Pittsburgh vs Syracuse Prediction — AI Finds CAN'T MISS CFB Lines & Props (Oct 18)

Updated: 2025-10-11T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

Pittsburgh travels to Syracuse on October 18, 2025, to face an Orange squad eager to protect home turf in a rivalry that carries considerable historical weight. The Panthers enter this matchup riding momentum and a newly stabilized offense, while the Orange must rediscover consistency in order to stay competitive in the ACC.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Oct 18, 2025

Start Time: 7:30 PM EST​

Venue: JMA Wireless Dome​

Orange Record: (3-3)

Panthers Record: (4-2)

OPENING ODDS

PITT Moneyline: -427

CUSE Moneyline: +329

PITT Spread: -11.5

CUSE Spread: +11.5

Over/Under: 56.5

PITT
Betting Trends

  • Pittsburgh has shown mixed performances ATS on the road in 2025, but when their offense is balanced and turnover-averse, they tend to cover even as underdogs.

CUSE
Betting Trends

  • Syracuse has had better ATS outcomes at home this season, leveraging familiarity and crowd backing, especially when they avoid defensive breakdowns late.

MATCHUP TRENDS

  • In recent Syracuse–Pittsburgh matchups, when Pittsburgh rushes for over 180 yards, they’ve covered the spread in over 70% of those games—suggesting the ground game could be a determining edge in this contest.

PITT vs. CUSE
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Johnson under 59.5 Receiving Yards.

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Pittsburgh vs Syracuse Prediction & Odds:
Free CFB Betting Insights for 10/18/25

The upcoming ACC clash between the Pittsburgh Panthers and the Syracuse Orange on October 18, 2025, brings together two programs desperate to define their conference trajectory and prove they belong in the upper half of the standings. These two teams, separated by just a few hundred miles and a long history of physical, defense-first football, often turn their matchups into gritty, momentum-swinging contests where execution and discipline outweigh flash and finesse. Pittsburgh enters this game with a sense of stability under head coach Pat Narduzzi, whose emphasis on toughness and gap integrity remains the backbone of the program. The Panthers’ offense has begun to find its rhythm thanks to quarterback Mason Heintschel’s composure and efficiency, coupled with the steady production of running back Desmond Reid, whose mix of burst and vision has been pivotal in sustaining drives. When Pittsburgh establishes the run, its offense opens up vertical opportunities for Heintschel to target key weapons like Konata Mumpfield and Bub Means, giving the Panthers a balanced identity that keeps defenses guessing. The offensive line has also shown improved chemistry and communication, reducing sacks and creating cleaner pockets for Heintschel to operate within. On the defensive side, Pittsburgh remains as physical as ever, anchored by a front seven that thrives on disruption and penetration. The combination of Dayon Hayes off the edge and Bangally Kamara’s versatility at linebacker gives the Panthers flexibility to bring pressure from multiple angles.

They’ve excelled at forcing negative plays, ranking near the top of the ACC in tackles for loss and sacks, which could spell trouble for a Syracuse offensive line that has struggled at times in pass protection. The secondary, led by MJ Devonshire and Javon McIntyre, has made strides in coverage discipline but must avoid giving up deep shots to a Syracuse passing game that can hit quickly when its timing is right. For the Orange, this matchup serves as a test of resilience and rhythm under head coach Fran Brown, who continues to retool a team that has battled inconsistency this season. Syracuse’s offense revolves around establishing tempo and rhythm through quarterback Kyle McCord, whose command has improved but still occasionally wavers under heavy pressure. Running back Yasin Willis gives the offense balance, while receivers Darrell Gill Jr. and Oronde Gadsden II stretch the field and challenge defenses vertically. Defensively, Syracuse’s challenge will be finding ways to contain Pittsburgh’s physical ground attack without overcommitting resources and leaving the secondary exposed. The front seven, led by Caleb Okechukwu and Denis Jaquez Jr., must hold firm in the trenches and limit yards after contact. The Orange’s defense has thrived when generating turnovers, so timely takeaways could prove critical in shifting momentum. Ultimately, this matchup may hinge on efficiency in the red zone and ball security, two areas that have haunted both programs at times. If Pittsburgh can maintain offensive balance and win early downs, they’ll have the upper hand in controlling tempo and dictating terms. But if Syracuse’s defense stiffens at home and the passing game can capitalize on chunk plays, the Orange could turn this rivalry into one of Week 8’s most compelling ACC upsets.

