USC vs Notre Dame Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 18)

Updated: 2025-10-11T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

USC visits South Bend on October 18, 2025, to face Notre Dame in a storied rivalry game with major playoff implications. The Trojans arrive with momentum in Lincoln Riley’s second season in the Big Ten, while the Irish aim to defend their home turf and reassert their national relevance.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Oct 18, 2025

Start Time: 7:30 PM EST​

Venue: Notre Dame Stadium​

Fighting Irish Record: (4-2)

Trojans Record: (5-1)

OPENING ODDS

USC Moneyline: +242

ND Moneyline: -304

USC Spread: +7.5

ND Spread: -7.5

Over/Under: 61.5

USC
Betting Trends

  • USC has been solid against the spread this season, covering in several games even when not as dominant—as bettors have given credence to their rising trajectory under Riley.

ND
Betting Trends

  • Notre Dame’s home ATS performance is mixed: when they control the trenches and limit turnovers, they generally cover; when their defense allows explosive plays, the spread tends to slip.

MATCHUP TRENDS

  • In Notre Dame–USC games over the past decade, the under has hit about 80% of the time, suggesting this rivalry often features tighter, lower-scoring contests than lines project.

USC vs. ND
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: E. Raridon under 37.5 Receiving Yards.

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USC vs Notre Dame Prediction & Odds:
Free CFB Betting Insights for 10/18/25

When the USC Trojans and the Notre Dame Fighting Irish meet on October 18, 2025, in South Bend, it will be more than just another chapter in one of college football’s most iconic rivalries—it will be a litmus test for both programs as they jockey for national positioning midway through the season. The Trojans arrive under Lincoln Riley looking to prove that their explosive offensive identity can translate against a physical, disciplined Notre Dame team built around balance and fundamentals. USC’s offensive system remains among the most feared in college football, with quarterback Jayden Maiava commanding the tempo and delivering deep, precise passes to a dynamic group of receivers led by Zachariah Branch and Duce Robinson. The Trojans continue to play fast, spreading defenses thin and forcing mismatches in space, but the challenge will be whether their offensive line can hold up against the relentless pressure of Notre Dame’s defensive front. The Irish, under Marcus Freeman, are anchored by a defense that excels at gap control, tackling efficiency, and forcing opponents into predictable passing situations. Their ability to get interior push from Howard Cross III and Rylie Mills will be pivotal in disrupting Maiava’s rhythm, as USC’s offense thrives when it can dictate pace without pressure. Offensively, Notre Dame leans on balance and physicality. Quarterback CJ Carr has provided steadiness and intelligence, operating efficiently in play-action and taking advantage of single coverage when defenses crowd the box to stop running back Jeremiyah Love.

Expect Notre Dame to try to control time of possession, limit USC’s offensive snaps, and wear down the Trojans’ front seven through sustained drives. The game’s key battle may come down to third-down conversions—USC’s explosive, quick-strike offense against Notre Dame’s bend-but-don’t-break defensive approach. Defensively, USC must show that its offseason investments in toughness and tackling have paid off. The Trojans have struggled in previous years against power-running teams, but under defensive coordinator D’Anton Lynn, the unit has improved its gap discipline and tackling form. The linebacker trio of Tackett Curtis, Eric Gentry, and Mason Cobb will need to fly to the football and limit yards after contact, while the secondary must stay alert against Notre Dame’s tight ends, who are often featured heavily in the passing game. On special teams, USC’s Branch remains one of the nation’s most dangerous returners, capable of flipping field position in a flash. Notre Dame’s home-field advantage, bolstered by one of the most raucous atmospheres in college football, could prove decisive if the game remains tight late. This matchup sets up as a classic contrast in styles—USC’s finesse, explosiveness, and offensive flair versus Notre Dame’s discipline, balance, and defensive resilience. Whichever team can impose its preferred tempo and win the battle at the line of scrimmage will likely walk away with a season-defining victory that could shape the College Football Playoff conversation in the weeks to come.

