadrunners have been unreliable ATS on the road (1-3 this season), which raises questions about whether they can sustain a large margin of victory. Charlotte, despite its record, has played more competitive football at home, particularly in the first halves of games before depth and fatigue take over. The total could lean toward the over given UTSA’s offensive explosiveness and Charlotte’s defensive vulnerability, but turnovers and pace could make it closer to the mid-50s. Ultimately, this game comes down to execution and focus. If UTSA limits mistakes and starts strong, they have the weapons to dominate and keep their postseason hopes alive. However, if Charlotte manages to control the clock, win the turnover battle, and feed off its home crowd, the 49ers could keep it closer than the spread suggests. Expect UTSA’s offense to pull away late, but not before Charlotte’s effort and pride make the Roadrunners earn every yard in what could be a tougher-than-expected conference battle.