Pittsburgh Panthers CFB Preview

The Pittsburgh Panthers head into their Week 8 showdown against Syracuse with growing confidence and a clear offensive identity that has begun to solidify after some early-season inconsistency. Under head coach Pat Narduzzi, Pittsburgh has reestablished its core values—discipline, physicality, and defensive toughness—while steadily improving its execution on the offensive side of the ball. Quarterback Mason Heintschel has emerged as a reliable leader, managing games with poise and displaying a strong command of the offense. His efficiency and decision-making have helped limit turnovers, and his chemistry with wide receivers Konata Mumpfield and Bub Means has elevated the Panthers’ passing attack to one of the more underrated units in the ACC. Pittsburgh’s offense thrives when Heintschel operates within rhythm, utilizing play-action to keep defenses off-balance and taking advantage of one-on-one matchups downfield. The running game, led by Desmond Reid, remains the foundation of their approach. Reid’s combination of burst and patience has allowed the Panthers to control time of possession and keep opposing defenses guessing, particularly when mixed with their heavy use of motion and zone blocking concepts. The offensive line, which faced scrutiny earlier in the year, has shown measurable improvement in both protection and push, paving the way for sustained drives and red-zone success.

Defensively, Pittsburgh’s identity remains tied to its ferocious front seven, a hallmark of Narduzzi’s tenure. Edge rusher Dayon Hayes continues to be a game-wrecker capable of dictating protection schemes, while linebacker Bangally Kamara’s range and instincts make him a vital piece in both coverage and run support. The Panthers’ defense ranks among the ACC’s best in generating pressure and forcing opponents into long third downs, often flipping field position with disruptive plays. Against Syracuse, Pittsburgh will need that same relentless approach to neutralize the Orange’s tempo-based attack. Syracuse quarterback Kyle McCord can be dangerous when given time, so maintaining gap integrity and disciplined rush lanes will be crucial to avoid giving up scrambles or broken plays. On the back end, cornerbacks MJ Devonshire and Marquis Williams will face the tough task of containing receivers Oronde Gadsden II and Darrell Gill Jr., both capable of stretching the field and breaking tackles after the catch. The Panthers have excelled at forcing turnovers in recent weeks, and those takeaways could play a deciding role in this matchup, particularly in what could be a hostile road environment. Special teams may also factor heavily, as field position and composure often decide games of this nature. If Pittsburgh can establish the run early, sustain drives, and limit big plays defensively, they’ll be well-positioned to grind out another statement road win. For Narduzzi’s squad, this matchup is more than just another game—it’s a chance to prove that their brand of disciplined, hard-nosed football can travel anywhere and that their recent momentum is no fluke as they push toward bowl contention in the second half of the season.

Pittsburgh travels to Syracuse on October 18, 2025, to face an Orange squad eager to protect home turf in a rivalry that carries considerable historical weight. The Panthers enter this matchup riding momentum and a newly stabilized offense, while the Orange must rediscover consistency in order to stay competitive in the ACC. Pittsburgh vs Syracuse AI Prediction: Free CFB Betting Insights for Oct 18. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Syracuse Orange CFB Preview

The Syracuse Orange return to the JMA Wireless Dome for their Week 8 matchup against the Pittsburgh Panthers, hoping to regain consistency and defend their home turf in a series that has historically been defined by grit and defensive intensity. Head coach Fran Brown has made clear strides in transforming Syracuse into a more dynamic and balanced football team, but inconsistency has plagued the Orange throughout the season—particularly on offense, where rhythm and execution have been fleeting. Quarterback Kyle McCord leads the unit with a strong arm and growing command of the offense, showing flashes of precision when given time to operate, but his biggest challenge has been dealing with pressure. Pittsburgh’s aggressive defensive front is likely to test that pocket composure early and often. McCord’s connection with standout receiver Oronde Gadsden II remains the focal point of the passing game, as Gadsden’s size and route-running ability make him a matchup nightmare for opposing secondaries. Wideout Darrell Gill Jr. has emerged as a complementary deep threat, stretching defenses and opening underneath windows for quick throws. The key for Syracuse will be sustaining drives and avoiding predictable third-and-long situations that invite Pittsburgh’s blitz packages. Running back Yasin Willis has provided toughness and balance to the offense, capable of moving the chains and keeping the defense honest, but the offensive line must create lanes and improve its cohesion against one of the ACC’s most physical fronts.

On defense, Syracuse’s success will hinge on limiting Pittsburgh’s rushing attack and containing quarterback Mason Heintschel’s efficiency in the short-to-intermediate passing game. The front seven, led by veteran linemen Caleb Okechukwu and Denis Jaquez Jr., must collapse the pocket while maintaining gap control to avoid being gashed by Desmond Reid’s powerful running style. Linebackers Marlowe Wax and Leon Lowery will play critical roles in diagnosing play-action and covering tight ends in space. In the secondary, safety Justin Barron provides leadership and range, but the corners will face a stiff challenge against Konata Mumpfield and Bub Means—both capable of turning routine plays into big gains. Syracuse’s defense thrives when it can generate turnovers and force offenses into mistakes, so opportunistic play in the secondary could be the difference-maker. Special teams have been a strength this season, with punter Jack Stonehouse consistently flipping field position and kicker Brady Denaburg providing reliability from distance. The home crowd at the Dome will add another layer of intensity, and if Syracuse can channel that energy into disciplined, mistake-free football, they have the tools to challenge Pittsburgh for four quarters. To pull off the win, the Orange must start fast, protect McCord, and capitalize on every red-zone opportunity—a combination that has often eluded them in close games. If Brown’s team can stay balanced offensively and avoid self-inflicted errors, Syracuse could earn a much-needed conference victory and reassert itself as a program on the rise within the ACC hierarchy.

Pittsburgh vs. Syracuse Prop Picks (AI)

Remi is pouring through mountains of datapoints on each player. In fact, anytime the Panthers and Orange play there’s always several intriguing trends to key in on. Not to mention games played at JMA Wireless Dome in Oct rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: K. Johnson under 59.5 Receiving Yards.

Pittsburgh vs. Syracuse Prediction (AI)

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Remi, our AI sports wizard, has been pouring over millions of data from every facet between the Panthers and Orange and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

The Algorithm has been most watching on the trending emphasis human bettors tend to put on Pittsburgh’s strength factors between a Panthers team going up against a possibly improved Orange team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.

Below is our current AI Pittsburgh vs Syracuse picks, computer picks Panthers vs Orange, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
CFB 10/21 KENSAW@FIU UNLOCK THIS PICK 3 EXECUTIVE Locked EXECUTIVE
CFB 10/21 WKY@LATECH UNLOCK THIS PICK 2 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule

Panthers Betting Trends

Pittsburgh has shown mixed performances ATS on the road in 2025, but when their offense is balanced and turnover-averse, they tend to cover even as underdogs.

Orange Betting Trends

Syracuse has had better ATS outcomes at home this season, leveraging familiarity and crowd backing, especially when they avoid defensive breakdowns late.

Panthers vs. Orange Matchup Trends

In recent Syracuse–Pittsburgh matchups, when Pittsburgh rushes for over 180 yards, they’ve covered the spread in over 70% of those games—suggesting the ground game could be a determining edge in this contest.

Pittsburgh vs. Syracuse Game Info

Pittsburgh vs Syracuse starts on October 18, 2025 at 7:30 PM EST.

Spread: Syracuse +11.5
Moneyline: Pittsburgh -427, Syracuse +329
Over/Under: 56.5

Pittsburgh: (4-2)  |  Syracuse: (3-3)

Remi's searched hard and found the best prop for this matchup: K. Johnson under 59.5 Receiving Yards.. Prices move—always shop for the best number.

In recent Syracuse–Pittsburgh matchups, when Pittsburgh rushes for over 180 yards, they’ve covered the spread in over 70% of those games—suggesting the ground game could be a determining edge in this contest.

PITT trend: Pittsburgh has shown mixed performances ATS on the road in 2025, but when their offense is balanced and turnover-averse, they tend to cover even as underdogs.

CUSE trend: Syracuse has had better ATS outcomes at home this season, leveraging familiarity and crowd backing, especially when they avoid defensive breakdowns late.

See our latest CFB picks and odds pages for 2025 to compare prices before you bet.

Pittsburgh vs. Syracuse Odds

AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Pittsburgh vs Syracuse trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

Pittsburgh vs Syracuse Opening Odds

PITT Moneyline: -427
CUSE Moneyline: +329
PITT Spread: -11.5
CUSE Spread: +11.5
Over/Under: 56.5

Pittsburgh vs Syracuse Live Odds

Games PTS ML SPR O/U
Oct 22, 2025 7:30PM EDT
MTSU Blue Raiders
Delaware Blue Hens
10/22/25 7:30PM
MTSU
DEL
 
-360
 
-9.5 (-108)
O 55.5 (-108)
U 55.5 (-112)
Oct 22, 2025 9:00PM EDT
Missouri State Bears
New Mexico State Aggies
10/22/25 9PM
MIZZST
NMEXST
-110
-110
-1.5 (-102)
+1.5 (-118)
O 50.5 (-112)
U 50.5 (-108)
Oct 23, 2025 7:30PM EDT
South Alabama Jaguars
Georgia State Panthers
10/23/25 7:30PM
SBAMA
GAST
-230
+190
-6.5 (-112)
+6.5 (-108)
O 55.5 (-112)
U 55.5 (-108)
Oct 24, 2025 7:00PM EDT
North Texas Mean Green
Charlotte 49ers
10/24/25 7PM
NOTEX
CHARLO
-4000
+1600
-26.5 (-112)
+26.5 (-108)
O 61.5 (-105)
U 61.5 (-115)
Oct 24, 2025 7:30PM EDT
California Golden Bears
Virginia Tech Hokies
10/24/25 7:30PM
CAL
VATECH
+164
-198
+4.5 (-110)
-4.5 (-110)
O 50.5 (-108)
U 50.5 (-112)
Oct 24, 2025 10:00PM EDT
Boise State Broncos
Nevada Wolf Pack
10/24/25 10PM
BOISE
NEVADA
-1800
+1000
-21.5 (-105)
+21.5 (-115)
O 50.5 (-108)
U 50.5 (-112)
Oct 25, 2025 12:00PM EDT
Virginia Cavaliers
North Carolina Tar Heels
10/25/25 12PM
UVA
UNC
-395
+310
-10.5 (-108)
+10.5 (-112)
O 51.5 (-110)
U 51.5 (-110)
Oct 25, 2025 12:00PM EDT
Bowling Green Falcons
Kent State Golden Flashes
10/25/25 12PM
BGREEN
KENT
-285
+230
-7.5 (-105)
+7.5 (-115)
O 48.5 (-108)
U 48.5 (-112)
Oct 25, 2025 12:00PM EDT
Rutgers Scarlet Knights
Purdue Boilermakers
10/25/25 12PM
RUT
PURDUE
-135
+114
-2.5 (-112)
+2.5 (-108)
O 58.5 (-112)
U 58.5 (-108)
Oct 25, 2025 12:00PM EDT
South Florida Bulls
Memphis Tigers
10/25/25 12PM
SFLA
MEMP
-205
+170
-4.5 (-112)
+4.5 (-108)
O 63.5 (-108)
U 63.5 (-112)
Oct 25, 2025 12:00PM EDT
UCLA Bruins
Indiana Hoosiers
10/25/25 12PM
UCLA
IND
+1400
-3200
+25.5 (-115)
-25.5 (-105)
O 54.5 (-115)
U 54.5 (-105)
Oct 25, 2025 12:00PM EDT
Northwestern Wildcats
Nebraska Cornhuskers
10/25/25 12PM
NWEST
NEB
+240
-298
+7.5 (-112)
-7.5 (-108)
O 43.5 (-110)
U 43.5 (-110)
Oct 25, 2025 12:00PM EDT
Ohio Bobcats
Eastern Michigan Eagles
10/25/25 12PM
OHIO
EMICH
-455
+350
-12.5 (-108)
+12.5 (-112)
O 59.5 (-110)
U 59.5 (-110)
Oct 25, 2025 12:00PM EDT
SMU Mustangs
Wake Forest Demon Deacons
10/25/25 12PM
SMU
WAKE
-170
+142
-3.5 (-105)
+3.5 (-115)
O 54.5 (-105)
U 54.5 (-115)
Oct 25, 2025 12:00PM EDT
Syracuse Orange
Georgia Tech Yellow Jackets
10/25/25 12PM
CUSE
GATECH
+625
-950
+17.5 (-110)
-17.5 (-110)
O 53.5 (-110)
U 53.5 (-110)
Oct 25, 2025 12:00PM EDT
App State Mountaineers
Old Dominion Monarchs
10/25/25 12PM
APPST
OLDDOM
 
-625
 
-14.5 (-108)
O 62.5 (-115)
U 62.5 (-105)
Oct 25, 2025 12:00PM EDT
Ole Miss Rebels
Oklahoma Sooners
10/25/25 12PM
OLEMISS
OKLA
+170
-205
+4.5 (-105)
-4.5 (-115)
O 54.5 (-108)
U 54.5 (-112)
Oct 25, 2025 12:00PM EDT
Kansas State Wildcats
Kansas Jayhawks
10/25/25 12PM
KSTATE
KANSAS
+124
-148
+3 (-112)
-3 (-108)
O 56.5 (-115)
U 56.5 (-105)
Oct 25, 2025 12:45PM EDT
Auburn Tigers
Arkansas Razorbacks
10/25/25 12:45PM
AUBURN
ARK
-105
-115
+1.5 (-115)
-1.5 (-105)
O 56.5 (-112)
U 56.5 (-108)
Oct 25, 2025 1:00PM EDT
Akron Zips
Buffalo Bulls
10/25/25 1PM
AKRON
BUFF
+285
-360
+9.5 (-110)
-9.5 (-110)
O 47.5 (-108)
U 47.5 (-112)
Oct 25, 2025 3:00PM EDT
UConn Huskies
Rice Owls
10/25/25 3PM
UCONN
RICE
-395
+310
-10.5 (-110)
+10.5 (-110)
O 49.5 (-105)
U 49.5 (-115)
Oct 25, 2025 3:00PM EDT
Utah State Aggies
New Mexico Lobos
10/25/25 3PM
UTAHST
NMEX
+130
-155
+3 (-112)
-3 (-108)
O 61.5 (-112)
U 61.5 (-108)
Oct 25, 2025 3:30PM EDT
Minnesota Golden Gophers
Iowa Hawkeyes
10/25/25 3:30PM
MINN
IOWA
+275
-345
+8.5 (-108)
-8.5 (-112)
O 39.5 (-108)
U 39.5 (-112)
Oct 25, 2025 3:30PM EDT
Alabama Crimson Tide
South Carolina Gamecocks
10/25/25 3:30PM
BAMA
SC
-455
+350
-12.5 (-110)
+12.5 (-110)
O 47.5 (-108)
U 47.5 (-112)
Oct 25, 2025 3:30PM EDT
BYU Cougars
Iowa State Cyclones
10/25/25 3:30PM
BYU
IOWAST
+124
-148
+2.5 (-102)
-2.5 (-118)
O 48.5 (-112)
U 48.5 (-108)
Oct 25, 2025 3:30PM EDT
Temple Owls
Tulsa Golden Hurricane
10/25/25 3:30PM
TEMPLE
TULSA
-230
+190
-6 (-110)
+6 (-110)
O 53.5 (-112)
U 53.5 (-108)
Oct 25, 2025 3:30PM EDT
Ball State Cardinals
Northern Illinois Huskies
10/25/25 3:30PM
BALLST
NILL
+185
-225
+5.5 (-112)
-5.5 (-108)
O 41.5 (-105)
U 41.5 (-115)
Oct 25, 2025 3:30PM EDT
Toledo Rockets
Washington State Cougars
10/25/25 3:30PM
TOLEDO
WASHST
-108
-112
+1.5 (-115)
-1.5 (-105)
O 46.5 (-108)
U 46.5 (-112)
Oct 25, 2025 3:30PM EDT
Florida Atlantic Owls
Navy Midshipmen
10/25/25 3:30PM
FAU
NAVY
+455
-625
+15.5 (-108)
-15.5 (-112)
O 62.5 (-112)
U 62.5 (-108)
Oct 25, 2025 3:30PM EDT
Illinois Fighting Illini
Washington Huskies
10/25/25 3:30PM
ILL
WASH
+164
-198
+4.5 (-110)
-4.5 (-110)
O 53.5 (-115)
U 53.5 (-105)
Oct 25, 2025 3:30PM EDT
Umass Minutemen
Central Michigan Chippewas
10/25/25 3:30PM
UMASS
CMICH
 
-675
 
-16.5 (-108)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 3:30PM EDT
San Diego State Aztecs
Fresno State Bulldogs
10/25/25 3:30PM
SDGST
FRESNO
-148
+124
-3 (-105)
+3 (-115)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 3:30PM EDT
Missouri Tigers
Vanderbilt Commodores
10/25/25 3:30PM
MIZZOU
VANDY
+120
-142
+2.5 (-105)
-2.5 (-115)
O 52.5 (-105)
U 52.5 (-115)
Oct 25, 2025 3:30PM EDT
NC State Wolfpack
Pittsburgh Panthers
10/25/25 3:30PM
NCST
PITT
+205
-250
+6.5 (-108)
-6.5 (-112)
O 56.5 (-110)
U 56.5 (-110)
Oct 25, 2025 3:30PM EDT
Western Michigan Broncos
Miami Ohio Redhawks
10/25/25 3:30PM
WMICH
MIAOH
+102
 
+1.5 (-110)
 
O 41.5 (-108)
U 41.5 (-112)
Oct 25, 2025 3:30PM EDT
UL Monroe Warhawks
USM Golden Eagles
10/25/25 3:30PM
MONROE
USM
+340
 
+10.5 (-105)
 
O 50.5 (-112)
U 50.5 (-108)
Oct 25, 2025 4:00PM EDT
Oklahoma State Cowboys
Texas Tech Red Raiders
10/25/25 4PM
OKLAST
TXTECH
+3000
-10000
+37.5 (-102)
-37.5 (-118)
O 56.5 (-108)
U 56.5 (-112)
Oct 25, 2025 4:00PM EDT
Baylor Bears
Cincinnati Bearcats
10/25/25 4PM
BAYLOR
CINCY
+160
-192
+4 (-108)
-4 (-112)
O 66.5 (-115)
U 66.5 (-105)
Oct 25, 2025 4:15PM EDT
Texas Longhorns
Mississippi State Bulldogs
10/25/25 4:15PM
TEXAS
MISSST
-265
+215
-7 (-105)
+7 (-115)
O 45.5 (-105)
U 45.5 (-115)
Oct 25, 2025 6:00PM EDT
TCU Horned Frogs
West Virginia Mountaineers
10/25/25 6PM
TCU
WVU
-650
+470
-15.5 (-110)
+15.5 (-110)
O 55.5 (-102)
U 55.5 (-118)
Oct 25, 2025 7:00PM EDT
Wisconsin Badgers
Oregon Ducks
10/25/25 7PM
WISC
OREG
 
 
+32.5 (-105)
-32.5 (-115)
O 44.5 (-112)
U 44.5 (-108)
Oct 25, 2025 7:00PM EDT
Louisiana Ragin Cajuns
Troy Trojans
10/25/25 7PM
UL
TROY
+280
-355
+8.5 (-108)
-8.5 (-112)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:00PM EDT
Stanford Cardinal
Miami Hurricanes
10/25/25 7PM
STNFRD
MIAMI
+2000
-10000
+30.5 (-115)
-30.5 (-105)
O 45.5 (-105)
U 45.5 (-115)
Oct 25, 2025 7:00PM EDT
Georgia Southern Eagles
Arkansas State Red Wolves
10/25/25 7PM
GASO
ARKST
+100
-120
+1.5 (-110)
-1.5 (-110)
O 63.5 (-105)
U 63.5 (-115)
Oct 25, 2025 7:30PM EDT
Michigan Wolverines
Michigan State Spartans
10/25/25 7:30PM
MICH
MICHST
-600
+440
-14 (-115)
+14 (-105)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Texas A&M Aggies
LSU Tigers
10/25/25 7:30PM
TEXAM
LSU
-142
+120
-2.5 (-115)
+2.5 (-105)
O 47.5 (-115)
U 47.5 (-105)
Oct 25, 2025 7:30PM EDT
Boston College Eagles
Louisville Cardinals
10/25/25 7:30PM
BC
LVILLE
+1300
-2800
+25.5 (-110)
-25.5 (-110)
O 55.5 (-102)
U 55.5 (-118)
Oct 25, 2025 7:30PM EDT
Colorado State Rams
Wyoming Cowboys
10/25/25 7:30PM
COLOST
WYO
+180
-218
+5.5 (-110)
-5.5 (-110)
O 46.5 (-112)
U 46.5 (-108)
Oct 25, 2025 7:45PM EDT
Tennessee Volunteers
Kentucky Wildcats
10/25/25 7:45PM
TENN
UK
-345
+275
-9.5 (-108)
+9.5 (-112)
O 54.5 (-110)
U 54.5 (-110)
Oct 25, 2025 8:00PM EDT
Houston Cougars
Arizona State Sun Devils
10/25/25 8PM
HOU
ARIZST
+230
-285
+7.5 (-115)
-7.5 (-105)
O 46.5 (-115)
U 46.5 (-105)
Oct 25, 2025 10:15PM EDT
Colorado Buffaloes
Utah Utes
10/25/25 10:15PM
COLO
UTAH
+410
-550
+13.5 (-110)
-13.5 (-110)
O 49.5 (-112)
U 49.5 (-108)
Oct 28, 2025 8:00PM EDT
James Madison Dukes
Texas State Bobcats
10/28/25 8PM
JMAD
TEXST
-265
+215
-7.5 (-104)
+7.5 (-118)
O 60.5 (-112)
U 60.5 (-108)
Oct 30, 2025 7:30PM EDT
Tulane Green Wave
UTSA Roadrunners
10/30/25 7:30PM
TULANE
UTSA
-205
+168
-5.5 (-110)
+5.5 (-110)
O 52.5 (-112)
U 52.5 (-108)
Nov 1, 2025 12:00PM EDT
Penn State Nittany Lions
Ohio State Buckeyes
11/1/25 12PM
PSU
OHIOST
+660
-1050
+17.5 (-115)
-17.5 (-105)
O 47.5 (-110)
U 47.5 (-110)
Nov 1, 2025 12:00PM EDT
Miami Hurricanes
SMU Mustangs
11/1/25 12PM
MIAMI
SMU
-450
+340
-10.5 (-110)
+10.5 (-110)
O 51.5 (-110)
U 51.5 (-110)
Nov 1, 2025 12:00PM EDT
Oklahoma Sooners
Tennessee Volunteers
11/1/25 12PM
OKLA
TENN
-105
-114
+1.5 (-114)
-1.5 (-106)
O 53.5 (-112)
U 53.5 (-108)
Nov 1, 2025 12:00PM EDT
Vanderbilt Commodores
Texas Longhorns
11/1/25 12PM
VANDY
TEXAS
+146
-178
+3.5 (-106)
-3.5 (-114)
O 45.5 (-110)
U 45.5 (-110)
Nov 1, 2025 3:30PM EDT
Georgia Bulldogs
Florida Gators
11/1/25 3:30PM
UGA
FLA
-300
+240
-7.5 (-110)
+7.5 (-110)
O 50.5 (-112)
U 50.5 (-108)

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Pittsburgh Panthers vs. Syracuse Orange on October 18, 2025 at JMA Wireless Dome.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
FSU@STNFRD STNFRD +18 56.6% 6 WIN
WASHST@UVA WASHST +17.5 58.8% 8 WIN
NEVADA@NMEX NEVADA +13.5 57.8% 7 WIN
TEXAS@UK ARCH MANNING UNDER 1.5 PASS TD 56.1% 6 WIN
ARMY@TULANE ARMY +10 55.3% 5 WIN
SJST@UTAHST SJST +4 54.4% 4 LOSS
LVILLE@MIAMI LVILLE +12.5 56.5% 6 WIN
LVILLE@MIAMI CJ DANIELS UNDER 4.5 RECEPTIONS 54.4 4 LOSS
DEL@JAXST DEL -2.5 57.6% 6 LOSS
UTEP@SAMST UTEP -2.5 53.9% 3 WIN
FIU@WKY FIU +10.5 54.6% 4 WIN
ARKST@SALA ARKST +7.5 54.5% 4 WIN
ARKST@SALA JAYLEN RAYNOR UNDER 40.5 LONGEST PASS COMP 53.3% 3 WIN
SJST@WYO SJST -120 59.8% 7 LOSS
UMASS@KENTST KENTST -135 60.2% 6 WIN
NOILL@EMICH EMICH +2.5 53.9% 3 WIN
BYU@ARIZ ARIZ +2.5 54.2% 3 LOSS
OKLA@TEXAS OKLA +2.5 54.7% 4 LOSS
NMEX@BOISE NMEX +16.5 56.4% 6 WIN
WAKE@OREGST WAKE -2.5 56.7% 6 WIN
ULMON@COASTAL ULMON -2.5 56.8% 6 LOSS
IOWA@WISC WISC +4 54.8% 4 LOSS
TOLEDO@BGREEN TOLEDO -10 56.3% 6 LOSS
SFLA@NOTEX SFLA +2.5 54.3% 4 WIN
FRESNO@COLOST RICHIE ANDERSON III LONGEST RECEPTION UNDER 16.5 54.4% 4 LOSS
JAXST@SAMST SAMST +7.5 55.3% 5 WIN
USM@GAS GAS +3.5 57.4% 7 WIN
LIB@UTEP UTEP +2 54.5% 4 LOSS
SALA@TROY SALA -118 55.2% 4 LOSS
TULSA@MEMP MEMP -20.5 53.8% 3 WIN
JMAD@GAST GAST +20.5 54.6% 4 WIN
WAKE@VATECH VATECH -5.5 56.6% 6 LOSS
UNLV@WYO WYO +4.5 55.5% 5 LOSS
PSU@UCLA PSU -24.5 56.3% 6 LOSS
TXSTSM@ARKST TXSTSM -13 56.7% 6 LOSS
UVA@LVILLE ISAAC BROWN OVER 70.5 RUSH YDS 56.6% 6 LOSS
WVU@BYU WVU +20.5 54.7% 4 WIN
SAMST@NMEXST SAMST -1.5 54.1% 3 LOSS
EMICH@CMICH CMICH -148 62.8% 7 WIN
SDGST@NOILL SDGST -118 55.7% 3 WIN
BAMA@GEORGIA GEORGIA -125 58.7% 7 LOSS
TENN@MISSST MISSST +7.5 54.3% 4 WIN
UK@SC SC -5.5 54.8% 4 WIN
WKY@MIZZST MIZZST +4.5 55.6% 6 LOSS
JAXST@USM USM -3.5 56.0% 5 WIN
NMEXST@NMEX NMEX -14.5 56.9% 6 WIN
ARIZ@IOWAST ROCCO BECHT UNDER 1.5 PASS TDS 55.5% 5 WIN
TCU@ARIZST JOSH HOOVER PASS YDS UNDER 287.5 53.4% 3 WIN
ARIZST@BAYLOR BAYLOR -130 58.4% 6 LOSS
WYO@COLO WYO +13.5 54.1% 3 LOSS
TULANE@OLEMISS MISS -11.5 54.3% 4 WIN