USC Trojans CFB Preview

The USC Trojans travel to South Bend with revenge, redemption, and validation all on their minds as they prepare to face the Notre Dame Fighting Irish on October 18, 2025. Under head coach Lincoln Riley, USC’s transition into a more balanced, physical version of its once high-flying Air Raid offense has begun to take shape, and this matchup represents the perfect opportunity to showcase that evolution on a national stage. Quarterback Jayden Maiava has seamlessly stepped into the leadership role, displaying composure beyond his years and the arm strength to attack every level of the field. His chemistry with wide receiver Zachariah Branch, one of the most electric playmakers in college football, has been the catalyst for USC’s offensive success, while tight end Duce Robinson continues to provide a reliable red-zone target and matchup nightmare for opposing linebackers. The Trojans’ offensive line remains the biggest question mark, particularly against Notre Dame’s formidable front seven, which thrives on interior pressure and collapsing pockets. If USC’s protection holds, expect Riley to dial up his signature tempo—stretching the field horizontally early before striking vertically with play-action shots designed to exploit Notre Dame’s safeties. Running backs Quinten Joyner and MarShawn Lloyd offer complementary skill sets that help sustain drives and keep the Trojans’ offense balanced, an essential factor in controlling the rhythm against a methodical Irish squad.

Defensively, USC’s improvement under coordinator D’Anton Lynn has been tangible, as the unit has placed greater emphasis on tackling fundamentals and gap integrity—areas that plagued them in past seasons. The Trojans’ defensive front, featuring Bear Alexander and Jamil Muhammad, must hold the point of attack and prevent Notre Dame’s offensive line from taking over the game. Linebackers Tackett Curtis and Mason Cobb are tasked with diagnosing run-pass reads quickly, as the Irish’s offense thrives on misdirection and play-action deception. In the secondary, Calen Bullock and Christian Roland-Wallace anchor a group that has shown flashes of excellence but still seeks consistency in coverage and communication. Against Notre Dame’s balanced offensive scheme, discipline will be key—USC cannot afford the busted coverages or missed assignments that turned previous marquee matchups into shootouts. On special teams, Zachariah Branch remains the ultimate X-factor, capable of changing momentum with one return. However, the Trojans’ focus must remain on executing cleanly in high-pressure moments, especially on the road in a hostile environment like Notre Dame Stadium. This trip to South Bend is not just another game—it’s a measuring stick for USC’s mental toughness, physical progress, and ability to thrive outside its comfort zone. If the Trojans can protect the football, establish offensive rhythm early, and match Notre Dame’s intensity in the trenches, they’ll have every chance to silence critics and prove they belong among the elite contenders in college football.

USC visits South Bend on October 18, 2025, to face Notre Dame in a storied rivalry game with major playoff implications. The Trojans arrive with momentum in Lincoln Riley’s second season in the Big Ten, while the Irish aim to defend their home turf and reassert their national relevance. USC vs Notre Dame AI Prediction: Free CFB Betting Insights for Oct 18. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Notre Dame Fighting Irish CFB Preview

The Notre Dame Fighting Irish return home to South Bend on October 18, 2025, with a sense of focus and confidence as they prepare for one of college football’s most storied rivalries against the USC Trojans. Under head coach Marcus Freeman, the Irish have continued to build an identity around physicality, discipline, and execution, blending old-school toughness with modern offensive flexibility. Quarterback CJ Carr, the latest in a long line of talented Notre Dame signal-callers, has brought poise and command to the offense, efficiently managing games while showing the arm strength to challenge defenses downfield. Carr’s connection with receivers Jordan Faison and Jaden Greathouse has added dimension to a passing attack that complements Notre Dame’s trademark power running game. In the backfield, Jeremiyah Love remains the centerpiece of the offense, running behind one of the nation’s most cohesive and experienced offensive lines. The Irish thrive when they establish tempo through the ground game, forcing defenses to crowd the box and opening up play-action opportunities for Carr to exploit downfield. Expect Notre Dame to lean on its physical offensive front to wear down USC’s defensive line, which has struggled in recent years against power-oriented teams. If Love and the Irish running backs can consistently churn out yardage on early downs, Notre Dame will be able to dictate pace and keep USC’s explosive offense on the sideline. Defensively, the Irish bring a blend of experience and explosiveness that has been the cornerstone of their success this season.

The defensive line, anchored by Howard Cross III and Rylie Mills, excels at collapsing pockets and controlling interior gaps, setting the tone for a unit that prides itself on limiting big plays. Linebackers Jack Kiser and JD Bertrand provide veteran leadership and outstanding instincts, often diagnosing plays before they fully develop. On the back end, cornerback Benjamin Morrison and safety Xavier Watts form one of the nation’s most formidable defensive duos, combining exceptional coverage skills with playmaking instincts that have turned momentum in Notre Dame’s favor multiple times this season. Their assignment will be challenging—containing USC’s vertical passing game led by Jayden Maiava and Zachariah Branch—but the Irish defense has proven capable of rising to the occasion in high-pressure environments. Special teams could also play a major role, with Spencer Shrader’s reliable leg and a disciplined coverage unit giving Notre Dame a potential edge in field position battles. Ultimately, Notre Dame’s formula for victory remains clear: control the clock with its run game, stay disciplined defensively, and capitalize on USC’s occasional lapses in ball security and tackling. Under the lights at Notre Dame Stadium, with the energy of a playoff-like atmosphere fueling them, the Irish will look to combine physical dominance and precise execution to not only defend their home turf but also make a statement that their balanced, fundamentally sound approach can still triumph over even the most explosive offenses in the country.

USC vs. Notre Dame Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the Trojans and Fighting Irish play there’s always several intriguing trends to key in on. Not to mention games played at Notre Dame Stadium in Oct almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: E. Raridon under 37.5 Receiving Yards.

USC vs. Notre Dame Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every facet between the Trojans and Fighting Irish and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

Remi has been most fixated on the linear correlation of factor human bettors often put on USC’s strength factors between a Trojans team going up against a possibly unhealthy Fighting Irish team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI USC vs Notre Dame picks, computer picks Trojans vs Fighting Irish, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Trojans Betting Trends

USC has been solid against the spread this season, covering in several games even when not as dominant—as bettors have given credence to their rising trajectory under Riley.

Fighting Irish Betting Trends

Notre Dame’s home ATS performance is mixed: when they control the trenches and limit turnovers, they generally cover; when their defense allows explosive plays, the spread tends to slip.

Trojans vs. Fighting Irish Matchup Trends

In Notre Dame–USC games over the past decade, the under has hit about 80% of the time, suggesting this rivalry often features tighter, lower-scoring contests than lines project.

USC vs. Notre Dame Game Info

USC vs Notre Dame starts on October 18, 2025 at 7:30 PM EST.

Venue: Notre Dame Stadium.

Spread: Notre Dame -7.5
Moneyline: USC +242, Notre Dame -304
Over/Under: 61.5

USC: (5-1)  |  Notre Dame: (4-2)

Remi's searched hard and found the best prop for this matchup: E. Raridon under 37.5 Receiving Yards.. Prices move—always shop for the best number.

In Notre Dame–USC games over the past decade, the under has hit about 80% of the time, suggesting this rivalry often features tighter, lower-scoring contests than lines project.

USC trend: USC has been solid against the spread this season, covering in several games even when not as dominant—as bettors have given credence to their rising trajectory under Riley.

ND trend: Notre Dame’s home ATS performance is mixed: when they control the trenches and limit turnovers, they generally cover; when their defense allows explosive plays, the spread tends to slip.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

USC vs. Notre Dame Odds

AI algorithm Remi is pouring through mountains of data on each team. In fact, anytime the USC vs Notre Dame trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.

USC vs Notre Dame Opening Odds

USC Moneyline: +242
ND Moneyline: -304
USC Spread: +7.5
ND Spread: -7.5
Over/Under: 61.5

USC vs Notre Dame Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-360
 
-9.5 (-105)
O 55 (-118)
U 55 (-107)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-115
-105
-1 (-110)
+1 (-110)
O 51 (-110)
U 51 (-110)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-240
+185
-6.5 (-112)
+6.5 (-109)
O 56 (-110)
U 56 (-112)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4500
+1550
-26.5 (-110)
+26.5 (-110)
O 61.5 (-105)
U 61.5 (-115)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+160
-205
+4.5 (-110)
-4.5 (-110)
O 50 (-112)
U 50 (-110)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1700
+950
-21.5 (-110)
+21.5 (-110)
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-400
+310
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-305
+240
-7.5 (-105)
+7.5 (-115)
O 48.5 (-110)
U 48.5 (-110)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+115
-2.5 (-110)
+2.5 (-110)
O 58.5 (-110)
U 58.5 (-110)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-210
+175
-5 (-110)
+5 (-110)
O 63.5 (-110)
U 63.5 (-110)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1200
-5000
+25.5 (-113)
-25.5 (-108)
O 54.5 (-115)
U 54.5 (-106)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+228
-285
+7 (-110)
-7 (-110)
O 43 (-110)
U 43 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-480
+360
-12.5 (-110)
+12.5 (-110)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-175
+148
-3.5 (-110)
+3.5 (-110)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+600
-1000
+17.5 (-112)
-17.5 (-109)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-600
 
-14.5 (-110)
O 63 (-110)
U 63 (-110)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+180
-220
+5 (-110)
-5 (-110)
O 54 (-110)
U 54 (-110)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+130
-155
+3 (-110)
-3 (-110)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
+100
-120
+1 (-110)
-1 (-110)
O 57 (-110)
U 57 (-110)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+285
-365
+9.5 (-110)
-9.5 (-110)
O 48 (-115)
U 48 (-105)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-420
+320
-10.5 (-115)
+10.5 (-105)
O 49 (-110)
U 49 (-110)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+130
-155
+3 (-110)
-3 (-110)
O 61.5 (-110)
U 61.5 (-110)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+270
-345
+8.5 (-110)
-8.5 (-110)
O 39 (-110)
U 39 (-110)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-480
+360
-12 (-110)
+12 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+120
-152
+2.5 (-105)
-2.5 (-117)
O 48.5 (-115)
U 48.5 (-106)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-225
+185
-6 (-110)
+6 (-110)
O 54 (-110)
U 54 (-110)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+175
-210
+5.5 (-110)
-5.5 (-110)
O 41 (-110)
U 41 (-110)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-105
-115
+1 (-110)
-1 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+475
-750
+15.5 (-110)
-15.5 (-110)
O 62.5 (-113)
U 62.5 (-108)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+162
-195
+4.5 (-110)
-4.5 (-110)
O 54 (-110)
U 54 (-110)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-800
 
-16.5 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-155
+130
-3 (-110)
+3 (-110)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+118
-140
+2.5 (-110)
-2.5 (-110)
O 52.5 (-105)
U 52.5 (-115)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+200
-260
+6.5 (-107)
-6.5 (-114)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+105
 
+1.5 (-110)
 
O 41 (-110)
U 41 (-110)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+335
 
+11 (-110)
 
O 50.5 (-110)
U 50.5 (-110)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+2800
-10000
+38.5 (-114)
-38.5 (-107)
O 56.5 (-110)
U 56.5 (-112)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+162
-195
+4.5 (-110)
-4.5 (-110)
O 67.5 (-110)
U 67.5 (-110)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-267
+215
-7 (-105)
+7 (-115)
O 44.5 (-115)
U 44.5 (-105)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-750
+450
-15.5 (-110)
+15.5 (-110)
O 55.5 (-107)
U 55.5 (-114)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+33.5 (-110)
-33.5 (-110)
O 44.5 (-110)
U 44.5 (-110)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+270
-345
+9.5 (-110)
-9.5 (-110)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+4000
-30000
+30 (-109)
-30 (-112)
O 45.5 (-112)
U 45.5 (-109)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 62.5 (-110)
U 62.5 (-110)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-650
+460
-14.5 (-115)
+14.5 (-105)
O 48 (-110)
U 48 (-110)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-145
+122
-2.5 (-115)
+2.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1350
-3500
+25.5 (-110)
-25.5 (-110)
O 55 (-110)
U 55 (-110)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+185
-225
+5.5 (-110)
-5.5 (-110)
O 46.5 (-110)
U 46.5 (-110)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-360
+275
-9.5 (-107)
+9.5 (-114)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+235
-310
+7.5 (-115)
-7.5 (-107)
O 47 (-110)
U 47 (-110)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+400
-550
+13.5 (-110)
-13.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-275
+220
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-200
+164
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-430
+330
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+150
-182
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers USC Trojans vs. Notre Dame Fighting Irish on October 18, 2025 at Notre Dame Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN